{"id":"https://openalex.org/W2018552583","doi":"https://doi.org/10.1111/dom.12008","title":"KH902 suppresses high glucose\u2010induced migration and sprouting of human retinal endothelial cells by blocking VEGF and PIGF","display_name":"KH902 suppresses high glucose\u2010induced migration and sprouting of human retinal endothelial cells by blocking VEGF and PIGF","publication_year":2012,"publication_date":"2012-09-07","ids":{"openalex":"https://openalex.org/W2018552583","doi":"https://doi.org/10.1111/dom.12008","mag":"2018552583","pmid":"https://pubmed.ncbi.nlm.nih.gov/22958404"},"language":"en","primary_location":{"id":"doi:10.1111/dom.12008","doi":"https://doi.org/10.1111/dom.12008","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12008","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043670132","display_name":"Xingfei Chen","orcid":"https://orcid.org/0000-0002-8647-0614","observed_orcids":["https://orcid.org/0000-0002-8647-0614"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Chen","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102767226","display_name":"Jianjun Li","orcid":"https://orcid.org/0000-0003-1304-3969","observed_orcids":["https://orcid.org/0000-0003-1304-3969"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Li","raw_affiliation_strings":["Department of Ophthalmology, Qilu Hospital Shandong University Jinan China","State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Qilu Hospital Shandong University Jinan China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351404","display_name":"Ming Li","orcid":"https://orcid.org/0000-0002-2540-1738","observed_orcids":["https://orcid.org/0000-0002-2540-1738","https://orcid.org/0000-0001-7934-6052"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"M. Li","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477703","display_name":"M. Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"M. Zeng","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. Li","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101510154","display_name":"Wei Xiao","orcid":"https://orcid.org/0000-0001-6974-8664","observed_orcids":["https://orcid.org/0000-0001-6974-8664"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Xiao","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102767226","display_name":"Jianjun Li","orcid":"https://orcid.org/0000-0003-1304-3969","observed_orcids":["https://orcid.org/0000-0003-1304-3969"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Li","raw_affiliation_strings":["Department of Ophthalmology, Qilu Hospital Shandong University  Jinan China","State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Qilu Hospital Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544640","display_name":"Quan Wu","orcid":"https://orcid.org/0000-0001-6502-8192","observed_orcids":["https://orcid.org/0000-0001-6502-8192"]},"institutions":[{"id":"https://openalex.org/I4405267191","display_name":"Chengdu Kanghong Biotech Co., Ltd. (China)","ror":"https://ror.org/01kjmx239","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405267191"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Wu","raw_affiliation_strings":["Chengdu Kanghong Biotechnology Co. Ltd Chengdu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu Kanghong Biotechnology Co. Ltd Chengdu China","institution_ids":["https://openalex.org/I4405267191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101583796","display_name":"Xiao Ke","orcid":"https://orcid.org/0000-0002-2992-3752","observed_orcids":["https://orcid.org/0000-0002-2992-3752"]},"institutions":[{"id":"https://openalex.org/I4405267191","display_name":"Chengdu Kanghong Biotech Co., Ltd. (China)","ror":"https://ror.org/01kjmx239","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405267191"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Ke","raw_affiliation_strings":["Chengdu Kanghong Biotechnology Co. Ltd Chengdu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu Kanghong Biotechnology Co. Ltd Chengdu China","institution_ids":["https://openalex.org/I4405267191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087054202","display_name":"Hongmei Luo","orcid":"https://orcid.org/0000-0001-8130-8565","observed_orcids":["https://orcid.org/0000-0001-8130-8565"]},"institutions":[{"id":"https://openalex.org/I4405267191","display_name":"Chengdu Kanghong Biotech Co., Ltd. (China)","ror":"https://ror.org/01kjmx239","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405267191"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Luo","raw_affiliation_strings":["Chengdu Kanghong Biotechnology Co. Ltd Chengdu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu Kanghong Biotechnology Co. Ltd Chengdu China","institution_ids":["https://openalex.org/I4405267191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031243964","display_name":"Shibo Tang","orcid":"https://orcid.org/0000-0003-2737-6780","observed_orcids":["https://orcid.org/0000-0003-2737-6780"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. Tang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055700863","display_name":"Yan Luo","orcid":"https://orcid.org/0000-0002-5262-4363","observed_orcids":["https://orcid.org/0000-0002-5262-4363","https://orcid.org/0000-0002-6009-5801"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Y. Luo","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5055700863"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":null,"fwci":1.4115,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.80172229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"224","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.3434999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7639999985694885},{"id":"https://openalex.org/keywords/placental-growth-factor","display_name":"placental growth factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinal-endothelial-cells","display_name":"retinal endothelial cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.7440000176429749},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ocular-neovascular-disease","display_name":"ocular neovascular disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/vegf-receptor-1","display_name":"VEGF receptor 1","score":0.5979999899864197},{"id":"https://openalex.org/keywords/vegf-receptor-2","display_name":"VEGF receptor 2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5554498434066772},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.547396719455719},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.535709023475647},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.5184606909751892},{"id":"https://openalex.org/C2776871010","wikidata":"https://www.wikidata.org/wiki/Q18030500","display_name":"Placental growth factor","level":4,"score":0.44224056601524353},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43164876103401184},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41063281893730164},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.32311391830444336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3033745288848877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21980014443397522},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.212683767080307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20825722813606262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1051168441772461},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/dom.12008","doi":"https://doi.org/10.1111/dom.12008","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12008","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmid:22958404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22958404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W44172448","https://openalex.org/W1542529343","https://openalex.org/W1565918933","https://openalex.org/W1587020653","https://openalex.org/W1605629534","https://openalex.org/W1966709403","https://openalex.org/W1975198479","https://openalex.org/W1983763042","https://openalex.org/W1984265335","https://openalex.org/W1988795095","https://openalex.org/W1992440046","https://openalex.org/W2002310665","https://openalex.org/W2013901561","https://openalex.org/W2014148719","https://openalex.org/W2028856461","https://openalex.org/W2033245558","https://openalex.org/W2037680183","https://openalex.org/W2042261909","https://openalex.org/W2044138670","https://openalex.org/W2051268134","https://openalex.org/W2057379707","https://openalex.org/W2073841280","https://openalex.org/W2081633887","https://openalex.org/W2085682483","https://openalex.org/W2087409531","https://openalex.org/W2094273616","https://openalex.org/W2096401506","https://openalex.org/W2111076061","https://openalex.org/W2117413404","https://openalex.org/W2123559545","https://openalex.org/W2128230789","https://openalex.org/W2128258742","https://openalex.org/W2128556846","https://openalex.org/W2129375983","https://openalex.org/W2171590915","https://openalex.org/W2331569881","https://openalex.org/W4212945288"],"related_works":["https://openalex.org/W2050312213","https://openalex.org/W2037680183","https://openalex.org/W2593818822","https://openalex.org/W3199757403","https://openalex.org/W101606460","https://openalex.org/W2981960646","https://openalex.org/W1977103711","https://openalex.org/W2088923778","https://openalex.org/W6891625589","https://openalex.org/W3176237778"],"abstract_inverted_index":{"AIMS:":[0],"Vascular":[1],"endothelial":[2,79],"growth":[3,8],"factor":[4,9],"(VEGF)":[5],"and":[6,41,45,51,88,96,111,134,185,195,202,214],"placental":[7],"(PlGF)":[10],"are":[11],"upregulated":[12],"in":[13,243],"many":[14],"ocular":[15,247],"neovascular":[16,248],"diseases":[17],"such":[18],"as":[19],"diabetic":[20],"retinopathy":[21],"(DR).":[22],"KH902":[23,74,142,158,179,209,233],"is":[24,234],"a":[25,235],"recombinant":[26],"fusion":[27],"protein":[28,125],"with":[29],"its":[30],"binding":[31,221],"ligand":[32],"taken":[33],"from":[34,146],"the":[35,61,144,191,197,228],"domains":[36],"of":[37,55,64,67,73,93,104,116,127,178,187,193,199,216,230],"VEGF":[38,42,95],"receptor-1":[39],"(VEGFR-1)":[40],"receptor-2":[43],"(VEGFR-2)":[44],"can":[46],"bind":[47],"all":[48],"VEGF-A":[49],"isoforms":[50],"PlGF.":[52],"The":[53,70,91,102,114,124],"aim":[54],"this":[56],"study":[57,206],"was":[58,82,106,118],"to":[59,149,155,226],"investigate":[60],"underlying":[62],"mechanisms":[63],"anti-angiogenic":[65],"effects":[66],"KH902.":[68],"METHODS:":[69],"toxic":[71],"effect":[72],"on":[75],"cultured":[76,156],"human":[77],"retinal":[78],"cells":[80],"(HRECs)":[81],"measured":[83,99,137],"by":[84,100,108,120,138,169],"Annexin":[85],"V/PI":[86],"staining":[87],"MTT":[89],"assay.":[90,113,123],"concentrations":[92,145],"secreted":[94,168],"PlGF":[97,165,225],"were":[98,136,167],"ELISA.":[101],"migration":[103,184,213],"HRECs":[105,117,170,188,217],"assessed":[107],"scratch":[109],"wound":[110],"transwell":[112],"sprouting":[115,186,215],"determined":[119],"tube":[121],"formation":[122],"levels":[126],"Src,":[128,200],"p-Src,":[129],"PI3K,":[130],"Akt1,":[131],"p-Akt1,":[132],"Erk1/2":[133],"p-Erk1/2":[135],"Western":[139],"blot.":[140],"RESULTS:":[141],"at":[143],"100":[147,150],"ng/ml":[148,177],"\u00b5g/ml":[151],"had":[152],"no":[153],"cytotoxicity":[154],"HRECs.":[157],"bound":[159],"not":[160,219],"only":[161,220],"VEGF165,":[162],"but":[163,223],"also":[164,224],"that":[166,208,237],"under":[171],"high":[172,182,211],"glucose":[173],"condition.":[174],"A":[175],"500":[176],"significantly":[180],"suppressed":[181],"glucose-induced":[183,212],"through":[189,218],"downregulating":[190],"expression":[192],"PI3K":[194],"inhibiting":[196],"activation":[198,229],"Akt1":[201],"Erk1/2.":[203],"CONCLUSION:":[204],"Our":[205],"indicates":[207],"suppresses":[210],"VEGF,":[222],"inhibit":[227],"Src-Akt1-Erk1/2":[231],"pathway.":[232],"drug":[236],"potentially":[238],"inhibits":[239],"angiogenic":[240],"pathways":[241],"involving":[242],"DR":[244],"or":[245],"other":[246],"diseases.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
