{"id":"https://openalex.org/W2018565712","doi":"https://doi.org/10.1110/ps.052059406","title":"Structural basis for the enantiospecificities of R\u2010 and S\u2010specific phenoxypropionate/\u03b1\u2010ketoglutarate dioxygenases","display_name":"Structural basis for the enantiospecificities of R\u2010 and S\u2010specific phenoxypropionate/\u03b1\u2010ketoglutarate dioxygenases","publication_year":2006,"publication_date":"2006-05-27","ids":{"openalex":"https://openalex.org/W2018565712","doi":"https://doi.org/10.1110/ps.052059406","mag":"2018565712","pmid":"https://pubmed.ncbi.nlm.nih.gov/16731970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2242530"},"language":"en","primary_location":{"id":"doi:10.1110/ps.052059406","doi":"https://doi.org/10.1110/ps.052059406","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.052059406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052059406","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052059406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067007014","display_name":"Tina M\u00fcller","orcid":"https://orcid.org/0000-0002-7612-139X","observed_orcids":["https://orcid.org/0000-0002-7612-139X"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina A. M\u00fcller","raw_affiliation_strings":["Department of Microbiology, Michigan State University, East Lansing, Michigan 48824-4320, USA","Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-4320, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073319922","display_name":"Maria I. Zavodszky","orcid":"https://orcid.org/0000-0001-7047-6643","observed_orcids":["https://orcid.org/0000-0001-7047-6643"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria I. Zavodszky","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061800523","display_name":"Michael Feig","orcid":"https://orcid.org/0000-0001-9380-6422","observed_orcids":["https://orcid.org/0000-0001-9380-6422"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Feig","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA","Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-4320, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029752062","display_name":"Leslie A. Kuhn","orcid":"https://orcid.org/0000-0001-9370-0978","observed_orcids":["https://orcid.org/0000-0001-9370-0978"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie A. Kuhn","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065700590","display_name":"Robert P. Hausinger","orcid":"https://orcid.org/0000-0002-3643-2054","observed_orcids":["https://orcid.org/0000-0002-3643-2054"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert P. Hausinger","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA","Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-4320, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-4320, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065700590"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.2251,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.46307953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"6","first_page":"1356","last_page":"1368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantiospecificity","display_name":"enantiospecificity","score":0.906000018119812},{"id":"https://openalex.org/keywords/dichlorprop","display_name":"dichlorprop","score":0.7200000286102295},{"id":"https://openalex.org/keywords/mecoprop","display_name":"mecoprop","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sdpa","display_name":"SDPA","score":1.0},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.6140000224113464},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.6460000276565552},{"id":"https://openalex.org/keywords/chiral-recognition","display_name":"chiral recognition","score":0.5690000057220459},{"id":"https://openalex.org/keywords/oxidative-cleavage","display_name":"oxidative cleavage","score":0.4659999907016754},{"id":"https://openalex.org/keywords/herbicide-degradation","display_name":"herbicide degradation","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2779761105","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propanoic acid","level":2,"score":0.7578748464584351},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.7245221138000488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7187247276306152},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6987610459327698},{"id":"https://openalex.org/C2781028444","wikidata":"https://www.wikidata.org/wiki/Q149452","display_name":"Mecoprop","level":4,"score":0.6507740020751953},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5016043186187744},{"id":"https://openalex.org/C127124265","wikidata":"https://www.wikidata.org/wiki/Q2100870","display_name":"Isotopomers","level":3,"score":0.43937334418296814},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4206737279891968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31405138969421387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1360032558441162},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.12640374898910522},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08681508898735046},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C2780659323","wikidata":"https://www.wikidata.org/wiki/Q149413","display_name":"MCPA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008456","descriptor_name":"2-Methyl-4-chlorophenoxyacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008456","descriptor_name":"2-Methyl-4-chlorophenoxyacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008456","descriptor_name":"2-Methyl-4-chlorophenoxyacetic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020578","descriptor_name":"Sphingomonas","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1110/ps.052059406","doi":"https://doi.org/10.1110/ps.052059406","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.052059406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052059406","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2242530","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2242530","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:16731970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16731970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1110/ps.052059406","doi":"https://doi.org/10.1110/ps.052059406","is_oa":true,"landing_page_url":"https://doi.org/10.1110/ps.052059406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1110/ps.052059406","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6214995148","display_name":"Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors","funder_award_id":"U01AI053877","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7078663027","display_name":"Characterization of Fe(II)/alpha-ketoglutarate-dependent hydroxylases","funder_award_id":"R01GM063584","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018565712.pdf","grobid_xml":"https://content.openalex.org/works/W2018565712.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W568659792","https://openalex.org/W1510561425","https://openalex.org/W1529838344","https://openalex.org/W1559633931","https://openalex.org/W1572955611","https://openalex.org/W1573717502","https://openalex.org/W1590262060","https://openalex.org/W1597350167","https://openalex.org/W1650854146","https://openalex.org/W1654652909","https://openalex.org/W1682099549","https://openalex.org/W1741317084","https://openalex.org/W1824851006","https://openalex.org/W1967314547","https://openalex.org/W1972021276","https://openalex.org/W1977412270","https://openalex.org/W1980374511","https://openalex.org/W1981641123","https://openalex.org/W1990670108","https://openalex.org/W1991055989","https://openalex.org/W1994964562","https://openalex.org/W1997588995","https://openalex.org/W2000975616","https://openalex.org/W2006575088","https://openalex.org/W2010105523","https://openalex.org/W2017991488","https://openalex.org/W2018289835","https://openalex.org/W2025524908","https://openalex.org/W2028079384","https://openalex.org/W2029245603","https://openalex.org/W2029327342","https://openalex.org/W2038316974","https://openalex.org/W2040776821","https://openalex.org/W2045574007","https://openalex.org/W2047841570","https://openalex.org/W2048936056","https://openalex.org/W2052918499","https://openalex.org/W2054556734","https://openalex.org/W2057339234","https://openalex.org/W2057631547","https://openalex.org/W2060010951","https://openalex.org/W2065960781","https://openalex.org/W2066414785","https://openalex.org/W2066427377","https://openalex.org/W2068053372","https://openalex.org/W2069690105","https://openalex.org/W2069920107","https://openalex.org/W2070314633","https://openalex.org/W2073607761","https://openalex.org/W2077598919","https://openalex.org/W2078591960","https://openalex.org/W2081912151","https://openalex.org/W2084266282","https://openalex.org/W2097612485","https://openalex.org/W2099254366","https://openalex.org/W2100837269","https://openalex.org/W2101518822","https://openalex.org/W2101871915","https://openalex.org/W2103885137","https://openalex.org/W2105573149","https://openalex.org/W2107434774","https://openalex.org/W2128586767","https://openalex.org/W2135472700","https://openalex.org/W2135983089","https://openalex.org/W2141210108","https://openalex.org/W2146481127","https://openalex.org/W2151763847","https://openalex.org/W2162166182","https://openalex.org/W2164133322","https://openalex.org/W2547211891","https://openalex.org/W2610505902","https://openalex.org/W2922017837"],"related_works":["https://openalex.org/W1966895059","https://openalex.org/W2017451622","https://openalex.org/W7097515451","https://openalex.org/W1993849022","https://openalex.org/W2151394233","https://openalex.org/W1985020729","https://openalex.org/W1995955714","https://openalex.org/W2962703015","https://openalex.org/W2034041982","https://openalex.org/W2783629329"],"abstract_inverted_index":{"(R)-":[0,113],"and":[1,5,15,38,88,164,180,188],"(S)-dichlorprop/alpha-ketoglutarate":[2],"dioxygenases":[3],"(RdpA":[4],"SdpA)":[6],"catalyze":[7],"the":[8,23,28,45,48,60,63,66,78,81,89,95,101,137,149,155,161,171,196,199,204,210],"oxidative":[9],"cleavage":[10],"of":[11,30,62,65,80,97,100,136,148,157,173,176,198],"2-(2,4-dichlorophenoxy)propanoic":[12],"acid":[13,17],"(dichlorprop)":[14],"2-(4-chloro-2-methyl-phenoxy)propanoic":[16],"(mecoprop)":[18],"to":[19,33,76,110],"form":[20],"pyruvate":[21],"plus":[22,35],"corresponding":[24],"phenol":[25],"concurrent":[26],"with":[27,112,127,144,154],"conversion":[29],"alpha-ketoglutarate":[31],"(alphaKG)":[32],"succinate":[34],"CO2.":[36],"RdpA":[37,179,187],"SdpA":[39,139,191],"are":[40,152,219],"strictly":[41],"enantiospecific,":[42],"converting":[43],"only":[44],"(R)":[46],"or":[47,114],"(S)":[49],"enantiomer,":[50],"respectively.":[51],"Homology":[52],"models":[53,163],"were":[54,91,141],"generated":[55],"for":[56,129],"both":[57],"enzymes":[58],"on":[59],"basis":[61],"structure":[64],"related":[67],"enzyme":[68],"TauD":[69],"(PDB":[70],"code":[71],"1OS7).":[72],"Docking":[73],"was":[74],"used":[75],"predict":[77],"orientation":[79],"appropriate":[82],"mecoprop":[83],"enantiomer":[84,201],"in":[85,132,160,178,186,190,213],"each":[86],"protein,":[87],"predictions":[90],"tested":[92],"by":[93,122,170,194,209,221],"characterizing":[94],"activities":[96],"site-directed":[98],"variants":[99,140],"enzymes.":[102],"Mutant":[103],"proteins":[104],"that":[105,166],"changed":[106],"at":[107],"residues":[108,131,177,184],"predicted":[109],"interact":[111],"(S)-mecoprop":[115],"exhibited":[116],"significantly":[117],"reduced":[118],"activity,":[119],"often":[120],"accompanied":[121],"increased":[123],"Km":[124,214],"values,":[125],"consistent":[126,153],"roles":[128],"these":[130,216],"substrate":[133],"binding.":[134],"Four":[135],"designed":[138],"(slightly)":[142],"active":[143],"(R)-mecoprop.":[145],"The":[146],"results":[147],"kinetic":[150],"investigations":[151],"identification":[156],"key":[158],"interactions":[159,172],"structural":[162],"demonstrate":[165],"enantiospecificity":[167],"is":[168],"coordinated":[169],"a":[174],"number":[175],"SdpA.":[181],"Most":[182],"significantly,":[183],"Phe171":[185],"Glu69":[189],"apparently":[192],"act":[193],"hindering":[195],"binding":[197],"wrong":[200],"more":[202],"than":[203],"correct":[205],"one,":[206],"as":[207],"judged":[208],"observed":[211],"decreases":[212],"when":[215],"side":[217],"chains":[218],"replaced":[220],"Ala.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
