{"id":"https://openalex.org/W2018636748","doi":"https://doi.org/10.1210/endo-90-5-1320","title":"Insulin and Obesity in the Zucker Genetically Obese Rat \u201cFatty\u201d","display_name":"Insulin and Obesity in the Zucker Genetically Obese Rat \u201cFatty\u201d","publication_year":1972,"publication_date":"1972-05-01","ids":{"openalex":"https://openalex.org/W2018636748","doi":"https://doi.org/10.1210/endo-90-5-1320","mag":"2018636748","pmid":"https://pubmed.ncbi.nlm.nih.gov/5012744"},"language":"en","primary_location":{"id":"doi:10.1210/endo-90-5-1320","doi":"https://doi.org/10.1210/endo-90-5-1320","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-90-5-1320","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018636748"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082021474","display_name":"Lois M. Zucker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LOIS M. ZUCKER","raw_affiliation_strings":["Harriet G. Bird Memorial Laboratory, Stow, Massachusetts, and Blood Research Institute and the Department of Nutrition, Harvard University School of Public Health Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harriet G. Bird Memorial Laboratory, Stow, Massachusetts, and Blood Research Institute and the Department of Nutrition, Harvard University School of Public Health Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111784805","display_name":"Harry N. Antoniades","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HARRY N. ANTONIADES","raw_affiliation_strings":["Harriet G. Bird Memorial Laboratory, Stow, Massachusetts, and Blood Research Institute and the Department of Nutrition, Harvard University School of Public Health Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harriet G. Bird Memorial Laboratory, Stow, Massachusetts, and Blood Research Institute and the Department of Nutrition, Harvard University School of Public Health Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.375,"has_fulltext":false,"cited_by_count":424,"citation_normalized_percentile":{"value":0.91159218,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"90","issue":"5","first_page":"1320","last_page":"1330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.1492999941110611,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.878000020980835},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7680000066757202},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.8880000114440918},{"id":"https://openalex.org/keywords/diaphragm","display_name":"diaphragm","score":0.6840000152587891},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9210000038146973},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.968999981880188},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.8349999785423279},{"id":"https://openalex.org/keywords/high-protein-diet","display_name":"high-protein diet","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adipocyte-size","display_name":"adipocyte size","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9205014109611511},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9012935161590576},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7700276374816895},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6999012231826782},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6875420808792114},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.6592453718185425},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.5814497470855713},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.46845006942749023},{"id":"https://openalex.org/C2780485761","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Blood sugar","level":3,"score":0.4390895962715149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41665756702423096},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3335818648338318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3284909427165985}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-90-5-1320","doi":"https://doi.org/10.1210/endo-90-5-1320","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-90-5-1320","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:5012744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5012744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007347894","https://openalex.org/W2414862394","https://openalex.org/W28452575","https://openalex.org/W1995953758","https://openalex.org/W1991050276","https://openalex.org/W2328905718","https://openalex.org/W2071378183","https://openalex.org/W1984807300","https://openalex.org/W2281126660","https://openalex.org/W2012735340"],"abstract_inverted_index":{"Insulin":[0],"status":[1],"and":[2,62,91,100,103,151,214,257,280],"functional":[3],"activity":[4],"have":[5],"been":[6],"studied":[7],"during":[8],"the":[9,12,186,220],"life":[10],"of":[11,36,142,157,178,219,231,234,255,287],"Zucker":[13],"\u201cfatty\u201d":[14],"rat":[15],"(an":[16],"obese":[17],"mutant).":[18],"Serum":[19],"immunoreactive":[20],"insulin":[21,187,235,288],"(IRI)":[22],"is":[23,30,69,96,104,138,168,190,205,215,228,245,289],"normal":[24,60,85,97,107,183,209,221],"at":[25,39,108],"2":[26],"weeks":[27,41],"when":[28],"fattening":[29,43,68],"beginning,":[31],"rises":[32],"to":[33,48,84,113,124,144,163,217,241,250],"a":[34,63,93,139,269],"peak":[35,109],"400":[37],"\u03bc-U/ml":[38],"15":[40],"while":[42],"proceeds":[44],"rapidly,":[45],"then":[46],"drops":[47],"near":[49],"200":[50],"\u03bcU/ml":[51],"in":[52,98,135,147,160,174,184,192,196,211,236],"older":[53,197,212],"rats.":[54],"This":[55],"was":[56],"observed":[57],"with":[58,118,225,264,272],"two":[59],"diets":[61],"high":[64,78],"protein":[65],"diet.":[66],"When":[67],"reversed":[70],"by":[71,166,247],"fasting":[72],"adult":[73],"\u201cfatties,\u201d":[74,102],"IRI":[75,266],"remains":[76,181],"abnormally":[77],"until":[79],"body":[80],"lipid":[81],"has":[82],"returned":[83],"(79":[86],"days).":[87],"Blood":[88],"sugar,":[89],"basally":[90,150],"after":[92,152],"glucose":[94,145,164,172,242,251],"load,":[95],"young":[99,193],"old":[101],"barely":[105],"above":[106,208],"IRI.":[110],"Sugar":[111],"falls":[112],"below":[114],"50":[115],"mg/100":[116],"ml":[117],"prolonged":[119],"fasting.":[120],"Amino":[121],"nitrogen":[122],"tends":[123],"be":[125],"slightly":[126],"low,":[127],"free":[128],"fatty":[129],"acids":[130],"(FFA)":[131],"are":[132,262],"very":[133],"high,":[134],"\u201cfatties.\u201d":[136],"There":[137,227],"developing":[140],"resistance":[141,162,240],"diaphragm":[143],"uptake":[146,165,173,201,243],"vivo,":[148],"both":[149],"injected":[153],"insulin.":[154,226],"The":[155],"role":[156],"elevated":[158],"FFA":[159],"this":[161],"muscle":[167],"not":[169,290],"known.":[170,291],"Basal":[171],"vivo":[175],"per":[176,202],"g":[177],"adipose":[179],"tissue":[180],"approximately":[182],"\u201cfatties\u201d":[185],"stimulated":[188,224],"response":[189],"excessive":[191],"rats,":[194],"subnormal":[195],"\u201cfatties\u201d.":[198],"However,":[199],"basal":[200],"fat":[203,222,259],"cell":[204,223,260],"probably":[206],"well":[207],"even":[210],"\u201cfatties\u201d,":[213],"comparable":[216],"that":[218,275],"no":[229],"evidence":[230],"biological":[232],"ineffectiveness":[233],"controlling":[237],"sugar.":[238],"Peripheral":[239],"(muscle)":[244],"countered":[246],"peripheral":[248],"receptiveness":[249],"(adipose":[252],"tissue).":[253],"Degree":[254],"obesity,":[256],"relative":[258],"size,":[261],"correlated":[263],"serum":[265],"elevation,":[267],"suggesting":[268],"causal":[270],"relation,":[271],"some":[273],"indication":[274],"obesity":[276,282],"precedes":[277],"hyperinsulinemia.":[278],"Whether,":[279],"how,":[281],"could":[283],"cause":[284],"increased":[285],"output":[286],"(Endocrinology90:":[292],"1320,":[293],"1972)":[294]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}