{"id":"https://openalex.org/W2018627745","doi":"https://doi.org/10.1210/jc.2003-030618","title":"Differential Expression and Regulation of Microsomal Prostaglandin E2 Synthase in Human Fetal Membranes and Placenta with Infection and in Cultured Trophoblast Cells","display_name":"Differential Expression and Regulation of Microsomal Prostaglandin E2 Synthase in Human Fetal Membranes and Placenta with Infection and in Cultured Trophoblast Cells","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2018627745","doi":"https://doi.org/10.1210/jc.2003-030618","mag":"2018627745","pmid":"https://pubmed.ncbi.nlm.nih.gov/14671209"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2003-030618","doi":"https://doi.org/10.1210/jc.2003-030618","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-030618","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008551964","display_name":"Marina Premyslova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176337269","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45","country_code":"CA","type":"government","lineage":["https://openalex.org/I176337269"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marina Premyslova","raw_affiliation_strings":["Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;","institution_ids":["https://openalex.org/I176337269","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176337269","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45","country_code":"CA","type":"government","lineage":["https://openalex.org/I176337269"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;","institution_ids":["https://openalex.org/I176337269","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031547379","display_name":"Nadia Alfaidy","orcid":"https://orcid.org/0000-0002-0718-2447","observed_orcids":["https://orcid.org/0000-0002-0718-2447"]},"institutions":[{"id":"https://openalex.org/I176337269","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45","country_code":"CA","type":"government","lineage":["https://openalex.org/I176337269"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nadia Alfaidy","raw_affiliation_strings":["Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;","institution_ids":["https://openalex.org/I176337269","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031693224","display_name":"Alan D. Bocking","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alan D. Bocking","raw_affiliation_strings":["Department of Obstetrics and Gynecology and Physiology (A.D.B., K.C.), University of Western Ontario, London, Ontario, Canada N6A 5B8;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology and Physiology (A.D.B., K.C.), University of Western Ontario, London, Ontario, Canada N6A 5B8;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065415434","display_name":"M. Karen Campbell","orcid":"https://orcid.org/0000-0001-7376-5301","observed_orcids":["https://orcid.org/0000-0001-7376-5301"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karen Campbell","raw_affiliation_strings":["Department of Obstetrics and Gynecology and Physiology (A.D.B., K.C.), University of Western Ontario, London, Ontario, Canada N6A 5B8;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology and Physiology (A.D.B., K.C.), University of Western Ontario, London, Ontario, Canada N6A 5B8;","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008972130","display_name":"William Gibb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"William Gibb","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (W.G.), University of Ottawa, Ottawa, Ontario, Canada K1N 6N5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (W.G.), University of Ottawa, Ottawa, Ontario, Canada K1N 6N5","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109262333","display_name":"John R. G. Challis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176337269","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45","country_code":"CA","type":"government","lineage":["https://openalex.org/I176337269"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John R. G. Challis","raw_affiliation_strings":["Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canadian Institute of Health Research (M.P., W.L., N.A., J.R.G.C.), Departments of Physiology, Obstetrics, Gynecology and Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8;","institution_ids":["https://openalex.org/I176337269","https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008551964"],"corresponding_institution_ids":["https://openalex.org/I176337269","https://openalex.org/I185261750"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.9017,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84660672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"88","issue":"12","first_page":"6040","last_page":"6047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chorioamnionitis","display_name":"chorioamnionitis","score":0.878000020980835},{"id":"https://openalex.org/keywords/preterm-labor","display_name":"preterm labor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.7149999737739563},{"id":"https://openalex.org/keywords/villous-trophoblast","display_name":"villous trophoblast","score":0.8349999785423279},{"id":"https://openalex.org/keywords/syncytiotrophoblast","display_name":"syncytiotrophoblast","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/cytokine-regulation","display_name":"cytokine regulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/fetal-membranes","display_name":"fetal membranes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prostaglandin-synthesis","display_name":"prostaglandin synthesis","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.7989612817764282},{"id":"https://openalex.org/C2779315647","wikidata":"https://www.wikidata.org/wiki/Q2745412","display_name":"Syncytiotrophoblast","level":5,"score":0.7765296101570129},{"id":"https://openalex.org/C2780899479","wikidata":"https://www.wikidata.org/wiki/Q5445907","display_name":"Fetal membrane","level":5,"score":0.7173714637756348},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.6255846619606018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5886870622634888},{"id":"https://openalex.org/C2780197806","wikidata":"https://www.wikidata.org/wiki/Q2531387","display_name":"Decidua","level":5,"score":0.5691991448402405},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5633284449577332},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5586954951286316},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5240290760993958},{"id":"https://openalex.org/C2780646683","wikidata":"https://www.wikidata.org/wiki/Q473749","display_name":"Amnion","level":4,"score":0.4858664870262146},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.47757819294929504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44642093777656555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42853909730911255},{"id":"https://openalex.org/C2777629866","wikidata":"https://www.wikidata.org/wiki/Q473739","display_name":"Chorioamnionitis","level":4,"score":0.41734617948532104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34159690141677856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1646277904510498},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.11947813630104065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07955291867256165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07009130716323853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002821","descriptor_name":"Chorioamnionitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002823","descriptor_name":"Chorion","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002824","descriptor_name":"Chorionic Villi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005321","descriptor_name":"Extraembryonic Membranes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005321","descriptor_name":"Extraembryonic Membranes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/jc.2003-030618","doi":"https://doi.org/10.1210/jc.2003-030618","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-030618","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:14671209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14671209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/82ef50e8-63a5-4564-9dc8-422ca8b8d762","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/82ef50e8-63a5-4564-9dc8-422ca8b8d762","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Premyslova, M, Li, W, Alfaidy, N, Bocking, AD, Campbell, K, Gibb, W & Challis, J 2003, 'Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells', Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 12, pp. 6040-6047. https://doi.org/10.1210/jc.2003-030618","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02385745v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02385745","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Endocrinology and Metabolism, 2003, 88 (12), pp.6040-6047. ⟨10.1210/jc.2003-030618⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W141984575","https://openalex.org/W1980758778","https://openalex.org/W1982444915","https://openalex.org/W1987401401","https://openalex.org/W1996017102","https://openalex.org/W1996528584","https://openalex.org/W2003609390","https://openalex.org/W2010062539","https://openalex.org/W2019754311","https://openalex.org/W2024072909","https://openalex.org/W2034315903","https://openalex.org/W2039096622","https://openalex.org/W2045960359","https://openalex.org/W2049807639","https://openalex.org/W2062818585","https://openalex.org/W2069174773","https://openalex.org/W2077641423","https://openalex.org/W2079859902","https://openalex.org/W2080978271","https://openalex.org/W2082457469","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2102318060","https://openalex.org/W2111199059","https://openalex.org/W2113770480","https://openalex.org/W2127006089","https://openalex.org/W2128635872","https://openalex.org/W2141159835","https://openalex.org/W2167029659","https://openalex.org/W2167503858","https://openalex.org/W2167910100","https://openalex.org/W2171336797","https://openalex.org/W2332739634","https://openalex.org/W6670827984"],"related_works":["https://openalex.org/W2127574275","https://openalex.org/W2143455325","https://openalex.org/W2027516347","https://openalex.org/W2998316800","https://openalex.org/W2101636692","https://openalex.org/W2069174773","https://openalex.org/W2025821654","https://openalex.org/W7053389903","https://openalex.org/W2148226187","https://openalex.org/W2073222882"],"abstract_inverted_index":{"We":[0,189],"have":[1],"evaluated":[2],"the":[3,8,38,65,74,89,95,119,208,213,230],"effect":[4,40],"of":[5,11,41,98,194,215,232],"chorioamnionitis":[6],"on":[7,45],"protein":[9,84,124,143,157,175,192],"expression":[10,51,99,112,120,144,158],"microsomal":[12],"and":[13,19,26,33,43,48,56,67,72,78,93,115,155,168,173,226],"cytosolic":[14],"prostaglandin":[15,210],"E(2)":[16],"synthases":[17],"(mPGES":[18],"cPGES)":[20],"in":[21,52,70,81,91,102,110,113,118,121,128,138,159,165,183],"preterm":[22,217],"human":[23],"placentae":[24],"(PL)":[25],"fetal":[27],"membranes":[28],"(FM),":[29],"by":[30,203],"Western":[31],"blot":[32],"immunohistochemistry,":[34],"as":[35,37,100,196,198],"well":[36,197],"regulatory":[39],"IL-1beta":[42,140,167,178],"TNF-alpha":[44,151,169,180],"mPGES,":[46,195],"cPGES,":[47],"cyclooxygenase":[49],"(COX)-2":[50],"villous":[53],"trophoblast":[54,58],"(VT)":[55],"chorion":[57],"(CT)":[59],"cell":[60],"cultures.":[61],"mPGES":[62,101,111,154,172],"localized":[63,86],"to":[64,73,88,207],"syncytiotrophoblast":[66,90],"vascular":[68],"endothelium":[69],"PL":[71,92,114,130],"amnion":[75],"epithelium,":[76],"CT,":[77],"decidual":[79],"cells":[80,137,164],"FM.":[82,103,122],"cPGES":[83,123,182],"was":[85,107],"only":[87],"had":[94],"same":[96],"profile":[97],"With":[104],"infection,":[105],"there":[106],"an":[108],"increase":[109],"a":[116],"decrease":[117],"did":[125,146],"not":[126,147],"change":[127],"either":[129,184],"or":[131,186],"FM":[132],"with":[133],"infection.":[134],"In":[135,162],"VT":[136,185],"culture,":[139,166],"up-regulated":[141],"COX-2":[142,156,174],"but":[145],"affect":[148],"mPGES.":[149],"However,":[150,219],"increased":[152,170,209],"both":[153,171],"these":[160,233],"cells.":[161,188],"CT":[163,187],"levels.":[176],"Neither":[177],"nor":[179],"affected":[181],"conclude":[190],"that":[191],"levels":[193],"COX-2,":[199],"can":[200],"be":[201],"stimulated":[202],"cytokines,":[204],"potentially":[205],"contributing":[206],"production":[211],"at":[212],"time":[214],"infection-driven":[216],"labor.":[218],"multiple":[220],"mechanisms,":[221],"which":[222],"apparently":[223],"are":[224],"inductor-":[225],"cell-type-specific,":[227],"exist":[228],"for":[229],"regulation":[231],"enzymes.":[234]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}