{"id":"https://openalex.org/W2018778191","doi":"https://doi.org/10.1371/journal.pone.0065744","title":"Cocoa Consumption Alters the Global DNA Methylation of Peripheral Leukocytes in Humans with Cardiovascular Disease Risk Factors: A Randomized Controlled Trial","display_name":"Cocoa Consumption Alters the Global DNA Methylation of Peripheral Leukocytes in Humans with Cardiovascular Disease Risk Factors: A Randomized Controlled Trial","publication_year":2013,"publication_date":"2013-06-26","ids":{"openalex":"https://openalex.org/W2018778191","doi":"https://doi.org/10.1371/journal.pone.0065744","mag":"2018778191","pmid":"https://pubmed.ncbi.nlm.nih.gov/23840361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3694105"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0065744","doi":"https://doi.org/10.1371/journal.pone.0065744","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0065744","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065744&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065744&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045738262","display_name":"Anna Crescenti","orcid":"https://orcid.org/0000-0001-8581-0616","observed_orcids":["https://orcid.org/0000-0001-8581-0616"]},"institutions":[{"id":"https://openalex.org/I4210095834","display_name":"Technological Center of Nutrition and Health","ror":"https://ror.org/00mzj5z57","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095834"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Anna Crescenti","raw_affiliation_strings":["Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain","institution_ids":["https://openalex.org/I4210095834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071646861","display_name":"Rosa Sol\u00e0","orcid":"https://orcid.org/0000-0002-8359-235X","observed_orcids":["https://orcid.org/0000-0002-8359-235X"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210101772","display_name":"Institut de Recerca Biom\u00e8dica Catalunya Sud","ror":"https://ror.org/01av3a615","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210101772","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210149100","display_name":"Hospital Universitari Sant Joan de Reus","ror":"https://ror.org/04f7pyb58","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210149100"]},{"id":"https://openalex.org/I55952717","display_name":"Universitat Rovira i Virgili","ror":"https://ror.org/00g5sqv46","country_code":"ES","type":"education","lineage":["https://openalex.org/I55952717"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Sol\u00e0","raw_affiliation_strings":["Unitat de Recerca en L\u00edpids i Arteriosclerosi, CIBERDEM, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Recerca en L\u00edpids i Arteriosclerosi, CIBERDEM, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain","institution_ids":["https://openalex.org/I4210092133","https://openalex.org/I4210101772","https://openalex.org/I4210149100","https://openalex.org/I55952717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073306842","display_name":"Rosa M. Valls","orcid":"https://orcid.org/0000-0002-3351-0942","observed_orcids":["https://orcid.org/0000-0002-3351-0942"]},"institutions":[{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210101772","display_name":"Institut de Recerca Biom\u00e8dica Catalunya Sud","ror":"https://ror.org/01av3a615","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210101772","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210149100","display_name":"Hospital Universitari Sant Joan de Reus","ror":"https://ror.org/04f7pyb58","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210149100"]},{"id":"https://openalex.org/I55952717","display_name":"Universitat Rovira i Virgili","ror":"https://ror.org/00g5sqv46","country_code":"ES","type":"education","lineage":["https://openalex.org/I55952717"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa M. Valls","raw_affiliation_strings":["Unitat de Recerca en L\u00edpids i Arteriosclerosi, CIBERDEM, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Recerca en L\u00edpids i Arteriosclerosi, CIBERDEM, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain","institution_ids":["https://openalex.org/I4210092133","https://openalex.org/I4210101772","https://openalex.org/I4210149100","https://openalex.org/I55952717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080541546","display_name":"Antoni Caimari","orcid":"https://orcid.org/0000-0001-6144-0294","observed_orcids":["https://orcid.org/0000-0001-6144-0294"]},"institutions":[{"id":"https://openalex.org/I4210095834","display_name":"Technological Center of Nutrition and Health","ror":"https://ror.org/00mzj5z57","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095834"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antoni Caimari","raw_affiliation_strings":["Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain","institution_ids":["https://openalex.org/I4210095834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084438598","display_name":"Josep M Del Bas-Prior","orcid":"https://orcid.org/0000-0002-0700-2004","observed_orcids":["https://orcid.org/0000-0002-0700-2004"]},"institutions":[{"id":"https://openalex.org/I4210095834","display_name":"Technological Center of Nutrition and Health","ror":"https://ror.org/00mzj5z57","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095834"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep M. del Bas","raw_affiliation_strings":["Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain","institution_ids":["https://openalex.org/I4210095834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040982465","display_name":"Anna Anguera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Anguera","raw_affiliation_strings":["Rottapharm/Madaus, S.L., Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rottapharm/Madaus, S.L., Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029118082","display_name":"Neus Angl\u00e8s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neus Angl\u00e9s","raw_affiliation_strings":["La Morella Nuts S.A.U., Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Morella Nuts S.A.U., Tarragona, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003416093","display_name":"Llu\u00eds Arola","orcid":"https://orcid.org/0000-0003-2767-1974","observed_orcids":["https://orcid.org/0000-0003-2767-1974"]},"institutions":[{"id":"https://openalex.org/I4210095834","display_name":"Technological Center of Nutrition and Health","ror":"https://ror.org/00mzj5z57","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095834"]},{"id":"https://openalex.org/I55952717","display_name":"Universitat Rovira i Virgili","ror":"https://ror.org/00g5sqv46","country_code":"ES","type":"education","lineage":["https://openalex.org/I55952717"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Llu\u00eds Arola","raw_affiliation_strings":["Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain","Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, Universitat Rovira i Virgili, Tarragona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Tecnol\u00f2gic de Nutrici\u00f3 i Salut (CTNS), TECNIO, Reus, Spain","institution_ids":["https://openalex.org/I4210095834"]},{"raw_affiliation_string":"Departament de Bioqu\u00edmica i Biotecnologia, Nutrigenomics Research Group, Universitat Rovira i Virgili, Tarragona, Spain","institution_ids":["https://openalex.org/I55952717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045738262"],"corresponding_institution_ids":["https://openalex.org/I4210095834"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9156,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.86300578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"8","issue":"6","first_page":"e65744","last_page":"e65744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12349","display_name":"Food Chemistry and Fat Analysis","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocoa-consumption","display_name":"cocoa consumption","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7519999742507935},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mtrr","display_name":"MTRR","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dnmt3b","display_name":"DNMT3B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2778087339","wikidata":"https://www.wikidata.org/wiki/Q18029587","display_name":"MTRR","level":5,"score":0.9158214330673218},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8453469276428223},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7140288352966309},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.6821191310882568},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6651926636695862},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5563358068466187},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.4875947833061218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4869481325149536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31258004903793335},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2788848876953125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.270242840051651},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.16090300679206848},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15299615263938904}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002099","descriptor_name":"Cacao","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0065744","doi":"https://doi.org/10.1371/journal.pone.0065744","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0065744","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065744&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2700115","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3694105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23840361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23840361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3694105","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3694105/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:urv.cat:imarina:9298170","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11797/imarina9298170","pdf_url":"https://repositori.urv.cat/repositori/getDocument/imarina%3A9298170?ds=DocumentPrincipal&amp;mime=application/pdf","source":{"id":"https://openalex.org/S7407055111","display_name":"Rovira & Virgili repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE. 8 (6): e65744-","raw_type":"Journal Publications"},{"id":"pmh:oai:doaj.org/article:0b373a1c917a43d3abb119363418029f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0b373a1c917a43d3abb119363418029f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 6, p e65744 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/732703","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Cocoa_Consumption_Alters_the_Global_DNA_Methylation_of_Peripheral_Leukocytes_in_Humans_with_Cardiovascular_Disease_Risk_Factors_A_Randomized_Controlled_Trial_/732703","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0065744","doi":"https://doi.org/10.1371/journal.pone.0065744","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0065744","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065744&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018778191.pdf","grobid_xml":"https://content.openalex.org/works/W2018778191.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1600800665","https://openalex.org/W1942149197","https://openalex.org/W1974851838","https://openalex.org/W1976618369","https://openalex.org/W1978230522","https://openalex.org/W1982356313","https://openalex.org/W1987220238","https://openalex.org/W1988050826","https://openalex.org/W2002314865","https://openalex.org/W2005734649","https://openalex.org/W2014203415","https://openalex.org/W2019841410","https://openalex.org/W2042461064","https://openalex.org/W2044783100","https://openalex.org/W2046387526","https://openalex.org/W2049767158","https://openalex.org/W2054020882","https://openalex.org/W2065833013","https://openalex.org/W2067093856","https://openalex.org/W2067691482","https://openalex.org/W2078750080","https://openalex.org/W2080261166","https://openalex.org/W2081219006","https://openalex.org/W2091047906","https://openalex.org/W2092344495","https://openalex.org/W2098602693","https://openalex.org/W2102516914","https://openalex.org/W2103368550","https://openalex.org/W2113305633","https://openalex.org/W2118668725","https://openalex.org/W2131509307","https://openalex.org/W2133112923","https://openalex.org/W2135965825","https://openalex.org/W2137595013","https://openalex.org/W2139002248","https://openalex.org/W2143033209","https://openalex.org/W2145564115","https://openalex.org/W2145921103","https://openalex.org/W2158380218","https://openalex.org/W2170134268"],"related_works":["https://openalex.org/W2588621673","https://openalex.org/W1982152565","https://openalex.org/W92911974","https://openalex.org/W3173755907","https://openalex.org/W421718512","https://openalex.org/W2883321302","https://openalex.org/W2948185620","https://openalex.org/W1986973529","https://openalex.org/W2619766079","https://openalex.org/W4399566309"],"abstract_inverted_index":{"UNLABELLED:":[0],"DNA":[1,30,46,57,74,138,155,172,217],"methylation":[2,31,47,58,75,156,173,218],"regulates":[3],"gene":[4],"expression":[5],"and":[6,48,110,144,174,182,200,247,261],"can":[7],"be":[8],"modified":[9],"by":[10,64],"different":[11],"bioactive":[12],"compounds":[13],"in":[14,29,55,61,70,77,83,178,186,222,254],"foods,":[15],"such":[16],"as":[17],"polyphenols.":[18],"Cocoa":[19,150],"is":[20,32],"a":[21,128],"rich":[22],"source":[23],"of":[24,42,136,196,212,219,244],"polyphenols,":[25],"but":[26],"its":[27],"role":[28],"still":[33],"unknown.":[34],"The":[35,72,93],"objective":[36],"was":[37],"to":[38,49,131],"assess":[39],"the":[40,52,56,62,78,116,133,137,154,168,179,188,193,197,206,210,215,242],"effect":[41,239],"cocoa":[43,66,104,129,169,189,213,235],"consumption":[44,151,211],"on":[45,171],"determine":[50],"whether":[51],"enzymes":[53],"involved":[54,253],"process":[59],"participate":[60],"mechanisms":[63],"which":[65,249],"exerts":[67],"these":[68],"effects":[69,170],"humans.":[71],"global":[73,216],"levels":[76,135,157,195],"peripheral":[79,117,220],"blood":[80,118],"were":[81,87,95,125],"evaluated":[82],"214":[84],"volunteers":[85,94],"who":[86,102],"pre-hypertensive,":[88],"stage-1":[89],"hypertensive":[90],"or":[91],"hypercholesterolemic.":[92],"divided":[96],"into":[97],"two":[98,108],"groups:":[99],"110":[100],"subjects":[101,124],"consumed":[103],"(6":[105],"g/d)":[106],"for":[107,205],"weeks":[109],"104":[111],"control":[112],"subjects.":[113],"In":[114,228],"addition,":[115],"mononuclear":[119],"cells":[120],"(PBMCs)":[121],"from":[122],"six":[123],"treated":[126],"with":[127,224,231],"extract":[130,190],"analyze":[132],"mRNA":[134,194],"methyltransferases":[139],"(DNMTs),":[140],"methylenetetrahydrofolate":[141],"reductase":[142,147],"(MTHFR),":[143],"methionine":[145],"synthase":[146],"(MTRR)":[148],"genes.":[149,184],"significantly":[152,191],"reduced":[153],"(2.991\u00b10.366":[158],"vs.":[159],"3.909\u00b10.380,":[160],"p<0.001).":[161],"Additionally,":[162],"we":[163],"found":[164],"an":[165],"association":[166],"between":[167],"three":[175],"polymorphisms":[176],"located":[177],"MTHFR,":[180,199],"MTRR,":[181,248],"DNMT3B":[183],"Furthermore,":[185],"PBMCs,":[187],"lowered":[192],"DNMTs,":[198,245],"MTRR.":[201],"Our":[202],"study":[203],"demonstrates":[204],"first":[207],"time":[208],"that":[209,234],"decreases":[214],"leukocytes":[221],"humans":[223],"cardiovascular":[225],"risk":[226],"factors.":[227],"vitro":[229],"experiments":[230],"PBMCs":[232],"suggest":[233],"may":[236],"exert":[237],"this":[238,255],"partially":[240],"via":[241],"down-regulation":[243],"MTHFR":[246],"are":[250],"key":[251],"genes":[252],"epigenetic":[256],"process.":[257],"TRIAL":[258],"REGISTRATION:":[259],"Clinicaltrials.govNCT00511420":[260],"NCT00502047.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
