{"id":"https://openalex.org/W2018714973","doi":"https://doi.org/10.1002/stem.160404","title":"Mature Accessory Cells Influence Long\u2010Term Growth of Human Hematopoietic Progenitors on a Murine Stromal Cell Feeder Layer","display_name":"Mature Accessory Cells Influence Long\u2010Term Growth of Human Hematopoietic Progenitors on a Murine Stromal Cell Feeder Layer","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2018714973","doi":"https://doi.org/10.1002/stem.160404","mag":"2018714973","pmid":"https://pubmed.ncbi.nlm.nih.gov/9831866"},"language":"en","primary_location":{"id":"doi:10.1002/stem.160404","doi":"https://doi.org/10.1002/stem.160404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.160404","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002323714","display_name":"Loubna Mazini","orcid":"https://orcid.org/0000-0003-3539-8365","observed_orcids":["https://orcid.org/0000-0003-3539-8365"]},"institutions":[{"id":"https://openalex.org/I4210139102","display_name":"Institut de Recherche en H\u00e9matologie et Transplantation","ror":"https://ror.org/039ztcx57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210139102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Mazini","raw_affiliation_strings":["Institut de Recherche en H\u00e9matologie et Transfusion, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en H\u00e9matologie et Transfusion, France","institution_ids":["https://openalex.org/I4210139102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001735155","display_name":"E. Wunder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139102","display_name":"Institut de Recherche en H\u00e9matologie et Transplantation","ror":"https://ror.org/039ztcx57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210139102"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"E. Wunder","raw_affiliation_strings":["D\u00e9partement d'H\u00e9matologie, France","Institut de Recherche en H\u00e9matologie et Transfusion, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'H\u00e9matologie, France","institution_ids":[]},{"raw_affiliation_string":"Institut de Recherche en H\u00e9matologie et Transfusion, France","institution_ids":["https://openalex.org/I4210139102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045576636","display_name":"Hanna Sovalat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139102","display_name":"Institut de Recherche en H\u00e9matologie et Transplantation","ror":"https://ror.org/039ztcx57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210139102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Sovalat","raw_affiliation_strings":["Institut de Recherche en H\u00e9matologie et Transfusion, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en H\u00e9matologie et Transfusion, France","institution_ids":["https://openalex.org/I4210139102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111699387","display_name":"Dominique Bourderont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117936","display_name":"Centre Hospitalier de Mulhouse","ror":"https://ror.org/02s8znz42","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210117936"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Bourderont","raw_affiliation_strings":["Unit\u00e9 Biostatistique du Centre Hospitalier de Mulhouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 Biostatistique du Centre Hospitalier de Mulhouse, France","institution_ids":["https://openalex.org/I4210117936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061983401","display_name":"M. Baerenzung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139102","display_name":"Institut de Recherche en H\u00e9matologie et Transplantation","ror":"https://ror.org/039ztcx57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210139102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Baerenzung","raw_affiliation_strings":["Institut de Recherche en H\u00e9matologie et Transfusion, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en H\u00e9matologie et Transfusion, France","institution_ids":["https://openalex.org/I4210139102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089931949","display_name":"J. Bachorz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139102","display_name":"Institut de Recherche en H\u00e9matologie et Transplantation","ror":"https://ror.org/039ztcx57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210139102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Bachorz","raw_affiliation_strings":["Institut de Recherche en H\u00e9matologie et Transfusion, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche en H\u00e9matologie et Transfusion, France","institution_ids":["https://openalex.org/I4210139102"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072243285","display_name":"Philippe R.G. Henon","orcid":"https://orcid.org/0000-0002-8798-5994","observed_orcids":["https://orcid.org/0000-0002-8798-5994"]},"institutions":[{"id":"https://openalex.org/I4210139102","display_name":"Institut de Recherche en H\u00e9matologie et Transplantation","ror":"https://ror.org/039ztcx57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210139102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. H\u00e9non","raw_affiliation_strings":["D\u00e9partement d'H\u00e9matologie, France","Institut de Recherche en H\u00e9matologie et Transfusion, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'H\u00e9matologie, France","institution_ids":[]},{"raw_affiliation_string":"Institut de Recherche en H\u00e9matologie et Transfusion, France","institution_ids":["https://openalex.org/I4210139102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001735155"],"corresponding_institution_ids":["https://openalex.org/I4210139102"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.0626,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75560706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"6","first_page":"404","last_page":"412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/cobblestone-area-forming-cells","display_name":"cobblestone area-forming cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5289999842643738},{"id":"https://openalex.org/keywords/leukapheresis","display_name":"leukapheresis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hematopoietic-cell-mobilization","display_name":"hematopoietic cell mobilization","score":0.7409999966621399},{"id":"https://openalex.org/keywords/long-term-culture","display_name":"long-term culture","score":0.6060000061988831},{"id":"https://openalex.org/keywords/accessory-cells","display_name":"accessory cells","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.8088840246200562},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.7498300075531006},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6782978177070618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6771884560585022},{"id":"https://openalex.org/C2777371436","wikidata":"https://www.wikidata.org/wiki/Q3237071","display_name":"Leukapheresis","level":4,"score":0.6331367492675781},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5129280090332031},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4773423969745636},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4704686105251312},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4577445387840271},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4440472424030304},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.42705297470092773},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3870254158973694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37218940258026123},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3556992709636688},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2412799894809723},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16609403491020203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06697660684585571},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05315905809402466},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/stem.160404","doi":"https://doi.org/10.1002/stem.160404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.160404","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},{"id":"pmid:9831866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9831866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W76368295","https://openalex.org/W93037232","https://openalex.org/W129232635","https://openalex.org/W160332237","https://openalex.org/W196303326","https://openalex.org/W244339440","https://openalex.org/W297611589","https://openalex.org/W341993295","https://openalex.org/W613638718","https://openalex.org/W654649841","https://openalex.org/W1538762819","https://openalex.org/W1838336174","https://openalex.org/W1966144382","https://openalex.org/W2012116415","https://openalex.org/W2016191371","https://openalex.org/W2044197569","https://openalex.org/W2063809730","https://openalex.org/W2073678538","https://openalex.org/W2085479011","https://openalex.org/W2086793358","https://openalex.org/W2088151154","https://openalex.org/W2208935567","https://openalex.org/W2298427610","https://openalex.org/W2306011669","https://openalex.org/W2395455593","https://openalex.org/W2400103088","https://openalex.org/W2407412428","https://openalex.org/W2411802233","https://openalex.org/W2413701099","https://openalex.org/W2414809291","https://openalex.org/W2417703957","https://openalex.org/W2427804383","https://openalex.org/W2442356882","https://openalex.org/W2470162010"],"related_works":["https://openalex.org/W2026240780","https://openalex.org/W129232635","https://openalex.org/W2082955070","https://openalex.org/W1998428445","https://openalex.org/W1977404622","https://openalex.org/W2145450602","https://openalex.org/W113632495","https://openalex.org/W1980138314","https://openalex.org/W2072845242","https://openalex.org/W2262782550"],"abstract_inverted_index":{"A":[0],"recently":[1],"described":[2],"long-term":[3],"culture":[4,79],"system":[5],"for":[6],"early":[7,203],"human":[8,194],"progenitor":[9],"cells":[10,30,61,150,181,196],"was":[11,111,122,137],"established":[12],"with":[13,93],"the":[14,44,82,104,119,125,135,148,152,158,162],"murine":[15],"preadipocyte":[16],"stromal":[17],"line":[18],"FBMD-1":[19],"grown":[20],"in":[21,33,57,81,85,115,130,143,161,176,186],"96-well":[22],"plates;":[23],"cobblestone":[24],"areas":[25],"formed":[26],"by":[27,51],"inoculated":[28,108,126],"hematopoietic":[29,97,180],"are":[31],"determined":[32],"a":[34],"limiting":[35],"dilution":[36],"setting":[37],"after":[38,76,133],"five":[39,77],"weeks'":[40,78],"culture.":[41],"To":[42],"compare":[43],"capacity":[45],"of":[46,63,96,147,178,202,213],"cobblestone-area-forming":[47],"cell":[48,72,102,109,128],"(CAFC)":[49],"formation":[50],"bone":[52,86],"marrow":[53,87],"and":[54,88,132],"leukapheresis":[55,89],"products":[56],"this":[58,206],"system,":[59],"mononuclear":[60],"(MNC)":[62],"both":[64,183],"origins":[65,184],"were":[66,80,174],"cultured.":[67],"As":[68],"related":[69,123],"to":[70,124,139,157,200,210],"CD34+":[71,101,127],"content,":[73],"CAFC":[74,105,120,153,173],"yields":[75],"same":[83],"range":[84],"stemming":[90],"from":[91,182],"patients":[92],"efficient":[94],"mobilization":[95],"cells.":[98],"In":[99],"purified":[100,144,179],"fractions,":[103],"yield":[106,136,154,212],"per":[107,172],"number":[110,121,129],"considerably":[112],"higher":[113],"than":[114,185],"MNC;":[116],"however,":[117],"if":[118],"MNC":[131,164],"purification,":[134],"four":[138],"eight":[140],"times":[141],"decreased":[142],"fractions.":[145],"Addition":[146],"mature":[149,193],"brought":[151],"back":[155],"up":[156],"numbers":[159],"obtained":[160],"unseparated":[163],"fraction.":[165],"By":[166],"contrast,":[167],"slightly":[168],"more":[169],"advanced":[170],"progenitors":[171,204],"found":[175],"cultures":[177],"whole":[187],"MNC.":[188],"The":[189],"results":[190],"suggest":[191],"that":[192],"accessory":[195],"give":[197],"noticeable":[198],"support":[199],"recruitment":[201],"on":[205],"feeder":[207],"but":[208],"lead":[209],"lower":[211],"GM":[214],"progenitors.":[215]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
