{"id":"https://openalex.org/W2018781131","doi":"https://doi.org/10.1002/jmv.2180","title":"Effect of lack of Interleukin\u20104, Interleukin\u201012, Interleukin\u201018, or the Interferon\u2010\u03b3 receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice","display_name":"Effect of lack of Interleukin\u20104, Interleukin\u201012, Interleukin\u201018, or the Interferon\u2010\u03b3 receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice","publication_year":2002,"publication_date":"2002-02-05","ids":{"openalex":"https://openalex.org/W2018781131","doi":"https://doi.org/10.1002/jmv.2180","mag":"2018781131","pmid":"https://pubmed.ncbi.nlm.nih.gov/11857536"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.2180","doi":"https://doi.org/10.1002/jmv.2180","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.2180","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042061862","display_name":"Anita Boelen","orcid":"https://orcid.org/0000-0002-4994-2918","observed_orcids":["https://orcid.org/0000-0002-4994-2918"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anita Boelen","raw_affiliation_strings":["Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008669331","display_name":"Joan Kwakkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joan Kwakkel","raw_affiliation_strings":["Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053974549","display_name":"M. Barends","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marion Barends","raw_affiliation_strings":["Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090012673","display_name":"Lia de Rond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lia de Rond","raw_affiliation_strings":["Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103528846","display_name":"Jan A. M. A. Dormans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Dormans","raw_affiliation_strings":["Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109916062","display_name":"Tjeerd G. Kimman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Tjeerd Kimman","raw_affiliation_strings":["Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109916062"],"corresponding_institution_ids":["https://openalex.org/I4210104433"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":3.304,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91493515,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"66","issue":"4","first_page":"552","last_page":"560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.765999972820282},{"id":"https://openalex.org/keywords/interferon-gamma-receptor","display_name":"interferon-gamma receptor","score":0.746999979019165},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8880000114440918},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":1.0},{"id":"https://openalex.org/keywords/th1-cytokine-response","display_name":"Th1 cytokine response","score":0.6460000276565552},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bronchiolitis","display_name":"bronchiolitis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alveolitis","display_name":"alveolitis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pulmonary-pathology","display_name":"lung pathology","score":0.5929999947547913},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.6140000224113464},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6700000166893005},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.7466458678245544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7038578987121582},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6664685606956482},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6197558641433716},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.566547155380249},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5069049000740051},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.5036637187004089},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4843481779098511},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4749474823474884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4633316099643707},{"id":"https://openalex.org/C2780813555","wikidata":"https://www.wikidata.org/wiki/Q911129","display_name":"Paramyxoviridae","level":4,"score":0.4416464567184448},{"id":"https://openalex.org/C2780355102","wikidata":"https://www.wikidata.org/wiki/Q1753162","display_name":"Mononegavirales","level":5,"score":0.4391572177410126},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.4330650269985199},{"id":"https://openalex.org/C2781445406","wikidata":"https://www.wikidata.org/wiki/Q24802277","display_name":"Pneumovirinae","level":5,"score":0.41388288140296936},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3918590247631073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35807856917381287},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.23954248428344727},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2323266565799713}],"mesh":[{"descriptor_ui":"D000096743","descriptor_name":"Interferon gamma Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012136","descriptor_name":"Respiratory Syncytial Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D012136","descriptor_name":"Respiratory Syncytial Viruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/jmv.2180","doi":"https://doi.org/10.1002/jmv.2180","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.2180","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:11857536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11857536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/b34a77aa-49c7-4f40-8908-faa40285b927","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/effect-of-lack-of-interleukin4-interleukin12-interleukin18-or-the-interferongamma-receptor-on-virus-replication-cytokine-response-and-lung-pathology-during-respiratory-syncytial-virus-infection-in-mice(b34a77aa-49c7-4f40-8908-faa40285b927).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of medical virology, 66(4), 552 - 560. Wiley-Liss Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/d2378b1e-896c-4e37-90a6-7c5cfa2742ed","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/d2378b1e-896c-4e37-90a6-7c5cfa2742ed","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boelen, A, Kwakkel, J, Barends, M, de Rond, L, Dormans, J & Kimman, T 2002, 'Effect of lack of Interleukin-4, Interleukin-12, Interleukin-18, or the Interferon-gamma receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice', Journal of medical virology, vol. 66, no. 4, pp. 552-560. https://doi.org/10.1002/jmv.2180","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:rivm.openrepository.com:10029/639375","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/639375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1493525579","https://openalex.org/W1554745563","https://openalex.org/W1584081415","https://openalex.org/W1589443504","https://openalex.org/W1690149833","https://openalex.org/W1844215996","https://openalex.org/W1923297008","https://openalex.org/W1963943570","https://openalex.org/W2019834844","https://openalex.org/W2026161448","https://openalex.org/W2027079842","https://openalex.org/W2035789611","https://openalex.org/W2040015615","https://openalex.org/W2063053561","https://openalex.org/W2063982696","https://openalex.org/W2067343653","https://openalex.org/W2068871282","https://openalex.org/W2099048568","https://openalex.org/W2106538501","https://openalex.org/W2128212391","https://openalex.org/W2139144899","https://openalex.org/W2141687336","https://openalex.org/W2165396917","https://openalex.org/W2191608347","https://openalex.org/W2336979047"],"related_works":["https://openalex.org/W2027079842","https://openalex.org/W1666510860","https://openalex.org/W2059712674","https://openalex.org/W1900827432","https://openalex.org/W2031931151","https://openalex.org/W1966856632","https://openalex.org/W2078941506","https://openalex.org/W2070496619","https://openalex.org/W1541399456","https://openalex.org/W2142214375"],"abstract_inverted_index":{"RSV":[0,64,129,167],"is":[1,154,159,198],"an":[2,63],"important":[3],"cause":[4],"of":[5,32,113,148],"bronchiolitis":[6,16,76],"in":[7,14,43,67,84,98,103,107,132,150,176],"infants.":[8],"Immunopathology":[9],"may":[10],"play":[11],"a":[12,25,68,133,162,184],"role":[13],"RSV-induced":[15,19,45,119],"and":[17,77,109,122,142,145,170,181],"severe":[18],"disease":[20],"has":[21,115],"been":[22],"associated":[23,73],"with":[24,58,74],"Th2":[26,182,185],"type":[27],"immune":[28],"response.":[29],"The":[30],"aim":[31],"the":[33,93,146,151,177],"study":[34],"was":[35,81],"to":[36,166,193],"identify":[37],"cytokine":[38,71,99],"pathways":[39],"that":[40,48,62,156],"are":[41,172],"crucial":[42],"influencing":[44],"disease.":[46],"For":[47],"purpose":[49],"we":[50],"inoculated":[51],"IFNgammaR-/-,":[52],"IL-12-/-,":[53],"IL-18-/-,":[54],"or":[55],"IL-4-/-":[56],"mice":[57],"RSV.":[59],"We":[60],"observed":[61,106],"infection":[65,130],"resulted":[66,131],"predominant":[69],"Th1":[70,120,135,164,180],"response":[72,136,165,186],"slight":[75],"alveolitis.":[78],"Pulmonary":[79],"histopathology":[80,104],"only":[82],"aggravated":[83,194],"IFN":[85],"R-/-":[86],"mice,":[87],"characterised":[88],"by":[89,188,201],"eosinophilic":[90],"influx":[91],"around":[92],"bronchioles.":[94],"Despite":[95],"subtle":[96],"changes":[97],"expression,":[100],"no":[101,116],"differences":[102],"were":[105],"IL-12-/-":[108],"IL-18-/-":[110],"mice.":[111],"Deficiency":[112],"IL-4":[114],"effect":[117],"on":[118,138],"cytokines":[121],"pulmonary":[123,195],"histopathology.":[124],"IFNgamma-receptor":[125],"deficiency":[126],"during":[127],"primary":[128],"disturbed":[134],"based":[137],"increased":[139],"IL-4,":[140],"IL-5,":[141],"IL-13":[143],"expression":[144],"presence":[147],"eosinophils":[149],"lungs.":[152],"It":[153],"concluded":[155],"IFNgamma":[157,190],"signalling":[158,191],"required":[160],"for":[161],"pronounced":[163],"while":[168],"IL-12":[169],"IL-18":[171],"not.":[173],"A":[174],"shift":[175],"balance":[178],"between":[179],"towards":[183],"induced":[187],"missing":[189],"leads":[192],"pathology.":[196],"This":[197],"not":[199],"caused":[200],"enhanced":[202],"viral":[203],"load.":[204]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}