{"id":"https://openalex.org/W2018664136","doi":"https://doi.org/10.1046/j.1365-2133.2003.05351.x","title":"The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5-aminolaevulinic acid photodynamic therapy","display_name":"The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5-aminolaevulinic acid photodynamic therapy","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2018664136","doi":"https://doi.org/10.1046/j.1365-2133.2003.05351.x","mag":"2018664136","pmid":"https://pubmed.ncbi.nlm.nih.gov/12890205"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2133.2003.05351.x","doi":"https://doi.org/10.1046/j.1365-2133.2003.05351.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2133.2003.05351.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053305061","display_name":"K. Choudry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Choudry","raw_affiliation_strings":["Photobiology Unit, Dermatology Centre, Hope Hospital, Salford, Manchester M6 8HD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photobiology Unit, Dermatology Centre, Hope Hospital, Salford, Manchester M6 8HD, U.K","institution_ids":["https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109136666","display_name":"Rebecca C.C. Brooke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R.C.C. Brooke","raw_affiliation_strings":["Photobiology Unit, Dermatology Centre, Hope Hospital, Salford, Manchester M6 8HD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photobiology Unit, Dermatology Centre, Hope Hospital, Salford, Manchester M6 8HD, U.K","institution_ids":["https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. Farrar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802775644","display_name":"Royal Liverpool University Hospital","ror":"https://ror.org/01ycr6b80","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160","https://openalex.org/I2802775644"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. Farrar","raw_affiliation_strings":["Department of Dermatology, Royal Liverpool University Hospital, Liverpool, L7 8XP, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Royal Liverpool University Hospital, Liverpool, L7 8XP, U.K","institution_ids":["https://openalex.org/I2802775644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026219635","display_name":"Lesley Elizabeth Rhodes","orcid":"https://orcid.org/0000-0002-9107-6654","observed_orcids":["https://orcid.org/0000-0002-9107-6654"]},"institutions":[{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"L.E. Rhodes","raw_affiliation_strings":["Photobiology Unit, Dermatology Centre, Hope Hospital, Salford, Manchester M6 8HD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photobiology Unit, Dermatology Centre, Hope Hospital, Salford, Manchester M6 8HD, U.K","institution_ids":["https://openalex.org/I4210111611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026219635"],"corresponding_institution_ids":["https://openalex.org/I4210111611"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":1.0784,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.74116834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"149","issue":"1","first_page":"124","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.8820000290870667},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.9480000138282776},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/phototoxicity","display_name":"phototoxicity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/iontophoresis","display_name":"iontophoresis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.7960000038146973},{"id":"https://openalex.org/keywords/bowen-s-disease","display_name":"Bowen's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/erythema","display_name":"erythema","score":0.8059999942779541},{"id":"https://openalex.org/keywords/topical-photosensitizer","display_name":"topical photosensitizer","score":0.5249999761581421},{"id":"https://openalex.org/keywords/skin-cancer-treatment","display_name":"skin cancer treatment","score":0.4860000014305115},{"id":"https://openalex.org/keywords/minimal-phototoxic-dose","display_name":"minimal phototoxic dose","score":0.824999988079071},{"id":"https://openalex.org/keywords/red-light","display_name":"red light","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.9576934576034546},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8736295700073242},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.8090677261352539},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.574320375919342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5670885443687439},{"id":"https://openalex.org/C2778417259","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin","level":3,"score":0.5529876351356506},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5135581493377686},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3963143229484558},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32852208614349365},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.1807326376438141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13406920433044434},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.1177385151386261},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09006154537200928},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001913","descriptor_name":"Bowen's Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001913","descriptor_name":"Bowen's Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004890","descriptor_name":"Erythema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1046/j.1365-2133.2003.05351.x","doi":"https://doi.org/10.1046/j.1365-2133.2003.05351.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2133.2003.05351.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:12890205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12890205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/d17c1f84-a7cc-41fd-abc1-2e075d693990","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/d17c1f84-a7cc-41fd-abc1-2e075d693990","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Choudry, K, Brooke, RCC, Farrar, W & Rhodes, L 2003, 'The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical ALA-PDT.', British Journal of Dermatology, vol. 149 (1), pp. 124-130.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2279692239","doi":null,"is_oa":false,"landing_page_url":"https://www.escholar.manchester.ac.uk/uk-ac-man-scw:1d25508","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Dermatology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320013","display_name":"British Skin Foundation","ror":"https://ror.org/02h7g2017"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1504186761","https://openalex.org/W1506108633","https://openalex.org/W1942518562","https://openalex.org/W1965996265","https://openalex.org/W1975464551","https://openalex.org/W1983747031","https://openalex.org/W1994870133","https://openalex.org/W2007776422","https://openalex.org/W2010050000","https://openalex.org/W2037429015","https://openalex.org/W2037761468","https://openalex.org/W2040858046","https://openalex.org/W2046285865","https://openalex.org/W2059943970","https://openalex.org/W2060574210","https://openalex.org/W2076565678","https://openalex.org/W2086254978","https://openalex.org/W2091210609","https://openalex.org/W2100592740","https://openalex.org/W2136667339","https://openalex.org/W2146682670","https://openalex.org/W2163190511","https://openalex.org/W4253817109"],"related_works":["https://openalex.org/W2034013141","https://openalex.org/W2106150628","https://openalex.org/W2279692239","https://openalex.org/W1487956274","https://openalex.org/W2499740511","https://openalex.org/W2514227379","https://openalex.org/W2060574210","https://openalex.org/W4360990722","https://openalex.org/W1989479846","https://openalex.org/W2024922249"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,194,273],"5-aminolaevulinic":[2],"acid":[3],"(ALA)-photodynamic":[4],"therapy":[5],"(PDT),":[6],"the":[7,14,32,35,61,82,104,126,168,261],"prodrug":[8],"ALA":[9,56,156,163,202,232,250,309],"is":[10],"endogenously":[11],"converted":[12],"to":[13,25,40,158,167,317],"active":[15,242],"sensitizer":[16],"protoporphyrin":[17],"IX":[18],"(PpIX),":[19],"while":[20,81],"further":[21],"conversion":[22],"of":[23,34,51,54,64,68,134,148,151,312,323],"PpIX":[24,42,98,174,197,212,284],"haem":[26],"requires":[27],"iron.":[28],"OBJECTIVES:":[29],"To":[30],"explore":[31],"potential":[33],"iron":[36,296],"chelator":[37],"desferrioxamine":[38],"(DFO)":[39],"enhance":[41],"levels":[43,286],"and":[44,131,161,206,243,291],"phototoxicity":[45,300],"in":[46,78,219,275,283,301,321],"ALA-PDT.":[47],"METHODS:":[48],"A":[49],"series":[50],"six":[52],"doses":[53],"2%":[55],"solution":[57],"was":[58,73,100,119,176,279],"iontophoresed":[59],"into":[60],"healthy":[62,195],"skin":[63,277,325],"each":[65],"ventral":[66],"forearm":[67],"10":[69],"volunteers.":[70],"One":[71],"arm":[72,84],"pretreated":[74],"with":[75,109,132,139,164,186,200,222,231,290],"20%":[76,155,162,165],"DFO":[77,166,313],"aqueous":[79,86],"cream,":[80],"control":[83,223,244],"received":[85,154],"cream":[87],"alone,":[88],"for":[89,170],"16":[90],"h.":[91,172],"At":[92],"5":[93,179],"h":[94,123],"following":[95,102,181],"iontophoresis,":[96],"skin-surface":[97],"fluorescence":[99,175,198,213,285],"measured,":[101],"which":[103,182],"forearms":[105],"were":[106,184,216],"simultaneously":[107],"irradiated":[108,185],"100":[110,187],"J":[111,188],"cm-2":[112,189],"broadband":[113,190],"red":[114,191],"light.":[115,192],"The":[116,255],"phototoxic":[117,128],"reaction":[118],"assessed":[120],"at":[121,178,204,248,260,264,307],"24":[122],"postirradiation":[124],"as":[125],"minimal":[127],"dose":[129,203,233,251],"(MPD)":[130],"quantification":[133],"erythema.":[135],"Next,":[136],"eight":[137],"patients":[138],"two":[140,146],"superficial":[141],"basal":[142],"cell":[143],"carcinomas":[144],"or":[145],"plaques":[147],"Bowen's":[149],"disease":[150],"similar":[152],"appearance":[153],"topically":[157],"one":[159],"lesion":[160],"other,":[169],"3":[171],"Skin-surface":[173],"measured":[177],"h,":[180],"lesions":[183],"RESULTS:":[193],"skin,":[196,303],"increased":[199],"increasing":[201],"DFO-treated":[205,220,262],"untreated":[207],"sites":[208,224,245],"(P":[209,225,234,252,270],"<":[210,226,235,253],"0.0005);":[211],"peak":[214],"values":[215],"consistently":[217],"higher":[218],"compared":[221],"0.02).":[227],"Erythema":[228],"also":[229],"correlated":[230],"0.0005),":[236],"but":[237],"a":[238],"significant":[239],"difference":[240,282],"between":[241,287],"occurred":[246,305],"only":[247,306],"low":[249,308],"0.05).":[254],"median":[256],"MPD":[257],"appeared":[258],"lower":[259],"sites,":[263],"6":[265],"mC":[266,269],"vs.":[267],"12":[268],"=":[271],"0.06).":[272],"contrast,":[274],"lesional":[276],"there":[278],"no":[280],"consistent":[281],"those":[288],"treated":[289],"without":[292],"DFO.":[293],"CONCLUSIONS:":[294],"While":[295],"chelation":[297],"augmented":[298],"ALA-PDT":[299,322],"normal":[302],"this":[304],"dose.":[310],"Addition":[311],"does":[314],"not":[315],"appear":[316],"confer":[318],"additional":[319],"benefit":[320],"nonmelanoma":[324],"cancers.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}