{"id":"https://openalex.org/W2018588361","doi":"https://doi.org/10.1038/ncb2028","title":"Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex","display_name":"Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex","publication_year":2010,"publication_date":"2010-01-31","ids":{"openalex":"https://openalex.org/W2018588361","doi":"https://doi.org/10.1038/ncb2028","mag":"2018588361","pmid":"https://pubmed.ncbi.nlm.nih.gov/20118921"},"language":"en","primary_location":{"id":"doi:10.1038/ncb2028","doi":"https://doi.org/10.1038/ncb2028","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncb2028","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/26642/3255_1775.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061243316","display_name":"Tohru Ishitani","orcid":"https://orcid.org/0000-0002-6200-7043","observed_orcids":["https://orcid.org/0000-0002-6200-7043"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tohru Ishitani","raw_affiliation_strings":["Unit on Nervous Development Systems, Nagoya 464-8602, Japan. tish@bioreg.kyushu-u.ac.jp","Unit on Nervous Development Systems, 464-8602, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit on Nervous Development Systems, Nagoya 464-8602, Japan. tish@bioreg.kyushu-u.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Unit on Nervous Development Systems, 464-8602, Nagoya, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoko Hirao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko Hirao","raw_affiliation_strings":["Unit on Nervous Development Systems, 464-8602, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit on Nervous Development Systems, 464-8602, Nagoya, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046051364","display_name":"Maho Suzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maho Suzuki","raw_affiliation_strings":["Division of Biological Science, Group of Signal Transduction, Laboratory of Cell Regulation, Graduate School of Science, 464-8602, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Science, Group of Signal Transduction, Laboratory of Cell Regulation, Graduate School of Science, 464-8602, Nagoya, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078047872","display_name":"Miho Isoda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miho Isoda","raw_affiliation_strings":["Unit on Nervous Development Systems, 464-8602, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit on Nervous Development Systems, 464-8602, Nagoya, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010371807","display_name":"Shizuka Ishitani","orcid":"https://orcid.org/0009-0001-1133-2663","observed_orcids":["https://orcid.org/0009-0001-1133-2663"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shizuka Ishitani","raw_affiliation_strings":["Division of Cell Regulation Systems, Department of Post-Genome Science Center, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Regulation Systems, Department of Post-Genome Science Center, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044277714","display_name":"Kenichi Harigaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Harigaya","raw_affiliation_strings":["Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 260-8670, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 260-8670, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031794322","display_name":"Motoo Kitagawa","orcid":"https://orcid.org/0000-0003-1036-840X","observed_orcids":["https://orcid.org/0000-0003-1036-840X"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoo Kitagawa","raw_affiliation_strings":["Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 260-8670, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 260-8670, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044516003","display_name":"Kunihiro Matsumoto","orcid":"https://orcid.org/0000-0003-4821-0106","observed_orcids":["https://orcid.org/0000-0003-4821-0106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunihiro Matsumoto","raw_affiliation_strings":["Division of Biological Science, Group of Signal Transduction, Laboratory of Cell Regulation, Graduate School of Science, 464-8602, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Science, Group of Signal Transduction, Laboratory of Cell Regulation, Graduate School of Science, 464-8602, Nagoya, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006860559","display_name":"Motoyuki Itoh","orcid":"https://orcid.org/0000-0001-5017-2482","observed_orcids":["https://orcid.org/0000-0001-5017-2482"]},"institutions":[{"id":"https://openalex.org/I4405287166","display_name":"Nagoya University Institute for Advanced Research","ror":"https://ror.org/049xpsw37","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287166","https://openalex.org/I60134161"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Motoyuki Itoh","raw_affiliation_strings":["Institute for Advanced Research, Nagoya University, 464-8602, Nagoya, Japan","Unit on Nervous Development Systems, 464-8602, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Research, Nagoya University, 464-8602, Nagoya, Japan","institution_ids":["https://openalex.org/I4405287166","https://openalex.org/I60134161"]},{"raw_affiliation_string":"Unit on Nervous Development Systems, 464-8602, Nagoya, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5006860559","https://openalex.org/A5061243316"],"corresponding_institution_ids":["https://openalex.org/I4405287166","https://openalex.org/I60134161"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.2035,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.97035035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"278","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nemo-like-kinase","display_name":"Nemo-like kinase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/notch1-intracellular-domain","display_name":"Notch1 intracellular domain","score":0.9459999799728394},{"id":"https://openalex.org/keywords/csl-transcription-factor","display_name":"CSL transcription factor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8864494562149048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7906435132026672},{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.6974624395370483},{"id":"https://openalex.org/C86756495","wikidata":"https://www.wikidata.org/wiki/Q7702931","display_name":"Ternary complex","level":3,"score":0.695936918258667},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5291110873222351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5217462778091431},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5082235336303711},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4971340000629425},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4720419645309448},{"id":"https://openalex.org/C116227048","wikidata":"https://www.wikidata.org/wiki/Q18021243","display_name":"Cyclin-dependent kinase 8","level":4,"score":0.41213175654411316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32893645763397217},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.326463520526886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17917895317077637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17328956723213196},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11567077040672302},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067778","descriptor_name":"ELAV-Like Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072056","descriptor_name":"Transcription Factor HES-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051819","descriptor_name":"Immunoglobulin J Recombination Signal Sequence-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051819","descriptor_name":"Immunoglobulin J Recombination Signal Sequence-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/ncb2028","doi":"https://doi.org/10.1038/ncb2028","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncb2028","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},{"id":"pmid:20118921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20118921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005983528","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2324/26642","pdf_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/26642/3255_1775.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Cell Biology","raw_type":"journal article"},{"id":"pmh:oai:catalog.lib.kyushu-u.ac.jp:2324/26642","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2324/26642","pdf_url":null,"source":{"id":"https://openalex.org/S4306400832","display_name":"Kyushu University Institutional Repository (QIR) (Kyushu University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135598925","host_organization_name":"Kyushu University","host_organization_lineage":["https://openalex.org/I135598925"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Cell Biology","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01211:0005983528","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2324/26642","pdf_url":"https://catalog.lib.kyushu-u.ac.jp/opac_download_md/26642/3255_1775.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Cell Biology","raw_type":"journal article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1294737688","display_name":"Spatio-temporal regulation of cellular trafficking and signal transduction","funder_award_id":"21247031","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3641861990","display_name":"Clarification both of function and regulation of protein kinase NLK, that fine-tunes the activity of multiple intracellular signaling pathway.","funder_award_id":"19687013","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018588361.pdf","grobid_xml":"https://content.openalex.org/works/W2018588361.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1508234976","https://openalex.org/W1640296793","https://openalex.org/W1902879109","https://openalex.org/W1927705215","https://openalex.org/W1966830858","https://openalex.org/W1975803734","https://openalex.org/W1977962361","https://openalex.org/W1981691061","https://openalex.org/W1982700103","https://openalex.org/W1983370748","https://openalex.org/W1992499209","https://openalex.org/W1999141408","https://openalex.org/W2036385874","https://openalex.org/W2046081464","https://openalex.org/W2058733797","https://openalex.org/W2060839416","https://openalex.org/W2064000380","https://openalex.org/W2069624136","https://openalex.org/W2071196711","https://openalex.org/W2095969687","https://openalex.org/W2097411118","https://openalex.org/W2106017246","https://openalex.org/W2113359377","https://openalex.org/W2118903548","https://openalex.org/W2128968777","https://openalex.org/W2131004933","https://openalex.org/W2131572146","https://openalex.org/W2144599076","https://openalex.org/W2154861644","https://openalex.org/W2158109806","https://openalex.org/W2162275131","https://openalex.org/W2165047377","https://openalex.org/W3144948038"],"related_works":["https://openalex.org/W1979006151","https://openalex.org/W2158571771","https://openalex.org/W1973167499","https://openalex.org/W2103722613","https://openalex.org/W1999141408","https://openalex.org/W2276441807","https://openalex.org/W3021517266","https://openalex.org/W2127122438","https://openalex.org/W2065963386","https://openalex.org/W2086059239"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}