{"id":"https://openalex.org/W2018564757","doi":"https://doi.org/10.1055/s-2006-944821","title":"Epigenetik in der Entstehung von Plattenenepithelkarzinomen des Kopf-Halses - m\u00f6gliche neue Therapieoption?","display_name":"Epigenetik in der Entstehung von Plattenenepithelkarzinomen des Kopf-Halses - m\u00f6gliche neue Therapieoption?","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2018564757","doi":"https://doi.org/10.1055/s-2006-944821","mag":"2018564757","pmid":"https://pubmed.ncbi.nlm.nih.gov/17226729"},"language":"de","primary_location":{"id":"doi:10.1055/s-2006-944821","doi":"https://doi.org/10.1055/s-2006-944821","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-944821","pdf_url":null,"source":{"id":"https://openalex.org/S140305009","display_name":"Laryngo-Rhino-Otologie","issn_l":"0935-8943","issn":["0935-8943","1438-8685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laryngo-Rhino-Otologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055893480","display_name":"Anna-Lena Weber","orcid":"https://orcid.org/0000-0002-2511-4296","observed_orcids":["https://orcid.org/0000-0002-2511-4296"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I4210128537","display_name":"Klinik und Poliklinik f\u00fcr Hals-, Nasen-, Ohrenheilkunde","ror":"https://ror.org/03cr5e788","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843","https://openalex.org/I4210128537"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Weber","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universit\u00e4tsklinikum Leipzig, Leipzig. Anette.Weber@medizin.unileipzig.de","Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universit\u00e4tsklinikum Leipzig"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universit\u00e4tsklinikum Leipzig, Leipzig. Anette.Weber@medizin.unileipzig.de","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I4210128537","https://openalex.org/I926574661"]},{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universit\u00e4tsklinikum Leipzig","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I4210128537","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103263275","display_name":"Andreas Dietz","orcid":"https://orcid.org/0000-0001-8254-1676","observed_orcids":["https://orcid.org/0000-0001-8254-1676"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I4210128537","display_name":"Klinik und Poliklinik f\u00fcr Hals-, Nasen-, Ohrenheilkunde","ror":"https://ror.org/03cr5e788","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843","https://openalex.org/I4210128537"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Dietz","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universit\u00e4tsklinikum Leipzig"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universit\u00e4tsklinikum Leipzig","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I4210128537","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036267814","display_name":"Iris Tischoff","orcid":"https://orcid.org/0009-0002-6452-2732","observed_orcids":["https://orcid.org/0009-0002-6452-2732"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Tischoff","raw_affiliation_strings":["Institut f\u00fcr Pathologie, Ruhr Universit\u00e4t Bochum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Ruhr Universit\u00e4t Bochum","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063413978","display_name":"Andrea Tannapfel","orcid":"https://orcid.org/0000-0002-0711-7100","observed_orcids":["https://orcid.org/0000-0002-0711-7100"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Tannapfel","raw_affiliation_strings":["Institut f\u00fcr Pathologie, Ruhr Universit\u00e4t Bochum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Ruhr Universit\u00e4t Bochum","institution_ids":["https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10996437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"86","issue":"1","first_page":"9","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9330000281333923},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.984000027179718},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8069999814033508},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6650000214576721},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7749999761581421},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.675000011920929},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7957855463027954},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6645617485046387},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5688148736953735},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5668438673019409},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5546935796737671},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5432760119438171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5221672058105469},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5173037052154541},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4497341215610504},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.359813928604126},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3374761939048767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24277567863464355},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2145046591758728},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.13784101605415344}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016153","descriptor_name":"Genes, Suppressor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016153","descriptor_name":"Genes, Suppressor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016153","descriptor_name":"Genes, Suppressor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052416","descriptor_name":"Targeted Gene Repair","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052416","descriptor_name":"Targeted Gene Repair","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052416","descriptor_name":"Targeted Gene Repair","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2006-944821","doi":"https://doi.org/10.1055/s-2006-944821","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-944821","pdf_url":null,"source":{"id":"https://openalex.org/S140305009","display_name":"Laryngo-Rhino-Otologie","issn_l":"0935-8943","issn":["0935-8943","1438-8685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laryngo-Rhino-Otologie","raw_type":"journal-article"},{"id":"pmid:17226729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17226729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laryngo- rhino- otologie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2214376880","https://openalex.org/W3212149434","https://openalex.org/W2073893804","https://openalex.org/W2291484187","https://openalex.org/W2902329290","https://openalex.org/W2139872319","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W2107880877","https://openalex.org/W2151182744"],"abstract_inverted_index":{"Auf":[0],"der":[1,15,19,29,63,70,109,145,149],"Suche":[2],"nach":[3,153],"innovativen,":[4],"individualisierten":[5],"Therapien":[6],"von":[7,88,103,124,135],"Plattenepithelkarzinomen":[8],"des":[9,78],"Kopf-Halses":[10],"ist":[11,60,132],"ein":[12],"besseres":[13],"Verst\u00e4ndnis":[14],"Karzinogenese":[16,30],"unabdingbar.":[17],"Entgegen":[18],"bisherigen":[20],"Vorstellung,":[21],"dass":[22,37],"allein":[23],"genetische":[24],"Ver\u00e4nderungen":[25,47],"den":[26],"schrittweisen":[27],"Prozess":[28],"initiieren":[31],"und":[32,81,98],"perpetuieren,":[33],"belegen":[34],"neuere":[35],"Studien,":[36],"auch":[38],"epigenetische":[39,58],"Ph\u00e4nomene":[40],"wesentlich":[41],"zur":[42,122],"Tumorentstehung":[43],"beitragen.":[44],"Bei":[45,86],"epigenetischen":[46],"kommt":[48,90],"es":[49,91],"zu":[50,95],"Genexpressionsver\u00e4nderungen":[51],"ohne":[52],"Genalterationen.":[53],"Das":[54],"am":[55],"besten":[56],"untersuchte":[57],"Ph\u00e4nomen":[59],"die":[61,68,73,76,83],"Hypermethylierung":[62,87,102],"Promotorregion":[64],"eines":[65],"Gens.":[66],"Durch":[67],"Bindung":[69],"Methylgruppen":[71],"an":[72],"DNA":[74,136],"wird":[75],"Anlagerung":[77],"Promotors":[79],"verhindert":[80],"somit":[82,92],"Transkription":[84],"unterbunden.":[85],"Tumorsuppressorgenen":[89,104],"z.":[93],"B.":[94],"ungehemmter":[96],"Proliferation":[97],"fehlender":[99],"Apoptose.":[100],"Eine":[101],"konnte":[105,142],"bereits":[106],"in":[107,151],"Vorstufen":[108],"Plattenepithelkarzinome":[110],"nachgewiesen":[111],"werden.":[112,158],"Daher":[113],"bietet":[114],"sich":[115],"Epigenetik":[116],"oder":[117],"DNA-Methylierung":[118],"m\u00f6glicherweise":[119],"als":[120],"\u201eBiomarker\u201d":[121],"Fr\u00fchentdeckung":[123],"Kopf-Hals-Karzinomen":[125],"an.":[126],"Die":[127],"durch":[128],"Methyltransferasen":[129],"vermittelte":[130],"Methylgruppenbindung":[131],"mit":[133,155],"Hilfe":[134],"Demethylierungsagenzien":[137,156],"reversibel.":[138],"In":[139],"mehreren":[140],"Studien":[141],"eine":[143],"Verminderung":[144],"Proliferationsrate":[146],"sowie":[147],"Steigerung":[148],"Apoptose":[150],"Tumorzellkulturen":[152],"Behandlung":[154],"erreicht":[157],"Diese":[159],"Ergebnisse":[160],"bieten":[161],"einen":[162],"interessanten":[163],"Ansatzpunkt":[164],"f\u00fcr":[165],"neue,":[166],"zielgerichtete":[167],"Therapien.":[168]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
