{"id":"https://openalex.org/W2018605250","doi":"https://doi.org/10.1128/aac.40.1.173","title":"Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum","display_name":"Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2018605250","doi":"https://doi.org/10.1128/aac.40.1.173","mag":"2018605250","pmid":"https://pubmed.ncbi.nlm.nih.gov/8787901","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/163078"},"language":"en","primary_location":{"id":"doi:10.1128/aac.40.1.173","doi":"https://doi.org/10.1128/aac.40.1.173","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.40.1.173","pdf_url":"https://aac.asm.org/content/aac/40/1/173.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/40/1/173.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082656914","display_name":"Joan Gavald\u00e0","orcid":"https://orcid.org/0000-0002-9829-3141","observed_orcids":["https://orcid.org/0000-0002-9829-3141"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J Gavald\u00e0","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000283880","display_name":"P\u00e8re-Joan Cardona","orcid":"https://orcid.org/0000-0001-5623-7873","observed_orcids":["https://orcid.org/0000-0001-5623-7873"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P J Cardona","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040864411","display_name":"Benito Almirante","orcid":"https://orcid.org/0000-0002-1189-2361","observed_orcids":["https://orcid.org/0000-0002-1189-2361"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"B Almirante","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004161312","display_name":"Josep Anton Capdevila","orcid":"https://orcid.org/0000-0001-8274-4131","observed_orcids":["https://orcid.org/0000-0001-8274-4131"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J A Capdevila","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077137999","display_name":"Maria Vispe Laguarda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M Laguarda","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113603967","display_name":"Leonor Pou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"L Pou","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110203389","display_name":"Ernesto Crespo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E Crespo","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088075462","display_name":"Carles Pigrau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C Pigrau","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108083876","display_name":"Albert Pahissa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A Pahissa","raw_affiliation_strings":["Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Laboratory, Barcelona, Spain. j_gavalda@ar.vhebron.es","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000283880","https://openalex.org/A5004161312","https://openalex.org/A5040864411","https://openalex.org/A5077137999","https://openalex.org/A5082656914","https://openalex.org/A5088075462","https://openalex.org/A5108083876","https://openalex.org/A5110203389","https://openalex.org/A5113603967"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9242,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.91265173,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"1","first_page":"173","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocarditis","display_name":"endocarditis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":1.0},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.9350000023841858},{"id":"https://openalex.org/keywords/aortic-valve-vegetation","display_name":"aortic valve vegetation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3400000035762787},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.9185383915901184},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.8317925333976746},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7796180844306946},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.728651762008667},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.7088959217071533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5983667373657227},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.46339136362075806},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.418923944234848},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4173338711261749},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4161979854106903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.285515159368515},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.22259733080863953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18339532613754272},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.07132959365844727},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06927835941314697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007260","descriptor_name":"Infusion Pumps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015610","descriptor_name":"Serum Bactericidal Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.40.1.173","doi":"https://doi.org/10.1128/aac.40.1.173","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.40.1.173","pdf_url":"https://aac.asm.org/content/aac/40/1/173.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:209763","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC163078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:163078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/163078","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:8787901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8787901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1128/aac.40.1.173","doi":"https://doi.org/10.1128/aac.40.1.173","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.40.1.173","pdf_url":"https://aac.asm.org/content/aac/40/1/173.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018605250.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W126027595","https://openalex.org/W1456990981","https://openalex.org/W1833207062","https://openalex.org/W1967976241","https://openalex.org/W1968871492","https://openalex.org/W1984324040","https://openalex.org/W2001900062","https://openalex.org/W2003536511","https://openalex.org/W2004705457","https://openalex.org/W2010427057","https://openalex.org/W2010728777","https://openalex.org/W2026698383","https://openalex.org/W2040889647","https://openalex.org/W2046215234","https://openalex.org/W2063239492","https://openalex.org/W2066685205","https://openalex.org/W2067034394","https://openalex.org/W2072291253","https://openalex.org/W2088188414","https://openalex.org/W2089061144","https://openalex.org/W2095337744","https://openalex.org/W2099712353","https://openalex.org/W2108370427","https://openalex.org/W2108443509","https://openalex.org/W2110507893","https://openalex.org/W2111884411","https://openalex.org/W2124482054","https://openalex.org/W2127011406","https://openalex.org/W2158632245","https://openalex.org/W2161153881","https://openalex.org/W2332262919","https://openalex.org/W2417430304"],"related_works":["https://openalex.org/W7100542920","https://openalex.org/W2161389954","https://openalex.org/W2135996246","https://openalex.org/W2101259645","https://openalex.org/W1680533140","https://openalex.org/W1568620301","https://openalex.org/W2147321906","https://openalex.org/W2049257474","https://openalex.org/W1981639908","https://openalex.org/W2071371555"],"abstract_inverted_index":{"We":[0],"compared":[1],"the":[2,25,40,61,74,155,190,202,240,244],"efficacy":[3,242],"of":[4,27,42,81,84,99,106,136,154,158,173,178,207,228,243,246],"ampicillin,":[5],"both":[6],"alone":[7,127,221],"and":[8,104,108,111,113,115,119,151],"in":[9,24,45,54,72,129,160,167,194,201,216],"combination":[10,130,245],"with":[11,65,90,96,125,131,170,205,219],"gentamicin":[12,132,210,229],"given":[13,211],"once":[14],"a":[15,21,66],"day":[16,22],"(q.d.)":[17],"or":[18,128,141,213],"three":[19],"times":[20],"(t.i.d.),":[23],"treatment":[26],"experimental":[28,181],"enterococcal":[29],"endocarditis.":[30],"Ampicillin":[31],"was":[32,57,198],"administered":[33,64],"by":[34,184],"using":[35],"humanlike":[36,156],"pharmacokinetics":[37,77,157],"that":[38,70,189],"simulated":[39,71],"profiles":[41],"this":[43,55],"drug":[44],"human":[46,75],"serum.":[47],"An":[48],"open":[49],"one-compartment":[50],"mathematical":[51],"model":[52],"developed":[53],"study":[56],"used":[58],"to":[59,164],"estimate":[60],"decreasing":[62],"doses":[63],"computer-controlled":[67],"infusion":[68],"pump":[69],"rabbits":[73,161],"serum":[76,148],"after":[78],"intravenous":[79],"administration":[80],"2":[82,110,134,171],"g":[83,172],"ampicillin":[85,107,126,149,159,174,208,220,247],"every":[86],"4":[87],"h.":[88],"Animals":[89],"catheter-induced":[91],"endocarditis":[92,182],"were":[93,120,162],"infected":[94],"intravenously":[95],"10(8)":[97],"CFU":[98],"Enterococcus":[100],"faecalis":[101,186],"J4":[102,187],"(MICs":[103],"MBCs":[105],"gentamicin,":[109],"128":[112],"16":[114],"64":[116],"micrograms/ml,":[117],"respectively)":[118],"treated":[121,169,204,218],"for":[122,180],"3":[123],"days":[124],"at":[133,142],"mg/kg":[135,144],"body":[137],"weight":[138],"subcutaneously":[139,145],"t.i.d.":[140,214],"6":[143],"q.d.":[146,212],"The":[147,176,225],"levels":[150],"pharmacokinetic":[152],"parameters":[153],"similar":[163],"those":[165,217],"found":[166],"humans":[168],"intravenously.":[175],"results":[177],"therapy":[179],"caused":[183],"E.":[185],"showed":[188],"residual":[191],"bacterial":[192],"concentration":[193],"aortic":[195],"valve":[196],"vegetation":[197],"significantly":[199,232],"lower":[200],"animals":[203],"combinations":[206],"plus":[209,248],"than":[215],"(P":[222],"<":[223],"0.01).":[224],"dosing":[226],"interval":[227],"did":[230],"not":[231],"affect":[233],"(q.d.":[234],"versus":[235],"t.i.d.;":[236],"P":[237],"=":[238],"0.673)":[239],"therapeutic":[241],"gentamicin.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}