{"id":"https://openalex.org/W2018678702","doi":"https://doi.org/10.1016/j.abb.2008.02.008","title":"Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase","display_name":"Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase","publication_year":2008,"publication_date":"2008-02-15","ids":{"openalex":"https://openalex.org/W2018678702","doi":"https://doi.org/10.1016/j.abb.2008.02.008","mag":"2018678702","pmid":"https://pubmed.ncbi.nlm.nih.gov/18298940"},"language":"en","primary_location":{"id":"doi:10.1016/j.abb.2008.02.008","doi":"https://doi.org/10.1016/j.abb.2008.02.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.abb.2008.02.008","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006304159","display_name":"Markus J. Fischer","orcid":"https://orcid.org/0000-0001-7243-4199","observed_orcids":["https://orcid.org/0000-0001-7243-4199"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Fischer","raw_affiliation_strings":["Institute of Food Chemistry, University of Hamburg, Grindelallee 117, D-20146 Hamburg, Germany. markus.fischer@uni-hamburg.de","Institute of Food Chemistry, University of Hamburg, Grindelallee 117, D-20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Chemistry, University of Hamburg, Grindelallee 117, D-20146 Hamburg, Germany. markus.fischer@uni-hamburg.de","institution_ids":["https://openalex.org/I159176309"]},{"raw_affiliation_string":"Institute of Food Chemistry, University of Hamburg, Grindelallee 117, D-20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068798153","display_name":"Adelbert Bacher","orcid":"https://orcid.org/0000-0001-5174-4139","observed_orcids":["https://orcid.org/0000-0001-5174-4139"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adelbert Bacher","raw_affiliation_strings":["Lehrstuhl f\u00fcr Biochemie, Technische Universit\u00e4t M\u00fcnchen, Lichtenbergstr 4, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lehrstuhl f\u00fcr Biochemie, Technische Universit\u00e4t M\u00fcnchen, Lichtenbergstr 4, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":0.4638,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.38390093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"474","issue":"2","first_page":"252","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riboflavin-biosynthesis","display_name":"riboflavin biosynthesis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/riboflavin-synthase","display_name":"riboflavin synthase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/6-7-dimethyl-8-ribityllumazine","display_name":"6,7-dimethyl-8-ribityllumazine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ribulose-5-phosphate","display_name":"ribulose 5-phosphate","score":0.953000009059906},{"id":"https://openalex.org/keywords/guanosine-triphosphate","display_name":"GTP","score":0.7549999952316284},{"id":"https://openalex.org/keywords/disproportionation","display_name":"disproportionation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.4269999861717224},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pyridine-nucleotide-biosynthesis","display_name":"pyridine nucleotide biosynthesis","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9015657901763916},{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.7615630626678467},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.7232058048248291},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.6316043138504028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5556631684303284},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48259031772613525},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4497615098953247},{"id":"https://openalex.org/C145782189","wikidata":"https://www.wikidata.org/wiki/Q628025","display_name":"Deamination","level":3,"score":0.44190889596939087},{"id":"https://openalex.org/C2779966244","wikidata":"https://www.wikidata.org/wiki/Q57830363","display_name":"Ribulose","level":4,"score":0.4142841100692749},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40775594115257263},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2185799479484558},{"id":"https://openalex.org/C165474305","wikidata":"https://www.wikidata.org/wiki/Q419615","display_name":"Oxygenase","level":3,"score":0.19414210319519043}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012258","descriptor_name":"Riboflavin Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012258","descriptor_name":"Riboflavin Synthase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.abb.2008.02.008","doi":"https://doi.org/10.1016/j.abb.2008.02.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.abb.2008.02.008","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:18298940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18298940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W273889473","https://openalex.org/W322095649","https://openalex.org/W1415686217","https://openalex.org/W1418217697","https://openalex.org/W1481378379","https://openalex.org/W1487867154","https://openalex.org/W1490421829","https://openalex.org/W1490443449","https://openalex.org/W1509938542","https://openalex.org/W1510061991","https://openalex.org/W1522340786","https://openalex.org/W1527512784","https://openalex.org/W1547638309","https://openalex.org/W1549295321","https://openalex.org/W1555028382","https://openalex.org/W1559761893","https://openalex.org/W1573505542","https://openalex.org/W1606628932","https://openalex.org/W1698351509","https://openalex.org/W1750090655","https://openalex.org/W1783059544","https://openalex.org/W1966489764","https://openalex.org/W1966766357","https://openalex.org/W1967517192","https://openalex.org/W1968713823","https://openalex.org/W1973603811","https://openalex.org/W1973957927","https://openalex.org/W1975886495","https://openalex.org/W1979074819","https://openalex.org/W1979415037","https://openalex.org/W1979882122","https://openalex.org/W1980938590","https://openalex.org/W1981776711","https://openalex.org/W1984265129","https://openalex.org/W1990834064","https://openalex.org/W1990927838","https://openalex.org/W1991060128","https://openalex.org/W1991659634","https://openalex.org/W1994896583","https://openalex.org/W1997967581","https://openalex.org/W2006544367","https://openalex.org/W2012820507","https://openalex.org/W2013953916","https://openalex.org/W2014437352","https://openalex.org/W2018573392","https://openalex.org/W2020867167","https://openalex.org/W2025591971","https://openalex.org/W2026119781","https://openalex.org/W2032387485","https://openalex.org/W2041368635","https://openalex.org/W2042258122","https://openalex.org/W2042880352","https://openalex.org/W2044241959","https://openalex.org/W2048117288","https://openalex.org/W2054002267","https://openalex.org/W2057406893","https://openalex.org/W2057741724","https://openalex.org/W2058487176","https://openalex.org/W2059308472","https://openalex.org/W2061373047","https://openalex.org/W2063627891","https://openalex.org/W2067133614","https://openalex.org/W2067698370","https://openalex.org/W2069669686","https://openalex.org/W2070071660","https://openalex.org/W2074287512","https://openalex.org/W2075420247","https://openalex.org/W2079536450","https://openalex.org/W2081821379","https://openalex.org/W2082249244","https://openalex.org/W2086407996","https://openalex.org/W2088555826","https://openalex.org/W2089331450","https://openalex.org/W2093815823","https://openalex.org/W2093968372","https://openalex.org/W2103096891","https://openalex.org/W2103723759","https://openalex.org/W2103832206","https://openalex.org/W2107412098","https://openalex.org/W2110075655","https://openalex.org/W2111736805","https://openalex.org/W2116761007","https://openalex.org/W2116883325","https://openalex.org/W2126218867","https://openalex.org/W2126865613","https://openalex.org/W2128570795","https://openalex.org/W2130597873","https://openalex.org/W2141947935","https://openalex.org/W2142997566","https://openalex.org/W2147469677","https://openalex.org/W2148054905","https://openalex.org/W2157471077","https://openalex.org/W2157829352","https://openalex.org/W2158660006","https://openalex.org/W2160475300","https://openalex.org/W2161071729","https://openalex.org/W2161214077","https://openalex.org/W2162192624","https://openalex.org/W2162651696","https://openalex.org/W2166071706","https://openalex.org/W2166679810","https://openalex.org/W2166756758","https://openalex.org/W2167002640","https://openalex.org/W2168836416","https://openalex.org/W2171881772","https://openalex.org/W2172094400","https://openalex.org/W2288655447","https://openalex.org/W2307635858","https://openalex.org/W2314752976","https://openalex.org/W2320481735","https://openalex.org/W2616645268","https://openalex.org/W2899862539","https://openalex.org/W2951857484","https://openalex.org/W3111785144","https://openalex.org/W4242872409"],"related_works":["https://openalex.org/W2166756758","https://openalex.org/W1481378379","https://openalex.org/W3021196967","https://openalex.org/W2171881772","https://openalex.org/W1988969394","https://openalex.org/W2042258122","https://openalex.org/W2020890335","https://openalex.org/W2414189057","https://openalex.org/W2129512868","https://openalex.org/W1581057986"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}