{"id":"https://openalex.org/W2018521741","doi":"https://doi.org/10.1074/jbc.m010417200","title":"A Macrophage Protein, Ym1, Transiently Expressed during Inflammation Is a Novel Mammalian Lectin","display_name":"A Macrophage Protein, Ym1, Transiently Expressed during Inflammation Is a Novel Mammalian Lectin","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2018521741","doi":"https://doi.org/10.1074/jbc.m010417200","mag":"2018521741","pmid":"https://pubmed.ncbi.nlm.nih.gov/11297523"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m010417200","doi":"https://doi.org/10.1074/jbc.m010417200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m010417200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925819319416/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021925819319416/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088744897","display_name":"Nan-Chi A. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Nan-Chi A. Chang","raw_affiliation_strings":["Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan 112, Republic of China. acchang@ym.edu.tw","\u00a7Center for Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan 112, Republic of China, the","\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan 112, Republic of China. acchang@ym.edu.tw","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"\u00a7Center for Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan 112, Republic of China, the","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057475035","display_name":"Wen\u2010Hung Chung","orcid":"https://orcid.org/0000-0001-6531-5538","observed_orcids":["https://orcid.org/0000-0001-6531-5538"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuen-Iu Hung","raw_affiliation_strings":["\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027762560","display_name":"Kuo\u2010Yuan Hwa","orcid":"https://orcid.org/0000-0003-1968-7909","observed_orcids":["https://orcid.org/0000-0003-1968-7909"]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Yuan Hwa","raw_affiliation_strings":["\u2016Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan 115, Republic of China, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2016Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan 115, Republic of China, and","institution_ids":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102123010","display_name":"Ikunoshin Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273692","display_name":"Takara Shuzo Co., Ltd. (Japan)","ror":"https://ror.org/009xcqz70","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405273692"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikunoshin Kato","raw_affiliation_strings":["**Biomedical Group, Takara Shuzo Co., Ltd., Otsu, Shiga 520-21, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Biomedical Group, Takara Shuzo Co., Ltd., Otsu, Shiga 520-21, Japan","institution_ids":["https://openalex.org/I4405273692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082378537","display_name":"Ju-Eng Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ju-Eng Chen","raw_affiliation_strings":["\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029792001","display_name":"Cheng-Hsiun Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng-Hsiun Liu","raw_affiliation_strings":["\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021From the Institute of Microbiology and Immunology,Taipei,Taiwan,112,Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109950848","display_name":"Alice Chien Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Alice Chien Chang","raw_affiliation_strings":["\u00a7Center for Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan 112, Republic of China, the","\u2021 From the Institute of Neuroscience, and Taipei,Taiwan,112,Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Center for Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan 112, Republic of China, the","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"\u2021 From the Institute of Neuroscience, and Taipei,Taiwan,112,Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088744897"],"corresponding_institution_ids":["https://openalex.org/I4387156312"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.0775,"has_fulltext":true,"cited_by_count":245,"citation_normalized_percentile":{"value":0.92445702,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"276","issue":"20","first_page":"17497","last_page":"17506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.15119999647140503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ym1","display_name":"Ym1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.6679999828338623},{"id":"https://openalex.org/keywords/lectins","display_name":"lectins","score":0.7879999876022339},{"id":"https://openalex.org/keywords/trichinella-spiralis-infection","display_name":"Trichinella spiralis infection","score":0.8040000200271606},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/peritoneal-exudate-cells","display_name":"peritoneal exudate cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6880000233650208},{"id":"https://openalex.org/keywords/heparin-binding","display_name":"heparin binding","score":0.6890000104904175},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.9570000171661377},{"id":"https://openalex.org/keywords/n-acetylglucosamine","display_name":"N-acetylglucosamine","score":0.6370000243186951},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.46399998664855957},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5901796221733093},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5516977906227112},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4825562834739685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45152512192726135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34303003549575806}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001202","descriptor_name":"Ascitic Fluid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001619","descriptor_name":"beta-N-Acetylhexosaminidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014235","descriptor_name":"Trichinellosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017160","descriptor_name":"Trichinella spiralis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m010417200","doi":"https://doi.org/10.1074/jbc.m010417200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m010417200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925819319416/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11297523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11297523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m010417200","doi":"https://doi.org/10.1074/jbc.m010417200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m010417200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925819319416/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018521741.pdf","grobid_xml":"https://content.openalex.org/works/W2018521741.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W280875868","https://openalex.org/W1482559745","https://openalex.org/W1488243135","https://openalex.org/W1492834548","https://openalex.org/W1493485729","https://openalex.org/W1522837765","https://openalex.org/W1568609804","https://openalex.org/W1574789459","https://openalex.org/W1606162058","https://openalex.org/W1606423922","https://openalex.org/W1772341111","https://openalex.org/W1900312847","https://openalex.org/W1927383279","https://openalex.org/W1929591819","https://openalex.org/W1932052686","https://openalex.org/W1959298931","https://openalex.org/W1966126000","https://openalex.org/W1971540677","https://openalex.org/W1975630826","https://openalex.org/W1979837673","https://openalex.org/W1979984378","https://openalex.org/W1984808204","https://openalex.org/W1998733027","https://openalex.org/W2000149921","https://openalex.org/W2001104014","https://openalex.org/W2002956679","https://openalex.org/W2003176514","https://openalex.org/W2004727400","https://openalex.org/W2007479564","https://openalex.org/W2010645431","https://openalex.org/W2015390110","https://openalex.org/W2016483318","https://openalex.org/W2017347652","https://openalex.org/W2018820394","https://openalex.org/W2019414596","https://openalex.org/W2022225506","https://openalex.org/W2028377819","https://openalex.org/W2029080316","https://openalex.org/W2029921422","https://openalex.org/W2032118018","https://openalex.org/W2032552530","https://openalex.org/W2041034132","https://openalex.org/W2045348184","https://openalex.org/W2049079346","https://openalex.org/W2055320083","https://openalex.org/W2061792951","https://openalex.org/W2065909887","https://openalex.org/W2075260321","https://openalex.org/W2079743166","https://openalex.org/W2091503771","https://openalex.org/W2092085734","https://openalex.org/W2093748890","https://openalex.org/W2100837269","https://openalex.org/W2102349489","https://openalex.org/W2107983150","https://openalex.org/W2108859348","https://openalex.org/W2111104826","https://openalex.org/W2111301002","https://openalex.org/W2115048327","https://openalex.org/W2115993724","https://openalex.org/W2117057407","https://openalex.org/W2133111763","https://openalex.org/W2138270253","https://openalex.org/W2144192610","https://openalex.org/W2144456776","https://openalex.org/W2144634347","https://openalex.org/W2149200346","https://openalex.org/W2160806937","https://openalex.org/W2169829977","https://openalex.org/W2170418572","https://openalex.org/W2172220794","https://openalex.org/W2214033675","https://openalex.org/W2314225431","https://openalex.org/W2318390251","https://openalex.org/W2326169151","https://openalex.org/W2329281679","https://openalex.org/W2368756114","https://openalex.org/W6610123746"],"related_works":["https://openalex.org/W1984808204","https://openalex.org/W4288081035","https://openalex.org/W3104289273","https://openalex.org/W2155382273","https://openalex.org/W2102558296","https://openalex.org/W2121587205","https://openalex.org/W2055323880","https://openalex.org/W1987740059","https://openalex.org/W1969564749","https://openalex.org/W7095769583"],"abstract_inverted_index":{"Oral":[0],"infections":[1],"of":[2,9,23,50,86,97,114,161,179,227],"mice":[3],"with":[4,37,52,90,129,205,214],"Trichinella":[5],"spiralis":[6],"induce":[7],"activation":[8],"peritoneal":[10,78],"exudate":[11,79],"cells":[12],"to":[13,25,41,123,127,144,146,163,173,181],"transiently":[14],"express":[15],"and":[16,54,102,155],"secrete":[17],"a":[18,31,38,91,130,225,228],"crystallizable":[19],"protein":[20,99],"Ym1.":[21,215],"Purification":[22],"Ym1":[24,51,119,162,180,222],"homogeneity":[26],"was":[27,100,166,211],"achieved.":[28],"It":[29],"is":[30,151],"single":[32,82],"chain":[33],"polypeptide":[34],"(45":[35],"kDa)":[36],"strong":[39],"tendency":[40],"crystallize":[42],"at":[43],"its":[44,60,189],"isoelectric":[45],"point":[46],"(pI":[47],"5.7).":[48],"Co-expression":[49],"Mac-1":[53],"scavenger":[55],"receptor":[56],"pinpoints":[57],"macrophages":[58],"as":[59,135],"main":[61],"producer.":[62],"Protein":[63],"microsequencing":[64],"data":[65],"provide":[66],"information":[67],"required":[68],"for":[69],"full-length":[70],"cDNA":[71],"cloning":[72],"from":[73,76],"libraries":[74],"constructed":[75],"activated":[77],"cells.":[80],"A":[81],"open":[83],"reading":[84],"frame":[85],"398":[87],"amino":[88],"acids":[89],"leader":[92],"peptide":[93],"(21":[94],"residues)":[95],"typical":[96],"secretory":[98],"deduced":[101],"later":[103],"deposited":[104],"in":[105,110,192],"GenBank":[106],"(accession":[107],"number":[108],"M94584)":[109],"1992.":[111],"By":[112],"means":[113],"surface":[115],"plasmon":[116],"resonance":[117],"analyses,":[118],"has":[120],"been":[121],"shown":[122],"exhibit":[124],"binding":[125,159,178],"specificity":[126],"saccharides":[128],"free":[131],"amine":[132],"group,":[133],"such":[134],"GlcN,":[136],"GalN,":[137],"or":[138],"GlcN":[139,164],"polymers,":[140],"but":[141,153],"it":[142,200],"failed":[143],"bind":[145],"other":[147],"saccharides.":[148],"The":[149,158],"interaction":[150],"pH-dependent":[152],"Ca2+":[154],"Mg2+":[156],"ion-independent.":[157],"avidity":[160],"oligosaccharides":[165],"enhanced":[167],"by":[168],"more":[169],"than":[170],"1000-fold":[171],"due":[172],"the":[174],"clustering":[175],"effect.":[176],"Specific":[177],"heparin":[182],"suggests":[183],"that":[184,221],"heparin/heparan":[185],"sulfate":[186],"may":[187,223],"be":[188],"physiological":[190],"ligand":[191],"vivo":[193],"during":[194],"inflammation":[195],"and/or":[196],"tissue":[197],"remodeling.":[198],"Although":[199],"shares":[201],"approximately":[202],"30%":[203],"homology":[204],"microbial":[206],"chitinases,":[207],"no":[208],"chitinase":[209],"activity":[210],"found":[212],"associated":[213],"Genomic":[216],"Southern":[217],"blot":[218],"analyses":[219],"suggest":[220],"represent":[224],"member":[226],"novel":[229],"lectin":[230],"gene":[231],"family.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}