{"id":"https://openalex.org/W2018481653","doi":"https://doi.org/10.1021/pr0499343","title":"The Statistical Significance of Protein Identification Results as a Function of the Number of Protein Sequences Searched","display_name":"The Statistical Significance of Protein Identification Results as a Function of the Number of Protein Sequences Searched","publication_year":2004,"publication_date":"2004-08-27","ids":{"openalex":"https://openalex.org/W2018481653","doi":"https://doi.org/10.1021/pr0499343","mag":"2018481653","pmid":"https://pubmed.ncbi.nlm.nih.gov/15473685"},"language":"en","primary_location":{"id":"doi:10.1021/pr0499343","doi":"https://doi.org/10.1021/pr0499343","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr0499343","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044288681","display_name":"Jan W. Eriksson","orcid":"https://orcid.org/0000-0002-2639-9481","observed_orcids":["https://orcid.org/0000-0002-2639-9481"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Jan Eriksson","raw_affiliation_strings":["Swedish University of Agricultural Sciences, Box 7015, SE-750 07 Uppsala, Sweden, Amersham Biosciences, 800 Centennial Avenue, Piscataway, New Jersey 08855, and The Rockefeller University, 1230 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish University of Agricultural Sciences, Box 7015, SE-750 07 Uppsala, Sweden, Amersham Biosciences, 800 Centennial Avenue, Piscataway, New Jersey 08855, and The Rockefeller University, 1230 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I298625061","https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065792746","display_name":"David Feny\u00f6","orcid":"https://orcid.org/0000-0001-5049-3825","observed_orcids":["https://orcid.org/0000-0001-5049-3825"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"David Feny\u00f6","raw_affiliation_strings":["Swedish University of Agricultural Sciences, Box 7015, SE-750 07 Uppsala, Sweden, Amersham Biosciences, 800 Centennial Avenue, Piscataway, New Jersey 08855, and The Rockefeller University, 1230 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish University of Agricultural Sciences, Box 7015, SE-750 07 Uppsala, Sweden, Amersham Biosciences, 800 Centennial Avenue, Piscataway, New Jersey 08855, and The Rockefeller University, 1230 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I298625061","https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.7911,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.83104335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"5","first_page":"979","last_page":"982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-identification","display_name":"protein identification","score":0.7919999957084656},{"id":"https://openalex.org/keywords/statistical-significance","display_name":"statistical significance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"false discovery rate","score":0.6010000109672546},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"mass spectrometry","score":0.7360000014305115},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6357433795928955},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.6186076402664185},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5425612926483154},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4921688437461853},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49184203147888184},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.48731884360313416},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.43994826078414917},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.4115701913833618},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34577396512031555},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3431433141231537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19277802109718323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09106597304344177},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/pr0499343","doi":"https://doi.org/10.1021/pr0499343","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr0499343","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:15473685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15473685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.717.6161","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.717.6161","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lab.rockefeller.edu/chait/pdf/04/04_eriksson_jpr.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.724.693","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.724.693","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.fenyolab.org/publications/pdf/04_eriksson_jpr.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1575714113","https://openalex.org/W1971403296","https://openalex.org/W1972791227","https://openalex.org/W1981593008","https://openalex.org/W1985560593","https://openalex.org/W1997206295","https://openalex.org/W2001137032","https://openalex.org/W2037036397","https://openalex.org/W2045340003","https://openalex.org/W2046461084","https://openalex.org/W2055063265","https://openalex.org/W2058590378","https://openalex.org/W2059648068","https://openalex.org/W2079056345","https://openalex.org/W2084619201","https://openalex.org/W2093828656","https://openalex.org/W2108560655","https://openalex.org/W2118127847","https://openalex.org/W2119376397","https://openalex.org/W2123960992","https://openalex.org/W2127042732","https://openalex.org/W2133201628","https://openalex.org/W2135427956","https://openalex.org/W2135472971","https://openalex.org/W2153283265","https://openalex.org/W4230501579","https://openalex.org/W4232440285"],"related_works":["https://openalex.org/W7095236830","https://openalex.org/W2135427956","https://openalex.org/W7101229871","https://openalex.org/W2058590378","https://openalex.org/W2168843933","https://openalex.org/W2135472971","https://openalex.org/W7097250702","https://openalex.org/W2124606291","https://openalex.org/W7100210709","https://openalex.org/W2082006641"],"abstract_inverted_index":{"The":[0],"potential":[1],"for":[2],"obtaining":[3,89],"a":[4,40,52,59],"true":[5],"mass":[6,30],"spectrometric":[7,31],"protein":[8,98,109],"identification":[9],"result":[10,41,60],"depends":[11,93,124],"on":[12,20,94,125,136],"the":[13,25,29,55,64,75,86,95,101,113,121,126,138,145],"choice":[14,47,83,140],"of":[15,48,54,84,88,97,107,128,141],"algorithm":[16,49],"as":[17,19],"well":[18],"experimental":[21],"factors":[22],"that":[23,39,58],"influence":[24],"information":[26],"content":[27],"in":[28,100],"data.":[32],"Current":[33],"methods":[34],"can":[35,50],"never":[36],"prove":[37],"definitively":[38],"is":[42,61],"true,":[43],"but":[44],"an":[45,70,134],"appropriate":[46],"provide":[51,133],"measure":[53],"statistical":[56,65,76,122,146],"risk":[57],"false,":[62],"i.e.,":[63],"significance.":[66,147],"We":[67,131],"recently":[68],"demonstrated":[69],"algorithm,":[71,85,115],"Probity,":[72],"which":[73],"assigns":[74],"significance":[77,123],"to":[78],"each":[79],"result.":[80],"For":[81],"any":[82],"difficulty":[87],"statistically":[90],"significant":[91],"results":[92],"number":[96,127],"sequences":[99,129],"sequence":[102],"collection":[103],"searched.":[104,130],"By":[105],"simulations":[106],"random":[108],"identifications":[110],"and":[111],"using":[112],"Probity":[114],"we":[116],"here":[117],"demonstrate":[118],"explicitly":[119],"how":[120,137],"also":[132],"example":[135],"practitioner's":[139],"taxonomic":[142],"constraints":[143],"influences":[144]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
