{"id":"https://openalex.org/W2018513548","doi":"https://doi.org/10.1097/00005768-200405001-00188","title":"Interaction Between ACE I/D Genotype and Exercise Training on Knee Extensor Strength in Older Individuals","display_name":"Interaction Between ACE I/D Genotype and Exercise Training on Knee Extensor Strength in Older Individuals","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2018513548","doi":"https://doi.org/10.1097/00005768-200405001-00188","mag":"2018513548"},"language":"en","primary_location":{"id":"doi:10.1097/00005768-200405001-00188","doi":"https://doi.org/10.1097/00005768-200405001-00188","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200405001-00188","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057209268","display_name":"Barbara J. Nicklas","orcid":"https://orcid.org/0000-0002-7726-6670","observed_orcids":["https://orcid.org/0000-0002-7726-6670"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J. Nicklas","raw_affiliation_strings":["Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089876350","display_name":"Stephen B. Kritchevsky","orcid":"https://orcid.org/0000-0003-3336-6781","observed_orcids":["https://orcid.org/0000-0003-3336-6781"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Kritchevsky","raw_affiliation_strings":["Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045817771","display_name":"Joe Mychaleckyj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Mychaleckyj","raw_affiliation_strings":["Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065966409","display_name":"Stephen P. Messier","orcid":"https://orcid.org/0000-0002-7033-8459","observed_orcids":["https://orcid.org/0000-0002-7033-8459"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P. Messier","raw_affiliation_strings":["Wake Forest University, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, NC","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019450724","display_name":"Eugene Bleecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Bleecker","raw_affiliation_strings":["Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110085503","display_name":"Marco Pahor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Pahor","raw_affiliation_strings":["Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"Supplement","first_page":"S39","last_page":"S39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ace-insertion-deletion-polymorphism","display_name":"ACE I/D polymorphism","score":0.9729999899864197},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.6489999890327454},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.8140000104904175},{"id":"https://openalex.org/keywords/quadriceps-strength","display_name":"quadriceps strength","score":0.9919999837875366},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8059999942779541},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.7649999856948853},{"id":"https://openalex.org/keywords/6-minute-walk-distance","display_name":"6-minute walk distance","score":0.8059999942779541},{"id":"https://openalex.org/keywords/weight-training","display_name":"weight training","score":0.6729999780654907},{"id":"https://openalex.org/keywords/walking","display_name":"walking","score":0.722000002861023},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/sedentary-aging","display_name":"sedentary aging","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6881271600723267},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.6637059450149536},{"id":"https://openalex.org/C123550912","wikidata":"https://www.wikidata.org/wiki/Q12834857","display_name":"Strength training","level":2,"score":0.557908833026886},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5190413594245911},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4997889995574951},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.37795719504356384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32709288597106934}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/00005768-200405001-00188","doi":"https://doi.org/10.1097/00005768-200405001-00188","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200405001-00188","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},{"id":"doi:10.1249/00005768-200405001-00188","doi":"https://doi.org/10.1249/00005768-200405001-00188","is_oa":false,"landing_page_url":"https://doi.org/10.1249/00005768-200405001-00188","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996780735","https://openalex.org/W1998661395","https://openalex.org/W2120421641","https://openalex.org/W2110534033","https://openalex.org/W2946759032","https://openalex.org/W2048946891","https://openalex.org/W2081458376","https://openalex.org/W2155616908","https://openalex.org/W4394713640","https://openalex.org/W1930023387"],"abstract_inverted_index":{"0275":[0],"Regular":[1],"exercise":[2,31,67,90,107,214,246],"improves":[3],"physical":[4,59],"function":[5,60,74],"in":[6,64,69,92,187,197,219,226,242,248],"older":[7,94,249],"persons;":[8],"however,":[9],"not":[10,232],"all":[11],"individuals":[12,202,250],"experience":[13],"the":[14,22,37,40,44,54,172,191],"same":[15],"magnitude":[16],"of":[17,39,110,169,179],"benefit.":[18],"In":[19],"young":[20],"people":[21],"angiotensinconverting":[23],"enzyme":[24],"(ACE)":[25],"insertion/deletion":[26],"(I/D)":[27],"polymorphism":[28],"interacts":[29],"with":[30,190,245],"to":[32,66,200],"affect":[33],"athletic":[34],"performance,":[35],"but":[36],"direction":[38],"effect":[41,178],"depends":[42],"on":[43,182,216,254],"outcome":[45],"assessed":[46],"(endurance":[47],"vs.":[48],"strength).":[49],"PURPOSE:":[50],"To":[51],"determine":[52],"whether":[53],"ACE":[55,129,180,210,255],"I/D":[56,130,211,256],"genotype":[57,131,181,212],"Influences":[58],"at":[61],"baseline":[62],"and":[63,83,104,114,132,184,213,236],"response":[65],"training":[68,113,247],"elderly":[70],"individuals.":[71],"METHODS:":[72],"Physical":[73],"(strength,":[75],"walking":[76,115,229],"speed,":[77],"stair":[78],"climb)":[79],"was":[80,175,205],"measured":[81],"before":[82],"after":[84],"an":[85],"18-month":[86,185],"randomized,":[87],"controlled,":[88],"clinical":[89],"trial":[91],"211":[93],"(+60":[95],"yrs),":[96],"obese":[97],"(BMI":[98],"=":[99,138,141,144,151,154,157,223],"+28":[100],"kg/m2),":[101],"sedentary":[102],"men":[103],"women.":[105],"The":[106],"intervention":[108],"consisted":[109],"combined":[111],"weight":[112],"for":[116],"1":[117],"hr":[118],"three":[119],"times/week.":[120],"RESULTS:":[121],"At":[122],"baseline,":[123],"there":[124,174],"were":[125,231],"no":[126],"associations":[127],"between":[128,209,234],"6":[133,227],"minute":[134,228],"walk":[135],"distance":[136,230],"(DD":[137,150],"1390\u00b1281,":[139],"ID":[140,153],"1388\u00b1285,":[142],"II":[143,156,201,235],"1412\u00b1231":[145],"feet),":[146],"knee":[147,188,220],"extensor":[148],"strength":[149,189,198,221,244],"2.3\u00b11.0,":[152],"2.6\u00b11.0,":[155],"2.6\u00b11.0":[158],"nm/kg":[159],"body":[160,162],"wt),":[161],"mass":[163],"index,":[164],"medication":[165],"use,":[166],"or":[167],"prevalence":[168],"comorbidities.":[170],"Among":[171],"exercisers,":[173],"a":[176,206],"significant":[177,207],"6-":[183],"changes":[186,241],"DD":[192,237],"genotypes":[193],"showing":[194],"greater":[195],"gains":[196],"compared":[199],"(Table).":[203],"There":[204],"interaction":[208],"treatment":[215],"percent":[217],"change":[218],"(P":[222],"0.014).":[224],"Changes":[225],"different":[233],"genotypes.":[238],"CONCLUSION:":[239],"Thus,":[240],"muscle":[243],"may":[251],"be":[252],"dependent":[253],"genotype.Table":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
