{"id":"https://openalex.org/W2018553516","doi":"https://doi.org/10.1371/journal.pone.0056837","title":"Inhibition of Pirfenidone on TGF-beta2 Induced Proliferation, Migration and Epithlial-Mesenchymal Transition of Human Lens Epithelial Cells Line SRA01/04","display_name":"Inhibition of Pirfenidone on TGF-beta2 Induced Proliferation, Migration and Epithlial-Mesenchymal Transition of Human Lens Epithelial Cells Line SRA01/04","publication_year":2013,"publication_date":"2013-02-21","ids":{"openalex":"https://openalex.org/W2018553516","doi":"https://doi.org/10.1371/journal.pone.0056837","mag":"2018553516","pmid":"https://pubmed.ncbi.nlm.nih.gov/23437252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3578851"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0056837","doi":"https://doi.org/10.1371/journal.pone.0056837","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056837","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056837&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056837&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101475006","display_name":"Yangfan Yang","orcid":"https://orcid.org/0000-0001-9021-9652","observed_orcids":["https://orcid.org/0000-0001-9021-9652","https://orcid.org/0000-0002-0007-6481"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangfan Yang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000076506","display_name":"Yiming Ye","orcid":"https://orcid.org/0000-0001-7737-6100","observed_orcids":["https://orcid.org/0000-0001-7737-6100"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Ye","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072095183","display_name":"Xianchai Lin","orcid":"https://orcid.org/0000-0002-9483-4043","observed_orcids":["https://orcid.org/0000-0002-9483-4043"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianchai Lin","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083220985","display_name":"Kaili Wu","orcid":"https://orcid.org/0000-0003-3606-683X","observed_orcids":["https://orcid.org/0000-0003-3606-683X","https://orcid.org/0000-0002-3938-7164"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaili Wu","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046082086","display_name":"Minbin Yu","orcid":"https://orcid.org/0000-0002-3938-7164","observed_orcids":["https://orcid.org/0000-0002-3938-7164"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Minbin Yu","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046082086"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.9114,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95830619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"2","first_page":"e56837","last_page":"e56837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pirfenidone","display_name":"pirfenidone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.9110000133514404},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sra01-04-cells","display_name":"SRA01/04 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/posterior-capsule-opacification","display_name":"posterior capsule opacification","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cataract-surgery-complications","display_name":"cataract surgery complications","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":1.0},{"id":"https://openalex.org/keywords/smad-nuclear-translocation","display_name":"Smad nuclear translocation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2779832356","wikidata":"https://www.wikidata.org/wiki/Q2060696","display_name":"Pirfenidone","level":4,"score":0.6121765375137329},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5493518710136414},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.548665463924408},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5437636375427246},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5339454412460327},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.523637056350708},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5225778818130493},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5182825922966003},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5135743618011475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.483253538608551},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.471293568611145},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.4689934551715851},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.4616791903972626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44000181555747986},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4340822100639343},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37999966740608215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35216325521469116},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3319224715232849},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32572221755981445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20914879441261292},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.20101648569107056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19689393043518066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16826575994491577},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.07792535424232483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053781","descriptor_name":"Transforming Growth Factor beta2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0056837","doi":"https://doi.org/10.1371/journal.pone.0056837","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056837","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056837&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2577649","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3578851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3578851","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3578851","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23437252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23437252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.787.6866","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.787.6866","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ce/3c/pone.0056837.PMC3578851.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6c487cc231c847ad83ad43382f805fac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6c487cc231c847ad83ad43382f805fac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 2, p e56837 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0056837","doi":"https://doi.org/10.1371/journal.pone.0056837","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056837","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056837&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320329903","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018553516.pdf","grobid_xml":"https://content.openalex.org/works/W2018553516.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W7975040","https://openalex.org/W1502066818","https://openalex.org/W1601848900","https://openalex.org/W1636022999","https://openalex.org/W1821257161","https://openalex.org/W1913053306","https://openalex.org/W1965185650","https://openalex.org/W1970441910","https://openalex.org/W1976957021","https://openalex.org/W1980018854","https://openalex.org/W1996605292","https://openalex.org/W2013095759","https://openalex.org/W2018659066","https://openalex.org/W2028494744","https://openalex.org/W2029181407","https://openalex.org/W2030837762","https://openalex.org/W2031374932","https://openalex.org/W2033728382","https://openalex.org/W2035653659","https://openalex.org/W2040923898","https://openalex.org/W2059988298","https://openalex.org/W2062387633","https://openalex.org/W2068774044","https://openalex.org/W2113481335","https://openalex.org/W2114522026","https://openalex.org/W2122290767","https://openalex.org/W2150361016","https://openalex.org/W2162755729","https://openalex.org/W2171180036","https://openalex.org/W2340174723","https://openalex.org/W2427459423","https://openalex.org/W4249588491","https://openalex.org/W4255703751"],"related_works":["https://openalex.org/W4306836132","https://openalex.org/W4297494352","https://openalex.org/W1983130739","https://openalex.org/W2896950570","https://openalex.org/W2588786207","https://openalex.org/W7028531025","https://openalex.org/W63098255","https://openalex.org/W3108928983","https://openalex.org/W2013095759","https://openalex.org/W3214489993"],"abstract_inverted_index":{"BACKGROUND:":[0],"Posterior":[1],"capsular":[2],"opacification":[3],"(PCO)":[4],"is":[5],"a":[6],"common":[7],"complication":[8],"of":[9,22,43,51,88,111,118,155,202,217,227,234,247,265],"cataract":[10],"surgery.":[11],"Transforming":[12],"growth":[13,113],"factor-\u03b22":[14,114],"(TGF-\u03b22)":[15],"plays":[16],"important":[17],"roles":[18],"in":[19,59,106,204,212,236,268],"the":[20,41,95,107,183,190,224,231],"development":[21],"PCO.":[23],"The":[24,116,132,143,207],"existing":[25],"pharmacological":[26],"treatments":[27],"are":[28],"not":[29,150],"satisfactory":[30],"and":[31,48,66,86,120,129,185,189,194,199,214,219,229,244],"can":[32],"have":[33],"toxic":[34],"side":[35],"effects.":[36],"METHODOLOGIES/PRINCIPAL":[37],"FINDINGS:":[38],"We":[39],"evaluated":[40,123],"effect":[42,174,258],"pirfenidone":[44,156],"on":[45,175],"proliferation,":[46,242],"migration":[47,100,188,243],"epithlial-mesenchymal":[49,245],"transition":[50,246],"human":[52,248],"lens":[53,249],"epithelial":[54,250],"cell":[55,70,99,187],"line":[56,252],"SRA01/04":[57,176,205,253,269],"(HLECs)":[58],"vitro.":[60],"After":[61],"treatment":[62],"with":[63,124],"0,":[64],"0.25,":[65],"0.5":[67,160],"mg/ml":[68],"pirfenidone,":[69],"proliferation":[71,184],"was":[72,79,101,138],"measured":[73,102],"by":[74,81,103,140,177,262],"MTT":[75],"assay.":[76,179],"Cell":[77],"viability":[78],"determined":[80],"trypan":[82],"blue":[83],"exclusion":[84],"assay":[85,105],"measurement":[87],"lactate":[89],"dehydrogenase":[90],"(LDH)":[91],"activity":[92],"released":[93],"from":[94],"damaged":[96],"cells.":[97,206,237,270],"And":[98],"scratch":[104],"absence":[108],"or":[109,161],"presence":[110],"transforming":[112],"(TGF-\u03b22).":[115],"expressions":[117],"TGF-\u03b22":[119,218],"SMADs":[121,228,235],"were":[122,192],"real-time":[125],"RT-PCR,":[126],"western":[127],"blot,":[128],"immunofluorescence":[130],"analyses.":[131,142],"mesenchymal":[133],"phenotypic":[134],"marker":[135],"fibronectin":[136],"(FN)":[137],"demonstrated":[139],"Immunocytofluorescence":[141],"cells":[144,208,251],"had":[145,170],"high":[146],"viability,":[147],"which":[148],"did":[149],"vary":[151],"across":[152],"different":[153],"concentrations":[154],"(0":[157],"[control]":[158],"0.3,":[159],"1.0":[162],"mg/ml)":[163,169],"after":[164],"24":[165],"hours.":[166],"Pirfenidone":[167,180,221,239],"(0\u223c0.5":[168],"no":[171],"significant":[172],"cytotoxicity":[173],"LDH":[178],"significantly":[181],"inhibited":[182,195],"TGF-\u03b22-induced":[186,196,200,225,241],"effects":[191],"dose-dependent,":[193],"fibroblastic":[197],"phenotypes":[198],"expression":[201,226],"FN":[203],"showed":[209],"dose-dependent":[210],"decreases":[211],"mRNA":[213],"protein":[215],"levels":[216],"SMADs.":[220],"also":[222],"depressed":[223],"blocked":[230],"nuclear":[232],"translocation":[233],"CONCLUSION:":[238],"inhibits":[240],"at":[254],"nontoxic":[255],"concentrations.":[256],"This":[257],"may":[259],"be":[260],"achieved":[261],"down":[263],"regulation":[264],"TGF-\u03b2/SAMD":[266],"signaling":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}