{"id":"https://openalex.org/W2018478013","doi":"https://doi.org/10.1152/ajpregu.00377.2012","title":"Leptin receptor antagonist treatment ameliorates the effects of long-term maternal hypoxia on adrenal expression of key steroidogenic genes in the ovine fetus","display_name":"Leptin receptor antagonist treatment ameliorates the effects of long-term maternal hypoxia on adrenal expression of key steroidogenic genes in the ovine fetus","publication_year":2013,"publication_date":"2013-01-24","ids":{"openalex":"https://openalex.org/W2018478013","doi":"https://doi.org/10.1152/ajpregu.00377.2012","mag":"2018478013","pmid":"https://pubmed.ncbi.nlm.nih.gov/23344230","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3602822"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00377.2012","doi":"https://doi.org/10.1152/ajpregu.00377.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00377.2012","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3602822","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022112939","display_name":"Charles A. Ducsay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles A. Ducsay","raw_affiliation_strings":["Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078555020","display_name":"Ken Furuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Furuta","raw_affiliation_strings":["Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113481798","display_name":"Vladimir E. Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir E. Vargas","raw_affiliation_strings":["Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083181286","display_name":"Kanchan M. Kaushal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanchan M. Kaushal","raw_affiliation_strings":["Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"1Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California; and","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087648642","display_name":"Krista Singleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista Singleton","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000456952","display_name":"Kimberly Hyatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Hyatt","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064042834","display_name":"Dean A. Myers","orcid":"https://orcid.org/0000-0002-2609-5605","observed_orcids":["https://orcid.org/0000-0002-2609-5605"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean A. Myers","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022112939"],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":null,"apc_paid":null,"fwci":1.5524,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83145663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"304","issue":"6","first_page":"R435","last_page":"R442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.12150000035762787,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin-receptor-antagonist","display_name":"leptin receptor antagonist","score":0.9010000228881836},{"id":"https://openalex.org/keywords/maternal-hypoxia","display_name":"maternal hypoxia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fetal-adrenal-cortex","display_name":"fetal adrenal cortex","score":0.7789999842643738},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cortisol-production","display_name":"cortisol production","score":0.8159999847412109},{"id":"https://openalex.org/keywords/steroidogenic-acute-regulatory-protein","display_name":"steroidogenic acute regulatory protein","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cyp11a1","display_name":"CYP11A1","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cyp17","display_name":"CYP17","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cyp21","display_name":"CYP21","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cyp11b1","display_name":"CYP11B1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/3beta-hydroxysteroid-dehydrogenase","display_name":"3\u03b2-hydroxysteroid dehydrogenase","score":0.8349999785423279},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.875},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.5870000123977661},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.7089999914169312},{"id":"https://openalex.org/keywords/high-altitude","display_name":"high altitude","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.864966630935669},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8525846600532532},{"id":"https://openalex.org/C80446465","wikidata":"https://www.wikidata.org/wiki/Q412483","display_name":"Cholesterol side-chain cleavage enzyme","level":4,"score":0.7053477764129639},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6401081085205078},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5814177393913269},{"id":"https://openalex.org/C2779670467","wikidata":"https://www.wikidata.org/wiki/Q24727595","display_name":"Steroidogenic acute regulatory protein","level":4,"score":0.5391168594360352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5253790616989136},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.5182340145111084},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.45638468861579895},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3129061460494995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2622886300086975},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.15722870826721191},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.15538474917411804},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.07813820242881775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013255","descriptor_name":"Steroid 21-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015067","descriptor_name":"17-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018043","descriptor_name":"Receptors, Corticotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpregu.00377.2012","doi":"https://doi.org/10.1152/ajpregu.00377.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00377.2012","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2934806","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3602822","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3602822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3602822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},{"id":"pmid:23344230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23344230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2934806","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3602822","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6126536748","display_name":" (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION:  FETUS AND ADULT","funder_award_id":"P01HD031226","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6813680748","display_name":"Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetus","funder_award_id":"R01HD051951","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W108496218","https://openalex.org/W1496459044","https://openalex.org/W1970666401","https://openalex.org/W1976317767","https://openalex.org/W1978450784","https://openalex.org/W2010632937","https://openalex.org/W2017555566","https://openalex.org/W2039130730","https://openalex.org/W2044808724","https://openalex.org/W2048107813","https://openalex.org/W2052432724","https://openalex.org/W2062052452","https://openalex.org/W2062126483","https://openalex.org/W2062570379","https://openalex.org/W2070738072","https://openalex.org/W2071563397","https://openalex.org/W2080647393","https://openalex.org/W2081832038","https://openalex.org/W2097110561","https://openalex.org/W2105882419","https://openalex.org/W2107825638","https://openalex.org/W2113276260","https://openalex.org/W2118660761","https://openalex.org/W2120629342","https://openalex.org/W2128801555","https://openalex.org/W2133471792","https://openalex.org/W2140974631","https://openalex.org/W2142945954","https://openalex.org/W2152046962","https://openalex.org/W2158784365","https://openalex.org/W2161187682","https://openalex.org/W2164341923","https://openalex.org/W2165170454","https://openalex.org/W2166005768","https://openalex.org/W2298233501","https://openalex.org/W2337993986","https://openalex.org/W4212849655","https://openalex.org/W4246721181","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2152046962","https://openalex.org/W2113276260","https://openalex.org/W2052432724","https://openalex.org/W2039130730","https://openalex.org/W2017555566","https://openalex.org/W2120629342","https://openalex.org/W2277728329","https://openalex.org/W2164341923","https://openalex.org/W2044808724","https://openalex.org/W4246721181"],"abstract_inverted_index":{"We":[0,239],"previously":[1],"reported":[2],"elevated":[3],"adipose":[4],"leptin":[5,8,12,26,137,243],"expression,":[6],"plasma":[7,229],"concentrations,":[9],"and":[10,62,83,113,120,136,153,160,174,191,206,253],"adrenocortical":[11],"receptor":[13],"expression":[14,35,176,201,249],"in":[15,216,247,255,264,268],"the":[16,106,166,217],"long-term":[17],"hypoxic":[18],"(LTH)":[19],"ovine":[20],"fetus.":[21],"This":[22],"study":[23],"addressed":[24],"whether":[25],"antagonist":[27],"(LA)":[28],"administration":[29],"to":[30,52,58,212,257],"LTH":[31,79,168,218],"fetal":[32,228],"sheep":[33],"altered":[34,235],"of":[36,129,155,188,202,250],"key":[37,251],"genes":[38],"governing":[39,248],"cortisol":[40,232,266],"synthesis.":[41],"Ewes":[42],"were":[43,99,194,234],"maintained":[44,72],"at":[45],"high":[46],"altitude":[47],"(3,820":[48],"meters)":[49],"from":[50],"40":[51],"130":[53],"days":[54,112],"gestation":[55],"(dG),":[56],"returned":[57],"Loma":[59],"Linda":[60],"University,":[61],"implanted":[63],"with":[64,102,181],"a":[65,245,262],"maternal":[66],"tracheal":[67],"catheter.":[68],"Reduced":[69],"Po2":[70],"was":[71,125,177],"by":[73,236],"nitrogen":[74],"infusion.":[75,238],"On":[76],"132":[77],"dG,":[78,97],"(n":[80,87],"=":[81,88],"11)":[82,89],"age-matched,":[84],"normoxic":[85],"control":[86,182,225],"fetuses":[90,98],"underwent":[91],"vascular":[92],"catheter":[93],"implantation.":[94],"At":[95],"138":[96],"continuously":[100],"infused":[101],"either":[103],"saline":[104],"or":[105],"LA":[107,198,237],"(1.5":[108],"mg\u00b7kg(-1)\u00b7day(-1))":[109],"for":[110,116,127],"4":[111],"samples":[114],"collected":[115,126],"blood":[117],"gases,":[118],"ACTH,":[119,135],"cortisol.":[121],"Fetal":[122],"adrenal":[123],"cortex":[124],"determination":[128],"steriodogenic":[130],"acute":[131],"regulatory":[132],"protein":[133],"(StAR),":[134],"receptor,":[138,172,211],"cholesterol":[139],"side-chain":[140],"cleavage":[141],"(CYP11A1),":[142],"cytochrome":[143],"P-450":[144],"11\u03b2-hydroxylase":[145],"(CYP11B1),":[146],"17\u03b1-hydroxylase":[147],"(CYP17),":[148],"21-hydroxylase":[149],"(CYP21),":[150],"signal":[151],"transducer":[152],"activator":[154],"transcription":[156],"3":[157],"(STAT3),":[158],"pSTAT3,":[159,204],"17\u03b2-hydroxysteroid":[161],"dehydrogenase":[162],"(HSD3B)":[163],"expression.":[164],"In":[165],"saline-infused":[167],"fetuses,":[169],"StAR,":[170,203],"ACTH":[171,210,230],"CYP11A1,":[173,205],"CYP17":[175],"significantly":[178],"lower":[179],"compared":[180],"(P":[183],"<":[184],"0.05),":[185],"whereas":[186],"levels":[187,215],"CYP11B1,":[189],"CYP21,":[190],"HSD3B":[192],"mRNA":[193],"similar":[195],"between":[196],"groups.":[197],"infusion":[199],"restored":[200],"CYP17,":[207],"but":[208],"not":[209],"normal":[213],"ontogenic":[214],"group":[219],"while":[220,242],"having":[221],"no":[222],"effect":[223],"on":[224],"fetuses.":[226,270],"Neither":[227],"nor":[231],"concentrations":[233],"speculate":[240],"that":[241],"plays":[244],"role":[246,263],"enzymes":[252],"StAR":[254],"response":[256],"LTH,":[258],"other":[259],"factors":[260],"play":[261],"modulating":[265],"synthesis":[267],"these":[269]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}