{"id":"https://openalex.org/W2018715031","doi":"https://doi.org/10.1021/pr900488q","title":"Differential Proteome Analysis of Host Cells Infected with Porcine Circovirus Type 2","display_name":"Differential Proteome Analysis of Host Cells Infected with Porcine Circovirus Type 2","publication_year":2009,"publication_date":"2009-08-27","ids":{"openalex":"https://openalex.org/W2018715031","doi":"https://doi.org/10.1021/pr900488q","mag":"2018715031","pmid":"https://pubmed.ncbi.nlm.nih.gov/19708719"},"language":"en","primary_location":{"id":"doi:10.1021/pr900488q","doi":"https://doi.org/10.1021/pr900488q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr900488q","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100327494","display_name":"Xin Zhang","orcid":"https://orcid.org/0000-0002-6308-5852","observed_orcids":["https://orcid.org/0000-0002-6308-5852"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhang","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042562510","display_name":"Jiyong Zhou","orcid":"https://orcid.org/0000-0002-8852-1227","observed_orcids":["https://orcid.org/0000-0002-8852-1227"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiyong Zhou","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongping Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongping Wu","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108597020","display_name":"Xiaojuan Zheng","orcid":"https://orcid.org/0009-0004-0092-7591","observed_orcids":["https://orcid.org/0009-0004-0092-7591"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Zheng","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102119756","display_name":"Guangpeng Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangpeng Ma","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115598407","display_name":"Zhongtian Wang","orcid":"https://orcid.org/0000-0003-3417-9865","observed_orcids":["https://orcid.org/0000-0003-3417-9865"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongtian Wang","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066096874","display_name":"Yulan Jin","orcid":"https://orcid.org/0000-0002-9716-1948","observed_orcids":["https://orcid.org/0000-0002-9716-1948","https://orcid.org/0000-0002-7752-5062"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulan Jin","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111900281","display_name":"Jialing He","orcid":"https://orcid.org/0000-0002-2478-6779","observed_orcids":["https://orcid.org/0000-0002-2478-6779"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialing He","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100395067","display_name":"Yan Yan","orcid":"https://orcid.org/0000-0002-5752-1910","observed_orcids":["https://orcid.org/0000-0002-5752-1910","https://orcid.org/0009-0002-1494-1621","https://orcid.org/0009-0002-2420-027X","https://orcid.org/0009-0003-4623-5526"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I4210136189","display_name":"China Rural Technology Development Center","ror":"https://ror.org/04ej3c950","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210136189"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Yan","raw_affiliation_strings":["Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou 310029, PR China, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, PR China, China Rural Technology Development Center, Beijing 100045, PR China, and Chinese Institute of Veterinary Drug Control, Beijing 100081, PR China","institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042562510"],"corresponding_institution_ids":["https://openalex.org/I4210127270","https://openalex.org/I4210136189","https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.1825,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.9729328,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"8","issue":"11","first_page":"5111","last_page":"5119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-circovirus-type-2","display_name":"porcine circovirus type 2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/host-cell-proteome","display_name":"host cell proteome","score":0.5690000057220459},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pk-15-cells","display_name":"PK-15 cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/postweaning-multisystemic-wasting-syndrome","display_name":"postweaning multisystemic wasting syndrome","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alpha-tubulin","display_name":"alpha-tubulin","score":0.7200000286102295},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.625},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cytoskeletal-proteins","display_name":"cytoskeletal proteins","score":0.8169999718666077},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9449999928474426},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2781045504","wikidata":"https://www.wikidata.org/wiki/Q128578","display_name":"Porcine circovirus","level":3,"score":0.8886834383010864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7810767889022827},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7576531171798706},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5510408282279968},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.517646849155426},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5148741006851196},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4825429320335388},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.4317840039730072},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42909711599349976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33430880308151245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22273528575897217},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1452719271183014}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017925","descriptor_name":"Circovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018173","descriptor_name":"Circoviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053570","descriptor_name":"Porcine Postweaning Multisystemic Wasting Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/pr900488q","doi":"https://doi.org/10.1021/pr900488q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr900488q","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:19708719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19708719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1516329113","https://openalex.org/W1648569894","https://openalex.org/W1685479121","https://openalex.org/W1883526957","https://openalex.org/W1964715120","https://openalex.org/W1969331835","https://openalex.org/W1974538638","https://openalex.org/W1986819159","https://openalex.org/W1988847882","https://openalex.org/W1991049614","https://openalex.org/W1994220194","https://openalex.org/W1995486038","https://openalex.org/W1995826732","https://openalex.org/W1999078023","https://openalex.org/W2002729192","https://openalex.org/W2006732267","https://openalex.org/W2014400195","https://openalex.org/W2016132812","https://openalex.org/W2018660950","https://openalex.org/W2024400556","https://openalex.org/W2028781991","https://openalex.org/W2033744339","https://openalex.org/W2034508297","https://openalex.org/W2036780034","https://openalex.org/W2039653286","https://openalex.org/W2041588590","https://openalex.org/W2048267371","https://openalex.org/W2054165784","https://openalex.org/W2054899985","https://openalex.org/W2056363732","https://openalex.org/W2057611152","https://openalex.org/W2058131949","https://openalex.org/W2062213309","https://openalex.org/W2074458632","https://openalex.org/W2075181140","https://openalex.org/W2085774974","https://openalex.org/W2089127440","https://openalex.org/W2089457247","https://openalex.org/W2091564154","https://openalex.org/W2111970919","https://openalex.org/W2113153354","https://openalex.org/W2113247978","https://openalex.org/W2117093009","https://openalex.org/W2126371427","https://openalex.org/W2128635872","https://openalex.org/W2131991546","https://openalex.org/W2133812456","https://openalex.org/W2134398475","https://openalex.org/W2135723950","https://openalex.org/W2136778970","https://openalex.org/W2140646127","https://openalex.org/W2140885472","https://openalex.org/W2146468359","https://openalex.org/W2147997790","https://openalex.org/W2150123812","https://openalex.org/W2153314219","https://openalex.org/W2156271670","https://openalex.org/W2162740552","https://openalex.org/W2229759080","https://openalex.org/W2342147849","https://openalex.org/W2417175201","https://openalex.org/W4211014298","https://openalex.org/W4238008274"],"related_works":["https://openalex.org/W1974865337","https://openalex.org/W1997461942","https://openalex.org/W2062972748","https://openalex.org/W3158465967","https://openalex.org/W2152222091","https://openalex.org/W2070577048","https://openalex.org/W2136960079","https://openalex.org/W2015650354","https://openalex.org/W3007169611","https://openalex.org/W1977580124"],"abstract_inverted_index":{"Porcine":[0],"circovirus":[1],"type":[2],"2":[3],"(PCV2)":[4],"is":[5,16],"the":[6,31,52,88,116,134,140,146,159,172,176],"primary":[7],"causative":[8],"agent":[9],"of":[10,48,54,68,118,143,179],"postweaning":[11],"multisystemic":[12],"wasting":[13],"syndrome,":[14],"which":[15],"an":[17],"emerging":[18],"swine":[19],"immunosuppressive":[20],"disease.":[21],"To":[22],"uncover":[23],"cellular":[24,86,135,152,173],"protein":[25,57,142],"responses":[26],"in":[27,56,145],"PCV2-infected":[28],"PK-15":[29,148],"cells,":[30],"comprehensive":[32],"proteome":[33],"profiles":[34],"were":[35,79],"analyzed":[36],"utilizing":[37],"two-dimensional":[38],"gel":[39],"electrophoresis":[40],"(2-DE)":[41],"coupled":[42],"with":[43,139,162],"MALDI-TOF/TOF":[44,82],"identification.":[45],"Multiple":[46],"comparisons":[47],"2-DE":[49],"revealed":[50],"that":[51,133],"majority":[53],"changes":[55,117],"expression":[58,90],"occurred":[59],"at":[60],"48-96":[61],"h":[62],"after":[63],"PCV2":[64,144,163,180],"infection.":[65,127],"A":[66],"total":[67],"34":[69],"host-encoded":[70],"proteins,":[71,78,99],"including":[72],"15":[73],"up-regulated":[74],"and":[75,123,129,164,182],"19":[76],"down-regulated":[77],"identified":[80,151],"by":[81],"analysis.":[83],"According":[84],"to":[85,170],"function,":[87],"differential":[89],"proteins":[91],"could":[92],"be":[93],"sorted":[94],"into":[95],"several":[96],"groups:":[97],"cytoskeleton":[98],"stress":[100],"response,":[101],"macromolecular":[102],"biosynthesis,":[103],"energy":[104],"metabolism,":[105],"ubiquitin-proteasome":[106],"pathway,":[107],"signal":[108],"transduction,":[109],"gene":[110],"regulation.":[111],"Western":[112],"blot":[113],"analysis":[114],"demonstrated":[115],"alpha":[119,136],"tubulin,":[120],"beta":[121],"actin,":[122],"cytokeratin":[124],"8":[125],"during":[126],"Colocalization":[128],"coimmunoprecipitation":[130],"analyses":[131],"confirmed":[132],"tubulin":[137],"interacts":[138],"Cap":[141],"infected":[147],"cells.":[149],"These":[150],"constituents":[153],"have":[154],"important":[155],"implications":[156],"for":[157,175],"understanding":[158],"host":[160],"interactions":[161],"brings":[165],"us":[166],"a":[167],"step":[168],"closer":[169],"defining":[171],"requirements":[174],"underlying":[177],"mechanism":[178],"replication":[181],"pathogenesis.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
