{"id":"https://openalex.org/W2018533313","doi":"https://doi.org/10.1097/00007890-199904150-00300","title":"MECHANISTIC CHARACTERIZATION OF TOLERANCE INDUCED WITH ALS, DONOR BONE MARROW AND SIROLIMUS","display_name":"MECHANISTIC CHARACTERIZATION OF TOLERANCE INDUCED WITH ALS, DONOR BONE MARROW AND SIROLIMUS","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2018533313","doi":"https://doi.org/10.1097/00007890-199904150-00300","mag":"2018533313"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199904150-00300","doi":"https://doi.org/10.1097/00007890-199904150-00300","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199904150-00300","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109046170","display_name":"D.A. Hale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Hale","raw_affiliation_strings":["Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Umemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Umemura","raw_affiliation_strings":["Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065633128","display_name":"Rita Gottschalk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Gottschalk","raw_affiliation_strings":["Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047141592","display_name":"Takashi Maki","orcid":"https://orcid.org/0000-0002-2143-3783","observed_orcids":["https://orcid.org/0000-0002-2143-3783"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Maki","raw_affiliation_strings":["Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038938677","display_name":"Anthony P. Monaco","orcid":"https://orcid.org/0000-0001-7480-3197","observed_orcids":["https://orcid.org/0000-0001-7480-3197"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A P Monaco","raw_affiliation_strings":["Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Ma","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1131,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42849193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"7","first_page":"S74","last_page":"S74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allograft-tolerance","display_name":"allograft tolerance","score":0.6650000214576721},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.656000018119812},{"id":"https://openalex.org/keywords/donor-bone-marrow","display_name":"donor bone marrow","score":0.8149999976158142},{"id":"https://openalex.org/keywords/clonal-deletion","display_name":"clonal deletion","score":0.7099999785423279},{"id":"https://openalex.org/keywords/thymectomy","display_name":"thymectomy","score":0.6200000047683716},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.6890000104904175},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.968999981880188},{"id":"https://openalex.org/keywords/skin-grafts","display_name":"skin grafts","score":0.30300000309944153},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4560000002384186},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.382999986410141},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6956236362457275},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.6475510001182556},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6238480806350708},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6013521552085876},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.5108258724212646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49190306663513184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45746830105781555},{"id":"https://openalex.org/C2777868816","wikidata":"https://www.wikidata.org/wiki/Q5134952","display_name":"Clonal deletion","level":5,"score":0.43714362382888794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32206565141677856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23780664801597595},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.22230088710784912},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.12238678336143494},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11314207315444946},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199904150-00300","doi":"https://doi.org/10.1097/00007890-199904150-00300","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199904150-00300","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044317644","https://openalex.org/W2114933778","https://openalex.org/W2159228497","https://openalex.org/W2362896681","https://openalex.org/W2014822543","https://openalex.org/W1965877966","https://openalex.org/W1997946337","https://openalex.org/W2376007306","https://openalex.org/W1870043206","https://openalex.org/W2036697564"],"abstract_inverted_index":{"272":[0],"Purpose:":[1],"A":[2],"method":[3],"has":[4],"been":[5],"developed":[6],"to":[7,28,67,119,238,253,315,334,369,379],"induce":[8],"permanent":[9],"tolerance":[10,163,202,227,239,250,264,301,319,365],"in":[11,125,325,392],"a":[12,322,361,395],"murine":[13],"model":[14,353],"through":[15,280],"the":[16,30,34,212,286,357],"administration":[17],"of":[18,38,111,173,187,195,201,206,214,282,307,342,360,364],"ALS,":[19],"donor":[20,76,120,147,196,270,283,335],"bone":[21,77],"marrow":[22,78],"and":[23,36,64,75,86,91,121,145,160,183,190,271,297,328,344,377,387],"sirolimus.":[24],"This":[25,204,275,352,389],"study":[26,216,390],"seeks":[27],"elucidate":[29],"mechanisms":[31],"responsible":[32],"for":[33,211],"induction":[35,228,240,251,265,302,320],"maintenance":[37],"this":[39,215],"state.":[40],"Methods:":[41],"B10.A":[42],"skin":[43,68,143,150],"grafts":[44,144,151],"were":[45,81,93,194],"placed":[46,152],"on":[47,60,70,83],"C57BL10":[48],"mice":[49,117,137,260,294,313],"(complete":[50],"mismatch).":[51],"Recipients":[52],"received":[53],"0.5":[54],"ml":[55],"rabbit":[56],"anti-mouse":[57],"polyclonal":[58],"ALS":[59],"days":[61,84,158,181,200,225,248,262,299,317],"\u22121,":[62],"2":[63],"5":[65],"relative":[66],"grafting":[69],"day":[71],"0.":[72],"Sirolimus":[73],"(24mg/kg)":[74],"(150\u00d7106":[79],"cells)":[80],"administered":[82],"6":[85],"7":[87],"respectively.":[88],"Clonal":[89,219],"deletion":[90,220,386],"chimerism":[92,208,376],"evaluated":[94,100],"with":[95,101,108,170,356,373],"flow":[96],"cytometry.":[97],"Suppression":[98],"was":[99,106,131,221,348],"co-culture":[102,289],"MLC.":[103,126],"Cytokine":[104],"production":[105,331],"determined":[107],"RT":[109],"PCR":[110],"mRNA":[112,330,347],"from":[113,115,259,285,293,312,397],"splenocytes":[114,189],"tolerant":[116,287],"exposed":[118,333],"third":[122,139,272,338],"party":[123,140,273,339],"stimulators":[124],"Results:":[127],"Skin":[128],"graft":[129],"survival":[130],"100%":[132],"at":[133,153,176,223,229,230],"200":[134],"days.":[135],"Tolerant":[136],"rejected":[138],"(BALB/c)":[141],"2nd":[142,149],"retained":[146],"specific":[148],"multiple":[154,177],"time":[155,178,233],"points":[156,179],"between":[157,180],"14":[159,182],"120":[161,298,316],"following":[162,226,249,263,300],"induction.":[164,203],"Tolerance":[165],"could":[166,277],"not":[167,337,349],"be":[168,278,380],"broken":[169],"5000":[171],"units":[172],"IL-2":[174],"given":[175],"120.":[184],"Ten":[185],"percent":[186],"recipient":[188],"peripheral":[191,384],"blood":[192],"leukocytes":[193],"origin":[197],"within":[198],"30":[199,261,314],"level":[205],"multilineage":[207,375],"remained":[209],"stable":[210],"duration":[213],"(>200":[217],"days).":[218],"detectable":[222],"20":[224],"all":[231],"subsequent":[232],"points.":[234],"Mice":[235,245],"thymectomized":[236,246],"prior":[237],"also":[241],"demonstrated":[242,303,321],"clonal":[243,255,385],"deletion.":[244,256],"60":[247],"continued":[252],"manifest":[254],"Splenocytes":[257,291,310],"harvested":[258,292,311],"consistently":[266],"suppressed":[267],"proliferation":[268],"against":[269],"stimulators.":[274],"suppression":[276],"ablated":[279],"depletion":[281],"cells":[284],"splenocyte":[288],"suspension.":[290],"60,":[295],"90":[296],"progressively":[304],"reduced":[305],"levels":[306],"suppressor":[308],"activity.":[309],"after":[318],"sustained":[323,382],"reduction":[324],"IL-2,":[326],"IL-4":[327],"IFN\u03b3":[329],"when":[332],"but":[336],"antigen.":[340],"Production":[341],"IL-10":[343],"TGF":[345],"\u03b2":[346],"affected.":[350],"Conclusions:":[351],"is":[354,367,371],"associated":[355,372],"early":[358],"establishment":[359],"robust":[362],"state":[363],"which":[366],"resistant":[368],"disruption,":[370],"persistent":[374],"appears":[378],"predominantly":[381],"via":[383],"immunoredirection.":[388],"supported":[391],"part":[393],"by":[394],"grant":[396],"Wyeth":[398],"Ayerst.":[399]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}