{"id":"https://openalex.org/W2018477409","doi":"https://doi.org/10.1093/brain/awv024","title":"Neuronal amyloid-\u03b2 accumulation within cholinergic basal forebrain in ageing and Alzheimer\u2019s disease","display_name":"Neuronal amyloid-\u03b2 accumulation within cholinergic basal forebrain in ageing and Alzheimer\u2019s disease","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2018477409","doi":"https://doi.org/10.1093/brain/awv024","mag":"2018477409","pmid":"https://pubmed.ncbi.nlm.nih.gov/25732182","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4542619"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awv024","doi":"https://doi.org/10.1093/brain/awv024","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awv024","pdf_url":"https://academic.oup.com/brain/article-pdf/138/6/1722/13799405/awv024.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018477409"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/brain/article-pdf/138/6/1722/13799405/awv024.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083437126","display_name":"Alaina Baker\u2010Nigh","orcid":"https://orcid.org/0000-0002-4627-6024","observed_orcids":["https://orcid.org/0000-0002-4627-6024"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alaina Baker-Nigh","raw_affiliation_strings":["1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059687042","display_name":"Shahrooz Vahedi","orcid":"https://orcid.org/0000-0002-5649-3006","observed_orcids":["https://orcid.org/0000-0002-5649-3006"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahrooz Vahedi","raw_affiliation_strings":["1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045372782","display_name":"Elena Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Goetz Davis","raw_affiliation_strings":["1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002754020","display_name":"Sandra We\u0131ntraub","orcid":"https://orcid.org/0000-0003-2605-5205","observed_orcids":["https://orcid.org/0000-0003-2605-5205"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Weintraub","raw_affiliation_strings":["1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068784480","display_name":"Eileen H. Bigio","orcid":"https://orcid.org/0000-0002-9554-1138","observed_orcids":["https://orcid.org/0000-0002-9554-1138"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen H. Bigio","raw_affiliation_strings":["1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054687151","display_name":"William L. Klein","orcid":"https://orcid.org/0000-0002-3047-9978","observed_orcids":["https://orcid.org/0000-0002-3047-9978"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Klein","raw_affiliation_strings":["2 Neurobiology, Northwestern University, Evanston, IL 60201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Neurobiology, Northwestern University, Evanston, IL 60201, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032709385","display_name":"Changiz Geula","orcid":"https://orcid.org/0000-0002-9311-3295","observed_orcids":["https://orcid.org/0000-0002-9311-3295"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changiz Geula","raw_affiliation_strings":["1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA c-geula@northwestern.edu","1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA c-geula@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"1 Cognitive Neurology and Alzheimer's Disease Centre, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":4224,"currency":"GBP","value_usd":5570},"apc_paid":null,"fwci":8.1309,"has_fulltext":true,"cited_by_count":210,"citation_normalized_percentile":{"value":0.98942662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"138","issue":"6","first_page":"1722","last_page":"1737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/intraneuronal-amyloid-beta","display_name":"intraneuronal amyloid-beta","score":0.878000020980835},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.7590000033378601},{"id":"https://openalex.org/keywords/basal-forebrain","display_name":"basal forebrain","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7929999828338623},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9200000166893005},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9300000071525574},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"globus pallidus","score":0.8090000152587891},{"id":"https://openalex.org/keywords/neuronal-vulnerability","display_name":"neuronal vulnerability","score":0.628000020980835},{"id":"https://openalex.org/keywords/selective-neurodegeneration","display_name":"selective neurodegeneration","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.8269443511962891},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.7086559534072876},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6408909559249878},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.540908694267273},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5183290243148804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4478227198123932},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.43414077162742615},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43376362323760986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37579014897346497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3704811632633209},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3475639224052429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19342979788780212},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1842499077320099}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005917","descriptor_name":"Globus Pallidus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066187","descriptor_name":"Basal Forebrain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/brain/awv024","doi":"https://doi.org/10.1093/brain/awv024","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awv024","pdf_url":"https://academic.oup.com/brain/article-pdf/138/6/1722/13799405/awv024.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmid:25732182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25732182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4542619","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4542619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/brain/awv024","doi":"https://doi.org/10.1093/brain/awv024","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awv024","pdf_url":"https://academic.oup.com/brain/article-pdf/138/6/1722/13799405/awv024.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2373043996","display_name":"CALBINDIN AND CHOLINERGIC NEURONS IN AGING AND AD","funder_award_id":"R01AG014706","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7840397398","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG013854","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000867426","display_name":"Predoctoral and Postdoctoral Training Program in Aging and Dementia","funder_award_id":"T32AG020506","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G97841148","display_name":"CaMKI, Apoptosis and Cholinergic Neurons in Aging and AD","funder_award_id":"R03AG027141","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018477409.pdf","grobid_xml":"https://content.openalex.org/works/W2018477409.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W180372312","https://openalex.org/W1521750200","https://openalex.org/W1584834830","https://openalex.org/W1607136952","https://openalex.org/W1758831574","https://openalex.org/W1964741226","https://openalex.org/W1967464880","https://openalex.org/W1976236800","https://openalex.org/W1976507192","https://openalex.org/W1979456711","https://openalex.org/W1980806973","https://openalex.org/W1986863491","https://openalex.org/W1993025871","https://openalex.org/W1996146314","https://openalex.org/W1998563588","https://openalex.org/W1998937554","https://openalex.org/W2000533565","https://openalex.org/W2001880035","https://openalex.org/W2003655335","https://openalex.org/W2007890001","https://openalex.org/W2013770936","https://openalex.org/W2014727433","https://openalex.org/W2019593939","https://openalex.org/W2030508474","https://openalex.org/W2036642860","https://openalex.org/W2037322147","https://openalex.org/W2038419623","https://openalex.org/W2041037585","https://openalex.org/W2045481351","https://openalex.org/W2048027386","https://openalex.org/W2048975745","https://openalex.org/W2053665966","https://openalex.org/W2054297131","https://openalex.org/W2054513621","https://openalex.org/W2059214757","https://openalex.org/W2064963539","https://openalex.org/W2069479156","https://openalex.org/W2072405601","https://openalex.org/W2075050842","https://openalex.org/W2077279038","https://openalex.org/W2078089860","https://openalex.org/W2078212921","https://openalex.org/W2082429191","https://openalex.org/W2085526143","https://openalex.org/W2092211788","https://openalex.org/W2094929105","https://openalex.org/W2095031277","https://openalex.org/W2105921557","https://openalex.org/W2106105738","https://openalex.org/W2110831253","https://openalex.org/W2115017507","https://openalex.org/W2138224217","https://openalex.org/W2143461767","https://openalex.org/W2146729934","https://openalex.org/W2152654293","https://openalex.org/W2156281143","https://openalex.org/W2157069791","https://openalex.org/W2158766477","https://openalex.org/W2162807572","https://openalex.org/W2171074844","https://openalex.org/W2606648674","https://openalex.org/W4231147928","https://openalex.org/W4299837043"],"related_works":["https://openalex.org/W1967221100","https://openalex.org/W2093910992","https://openalex.org/W2159515399","https://openalex.org/W2129031534","https://openalex.org/W2095555652","https://openalex.org/W2140343650","https://openalex.org/W1981431623","https://openalex.org/W2024362280","https://openalex.org/W2107142452","https://openalex.org/W1972736369"],"abstract_inverted_index":{"The":[0,50,117],"mechanisms":[1,35],"that":[2,132,295],"contribute":[3],"to":[4,87,242,349],"selective":[5,89,302],"vulnerability":[6,90],"of":[7,36,58,63,91,111,119,150,158,163,166,275,279,304,318,352],"the":[8,28,54,64,88,105,141,194,216,235,273,280,316,343,350],"magnocellular":[9,138],"basal":[10,70,169,258,305,353],"forebrain":[11,71,170,259,306,354],"cholinergic":[12,72,107,307,355],"neurons":[13,73,93,139,308,356],"in":[14,42,74,104,133,140,168,172,182,193,208,227,257,260,269,277,310,315,337,357],"neurodegenerative":[15],"diseases,":[16],"such":[17],"as":[18,83,122,284],"Alzheimer's":[19,33,80,114,263,331,358],"disease,":[20,34],"are":[21,325,346],"not":[22,145,272],"fully":[23],"understood.":[24],"Because":[25],"age":[26,112],"is":[27,299],"primary":[29],"risk":[30],"factor":[31],"for":[32],"interest":[37],"must":[38],"include":[39],"age-related":[40,267],"alterations":[41,276],"protein":[43],"expression,":[44],"cell":[45],"type-specific":[46],"markers":[47],"and":[48,56,79,96,137,210,229,252,262,266,289,313,320,330,340],"pathology.":[49],"present":[51],"study":[52],"explored":[53],"extent":[55,149],"characteristics":[57],"intraneuronal":[59,296,334],"amyloid-\u03b2":[60,159,167,184,297,335],"accumulation,":[61],"particularly":[62],"fibrillogenic":[65],"42-amino":[66],"acid":[67],"isoform,":[68],"within":[69,186],"normal":[75,77],"young,":[76],"aged":[78,209,228],"disease":[81,115],"brains":[82,212,231],"a":[84,147,156,204,300],"potential":[85,347],"contributor":[86],"these":[92],"using":[94,237],"immunohistochemistry":[95],"western":[97,290],"blot":[98],"analysis.":[99],"Amyloid-\u03b21-42":[100],"immunoreactivity":[101],"was":[102,128,176,201],"observed":[103,202],"entire":[106],"neuronal":[108],"population":[109],"regardless":[110],"or":[113,179],"diagnosis.":[116],"magnitude":[118],"this":[120,187],"accumulation":[121,162,270,298,336],"revealed":[123],"by":[124,286],"optical":[125],"density":[126],"measures":[127],"significantly":[129],"greater":[130],"than":[131],"cortical":[134,243],"pyramidal":[135],"neurons,":[136],"globus":[142],"pallidus":[143],"did":[144],"demonstrate":[146,294],"similar":[148],"amyloid":[151,281],"immunoreactivity.":[152],"Immunoblot":[153],"analysis":[154],"with":[155,203,215,234,327],"panel":[157],"antibodies":[160],"confirmed":[161,285],"high":[164],"concentration":[165],"early":[171,309],"adult":[173,311,338],"life.":[174],"There":[175],"no":[177],"age-":[178],"Alzheimer-related":[180],"alteration":[181],"total":[183],"content":[185],"region.":[188],"In":[189],"contrast,":[190],"an":[191,225],"increase":[192,226],"large":[195,321],"molecular":[196,220,246],"weight":[197,221,247],"soluble":[198],"oligomer":[199],"species":[200,223,249,254],"highly":[205],"oligomer-specific":[206],"antibody":[207],"Alzheimer":[211,230],"when":[213,232],"compared":[214,233],"young.":[217],"Similarly,":[218],"intermediate":[219,253,319],"oligomeric":[222,248,322],"displayed":[224],"young":[236],"two":[238],"amyloid-\u03b242":[239],"antibodies.":[240],"Compared":[241],"homogenates,":[244],"small":[245],"were":[250,255,271],"lower":[251],"enriched":[256],"ageing":[261,329,344],"disease.":[264,332,359],"Regional":[265],"differences":[268],"result":[274],"expression":[278],"precursor":[282],"protein,":[283],"both":[287,328],"immunostaining":[288],"blot.":[291],"Our":[292],"results":[293],"relatively":[301],"trait":[303],"life,":[312],"increases":[314],"prevalence":[317],"assembly":[323],"states":[324],"associated":[326],"Selective":[333],"life":[339],"oligomerization":[341],"during":[342],"process":[345],"contributors":[348],"degeneration":[351]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}