{"id":"https://openalex.org/W2018533699","doi":"https://doi.org/10.1163/156856208786052353","title":"Fibrinogen and von Willebrand factor mediated platelet adhesion to polystyrene under flow conditions","display_name":"Fibrinogen and von Willebrand factor mediated platelet adhesion to polystyrene under flow conditions","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2018533699","doi":"https://doi.org/10.1163/156856208786052353","mag":"2018533699","pmid":"https://pubmed.ncbi.nlm.nih.gov/18854129"},"language":"en","primary_location":{"id":"doi:10.1163/156856208786052353","doi":"https://doi.org/10.1163/156856208786052353","is_oa":false,"landing_page_url":"https://doi.org/10.1163/156856208786052353","pdf_url":null,"source":{"id":"https://openalex.org/S150667925","display_name":"Journal of Biomaterials Science Polymer Edition","issn_l":"0920-5063","issn":["0920-5063","1568-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Science, Polymer Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100403007","display_name":"Min Zhang","orcid":"https://orcid.org/0000-0003-4214-9631","observed_orcids":["https://orcid.org/0000-0003-4214-9631"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["a Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. minz@u.washington.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. minz@u.washington.edu","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100868974","display_name":"Yuguang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuguang Wu","raw_affiliation_strings":["b Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079362122","display_name":"Kip D. Hauch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kip Hauch","raw_affiliation_strings":["c Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112202859","display_name":"Thomas A. Horbett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Horbett","raw_affiliation_strings":["d Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"d Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, Mail Box 355061, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":0.8495,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74885496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"10","first_page":"1383","last_page":"1410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.09830000251531601,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9929999709129333},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":1.0},{"id":"https://openalex.org/keywords/polystyrene","display_name":"polystyrene","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hydrophobic-surfaces","display_name":"hydrophobic surfaces","score":0.9430000185966492},{"id":"https://openalex.org/keywords/flow-conditions","display_name":"flow conditions","score":0.5600000023841858},{"id":"https://openalex.org/keywords/shear-rate","display_name":"shear rate","score":0.9570000171661377},{"id":"https://openalex.org/keywords/platelet-spreading","display_name":"platelet spreading","score":0.7599999904632568},{"id":"https://openalex.org/keywords/platelet-morphology","display_name":"platelet morphology","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.7371273040771484},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.7297070026397705},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6517458558082581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6482365131378174},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.5787960290908813},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.5612981915473938},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4781721234321594},{"id":"https://openalex.org/C2780009322","wikidata":"https://www.wikidata.org/wiki/Q7202246","display_name":"Platelet adhesiveness","level":4,"score":0.47178977727890015},{"id":"https://openalex.org/C2777922577","wikidata":"https://www.wikidata.org/wiki/Q146243","display_name":"Polystyrene","level":3,"score":0.4225751459598541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17431968450546265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1636381447315216},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08830451965332031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07274797558784485},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.053946226835250854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04761946201324463},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.044319361448287964}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010973","descriptor_name":"Platelet Adhesiveness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013535","descriptor_name":"Suspensions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1163/156856208786052353","doi":"https://doi.org/10.1163/156856208786052353","is_oa":false,"landing_page_url":"https://doi.org/10.1163/156856208786052353","pdf_url":null,"source":{"id":"https://openalex.org/S150667925","display_name":"Journal of Biomaterials Science Polymer Edition","issn_l":"0920-5063","issn":["0920-5063","1568-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Science, Polymer Edition","raw_type":"journal-article"},{"id":"pmid:18854129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18854129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomaterials science. Polymer edition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8356477748","display_name":"Ultralow Protein Adsorption Hemocompatible Biomaterials","funder_award_id":"R01HL067923","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W122479260","https://openalex.org/W138570360","https://openalex.org/W164651796","https://openalex.org/W300003562","https://openalex.org/W1543884598","https://openalex.org/W1555561206","https://openalex.org/W1561189761","https://openalex.org/W1924175076","https://openalex.org/W1970241950","https://openalex.org/W1973815088","https://openalex.org/W1981689350","https://openalex.org/W1983227317","https://openalex.org/W1983511276","https://openalex.org/W1986586769","https://openalex.org/W1990312664","https://openalex.org/W1990617987","https://openalex.org/W1992392611","https://openalex.org/W1999364304","https://openalex.org/W2020063827","https://openalex.org/W2020648175","https://openalex.org/W2022755299","https://openalex.org/W2022771383","https://openalex.org/W2029231027","https://openalex.org/W2030665169","https://openalex.org/W2033821350","https://openalex.org/W2035799618","https://openalex.org/W2039012502","https://openalex.org/W2046499889","https://openalex.org/W2052041278","https://openalex.org/W2052506903","https://openalex.org/W2054652238","https://openalex.org/W2055496857","https://openalex.org/W2058535582","https://openalex.org/W2060935167","https://openalex.org/W2067667307","https://openalex.org/W2068318864","https://openalex.org/W2069851017","https://openalex.org/W2075013504","https://openalex.org/W2075992820","https://openalex.org/W2076129545","https://openalex.org/W2083177431","https://openalex.org/W2098067316","https://openalex.org/W2102374658","https://openalex.org/W2110007918","https://openalex.org/W2126683943","https://openalex.org/W2129345995","https://openalex.org/W2132905504","https://openalex.org/W2136445687","https://openalex.org/W2137699511","https://openalex.org/W2149823536","https://openalex.org/W2152834983","https://openalex.org/W2158334499","https://openalex.org/W2165207329","https://openalex.org/W2171313920","https://openalex.org/W2187152788","https://openalex.org/W2243662402","https://openalex.org/W2359136468","https://openalex.org/W2396345262","https://openalex.org/W2405525690","https://openalex.org/W2415389038","https://openalex.org/W2416832796","https://openalex.org/W2417047394","https://openalex.org/W2427128107","https://openalex.org/W2429117852","https://openalex.org/W2436772193","https://openalex.org/W2475067738","https://openalex.org/W2480713279","https://openalex.org/W2506911400","https://openalex.org/W2794411860","https://openalex.org/W4254351086"],"related_works":["https://openalex.org/W1970241950","https://openalex.org/W2068318864","https://openalex.org/W1983511276","https://openalex.org/W1932675113","https://openalex.org/W3041842975","https://openalex.org/W1990312664","https://openalex.org/W1975383019","https://openalex.org/W2889455494","https://openalex.org/W1948546608","https://openalex.org/W122479260"],"abstract_inverted_index":{"The":[0,212,236],"roles":[1],"of":[2,52,110,196,214,222,238,250,255,277],"adsorbed":[3,116,198,215],"fibrinogen":[4],"(Fg)":[5],"and":[6,46,97,217],"von":[7],"Willebrand":[8],"factor":[9],"(VWF)":[10],"in":[11,58,104,244,247,269,274],"mediating":[12],"platelet":[13,32,123,131,202,251,256],"adhesion":[14,33,124,132,150,164,174,203,257],"to":[15,34,85,120,151,163,165,175,266],"synthetic":[16],"surfaces":[17],"under":[18,94,125,205,209,258,279],"flow":[19,68,278],"were":[20,64,233],"investigated":[21],"using":[22],"polystyrene":[23],"(PS)":[24],"as":[25,184,193],"a":[26,59,67,105,270],"model":[27],"hydrophobic":[28],"surface.":[29],"We":[30],"measured":[31],"PS":[35,86,134,144,152,166,176,186],"pre-adsorbed":[36,87,135,145,153,167,177,187],"with":[37,49,88,108,136,146,154,157,168,178,188],"Fg,":[38],"VWF,":[39],"normal":[40,147,169,189],"plasma,":[41,43,148],"afibrinogenemic":[42,89],"VWF-deficient":[44,137,155,179],"plasma":[45,90,138,156,180,200],"deficient":[47],"plasmas":[48],"various":[50],"concentrations":[51],"added":[53,158],"Fg":[54,117,216,240],"or":[55,74,77,80,241],"VWF.":[56],"Platelets":[57],"red":[60],"blood":[61],"cell":[62],"suspension":[63],"passed":[65],"through":[66],"chamber":[69],"at":[70,229],"either":[71,239],"low":[72,93,96,172,210],"(50":[73],"100":[75],"s(-1))":[76,82],"high":[78,98,128,206,230,280],"(500":[79],"1000":[81],"shear.":[83,211],"Adhesion":[84],"was":[91,102,118,139,160,181],"very":[92,161],"both":[95],"shear":[99,129,207,231,281],"conditions,":[100],"but":[101,149],"restored":[103],"dose-dependent":[106],"manner":[107],"addition":[109],"Fg.":[111],"Less":[112],"than":[113,142,208],"20":[114],"ng/cm(2)of":[115],"sufficient":[119],"support":[121],"full-scale":[122],"flow.":[126],"At":[127,171],"rate,":[130],"on":[133,143,185,219],"much":[140],"less":[141],"VWF":[159,197,218,242],"similar":[162],"plasma.":[170,190],"shear,":[173],"the":[182,220,248,267,275],"same":[183],"As":[191],"little":[192],"1":[194],"ng/cm(2)":[195],"from":[199,226],"made":[201],"higher":[204],"effects":[213],"morphologies":[221],"platelets":[223,264],"that":[224,263],"adhered":[225,265],"suspensions":[227],"flowing":[228],"rates":[232],"also":[234],"investigated.":[235],"lack":[237],"resulted":[243],"marked":[245],"decreases":[246],"extent":[249],"spreading.":[252],"Real-time":[253],"observation":[254],"an":[259],"epifluorescent":[260],"microscope":[261],"showed":[262],"surface":[268],"linear":[271],"pattern":[272],"aligned":[273],"direction":[276],"conditions.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}