{"id":"https://openalex.org/W2018719279","doi":"https://doi.org/10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","title":"Myelin protein zero and membrane adhesion","display_name":"Myelin protein zero and membrane adhesion","publication_year":1998,"publication_date":"1998-10-15","ids":{"openalex":"https://openalex.org/W2018719279","doi":"https://doi.org/10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","mag":"2018719279","pmid":"https://pubmed.ncbi.nlm.nih.gov/9788273"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010856300","display_name":"Lisa Beth Spiryda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lisa Spiryda","raw_affiliation_strings":["Department of Cell Biology, Mount Sinai School of Medicine, New York, New York 10029, USA. spiryda@msvax.mssm.edu","Department of Cell Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Mount Sinai School of Medicine, New York, New York 10029, USA. spiryda@msvax.mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Cell Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010856300"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.5693,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.5112782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"54","issue":"2","first_page":"137","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelin-protein-zero","display_name":"myelin protein zero","score":0.9670000076293945},{"id":"https://openalex.org/keywords/p0-glycoprotein","display_name":"P0 glycoprotein","score":0.8619999885559082},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/peripheral-nerve-myelin","display_name":"peripheral nerve myelin","score":0.890999972820282},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.8320000171661377},{"id":"https://openalex.org/keywords/immunoglobulin-superfamily","display_name":"immunoglobulin superfamily","score":0.7409999966621399},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.7129999995231628},{"id":"https://openalex.org/keywords/myelin-glycoproteins","display_name":"myelin glycoproteins","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.6559610366821289},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6289047598838806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6285396814346313},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5876017808914185},{"id":"https://openalex.org/C8162170","wikidata":"https://www.wikidata.org/wiki/Q14906304","display_name":"Myelin-associated glycoprotein","level":4,"score":0.5321452021598816},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5275962948799133},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4602237343788147},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.45811930298805237},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.447780042886734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4431602954864502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3649636507034302},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25999221205711365},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.20152854919433594},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1414288580417633},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018993","descriptor_name":"Myelin P0 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(19981015)54:2<137::aid-jnr2>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:9788273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9788273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4702017168","display_name":"Biosynthesis and Assembly of Myelin Membrane Proteins","funder_award_id":"R01NS020147","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W186191011","https://openalex.org/W1504494544","https://openalex.org/W1561260527","https://openalex.org/W1595212185","https://openalex.org/W1897108213","https://openalex.org/W1958675029","https://openalex.org/W1968902065","https://openalex.org/W1971479257","https://openalex.org/W1971589029","https://openalex.org/W1980771298","https://openalex.org/W1980772857","https://openalex.org/W1982327997","https://openalex.org/W1984214481","https://openalex.org/W1985065137","https://openalex.org/W1985203951","https://openalex.org/W1985354097","https://openalex.org/W1988191548","https://openalex.org/W1992001038","https://openalex.org/W2001959802","https://openalex.org/W2004222109","https://openalex.org/W2005079294","https://openalex.org/W2005597408","https://openalex.org/W2005937859","https://openalex.org/W2006591452","https://openalex.org/W2006863427","https://openalex.org/W2009657747","https://openalex.org/W2010265636","https://openalex.org/W2012132694","https://openalex.org/W2013217510","https://openalex.org/W2019003938","https://openalex.org/W2019187148","https://openalex.org/W2020453274","https://openalex.org/W2023262022","https://openalex.org/W2026041941","https://openalex.org/W2028224423","https://openalex.org/W2030046231","https://openalex.org/W2030968761","https://openalex.org/W2031209863","https://openalex.org/W2034325225","https://openalex.org/W2035340480","https://openalex.org/W2035389916","https://openalex.org/W2037691396","https://openalex.org/W2041355051","https://openalex.org/W2046707099","https://openalex.org/W2048438362","https://openalex.org/W2049588312","https://openalex.org/W2051738169","https://openalex.org/W2053094552","https://openalex.org/W2057370470","https://openalex.org/W2058486555","https://openalex.org/W2060960668","https://openalex.org/W2063251624","https://openalex.org/W2063499134","https://openalex.org/W2067801563","https://openalex.org/W2070042427","https://openalex.org/W2070926738","https://openalex.org/W2072253707","https://openalex.org/W2072254697","https://openalex.org/W2074968543","https://openalex.org/W2078062494","https://openalex.org/W2081426113","https://openalex.org/W2081768334","https://openalex.org/W2084313287","https://openalex.org/W2085880342","https://openalex.org/W2087656850","https://openalex.org/W2089737322","https://openalex.org/W2090205264","https://openalex.org/W2093589942","https://openalex.org/W2097742056","https://openalex.org/W2111157528","https://openalex.org/W2117731766","https://openalex.org/W2123528394","https://openalex.org/W2129329466","https://openalex.org/W2138707664","https://openalex.org/W2146538952","https://openalex.org/W2147268058","https://openalex.org/W2158115811","https://openalex.org/W2162593602","https://openalex.org/W2168880454","https://openalex.org/W2188070684","https://openalex.org/W2463736671","https://openalex.org/W2485347927","https://openalex.org/W2592861607","https://openalex.org/W4235372206","https://openalex.org/W4240331679"],"related_works":["https://openalex.org/W96323748","https://openalex.org/W2148424051","https://openalex.org/W4319880579","https://openalex.org/W2004573403","https://openalex.org/W2089737322","https://openalex.org/W2058486555","https://openalex.org/W3024561704","https://openalex.org/W2085880342","https://openalex.org/W2036527769","https://openalex.org/W157536635"],"abstract_inverted_index":{"Protein":[0],"zero":[1],"(P0)":[2],"is":[3,13,33,56],"a":[4,78],"member":[5],"of":[6,38,45,54,65,80],"the":[7,34,46,52,62,109,134],"immunoglobulin":[8],"gene":[9],"superfamily":[10],"(IgCAM)":[11],"that":[12],"expressed":[14,76],"at":[15,108],"high":[16],"levels":[17],"in":[18,21,77,120,124,133],"myelinated":[19],"vertebrates":[20],"central":[22],"(fish":[23],"and":[24,26,72,93],"amphibia)":[25],"peripheral":[27,39],"(all":[28],"species)":[29],"myelin.":[30],"This":[31],"glycoprotein":[32],"major":[35],"adhesive":[36],"component":[37],"myelin,":[40],"where":[41],"it":[42],"mediates":[43,106],"self-adhesion":[44],"Schwann":[47,60],"cell":[48,81],"plasma":[49],"membrane.":[50],"Although":[51],"expression":[53],"P0":[55,83,105,125,136],"naturally":[57],"limited":[58],"to":[59,115,131],"cells,":[61],"molecular":[63],"mechanisms":[64],"P0-mediated":[66],"adhesion":[67,107],"can":[68],"be":[69,116],"considered":[70],"general":[71],"\"obligatory\"":[73],"because,":[74],"when":[75],"variety":[79],"lines,":[82],"induces":[84],"strong":[85],"intercellular":[86],"adhesion.":[87],"Modeling":[88],"studies,":[89],"X-ray":[90],"crystallographic":[91],"analysis,":[92],"experimental":[94],"site-directed":[95],"mutagenesis":[96],"have":[97],"provided":[98],"excellent":[99],"working":[100],"models":[101,113],"for":[102],"understanding":[103],"how":[104],"atomic":[110],"level.":[111],"These":[112],"remain":[114],"experimentally":[117],"tested.":[118],"However,":[119],"humans,":[121],"certain":[122],"mutations":[123],"produce":[126],"dysmyelinating":[127],"disease,":[128],"possibly":[129],"due":[130],"disruptions":[132],"predicted":[135],"lattice.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
