{"id":"https://openalex.org/W2018560171","doi":"https://doi.org/10.1038/218069a0","title":"Specific Hydrogen Bonding of Barbiturates to Adenine Derivatives","display_name":"Specific Hydrogen Bonding of Barbiturates to Adenine Derivatives","publication_year":1968,"publication_date":"1968-04-01","ids":{"openalex":"https://openalex.org/W2018560171","doi":"https://doi.org/10.1038/218069a0","mag":"2018560171","pmid":"https://pubmed.ncbi.nlm.nih.gov/5643543"},"language":"en","primary_location":{"id":"doi:10.1038/218069a0","doi":"https://doi.org/10.1038/218069a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/218069a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025983870","display_name":"Yoshimasa Kyogoku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YOSHIMASA KYOGOKU","raw_affiliation_strings":["Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts","Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107639449","display_name":"R. C. Lord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. C. LORD","raw_affiliation_strings":["Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts","Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103066840","display_name":"Alexander Rich","orcid":"https://orcid.org/0000-0002-1951-1180","observed_orcids":["https://orcid.org/0000-0002-1951-1180"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ALEXANDER RICH","raw_affiliation_strings":["Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts","Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Spectroscopy Laboratory and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":8.9694,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.99426257,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"218","issue":"5136","first_page":"69","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.11540000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":1.0},{"id":"https://openalex.org/keywords/adenine-derivatives","display_name":"adenine derivatives","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nucleobase-interactions","display_name":"nucleobase interactions","score":0.6010000109672546},{"id":"https://openalex.org/keywords/thymine-derivatives","display_name":"thymine derivatives","score":0.8489999771118164},{"id":"https://openalex.org/keywords/uracil-derivatives","display_name":"uracil derivatives","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nucleic-acid-binding","display_name":"nucleic acid binding","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.8217777609825134},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7746672630310059},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.7655020952224731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6374567151069641},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.42344173789024353},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36713021993637085},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3081471621990204},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28469738364219666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1840766966342926},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09623247385025024}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001463","descriptor_name":"Barbiturates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/218069a0","doi":"https://doi.org/10.1038/218069a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/218069a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:5643543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5643543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1508989419","https://openalex.org/W1964690732","https://openalex.org/W1969224882","https://openalex.org/W1980550041","https://openalex.org/W1986040723","https://openalex.org/W2023578860","https://openalex.org/W2024828007","https://openalex.org/W2027127607","https://openalex.org/W2050088472","https://openalex.org/W2061569958","https://openalex.org/W2062913534","https://openalex.org/W2093968976","https://openalex.org/W2140151251","https://openalex.org/W2151021388","https://openalex.org/W2324985954","https://openalex.org/W2597738519","https://openalex.org/W4243217954"],"related_works":["https://openalex.org/W2094096184","https://openalex.org/W2022448884","https://openalex.org/W269314050","https://openalex.org/W4220836850","https://openalex.org/W2090029214","https://openalex.org/W1967732171","https://openalex.org/W2950317311","https://openalex.org/W2034703732","https://openalex.org/W2952487717","https://openalex.org/W1988060526"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}