{"id":"https://openalex.org/W2018466017","doi":"https://doi.org/10.1007/bf01070943","title":"Dissolution rate and bioavailability of griseofulvin from a ground mixture with microcrystalline cellulose","display_name":"Dissolution rate and bioavailability of griseofulvin from a ground mixture with microcrystalline cellulose","publication_year":1974,"publication_date":"1974-12-01","ids":{"openalex":"https://openalex.org/W2018466017","doi":"https://doi.org/10.1007/bf01070943","mag":"2018466017","pmid":"https://pubmed.ncbi.nlm.nih.gov/4461779"},"language":"en","primary_location":{"id":"doi:10.1007/bf01070943","doi":"https://doi.org/10.1007/bf01070943","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01070943","pdf_url":null,"source":{"id":"https://openalex.org/S92131368","display_name":"Journal of Pharmacokinetics and Biopharmaceutics","issn_l":"0090-466X","issn":["0090-466X","2168-5789"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacokinetics and Biopharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086629255","display_name":"Keiji Yamamoto","orcid":"https://orcid.org/0000-0002-2800-2329","observed_orcids":["https://orcid.org/0000-0002-2800-2329"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiji Yamamoto","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan","Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078560437","display_name":"Masahiro Nakano","orcid":"https://orcid.org/0000-0003-4247-9008","observed_orcids":["https://orcid.org/0000-0003-4247-9008"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Nakano","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan","Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111921352","display_name":"Takaichi Arita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaichi Arita","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan","Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102132162","display_name":"Yoshinobu Nakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Nakai","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Chiba, Yayoicho, 280, Chiba, Japan","Faculty of Pharmaceutical Sciences, University of Chiba, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Chiba, Yayoicho, 280, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.1353211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"2","issue":"6","first_page":"487","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10615","display_name":"Granular flow and fluidized beds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/griseofulvin","display_name":"griseofulvin","score":1.0},{"id":"https://openalex.org/keywords/microcrystalline-cellulose","display_name":"microcrystalline cellulose","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.7860000133514404},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-excipient-mixtures","display_name":"drug-excipient mixtures","score":0.4099999964237213},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2779819575","wikidata":"https://www.wikidata.org/wiki/Q416096","display_name":"Griseofulvin","level":2,"score":0.9593610763549805},{"id":"https://openalex.org/C2779351475","wikidata":"https://www.wikidata.org/wiki/Q417374","display_name":"Microcrystalline cellulose","level":3,"score":0.9312969446182251},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7271416187286377},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7066170573234558},{"id":"https://openalex.org/C2777571299","wikidata":"https://www.wikidata.org/wiki/Q3680646","display_name":"Grinding","level":2,"score":0.6544328927993774},{"id":"https://openalex.org/C201370411","wikidata":"https://www.wikidata.org/wiki/Q388283","display_name":"Microcrystalline","level":2,"score":0.5989097952842712},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5403547286987305},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.4412725567817688},{"id":"https://openalex.org/C132186339","wikidata":"https://www.wikidata.org/wiki/Q781139","display_name":"Ball mill","level":2,"score":0.4272300899028778},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41858386993408203},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31165003776550293},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17668545246124268},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1322004497051239},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.10503894090652466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006118","descriptor_name":"Griseofulvin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf01070943","doi":"https://doi.org/10.1007/bf01070943","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01070943","pdf_url":null,"source":{"id":"https://openalex.org/S92131368","display_name":"Journal of Pharmacokinetics and Biopharmaceutics","issn_l":"0090-466X","issn":["0090-466X","2168-5789"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacokinetics and Biopharmaceutics","raw_type":"journal-article"},{"id":"pmid:4461779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4461779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacokinetics and biopharmaceutics","raw_type":"Journal Article"},{"id":"mag:2028325067","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/BF01070943.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1968667721","https://openalex.org/W2008485886","https://openalex.org/W2062078162","https://openalex.org/W2083666950","https://openalex.org/W2086482946","https://openalex.org/W2090397104","https://openalex.org/W2091055916","https://openalex.org/W2106920018","https://openalex.org/W2129537011","https://openalex.org/W2152240524","https://openalex.org/W2157094021","https://openalex.org/W2171211821","https://openalex.org/W2343399392"],"related_works":["https://openalex.org/W2028325067","https://openalex.org/W2136038133","https://openalex.org/W2080779843","https://openalex.org/W2921263039","https://openalex.org/W2950919987","https://openalex.org/W2417566118","https://openalex.org/W2111532413","https://openalex.org/W2157094021","https://openalex.org/W2118290246","https://openalex.org/W1997165094"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}