{"id":"https://openalex.org/W2018462102","doi":"https://doi.org/10.1504/ijnbm.2011.045884","title":"Bioactive compounds obtained by immobilisation of serine protease inhibitors","display_name":"Bioactive compounds obtained by immobilisation of serine protease inhibitors","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2018462102","doi":"https://doi.org/10.1504/ijnbm.2011.045884","mag":"2018462102"},"language":"en","primary_location":{"id":"doi:10.1504/ijnbm.2011.045884","doi":"https://doi.org/10.1504/ijnbm.2011.045884","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijnbm.2011.045884","pdf_url":null,"source":{"id":"https://openalex.org/S183291161","display_name":"International Journal of Nano and Biomaterials","issn_l":"1752-8933","issn":["1752-8933","1752-8941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nano and Biomaterials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004820743","display_name":"Mihaela Carmen Eremia","orcid":"https://orcid.org/0000-0002-2906-6148","observed_orcids":["https://orcid.org/0000-0002-2906-6148"]},"institutions":[{"id":"https://openalex.org/I4210115987","display_name":"National Institute For Chemical Pharmaceutical Research and Development","ror":"https://ror.org/024h27x67","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210115987"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mihaela Carmen Eremia","raw_affiliation_strings":["Department of Pharmaceutical Biotechnologies, National Institute for Chemical Pharmaceutical Research and Development, ICCF, 112 Calea Vitan, 031299, Bucharest 3, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biotechnologies, National Institute for Chemical Pharmaceutical Research and Development, ICCF, 112 Calea Vitan, 031299, Bucharest 3, Romania","institution_ids":["https://openalex.org/I4210115987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075987946","display_name":"Irina Lupescu","orcid":"https://orcid.org/0000-0002-1010-1185","observed_orcids":["https://orcid.org/0000-0002-1010-1185"]},"institutions":[{"id":"https://openalex.org/I4210115987","display_name":"National Institute For Chemical Pharmaceutical Research and Development","ror":"https://ror.org/024h27x67","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210115987"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Irina Lupescu","raw_affiliation_strings":["National Institute for Chemical Pharmaceutical Research and Development, ICCF, 112 Calea Vitan, 031299, Bucharest 3, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Chemical Pharmaceutical Research and Development, ICCF, 112 Calea Vitan, 031299, Bucharest 3, Romania","institution_ids":["https://openalex.org/I4210115987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029668267","display_name":"Lumini\u0163a Tcacenco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115638","display_name":"National Institute of Research and Development for Biological Sciences","ror":"https://ror.org/028wkbm97","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210115638"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Luminita Tcacenco","raw_affiliation_strings":["Biomaterials, Bioproducts Department, National Institute of Research and Development for Biological Science, 060031, 296 Splaiul Independentei, Bucharest 6, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomaterials, Bioproducts Department, National Institute of Research and Development for Biological Science, 060031, 296 Splaiul Independentei, Bucharest 6, Romania","institution_ids":["https://openalex.org/I4210115638"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"4","first_page":"335","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/serpins","display_name":"serpins","score":0.7590000033378601},{"id":"https://openalex.org/keywords/soybean-trypsin-inhibitor","display_name":"soybean trypsin inhibitor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/polyhydroxybutyrate","display_name":"polyhydroxybutyrate","score":0.968999981880188},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polymeric-membranes","display_name":"polymer membranes","score":0.8529999852180481},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.8820000290870667},{"id":"https://openalex.org/keywords/biodegradable-biomaterials","display_name":"biodegradable biomaterials","score":0.7689999938011169},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.6179999709129333},{"id":"https://openalex.org/keywords/adsorption","display_name":"adsorption","score":0.5099999904632568},{"id":"https://openalex.org/keywords/hydrophilicity","display_name":"hydrophilicity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6864970922470093},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.6236379146575928},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5715053081512451},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5590178370475769},{"id":"https://openalex.org/C141814087","wikidata":"https://www.wikidata.org/wiki/Q24770831","display_name":"Kunitz STI protease inhibitor","level":4,"score":0.5527118444442749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5053382515907288},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.46920719742774963},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4285290539264679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40321019291877747},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2974896728992462},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29419857263565063}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijnbm.2011.045884","doi":"https://doi.org/10.1504/ijnbm.2011.045884","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijnbm.2011.045884","pdf_url":null,"source":{"id":"https://openalex.org/S183291161","display_name":"International Journal of Nano and Biomaterials","issn_l":"1752-8933","issn":["1752-8933","1752-8941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nano and Biomaterials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992571014","https://openalex.org/W2968803881","https://openalex.org/W2196312316","https://openalex.org/W2076374009","https://openalex.org/W2037655420","https://openalex.org/W2168810442","https://openalex.org/W1976928264","https://openalex.org/W1989390170","https://openalex.org/W2390567962","https://openalex.org/W2030771596"],"abstract_inverted_index":{"We":[0,65],"studied":[1,68],"the":[2,27,30,34,37,52,69,75,100],"preparation":[3],"of":[4,8,10,36,39,54,57,71,95],"polymeric":[5,43],"membranes":[6],"formed":[7],"solutions":[9,19],"poly-3-hydroxybutyrate":[11],"(PHB)":[12],"and":[13,33,63,67,84,108,122],"chitosan.":[14],"PHB-chitosan":[15],"biomaterials":[16],"from":[17,42],"these":[18],"may":[20],"form":[21],"various":[22],"structural":[23],"types,":[24],"which":[25],"determine":[26],"biodegradation":[28],"time,":[29],"adsorption":[31],"capacity,":[32],"kinetics":[35],"release":[38],"medicinal":[40],"compounds":[41,97],"matrices.":[44],"Serine":[45],"protease":[46,77],"inhibitors,":[47,78],"SERPINs,":[48],"continue":[49],"to":[50,99],"catch":[51],"attention":[53],"researchers":[55],"because":[56],"their":[58,113],"increasing":[59],"use":[60,114],"in":[61,115],"medicine":[62],"biotechnology.":[64],"prepared":[66],"properties":[70],"biodegradable":[72],"materials":[73],"containing":[74],"serine":[76],"soybean":[79],"trypsin":[80,90],"inhibitor":[81,91],"(abbreviate":[82,92],"STI)":[83],"watermelon":[85],"(":[86],"Citrullus":[87],"vulgaris":[88],")":[89],"CVTI).":[93],"Properties":[94],"bioactive":[96],"bound":[98],"above":[101],"mentioned":[102],"polymers":[103],"(proteolytic":[104],"activity,":[105],"porous":[106],"structure,":[107],"increased":[109],"hydrophilicity)":[110],"account":[111],"for":[112],"two":[116],"key":[117],"medical":[118],"applications:":[119],"drug":[120],"delivery":[121],"tissue":[123],"engineering.":[124]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}