{"id":"https://openalex.org/W2018608979","doi":"https://doi.org/10.1073/pnas.92.25.11623","title":"Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.","display_name":"Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.","publication_year":1995,"publication_date":"1995-12-05","ids":{"openalex":"https://openalex.org/W2018608979","doi":"https://doi.org/10.1073/pnas.92.25.11623","mag":"2018608979","pmid":"https://pubmed.ncbi.nlm.nih.gov/8524816","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/40454"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.92.25.11623","doi":"https://doi.org/10.1073/pnas.92.25.11623","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.25.11623","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC40454","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078306032","display_name":"Vincenzo Casolaro","orcid":"https://orcid.org/0000-0001-9810-0488","observed_orcids":["https://orcid.org/0000-0001-9810-0488"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Casolaro","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067941775","display_name":"Steve N. Georas","orcid":"https://orcid.org/0000-0002-2361-422X","observed_orcids":["https://orcid.org/0000-0002-2361-422X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S N Georas","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Song","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066388492","display_name":"Ira Zubkoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I D Zubkoff","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066860794","display_name":"Sarki Abba Abdulkadir","orcid":"https://orcid.org/0000-0003-2963-2899","observed_orcids":["https://orcid.org/0000-0003-2963-2899"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S A Abdulkadir","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031613070","display_name":"Dimitris Thanos","orcid":"https://orcid.org/0000-0003-4288-3027","observed_orcids":["https://orcid.org/0000-0003-4288-3027"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Thanos","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104042187","display_name":"Santa Jeremy Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Ono","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":3.4683,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.93716191,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"92","issue":"25","first_page":"11623","last_page":"11627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nfat","display_name":"NFAT","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9819999933242798},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.9419999718666077},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8069999814033508},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/t-helper-cell-differentiation","display_name":"T helper cell differentiation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6309999823570251},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.7839400172233582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6387355923652649},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5967264771461487},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5683245658874512},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.552187442779541},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.5046185255050659},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46149739623069763},{"id":"https://openalex.org/C2781136212","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"T helper cell","level":4,"score":0.44700926542282104},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4358506500720978},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42611610889434814},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41549211740493774},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39567679166793823},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3051964044570923},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21432119607925415},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12264516949653625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10863351821899414}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.92.25.11623","doi":"https://doi.org/10.1073/pnas.92.25.11623","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.25.11623","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:241237","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC40454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:40454","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/40454","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:8524816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8524816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:241237","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC40454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W128911665","https://openalex.org/W1495336804","https://openalex.org/W1561202481","https://openalex.org/W1577781573","https://openalex.org/W1607881510","https://openalex.org/W1827812119","https://openalex.org/W1896886890","https://openalex.org/W1908339458","https://openalex.org/W1977348907","https://openalex.org/W1987784311","https://openalex.org/W1990197546","https://openalex.org/W1991606993","https://openalex.org/W1995184275","https://openalex.org/W1999403180","https://openalex.org/W2002485919","https://openalex.org/W2012612191","https://openalex.org/W2017311565","https://openalex.org/W2026181894","https://openalex.org/W2029836713","https://openalex.org/W2051237803","https://openalex.org/W2055904083","https://openalex.org/W2063500485","https://openalex.org/W2069317034","https://openalex.org/W2069522108","https://openalex.org/W2069659862","https://openalex.org/W2073993982","https://openalex.org/W2093939923","https://openalex.org/W2104459600","https://openalex.org/W2124473841","https://openalex.org/W2128725097","https://openalex.org/W2131656392","https://openalex.org/W2137407985","https://openalex.org/W2139313903","https://openalex.org/W2151025733","https://openalex.org/W2157856503","https://openalex.org/W2172466148","https://openalex.org/W2239911109","https://openalex.org/W4232300325"],"related_works":["https://openalex.org/W1975759850","https://openalex.org/W2128725097","https://openalex.org/W2239911109","https://openalex.org/W2105598775","https://openalex.org/W2107412423","https://openalex.org/W1558954552","https://openalex.org/W2039766781","https://openalex.org/W2120478829","https://openalex.org/W1529612369","https://openalex.org/W1577781573"],"abstract_inverted_index":{"Activation":[0],"of":[1,56,68,79,106,121,165,202],"individual":[2],"CD4+":[3],"T":[4,18,96],"cells":[5,135],"results":[6],"in":[7,27,52,94,133,148,217],"differential":[8,214],"lymphokine":[9,59],"expression:":[10],"interleukin":[11],"2":[12],"(IL-2)":[13],"is":[14,33,87,100,131,176],"preferentially":[15],"produced":[16],"by":[17,35,89],"helper":[19],"type":[20],"1":[21],"(TH1)":[22],"cells,":[23,37],"which":[24,38,175],"are":[25,39],"involved":[26],"cell-mediated":[28],"immune":[29],"responses,":[30],"whereas":[31],"IL-4":[32],"synthesized":[34],"TH2":[36],"essential":[40],"for":[41,180,186],"humoral":[42],"immunity.":[43],"The":[44],"Ca(2+)-dependent":[45,85],"factor":[46,144],"NF-ATp":[47,107,181],"plays":[48],"a":[49,166,171,177,183],"key":[50],"role":[51],"the":[53,66,84,112,122,138,163,199],"inducible":[54],"transcription":[55,82,124,130],"both":[57],"these":[58],"genes.":[60],"However,":[61],"while":[62],"IL2":[63],"expression":[64,209,216],"requires":[65],"contribution":[67],"Ca(2+)-":[69],"and":[70,108,146,182,196,210],"protein":[71,90,153,203],"kinase":[72,91,154,204],"C-dependent":[73],"signals,":[74],"we":[75],"report":[76],"that":[77],"activation":[78],"human":[80,167],"IL4":[81,123,128,168,208],"through":[83],"pathway":[86],"diminished":[88],"C":[92,155,205],"stimulation":[93,156,206],"Jurkat":[95,134],"cells.":[97,150,219],"This":[98],"phenomenon":[99],"due":[101],"to":[102,111,213],"mutually":[103],"exclusive":[104],"binding":[105],"NF-kappa":[109,139],"B":[110],"P":[113,173],"sequence,":[114,174],"an":[115],"element":[116],"located":[117],"69":[118],"bp":[119],"upstream":[120],"initiation":[125],"site.":[126],"Human":[127],"promoter-mediated":[129],"downregulated":[132],"stimulated":[136],"with":[137],"B-activating":[140],"cytokine":[141],"tumor":[142],"necrosis":[143],"alpha":[145],"suppressed":[147],"RelA-overexpressing":[149],"In":[151],"contrast,":[152],"or":[157],"RelA":[158,195],"overexpression":[159],"does":[160],"not":[161],"affect":[162],"activity":[164],"promoter":[169],"containing":[170],"mouse":[172],"higher-affinity":[178],"site":[179,185],"lower-affinity":[184],"RelA.":[187],"Thus,":[188],"competition":[189],"between":[190],"two":[191],"general":[192],"transcriptional":[193],"activators,":[194],"NF-ATp,":[197],"mediates":[198],"inhibitory":[200],"effect":[201],"on":[207],"may":[211],"contribute":[212],"gene":[215],"TH":[218]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}