{"id":"https://openalex.org/W2018495362","doi":"https://doi.org/10.1097/00005768-199801000-00013","title":"Regulation of blood volume during training in post-menopausal women","display_name":"Regulation of blood volume during training in post-menopausal women","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2018495362","doi":"https://doi.org/10.1097/00005768-199801000-00013","mag":"2018495362","pmid":"https://pubmed.ncbi.nlm.nih.gov/9475649"},"language":"en","primary_location":{"id":"doi:10.1097/00005768-199801000-00013","doi":"https://doi.org/10.1097/00005768-199801000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-199801000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp;amp Science in Sports &amp;amp Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025562404","display_name":"Nina S. Stachenfeld","orcid":"https://orcid.org/0000-0002-6597-5031","observed_orcids":["https://orcid.org/0000-0002-6597-5031"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"NINA S. STACHENFELD","raw_affiliation_strings":["Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06519, USA. nstach@jbpierce.com","Submitted for publication June 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06519, USA. nstach@jbpierce.com","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Submitted for publication June 1997","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052053308","display_name":"Gary W. Mack","orcid":"https://orcid.org/0000-0003-2634-4752","observed_orcids":["https://orcid.org/0000-0003-2634-4752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GARY W. MACK","raw_affiliation_strings":["Submitted for publication June 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication June 1997","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038558566","display_name":"Loretta DiPietro","orcid":"https://orcid.org/0000-0002-3064-3977","observed_orcids":["https://orcid.org/0000-0002-3064-3977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LORETTA DiPIETRO","raw_affiliation_strings":["Submitted for publication June 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication June 1997","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062636689","display_name":"Tamara S. Morocco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TAMARA S. MOROCCO","raw_affiliation_strings":["Submitted for publication June 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication June 1997","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080485910","display_name":"Alison C. Jozsi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALISON C. JOZSI","raw_affiliation_strings":["Submitted for publication June 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication June 1997","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108548017","display_name":"ETHAN R. NADEL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ETHAN R. NADEL","raw_affiliation_strings":["Submitted for publication June 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication June 1997","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.347,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.95450464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"1","first_page":"92","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-volume-expansion","display_name":"blood volume expansion","score":0.925000011920929},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8180000185966492},{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.9390000104904175},{"id":"https://openalex.org/keywords/peak-oxygen-uptake","display_name":"peak oxygen uptake","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cardiopulmonary-baroreflex","display_name":"cardiopulmonary baroreflex","score":0.9779999852180481},{"id":"https://openalex.org/keywords/forearm-vascular-resistance","display_name":"forearm vascular resistance","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lower-body-negative-pressure","display_name":"lower body negative pressure","score":0.7590000033378601},{"id":"https://openalex.org/keywords/central-venous-pressure","display_name":"central venous pressure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/training-adaptation","display_name":"training effects","score":0.42899999022483826},{"id":"https://openalex.org/keywords/yoga","display_name":"yoga","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7276395559310913},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6639275550842285},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6515337228775024},{"id":"https://openalex.org/C2778230795","wikidata":"https://www.wikidata.org/wiki/Q1614115","display_name":"Hypervolemia","level":3,"score":0.6402803063392639},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5736121535301208},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.5494463443756104},{"id":"https://openalex.org/C2780214079","wikidata":"https://www.wikidata.org/wiki/Q228537","display_name":"Forearm","level":2,"score":0.5293624401092529},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5243485569953918},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.5224094390869141},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4358466565608978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3975267708301544},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.375762403011322},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2242981195449829}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005768-199801000-00013","doi":"https://doi.org/10.1097/00005768-199801000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-199801000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp;amp Science in Sports &amp;amp Exercise","raw_type":"journal-article"},{"id":"pmid:9475649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9475649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine and science in sports and exercise","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1393609057","display_name":"General Clinical Research Center","funder_award_id":"M01RR000125","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3149414283","display_name":null,"funder_award_id":"AG09872","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G621074823","display_name":"BODY FLUID REGULATION IN AGING ADULTS WITH EXERCISE","funder_award_id":"5r01ag009872-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1782012174","https://openalex.org/W1858477380","https://openalex.org/W1901627834","https://openalex.org/W1929143193","https://openalex.org/W1951805102","https://openalex.org/W1964079568","https://openalex.org/W1974242043","https://openalex.org/W1995331250","https://openalex.org/W1997455237","https://openalex.org/W2011898448","https://openalex.org/W2013995202","https://openalex.org/W2023718378","https://openalex.org/W2042759323","https://openalex.org/W2062592527","https://openalex.org/W2088136173","https://openalex.org/W2102941138","https://openalex.org/W2105058411","https://openalex.org/W2114090657","https://openalex.org/W2169215390","https://openalex.org/W2196373679","https://openalex.org/W2226327246","https://openalex.org/W2261967522","https://openalex.org/W2263575419","https://openalex.org/W2276189818","https://openalex.org/W2282435812","https://openalex.org/W2325992887","https://openalex.org/W2339640055","https://openalex.org/W2464067459","https://openalex.org/W2994006338"],"related_works":["https://openalex.org/W2006691006","https://openalex.org/W2276189818","https://openalex.org/W1995524370","https://openalex.org/W2758764737","https://openalex.org/W7095149109","https://openalex.org/W1965260204","https://openalex.org/W2160538054","https://openalex.org/W3014947400","https://openalex.org/W2021188847","https://openalex.org/W2143387144"],"abstract_inverted_index":{"UNLABELLED:":[0],"In":[1,298],"younger":[2,242],"people":[3],"the":[4,21,48,148,161,191,281,300,309],"increase":[5,192],"in":[6,13,24,36,52,59,75,144,193,201,241,286,295,313,315],"aerobic":[7,186],"capacity":[8],"following":[9],"training":[10,58,89,108,214,294],"is":[11,31,62],"related,":[12],"part,":[14],"to":[15,112,166,208,225,283,308],"blood":[16],"volume":[17,245],"(BV)":[18],"expansion":[19,71,292],"and":[20,72,97,128,160,184,249,256,262,273],"consequent":[22],"improvements":[23,312],"maximal":[25],"cardiac":[26],"output.":[27],"This":[28],"training-induced":[29],"hypervolemia":[30],"associated":[32,63],"with":[33,64],"a":[34,73,235],"decrease":[35,200],"cardiopulmonary":[37],"baroreflex":[38],"(CPBR)":[39],"control":[40,77,98,141],"of":[41,78,174,190,302,323],"peripheral":[42],"vascular":[43,79,163,195],"tone.":[44,80],"PURPOSE:":[45],"To":[46],"test":[47],"hypothesis":[49],"that":[50,280],"improvement":[51,237],"peak":[53,122,134],"oxygen":[54],"consumption":[55],"(VO2peak)":[56],"during":[57,171,293,318],"older":[60,84,296,316],"women":[61,85,317],"specific":[65,304],"central":[66,202],"adaptations,":[67],"such":[68],"as":[69],"BV":[70,155,291],"reduction":[74],"CPBR":[76,210,257,287],"METHODS:":[81],"Seventeen":[82],"healthy":[83],"were":[86,270],"randomized":[87],"into":[88],"(N":[90,99],"=":[91,100],"9,":[92],"71":[93],"+/-":[94,103,247,251,260,264],"2":[95],"yr)":[96,105],"8,":[101],"73":[102],"3":[104],"groups.":[106],"The":[107,140,188],"group":[109,142],"exercised":[110],"three":[111],"four":[113],"times":[114],"per":[115,198],"wk":[116,127],"for":[117,125,137],"30":[118],"min":[119,131],"at":[120,132],"60%":[121],"heart":[123,135],"rate":[124,136],"12":[126,138],"then":[129],"40-50":[130],"75%":[133],"wk.":[139],"participated":[143],"yoga":[145],"exercises":[146],"over":[147],"same":[149],"time":[150],"period.":[151],"We":[152],"measured":[153],"resting":[154],"(Evans":[156],"blue":[157],"dye),":[158],"VO2peak,":[159],"forearm":[162,194],"resistance":[164,196],"response":[165],"unloading":[167],"low":[168,172],"pressure":[169,178,204],"mechanoreceptors":[170],"levels":[173],"lower":[175],"body":[176],"negative":[177],"(through":[179],"-20":[180],"mm":[181],"Hg)":[182,269],"before":[183,272],"after":[185,274],"training.":[187,275,324],"slope":[189],"(response)":[197],"unit":[199],"venous":[203],"(stimulus)":[205],"was":[206],"used":[207],"assess":[209],"responsiveness.":[211],"RESULTS:":[212],"Aerobic":[213],"increased":[215],"VO2peak":[216,314],"14.2%":[217],"from":[218],"24.2":[219],"mL":[220,227,253],"x":[221,223,228,230,254,267],"kg(-1)":[222,229],"min(-1)":[224,231],"27.7":[226],"(P":[232],"<":[233],"0.05),":[234],"smaller":[236],"than":[238],"typically":[239],"seen":[240],"subjects.":[243],"Blood":[244],"(59.9":[246],"1.9":[248,252],"60.9":[250],"kg[-1])":[255],"function":[258,288],"(-3.98":[259],"0.92":[261],"-3.46":[263],"0.94":[265],"units":[266],"mm(-1)":[268],"similar":[271],"CONCLUSIONS:":[276],"These":[277],"data":[278],"indicate":[279],"inability":[282],"induce":[284],"adaptations":[285,305],"may":[289,306],"limit":[290],"women.":[297],"addition,":[299],"absence":[301],"these":[303],"contribute":[307],"relatively":[310],"poor":[311],"short":[319],"(10-12":[320],"wk)":[321],"periods":[322]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}