{"id":"https://openalex.org/W2018509153","doi":"https://doi.org/10.1073/pnas.1323941111","title":"Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs","display_name":"Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs","publication_year":2014,"publication_date":"2014-06-09","ids":{"openalex":"https://openalex.org/W2018509153","doi":"https://doi.org/10.1073/pnas.1323941111","mag":"2018509153","pmid":"https://pubmed.ncbi.nlm.nih.gov/24927536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4078797"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1323941111","doi":"https://doi.org/10.1073/pnas.1323941111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1323941111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4078797","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043670454","display_name":"Chul\u2010Yong Park","orcid":"https://orcid.org/0000-0002-4467-9268","observed_orcids":["https://orcid.org/0000-0002-4467-9268"]},"institutions":[{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chul-Yong Park","raw_affiliation_strings":["Department of Physiology,","Severance Biomedical Research Institute,","Department of Physiology,Severance Biomedical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology,","institution_ids":[]},{"raw_affiliation_string":"Severance Biomedical Research Institute,","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology,Severance Biomedical Research Institute","institution_ids":["https://openalex.org/I2799970807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452992","display_name":"Jung\u2010Eun Kim","orcid":"https://orcid.org/0000-0002-5173-9134","observed_orcids":["https://orcid.org/0000-0002-5173-9134"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jungeun Kim","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062788622","display_name":"Jiyeon Kweon","orcid":"https://orcid.org/0000-0002-9116-8305","observed_orcids":["https://orcid.org/0000-0002-9116-8305"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiyeon Kweon","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062396148","display_name":"Jeong Sang Son","orcid":"https://orcid.org/0000-0001-8238-2169","observed_orcids":["https://orcid.org/0000-0001-8238-2169"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong Sang Son","raw_affiliation_strings":["Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006189471","display_name":"Jae Souk Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae Souk Lee","raw_affiliation_strings":["Brain Korea 21 Plus Project for Medical Science, and","Department of Physiology,","Department of Physiology,Brain Korea 21 Plus Project for Medical Science, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Korea 21 Plus Project for Medical Science, and","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology,","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology,Brain Korea 21 Plus Project for Medical Science, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111667160","display_name":"Jeong-Eun Yoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeong-Eun Yoo","raw_affiliation_strings":["Brain Korea 21 Plus Project for Medical Science, and","Department of Physiology,","Department of Physiology,Brain Korea 21 Plus Project for Medical Science, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Korea 21 Plus Project for Medical Science, and","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology,","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology,Brain Korea 21 Plus Project for Medical Science, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073657262","display_name":"Sung\u2010Rae Cho","orcid":"https://orcid.org/0000-0003-1429-2684","observed_orcids":["https://orcid.org/0000-0003-1429-2684"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Rae Cho","raw_affiliation_strings":["Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea;","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781827","display_name":"Jong\u2010Hoon Kim","orcid":"https://orcid.org/0000-0003-3419-0538","observed_orcids":["https://orcid.org/0000-0003-3419-0538","https://orcid.org/0000-0001-6690-5943"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Hoon Kim","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390285","display_name":"Jin\u2010Soo Kim","orcid":"https://orcid.org/0000-0003-4847-1306","observed_orcids":["https://orcid.org/0000-0003-4847-1306","https://orcid.org/0000-0003-0806-5979"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Soo Kim","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Seoul 151-742, South Korea;","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul 151-742, South Korea; and","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul 136-713, South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100359360","display_name":"Dong\u2010Wook Kim","orcid":"https://orcid.org/0000-0002-5025-1532","observed_orcids":["https://orcid.org/0000-0002-5025-1532","https://orcid.org/0000-0003-3419-0538"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Wook Kim","raw_affiliation_strings":["Brain Korea 21 Plus Project for Medical Science, and","Department of Physiology,","Severance Biomedical Research Institute,","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Korea 21 Plus Project for Medical Science, and","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology,","institution_ids":[]},{"raw_affiliation_string":"Severance Biomedical Research Institute,","institution_ids":[]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.2128,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.9920045,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"111","issue":"25","first_page":"9253","last_page":"9258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.1404999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9909999966621399},{"id":"https://openalex.org/keywords/factor-viii-gene","display_name":"factor VIII gene","score":0.8579999804496765},{"id":"https://openalex.org/keywords/chromosomal-inversions","display_name":"chromosomal inversions","score":0.9229999780654907},{"id":"https://openalex.org/keywords/transcription-activator-like-effector-nucleases","display_name":"TALEN","score":0.7689999938011169},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/gene-inversion","display_name":"gene inversion","score":0.5870000123977661},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.796999990940094},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C31909778","wikidata":"https://www.wikidata.org/wiki/Q7833921","display_name":"Transcription activator-like effector nuclease","level":5,"score":0.9470350742340088},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7911950349807739},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5969908237457275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5950530171394348},{"id":"https://openalex.org/C165984737","wikidata":"https://www.wikidata.org/wiki/Q1070877","display_name":"Chromosomal inversion","level":5,"score":0.562574565410614},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.5567950010299683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5135831832885742},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4449809193611145},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.4277893304824829},{"id":"https://openalex.org/C55548728","wikidata":"https://www.wikidata.org/wiki/Q1465102","display_name":"Gene dosage","level":4,"score":0.4191584289073944},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.23771312832832336},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.23317953944206238},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20693770051002502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19970735907554626},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.13184186816215515},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.09315332770347595}],"mesh":[{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007446","descriptor_name":"Chromosome Inversion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.1323941111","doi":"https://doi.org/10.1073/pnas.1323941111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1323941111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3056766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4078797","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4078797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4078797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:24927536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24927536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/98911","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/98911","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"T201401732.pdf","raw_type":"Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/165646","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/165646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3056766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4078797","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1754568015","https://openalex.org/W1963634449","https://openalex.org/W1976391205","https://openalex.org/W1976462890","https://openalex.org/W1976508887","https://openalex.org/W1977036449","https://openalex.org/W1982764859","https://openalex.org/W1992631972","https://openalex.org/W1994219607","https://openalex.org/W2000046950","https://openalex.org/W2000255763","https://openalex.org/W2003171404","https://openalex.org/W2004324104","https://openalex.org/W2008056703","https://openalex.org/W2009626008","https://openalex.org/W2020505437","https://openalex.org/W2020755558","https://openalex.org/W2025074364","https://openalex.org/W2035121417","https://openalex.org/W2036824880","https://openalex.org/W2038222836","https://openalex.org/W2041797639","https://openalex.org/W2051395442","https://openalex.org/W2052218777","https://openalex.org/W2053356129","https://openalex.org/W2053778102","https://openalex.org/W2055248690","https://openalex.org/W2062049325","https://openalex.org/W2064815984","https://openalex.org/W2066304010","https://openalex.org/W2077177396","https://openalex.org/W2085468717","https://openalex.org/W2085755265","https://openalex.org/W2093022521","https://openalex.org/W2093888082","https://openalex.org/W2095718298","https://openalex.org/W2096844650","https://openalex.org/W2105464583","https://openalex.org/W2116305743","https://openalex.org/W2116753165","https://openalex.org/W2121880420","https://openalex.org/W2122304523","https://openalex.org/W2122563582","https://openalex.org/W2123746851","https://openalex.org/W2130261067","https://openalex.org/W2133704193","https://openalex.org/W2135925682","https://openalex.org/W2138281066","https://openalex.org/W2143208261","https://openalex.org/W2144141440","https://openalex.org/W2145247297","https://openalex.org/W2146145436","https://openalex.org/W2155707112","https://openalex.org/W2158168411","https://openalex.org/W2160261558","https://openalex.org/W2162212014"],"related_works":["https://openalex.org/W2098669942","https://openalex.org/W2222135202","https://openalex.org/W2276582211","https://openalex.org/W7005662091","https://openalex.org/W3094876212","https://openalex.org/W2939163601","https://openalex.org/W3132485019","https://openalex.org/W2945199469","https://openalex.org/W3093795049","https://openalex.org/W3047581885"],"abstract_inverted_index":{"Hemophilia":[0],"A,":[1,30],"one":[2],"of":[3,34,41,52,80,186],"the":[4,16,24,42,78,81,103,112,117,124,131,141,144,184],"most":[5,46],"common":[6],"genetic":[7,169,191],"bleeding":[8],"disorders,":[9],"is":[10],"caused":[11,171,193],"by":[12,172,194],"various":[13],"mutations":[14],"in":[15,28,84,111,127,137,164],"blood":[17],"coagulation":[18],"factor":[19],"VIII":[20],"(F8)":[21],"gene.":[22],"Among":[23],"genotypes":[25],"that":[26,37,76,150],"result":[27],"hemophilia":[29,55,94,113,187],"two":[31],"different":[32],"types":[33],"chromosomal":[35,74,162,173,195],"inversions":[36],"involve":[38],"a":[39,63,72,93],"portion":[40,79],"F8":[43,82,125],"gene":[44,83],"are":[45],"frequent,":[47],"accounting":[48],"for":[49,156,167,183],"almost":[50],"half":[51],"all":[53],"severe":[54],"A":[56,95,188],"cases.":[57],"In":[58,99],"this":[59],"study,":[60],"we":[61,101,122,148],"used":[62,154],"transcription":[64],"activator-like":[65],"effector":[66],"nuclease":[67],"(TALEN)":[68],"pair":[69],"to":[70,91,107],"invert":[71],"140-kbp":[73],"segment":[75,105],"spans":[77],"human":[85],"induced":[86],"pluripotent":[87],"stem":[88],"cells":[89,128],"(iPSCs)":[90],"create":[92],"model":[96,114],"cell":[97],"line.":[98],"addition,":[100],"reverted":[102,132],"inverted":[104,145],"back":[106],"its":[108],"normal":[109],"orientation":[110],"iPSCs":[115,133,165],"using":[116],"same":[118],"TALEN":[119],"pair.":[120],"Importantly,":[121],"detected":[123],"mRNA":[126],"derived":[129,139],"from":[130,140],"lines,":[134],"but":[135],"not":[136],"those":[138],"clones":[142],"with":[143,161],"segment.":[146],"Thus,":[147],"showed":[149],"TALENs":[151],"can":[152],"be":[153],"both":[155],"creating":[157],"disease":[158],"models":[159],"associated":[160],"rearrangements":[163],"and":[166,189],"correcting":[168],"defects":[170],"inversions.":[174,196],"This":[175],"strategy":[176],"provides":[177],"an":[178],"iPSC-based":[179],"novel":[180],"therapeutic":[181],"option":[182],"treatment":[185],"other":[190],"diseases":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
