{"id":"https://openalex.org/W2018545641","doi":"https://doi.org/10.1038/nrcardio.2011.208","title":"Systems-based approaches to cardiovascular disease","display_name":"Systems-based approaches to cardiovascular disease","publication_year":2012,"publication_date":"2012-01-10","ids":{"openalex":"https://openalex.org/W2018545641","doi":"https://doi.org/10.1038/nrcardio.2011.208","mag":"2018545641","pmid":"https://pubmed.ncbi.nlm.nih.gov/22231714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3823242"},"language":"en","primary_location":{"id":"doi:10.1038/nrcardio.2011.208","doi":"https://doi.org/10.1038/nrcardio.2011.208","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrcardio.2011.208","pdf_url":null,"source":{"id":"https://openalex.org/S62674001","display_name":"Nature Reviews Cardiology","issn_l":"1759-5002","issn":["1759-5002","1759-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cardiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3823242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102900534","display_name":"William Robb MacLellan","orcid":"https://orcid.org/0000-0002-3066-2545","observed_orcids":["https://orcid.org/0000-0002-3066-2545"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Robb MacLellan","raw_affiliation_strings":["Cardiovascular Research Laboratories, University of California Los Angeles, 675 Charles E. Young Drive South, MRL 3645, University of California Los Angeles, Los Angeles, CA 90095-1760, USA","Cardiovascular Research Laboratories, University of California Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Laboratories, University of California Los Angeles, 675 Charles E. Young Drive South, MRL 3645, University of California Los Angeles, Los Angeles, CA 90095-1760, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Cardiovascular Research Laboratories, University of California Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100710570","display_name":"Yibin Wang","orcid":"https://orcid.org/0000-0003-0852-0767","observed_orcids":["https://orcid.org/0000-0003-0852-0767","https://orcid.org/0009-0004-8559-1619"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yibin Wang","raw_affiliation_strings":["Department of Anesthesiology, BH\u2013569 CHS, University of California Los Angeles, Los Angeles, 90095\u20137115, CA, USA","Department of Anesthesiology, BH\u2013569 CHS, University of California Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, BH\u2013569 CHS, University of California Los Angeles, Los Angeles, 90095\u20137115, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Anesthesiology, BH\u2013569 CHS, University of California Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024741961","display_name":"Aldons Jake Lusis","orcid":"https://orcid.org/0000-0001-9013-0228","observed_orcids":["https://orcid.org/0000-0001-9013-0228"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aldons J. Lusis","raw_affiliation_strings":["David Geffen School of Medicine, University of California Los Angeles, 695 Charles E. Young Drive South, 6524A Gonda Building, Los Angeles, 90095\u20131679, CA, USA","David Geffen School of Medicine, University of California, Los Angeles. Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine, University of California Los Angeles, 695 Charles E. Young Drive South, 6524A Gonda Building, Los Angeles, 90095\u20131679, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"David Geffen School of Medicine, University of California, Los Angeles. Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024741961"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.2986,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.79521081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"172","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":1.0},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nonlinear-interactions","display_name":"nonlinear interactions","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9570000171661377},{"id":"https://openalex.org/keywords/maternal-environment","display_name":"maternal environment","score":0.9179999828338623},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.7080000042915344},{"id":"https://openalex.org/keywords/high-throughput-technologies","display_name":"high-throughput technologies","score":0.574999988079071},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6237130761146545},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5789111256599426},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.5233011841773987},{"id":"https://openalex.org/C173366509","wikidata":"https://www.wikidata.org/wiki/Q206829","display_name":"Reductionism","level":2,"score":0.5002474784851074},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.48742368817329407},{"id":"https://openalex.org/C36415437","wikidata":"https://www.wikidata.org/wiki/Q7663871","display_name":"Systems medicine","level":3,"score":0.47658607363700867},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4510754942893982},{"id":"https://openalex.org/C3018605307","wikidata":"https://www.wikidata.org/wiki/Q200779","display_name":"Complex disease","level":3,"score":0.4141695499420166},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41320404410362244},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3932771682739258},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3931834101676941},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3770918846130371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17386621236801147},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11864343285560608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1071004867553711},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/nrcardio.2011.208","doi":"https://doi.org/10.1038/nrcardio.2011.208","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrcardio.2011.208","pdf_url":null,"source":{"id":"https://openalex.org/S62674001","display_name":"Nature Reviews Cardiology","issn_l":"1759-5002","issn":["1759-5002","1759-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cardiology","raw_type":"journal-article"},{"id":"pmid:22231714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22231714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2813526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3823242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3823242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3823242","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Cardiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2813526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3823242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3276713972","display_name":"UCLA Clinical and Translational Science Institute","funder_award_id":"UL1TR000124","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3761514328","display_name":"A Systems Approach to Uncover Novel Genes and Networks in Heart Failure","funder_award_id":"R21HL110667","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7227194379","display_name":"Genetic Analysis of Cardiac Growth","funder_award_id":"R01HL070748","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":116,"referenced_works":["https://openalex.org/W250626939","https://openalex.org/W1490370778","https://openalex.org/W1532250764","https://openalex.org/W1543415010","https://openalex.org/W1604547439","https://openalex.org/W1964305071","https://openalex.org/W1964735403","https://openalex.org/W1965371036","https://openalex.org/W1968747399","https://openalex.org/W1969154599","https://openalex.org/W1970750464","https://openalex.org/W1973651601","https://openalex.org/W1974033269","https://openalex.org/W1975387345","https://openalex.org/W1975919464","https://openalex.org/W1982140992","https://openalex.org/W1987959788","https://openalex.org/W1995213405","https://openalex.org/W1996866382","https://openalex.org/W1998365264","https://openalex.org/W2008161741","https://openalex.org/W2008945055","https://openalex.org/W2009405916","https://openalex.org/W2009964354","https://openalex.org/W2012280706","https://openalex.org/W2017771330","https://openalex.org/W2018045523","https://openalex.org/W2018934112","https://openalex.org/W2020541351","https://openalex.org/W2020960792","https://openalex.org/W2022216532","https://openalex.org/W2022957626","https://openalex.org/W2024797223","https://openalex.org/W2025179823","https://openalex.org/W2033270597","https://openalex.org/W2036263593","https://openalex.org/W2037462241","https://openalex.org/W2045373134","https://openalex.org/W2047031939","https://openalex.org/W2052228332","https://openalex.org/W2054029926","https://openalex.org/W2056961883","https://openalex.org/W2059424963","https://openalex.org/W2065739428","https://openalex.org/W2065769502","https://openalex.org/W2068337616","https://openalex.org/W2069450192","https://openalex.org/W2070736092","https://openalex.org/W2072326327","https://openalex.org/W2072999024","https://openalex.org/W2078118484","https://openalex.org/W2083045667","https://openalex.org/W2083380010","https://openalex.org/W2087200610","https://openalex.org/W2090808827","https://openalex.org/W2091901410","https://openalex.org/W2095821741","https://openalex.org/W2100203914","https://openalex.org/W2103237492","https://openalex.org/W2104689123","https://openalex.org/W2106357843","https://openalex.org/W2107213998","https://openalex.org/W2108723074","https://openalex.org/W2112044524","https://openalex.org/W2112848098","https://openalex.org/W2115944543","https://openalex.org/W2116054884","https://openalex.org/W2117007075","https://openalex.org/W2117355278","https://openalex.org/W2117625122","https://openalex.org/W2119106393","https://openalex.org/W2121297824","https://openalex.org/W2122450058","https://openalex.org/W2123168196","https://openalex.org/W2125987139","https://openalex.org/W2130139139","https://openalex.org/W2130410032","https://openalex.org/W2135120744","https://openalex.org/W2135498889","https://openalex.org/W2136489990","https://openalex.org/W2138450760","https://openalex.org/W2138730742","https://openalex.org/W2139511828","https://openalex.org/W2140247552","https://openalex.org/W2141823377","https://openalex.org/W2142887429","https://openalex.org/W2144885342","https://openalex.org/W2145264435","https://openalex.org/W2147839361","https://openalex.org/W2149640531","https://openalex.org/W2152435464","https://openalex.org/W2153483268","https://openalex.org/W2157065952","https://openalex.org/W2161503382","https://openalex.org/W2161927231","https://openalex.org/W2164362099","https://openalex.org/W2168198223","https://openalex.org/W2168301815","https://openalex.org/W2168312688","https://openalex.org/W2168790777","https://openalex.org/W2171419763","https://openalex.org/W2187181884","https://openalex.org/W2402625606","https://openalex.org/W2758736566","https://openalex.org/W2782069931","https://openalex.org/W3088048311","https://openalex.org/W3103071483","https://openalex.org/W3128894147","https://openalex.org/W3216731846","https://openalex.org/W4238452917","https://openalex.org/W4255009698","https://openalex.org/W4256475235","https://openalex.org/W4285719527","https://openalex.org/W4388166335","https://openalex.org/W7097027624","https://openalex.org/W7099251890"],"related_works":["https://openalex.org/W3034169670","https://openalex.org/W2990472811","https://openalex.org/W2516129361","https://openalex.org/W2485341289","https://openalex.org/W2593260643","https://openalex.org/W1968621958","https://openalex.org/W2805173872","https://openalex.org/W3091656850","https://openalex.org/W121102000","https://openalex.org/W2027500865"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}