{"id":"https://openalex.org/W2018753422","doi":"https://doi.org/10.1371/journal.pntd.0000998","title":"Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus","display_name":"Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus","publication_year":2011,"publication_date":"2011-03-29","ids":{"openalex":"https://openalex.org/W2018753422","doi":"https://doi.org/10.1371/journal.pntd.0000998","mag":"2018753422","pmid":"https://pubmed.ncbi.nlm.nih.gov/21468315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3066159"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0000998","doi":"https://doi.org/10.1371/journal.pntd.0000998","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0000998","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pntd.0000998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006420902","display_name":"Mike Yaw Osei-Atweneboana","orcid":"https://orcid.org/0000-0002-8541-5015","observed_orcids":["https://orcid.org/0000-0002-8541-5015"]},"institutions":[{"id":"https://openalex.org/I4210137126","display_name":"Council for Scientific and Industrial Research","ror":"https://ror.org/03ad6kn10","country_code":"GH","type":"facility","lineage":["https://openalex.org/I4210137126"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA","GH"],"is_corresponding":false,"raw_author_name":"Mike Y. Osei-Atweneboana","raw_affiliation_strings":["Institute of Parasitology, McGill University, Montreal, Canada","Council for Scientific and Industrial Research, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Parasitology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Council for Scientific and Industrial Research, Accra, Ghana","institution_ids":["https://openalex.org/I4210137126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419918","display_name":"Kwablah Awadzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwablah Awadzi","raw_affiliation_strings":["Onchocerciasis Chemotherapy Research Centre, Hohoe, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onchocerciasis Chemotherapy Research Centre, Hohoe, Ghana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111654050","display_name":"Simon Kwaku Attah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon K. Attah","raw_affiliation_strings":["Onchocerciasis Chemotherapy Research Centre, Hohoe, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onchocerciasis Chemotherapy Research Centre, Hohoe, Ghana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000076915","display_name":"Daniel Adjei Boakye","orcid":"https://orcid.org/0000-0001-6434-7298","observed_orcids":["https://orcid.org/0000-0001-6434-7298"]},"institutions":[{"id":"https://openalex.org/I138690464","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83","country_code":"GH","type":"education","lineage":["https://openalex.org/I138690464"]},{"id":"https://openalex.org/I4210091910","display_name":"Noguchi Memorial Institute for Medical Research","ror":"https://ror.org/00f1qr933","country_code":"GH","type":"nonprofit","lineage":["https://openalex.org/I138690464","https://openalex.org/I4210091910"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Daniel A. Boakye","raw_affiliation_strings":["Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana","institution_ids":["https://openalex.org/I138690464","https://openalex.org/I4210091910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009210238","display_name":"John Owusu Gyapong","orcid":"https://orcid.org/0000-0002-8415-1468","observed_orcids":["https://orcid.org/0000-0002-8415-1468"]},"institutions":[{"id":"https://openalex.org/I4210159584","display_name":"Ghana Health Service","ror":"https://ror.org/052ss8w32","country_code":"GH","type":"government","lineage":["https://openalex.org/I111406484","https://openalex.org/I4210159584"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"John O. Gyapong","raw_affiliation_strings":["Health Research Unit, Ghana Health Service, Accra, Ghana","Ochocerciasis Control Programme of Ghana, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Research Unit, Ghana Health Service, Accra, Ghana","institution_ids":["https://openalex.org/I4210159584"]},{"raw_affiliation_string":"Ochocerciasis Control Programme of Ghana, Accra, Ghana","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073368410","display_name":"Roger K. Prichard","orcid":"https://orcid.org/0000-0002-0601-2171","observed_orcids":["https://orcid.org/0000-0002-0601-2171"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Roger K. Prichard","raw_affiliation_strings":["Institute of Parasitology, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Parasitology, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073368410"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":16.3223,"has_fulltext":true,"cited_by_count":307,"citation_normalized_percentile":{"value":0.9958807,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"3","first_page":"e998","last_page":"e998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ivermectin-resistance","display_name":"ivermectin resistance","score":0.9789999723434448},{"id":"https://openalex.org/keywords/onchocerca-volvulus","display_name":"Onchocerca volvulus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/onchocerciasis","display_name":"onchocerciasis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/microfilaria-density","display_name":"microfilaria density","score":0.6029999852180481},{"id":"https://openalex.org/keywords/onchocerciasis-control","display_name":"onchocerciasis control","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2777499811","wikidata":"https://www.wikidata.org/wiki/Q415178","display_name":"Ivermectin","level":2,"score":0.958710253238678},{"id":"https://openalex.org/C2779027325","wikidata":"https://www.wikidata.org/wiki/Q137224","display_name":"Onchocerca volvulus","level":3,"score":0.9495527148246765},{"id":"https://openalex.org/C2780727990","wikidata":"https://www.wikidata.org/wiki/Q1137321","display_name":"Onchocerciasis","level":2,"score":0.8762502670288086},{"id":"https://openalex.org/C2779359454","wikidata":"https://www.wikidata.org/wiki/Q6839512","display_name":"Microfilaria","level":4,"score":0.8287777900695801},{"id":"https://openalex.org/C2776912151","wikidata":"https://www.wikidata.org/wiki/Q2679195","display_name":"Onchocerca","level":4,"score":0.5451331734657288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45402273535728455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4425012171268463},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.430752694606781},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2746148109436035},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.24970465898513794},{"id":"https://openalex.org/C2777629521","wikidata":"https://www.wikidata.org/wiki/Q815753","display_name":"Filariasis","level":3,"score":0.20161834359169006},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.18551567196846008}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005869","descriptor_name":"Ghana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017181","descriptor_name":"Onchocerca volvulus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017181","descriptor_name":"Onchocerca volvulus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pntd.0000998","doi":"https://doi.org/10.1371/journal.pntd.0000998","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0000998","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3066159","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3066159/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3066159/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2082240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3066159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21468315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21468315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.7899","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.7899","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5a/3b/PLoS_Negl_Trop_Dis_2011_Mar_29_5(3)_e998.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.974.7740","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.974.7740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ugspace.ug.edu.gh/bitstream/handle/123456789/1853/Phenotypic%20Evidence%20of%20Emerging%20Ivermectin%20Resistance%20in%20Onchocerca%20volvulus.pdf%3Bjsessionid%3D5E0E297F9A3D6DEC315323AE78EF80A4?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:cf8b428af2de45498343b6ef44635ead","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cf8b428af2de45498343b6ef44635ead","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e998 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/137921","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Phenotypic_Evidence_of_Emerging_Ivermectin_Resistance_in_Onchocerca_volvulus_/137921","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"mag:2230867996","doi":null,"is_oa":false,"landing_page_url":"http://ugspace.ug.edu.gh/handle/123456789/1853","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.60692/bt596-rg318","doi":"https://doi.org/10.60692/bt596-rg318","is_oa":true,"landing_page_url":"https://doi.org/10.60692/bt596-rg318","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/nga76-mwj79","doi":"https://doi.org/10.60692/nga76-mwj79","is_oa":true,"landing_page_url":"https://doi.org/10.60692/nga76-mwj79","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0000998","doi":"https://doi.org/10.1371/journal.pntd.0000998","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0000998","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6231813280","display_name":null,"funder_award_id":"94593","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018753422.pdf","grobid_xml":"https://content.openalex.org/works/W2018753422.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W178858234","https://openalex.org/W275128250","https://openalex.org/W1508588772","https://openalex.org/W1529910965","https://openalex.org/W1575449812","https://openalex.org/W1576728000","https://openalex.org/W1583221518","https://openalex.org/W1588946185","https://openalex.org/W1970947514","https://openalex.org/W1987615602","https://openalex.org/W1998183716","https://openalex.org/W2006626132","https://openalex.org/W2017680520","https://openalex.org/W2038365622","https://openalex.org/W2057616942","https://openalex.org/W2061878700","https://openalex.org/W2062380710","https://openalex.org/W2071685455","https://openalex.org/W2084881364","https://openalex.org/W2085577839","https://openalex.org/W2086727545","https://openalex.org/W2094143702","https://openalex.org/W2106598473","https://openalex.org/W2117824521","https://openalex.org/W2119974492","https://openalex.org/W2138236452","https://openalex.org/W2140608125","https://openalex.org/W2146263980","https://openalex.org/W2149843007","https://openalex.org/W2158980331","https://openalex.org/W2399376431","https://openalex.org/W2404287599","https://openalex.org/W2409923960","https://openalex.org/W2427974379","https://openalex.org/W2613729033","https://openalex.org/W6630266193"],"related_works":["https://openalex.org/W7096984516","https://openalex.org/W1968208599","https://openalex.org/W7048885763","https://openalex.org/W2146263980","https://openalex.org/W1971179225","https://openalex.org/W7100748269","https://openalex.org/W2119974492","https://openalex.org/W2166446259","https://openalex.org/W2270723315","https://openalex.org/W3089996978"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ivermectin":[1],"(IVM)":[2],"has":[3,29],"been":[4,20],"used":[5],"in":[6,41,65,109,214,284],"Ghana":[7],"for":[8,12],"over":[9],"two":[10,110],"decades":[11],"onchocerciasis":[13],"control.":[14],"In":[15,47,82],"recent":[16],"years":[17],"there":[18],"have":[19,88],"reports":[21],"of":[22,33,58,93,127,181,189,202,212,227,241,252,298,305,309],"persistent":[23],"microfilaridermias":[24],"despite":[25],"multiple":[26,97,267,299,315],"treatments.":[27],"This":[28],"necessitated":[30],"a":[31,168],"reexamination":[32],"its":[34],"microfilaricidal":[35,56],"and":[36,75,112,130,161,174,177,193,205,234,249,261],"suppressive":[37],"effects":[38,297],"on":[39],"reproduction":[40],"the":[42,53,67,90,144,149,153,178,187,215,228,242,253,258,295,306,310],"adult":[43,218,287,311],"female":[44,94,182,219,229,288,312],"Onchocerca":[45],"volvulus.":[46],"an":[48],"initial":[49,145],"study,":[50],"we":[51,61,87,198],"demonstrated":[52],"continued":[54],"potent":[55],"effect":[57],"IVM.":[59,100,225,302],"However,":[60],"also":[62,207],"found":[63],"communities":[64,118,286],"which":[66],"skin":[68,162,190,194],"microfilarial":[69,235],"repopulation":[70,192],"rates":[71,197],"at":[72],"days":[73,142,166],"90":[74,165],"180":[76],"were":[77,135,139,159,184,244,255,290],"much":[78],"higher":[79],"than":[80],"expected.":[81],"this":[83],"follow":[84],"up":[85],"study":[86,150,170,216],"investigated":[89],"reproductive":[91,179],"response":[92],"worms":[95,183,220,230,243,263,274,289],"to":[96,107,123,151,224,266,294,314],"treatments":[98,268,300,316],"with":[99,269,301],"METHODS":[101],"AND":[102],"FINDINGS:":[103],"The":[104,280],"parasitological":[105],"responses":[106,308],"IVM":[108,128,146,171],"hundred":[111],"sixty-eight":[113],"microfilaridermic":[114],"subjects":[115,213],"from":[116,272,276],"nine":[117],"that":[119,209,221,238,250,283],"had":[120],"received":[121],"10":[122],"19":[124],"annual":[125],"doses":[126],"treatment":[129,147],"one":[131],"pre-study":[132],"IVM-na\u00efve":[133],"community":[134],"followed.":[136],"Skin":[137],"snips":[138,163],"taken":[140,164],"364":[141],"after":[143],"during":[148],"determine":[152],"microfilaria":[154],"(mf)":[155],"recovery":[156,196],"rate.":[157],"Nodules":[158],"excised":[160],"following":[167],"second":[169],"treatment.":[172],"Nodule":[173],"worm":[175,313],"density":[176],"status":[180],"determined.":[185],"On":[186],"basis":[188],"mf":[191,195,254],"defined":[199],"three":[200],"categories":[201],"response--good,":[203],"intermediate":[204],"poor--and":[206],"determined":[208],"approximately":[210],"25%":[211],"carried":[217],"responded":[222],"suboptimally":[223],"Stratification":[226],"by":[231,257],"morphological":[232],"age":[233],"content":[236],"showed":[237],"almost":[239],"90%":[240],"older":[245,262],"or":[246,292],"middle":[247,259],"aged":[248,260],"most":[251],"produced":[256],"previously":[264],"exposed":[265],"little":[270],"contribution":[271],"young":[273],"derived":[275],"ongoing":[277],"transmission.":[278],"CONCLUSIONS:":[279],"results":[281],"confirm":[282],"some":[285],"non-responsive":[291],"resistant":[293],"anti-fecundity":[296],"A":[303],"scheme":[304],"varied":[307],"is":[317],"proposed.":[318]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}