{"id":"https://openalex.org/W2018483616","doi":"https://doi.org/10.3164/jcbn.10-02","title":"Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway","display_name":"Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2018483616","doi":"https://doi.org/10.3164/jcbn.10-02","mag":"2018483616","pmid":"https://pubmed.ncbi.nlm.nih.gov/20664734","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901767"},"language":"en","primary_location":{"id":"doi:10.3164/jcbn.10-02","doi":"https://doi.org/10.3164/jcbn.10-02","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.10-02","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/47/1/47_10-02/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jcbn/47/1/47_10-02/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100741453","display_name":"Jun-Hee Kim","orcid":"https://orcid.org/0000-0003-0779-3392","observed_orcids":["https://orcid.org/0000-0003-0779-3392"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun-Hee Kim","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea","Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025533376","display_name":"Ji\u2010Youn Jung","orcid":"https://orcid.org/0000-0002-8153-4455","observed_orcids":["https://orcid.org/0000-0002-8153-4455","https://orcid.org/0000-0003-4388-1509"]},"institutions":[{"id":"https://openalex.org/I206597221","display_name":"Kongju National University","ror":"https://ror.org/0373nm262","country_code":"KR","type":"education","lineage":["https://openalex.org/I206597221"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Youn Jung","raw_affiliation_strings":["Department of Companion and Laboratory Animal Science, Kongju National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Companion and Laboratory Animal Science, Kongju National University","institution_ids":["https://openalex.org/I206597221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011547643","display_name":"Jung\u2010Hyun Shim","orcid":"https://orcid.org/0000-0002-4062-4016","observed_orcids":["https://orcid.org/0000-0002-4062-4016"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Hyun Shim","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380871","display_name":"Jin Kim","orcid":"https://orcid.org/0000-0002-5484-380X","observed_orcids":["https://orcid.org/0000-0002-5484-380X","https://orcid.org/0009-0005-3047-7584"]},"institutions":[{"id":"https://openalex.org/I206597221","display_name":"Kongju National University","ror":"https://ror.org/0373nm262","country_code":"KR","type":"education","lineage":["https://openalex.org/I206597221"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Kim","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea","Department of Companion and Laboratory Animal Science, Kongju National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University, Jeonju 561-756, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Department of Companion and Laboratory Animal Science, Kongju National University","institution_ids":["https://openalex.org/I206597221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016234851","display_name":"Kyeong\u2010Hee Choi","orcid":"https://orcid.org/0000-0002-4160-2003","observed_orcids":["https://orcid.org/0000-0002-4160-2003"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyeong-Hee Choi","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112903059","display_name":"Ji\u2010Ae Shin","orcid":"https://orcid.org/0000-0002-5407-2611","observed_orcids":["https://orcid.org/0000-0002-5407-2611"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Ae Shin","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526426","display_name":"Eun\u2010Sun Choi","orcid":"https://orcid.org/0000-0002-5432-1059","observed_orcids":["https://orcid.org/0000-0002-5432-1059"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Sun Choi","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036752356","display_name":"Syng\u2010Ook Lee","orcid":"https://orcid.org/0000-0002-8958-8634","observed_orcids":["https://orcid.org/0000-0002-8958-8634"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syng-Ook Lee","raw_affiliation_strings":["Institute of Biosciences and Technology, Texas A&M University Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biosciences and Technology, Texas A&M University Health Science Center","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003229513","display_name":"Sudhakar R. Chintharlapalli","orcid":"https://orcid.org/0009-0000-2812-8557","observed_orcids":["https://orcid.org/0009-0000-2812-8557","https://orcid.org/0000-0001-7848-1674"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhakar Chintharlapalli","raw_affiliation_strings":["Institute of Biosciences and Technology, Texas A&M University Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biosciences and Technology, Texas A&M University Health Science Center","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065680403","display_name":"Ki Han Kwon","orcid":"https://orcid.org/0000-0001-6078-5899","observed_orcids":["https://orcid.org/0000-0001-6078-5899"]},"institutions":[{"id":"https://openalex.org/I79056234","display_name":"Gwangju University","ror":"https://ror.org/01gcnxt20","country_code":"KR","type":"education","lineage":["https://openalex.org/I79056234"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki Han Kwon","raw_affiliation_strings":["Department of Food Science and Nutrition, College of Health, Social Welfare and Education, Gwangju University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, College of Health, Social Welfare and Education, Gwangju University","institution_ids":["https://openalex.org/I79056234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076661925","display_name":"Dae\u2010Ho Leem","orcid":"https://orcid.org/0000-0001-6735-8275","observed_orcids":["https://orcid.org/0000-0001-6735-8275"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Ho Leem","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, School of Dentistry and Research of Clinical Medicine, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, School of Dentistry and Research of Clinical Medicine, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027026269","display_name":"Nam\u2010Pyo Cho","orcid":"https://orcid.org/0000-0002-3772-4630","observed_orcids":["https://orcid.org/0000-0002-3772-4630"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Nam-Pyo Cho","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023724281","display_name":"Sung\u2010Dae Cho","orcid":"https://orcid.org/0000-0001-8670-9579","observed_orcids":["https://orcid.org/0000-0001-8670-9579"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sung-Dae Cho","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","Laboratory for Oral disease-related Compounds, Chonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 project, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Laboratory for Oral disease-related Compounds, Chonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023724281","https://openalex.org/A5027026269"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":null,"apc_paid":null,"fwci":1.5315,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80318251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"1","first_page":"74","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tolfenamic-acid","display_name":"tolfenamic acid","score":1.0},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.75},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/p38-mapk-pathway","display_name":"p38 MAPK pathway","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cox-independent-mechanism","display_name":"COX-independent mechanism","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8270000219345093},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase-cleavage","display_name":"poly(ADP-ribose) polymerase cleavage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6620000004768372},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6980440616607666},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6214462518692017},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5362602472305298},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5211474895477295},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.49119874835014343},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4710939824581146},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4564386308193207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4446997046470642},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43357154726982117},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4284760355949402},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41461920738220215},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41367307305336},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32142049074172974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28677061200141907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.286282479763031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25706109404563904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1481778621673584},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3164/jcbn.10-02","doi":"https://doi.org/10.3164/jcbn.10-02","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.10-02","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/47/1/47_10-02/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},{"id":"pmid:20664734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20664734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical biochemistry and nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2901767","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2901767/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Biochem Nutr","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.354.1852","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.1852","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ab/c9/J_Clin_Biochem_Nutr_2010_Jul_17_47(1)_74-80.tar.gz","raw_type":"text"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/208968","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/208968","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3164/jcbn.10-02","doi":"https://doi.org/10.3164/jcbn.10-02","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.10-02","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/47/1/47_10-02/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321330","display_name":"Gwangju University","ror":"https://ror.org/01gcnxt20"},{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018483616.pdf","grobid_xml":"https://content.openalex.org/works/W2018483616.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1543630008","https://openalex.org/W1606022491","https://openalex.org/W1623616299","https://openalex.org/W1752932536","https://openalex.org/W1815431626","https://openalex.org/W1979201752","https://openalex.org/W1979995768","https://openalex.org/W2021975445","https://openalex.org/W2029135570","https://openalex.org/W2034580062","https://openalex.org/W2035768602","https://openalex.org/W2047004367","https://openalex.org/W2076150416","https://openalex.org/W2094242183","https://openalex.org/W2120145505","https://openalex.org/W2121212064","https://openalex.org/W2121407330","https://openalex.org/W2122635542","https://openalex.org/W2128519797","https://openalex.org/W2136789423","https://openalex.org/W2137436941","https://openalex.org/W2145149010","https://openalex.org/W2150479709","https://openalex.org/W2158247942","https://openalex.org/W2162044344","https://openalex.org/W2164290354","https://openalex.org/W2170241782"],"related_works":["https://openalex.org/W7097898902","https://openalex.org/W2606876277","https://openalex.org/W2574076446","https://openalex.org/W2136508783","https://openalex.org/W2002186012","https://openalex.org/W2493417507","https://openalex.org/W2055461483","https://openalex.org/W2138770474","https://openalex.org/W2266686766","https://openalex.org/W2149689953"],"abstract_inverted_index":{"Nonsteroidal":[0],"anti-inflammatory":[1],"drugs":[2],"(NSAIDs)":[3],"are":[4,132],"known":[5],"to":[6,119,134],"inhibit":[7],"cancer":[8,52,68,154,163],"growth":[9,91,155],"by":[10,97,156],"inhibiting":[11],"the":[12,23,31,55,58,81,84,98,107,123,135,158],"activity":[13,47],"of":[14,34,61,83,109,122,137],"cyclooxygenase":[15],"(COX).":[16],"However,":[17],"there":[18],"is":[19,41,70],"increasing":[20],"evidence":[21],"that":[22,44,75,147],"COX-independent":[24],"pathway":[25,161],"may":[26],"be":[27],"also":[28,117],"involved":[29],"in":[30,48,64,127],"inhibitory":[32],"effect":[33,60],"NSAIDs":[35],"against":[36],"tumor":[37],"progression.":[38],"Tolfenamic":[39],"acid":[40,63,77,116],"a":[42,120],"NSAID":[43],"exhibits":[45],"anticancer":[46],"pancreatic":[49],"and":[50,92,106],"colorectal":[51],"models.":[53],"In":[54,113],"present":[56],"study,":[57],"anti-tumor":[59],"tolfenamic":[62,76,115,148],"KB":[65,128],"human":[66],"oral":[67],"cells":[69],"investigated.":[71],"The":[72],"results":[73,145],"showed":[74],"does":[78],"not":[79],"alter":[80],"expression":[82],"COX":[85],"proteins,":[86],"but":[87],"it":[88],"inhibits":[89,153],"cell":[90,151],"induces":[93],"apoptosis":[94],"as":[95],"evidenced":[96],"annexin":[99],"V":[100],"positivity,":[101],"sub-G(1)":[102],"population,":[103],"nuclear":[104],"fragmentation":[105],"cleavage":[108],"poly":[110],"ADP-ribose":[111],"polymerase.":[112],"addition,":[114],"leads":[118],"loss":[121],"mitochondrial":[124],"membrane":[125],"potential":[126],"cells.":[129],"These":[130,144],"effects":[131],"related":[133],"activation":[136],"p38":[138,159],"mitogen-activated":[139],"protein":[140],"kinase":[141],"(MAPK)":[142],"pathway.":[143],"suggest":[146],"acid-induced":[149],"apoptotic":[150],"death":[152],"activating":[157],"MAPK":[160],"for":[162],"prevention.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
