{"id":"https://openalex.org/W2018538565","doi":"https://doi.org/10.1002/jmv.1890020106","title":"A nonlytic transforming mutant of herpes simplex virus type 2","display_name":"A nonlytic transforming mutant of herpes simplex virus type 2","publication_year":1978,"publication_date":"1978-01-01","ids":{"openalex":"https://openalex.org/W2018538565","doi":"https://doi.org/10.1002/jmv.1890020106","mag":"2018538565","pmid":"https://pubmed.ncbi.nlm.nih.gov/210252"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.1890020106","doi":"https://doi.org/10.1002/jmv.1890020106","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.1890020106","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060274748","display_name":"Mary K. Howett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Howett","raw_affiliation_strings":["Department of Microbiology and Specialized Cancer Research Center, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Specialized Cancer Research Center, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055902964","display_name":"Fred Rapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred Rapp","raw_affiliation_strings":["Department of Microbiology and Specialized Cancer Research Center, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey","Department of Microbiology, The Milton S. Hershey Medical Center, The Pennsylvania State Univ College of Medicine, Hershey, PA 17033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Specialized Cancer Research Center, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Microbiology, The Milton S. Hershey Medical Center, The Pennsylvania State Univ College of Medicine, Hershey, PA 17033","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055902964"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":0.5636,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69165417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":"29","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":1.0},{"id":"https://openalex.org/keywords/thymidine-kinase-gene","display_name":"thymidine kinase gene","score":0.8920000195503235},{"id":"https://openalex.org/keywords/viral-oncogenicity","display_name":"viral oncogenicity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.5059999823570251},{"id":"https://openalex.org/keywords/nonpermissive-temperature","display_name":"nonpermissive temperature","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7744423151016235},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7683538198471069},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7406994700431824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7050150632858276},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6895431280136108},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.5553907155990601},{"id":"https://openalex.org/C92706935","wikidata":"https://www.wikidata.org/wiki/Q17162815","display_name":"Viral transformation","level":3,"score":0.489062637090683},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47729647159576416},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.4538794755935669},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4378282129764557},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.433674156665802},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.43328186869621277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3983886241912842},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38326141238212585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12027120590209961}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003588","descriptor_name":"Cytopathogenic Effect, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jmv.1890020106","doi":"https://doi.org/10.1002/jmv.1890020106","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.1890020106","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:210252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/210252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1483605247","https://openalex.org/W1549731100","https://openalex.org/W1563598610","https://openalex.org/W1580353150","https://openalex.org/W1665763820","https://openalex.org/W1820383529","https://openalex.org/W1827992862","https://openalex.org/W1883883651","https://openalex.org/W1922286450","https://openalex.org/W1959686341","https://openalex.org/W1980709382","https://openalex.org/W1984262013","https://openalex.org/W1988886485","https://openalex.org/W2000559154","https://openalex.org/W2009417862","https://openalex.org/W2020338189","https://openalex.org/W2024516429","https://openalex.org/W2027015145","https://openalex.org/W2044838003","https://openalex.org/W2051364140","https://openalex.org/W2057595718","https://openalex.org/W2061796759","https://openalex.org/W2063416092","https://openalex.org/W2063697144","https://openalex.org/W2073749796","https://openalex.org/W2114360175","https://openalex.org/W2338730499","https://openalex.org/W2413885025","https://openalex.org/W2464925649"],"related_works":["https://openalex.org/W1959686341","https://openalex.org/W2063009401","https://openalex.org/W2057595718","https://openalex.org/W1530003127","https://openalex.org/W2033677505","https://openalex.org/W2124403381","https://openalex.org/W2091084126","https://openalex.org/W1898864093","https://openalex.org/W2416228159","https://openalex.org/W2155052944"],"abstract_inverted_index":{"A":[0],"small-plaque":[1],"mutant":[2,23,93,118],"(NO.69)":[3],"of":[4,31,53,70,85,106,139],"herpes":[5],"simplex":[6],"virus":[7,72,146],"type":[8],"2":[9],"(HSV-2)":[10],"strain":[11],"333":[12],"has":[13,99],"been":[14],"previously":[15],"isolated":[16],"and":[17,48,110,123,150],"characterized":[18],"in":[19,42,77,131],"this":[20,57,71,145],"laboratory.":[21],"This":[22,92],"was":[24],"shown":[25],"to":[26,33,66,103,128],"produce":[27],"a":[28,78,95,100],"high":[29],"ratio":[30],"noninfectious":[32,68],"infectious":[34],"particles":[35],"when":[36],"grown":[37],"at":[38,119],"the":[39,86,104,117,121,135],"nonpermissive":[40,124],"temperature":[41,125],"hamster":[43],"embryo":[44],"fibroblasts":[45],"[Westmoreland":[46],"D.":[47],"Rapp":[49],"F.":[50],"(1976).":[51],"Journal":[52],"Virology":[54],"[8:92--102].":[55],"In":[56],"study,":[58],"we":[59],"have":[60],"demonstrated":[61],"that":[62,98,129],"it":[63],"is":[64],"possible":[65],"obtain":[67],"stocks":[69],"which":[73],"retain":[74],"transforming":[75],"ability":[76],"biochemical":[79],"transformation":[80],"assay":[81],"specific":[82],"for":[83,89,155],"detection":[84],"HSV":[87,148],"gene":[88],"thymidine":[90],"kinase.":[91],"contains":[94],"DNA":[96,105,112],"genome":[97],"density":[101],"identical":[102],"wild-type":[107],"virus.":[108,137],"Virus":[109],"cell":[111],"synthesis":[113],"after":[114],"infection":[115],"with":[116,134],"both":[120],"permissive":[122],"are":[126,151],"similar":[127],"observed":[130],"cultures":[132],"infected":[133],"parental":[136],"Clones":[138],"mouse":[140],"cells":[141],"biochemically":[142],"transformed":[143],"by":[144],"contain":[147],"antigens":[149],"presently":[152],"being":[153],"examined":[154],"oncogenicity.":[156]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}