{"id":"https://openalex.org/W2018460745","doi":"https://doi.org/10.1073/pnas.0603499103","title":"Loss of hepatic NF-\u03baB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation","display_name":"Loss of hepatic NF-\u03baB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation","publication_year":2006,"publication_date":"2006-06-28","ids":{"openalex":"https://openalex.org/W2018460745","doi":"https://doi.org/10.1073/pnas.0603499103","mag":"2018460745","pmid":"https://pubmed.ncbi.nlm.nih.gov/16807293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1502270"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0603499103","doi":"https://doi.org/10.1073/pnas.0603499103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0603499103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1502270/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005124549","display_name":"Toshiharu Sakurai","orcid":"https://orcid.org/0000-0002-7798-6862","observed_orcids":["https://orcid.org/0000-0002-7798-6862"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Toshiharu Sakurai","raw_affiliation_strings":["*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan;","Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan;","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017568301","display_name":"Shin Maeda","orcid":"https://orcid.org/0000-0002-0246-1594","observed_orcids":["https://orcid.org/0000-0002-0246-1594"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087332","display_name":"The Institute of Medical Science, Asahi Life Foundation","ror":"https://ror.org/000hskt11","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210087332"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shin Maeda","raw_affiliation_strings":["*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","Division of Gastroenterology, The Institute for Adult Disease, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Gastroenterology, The Institute for Adult Disease, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005, Japan; and","institution_ids":["https://openalex.org/I4210087332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113616822","display_name":"Lufen Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lufen Chang","raw_affiliation_strings":["*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 East Duarte Road, KCRB 3009, Duarte, CA 91010-3000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 East Duarte Road, KCRB 3009, Duarte, CA 91010-3000","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056315342","display_name":"Michael Karin","orcid":"https://orcid.org/0000-0002-2758-6473","observed_orcids":["https://orcid.org/0000-0002-2758-6473"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Karin","raw_affiliation_strings":["*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093-0723;","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.5366,"has_fulltext":false,"cited_by_count":406,"citation_normalized_percentile":{"value":0.98779803,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"103","issue":"28","first_page":"10544","last_page":"10551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.796999990940094},{"id":"https://openalex.org/keywords/ikappab-kinase-beta","display_name":"I\u03baB kinase \u03b2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/jnk1","display_name":"JNK1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hepatocyte-death","display_name":"hepatocyte death","score":0.9169999957084656},{"id":"https://openalex.org/keywords/compensatory-proliferation","display_name":"compensatory proliferation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cyclin-d","display_name":"cyclin D","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/inflammation-and-cancer","display_name":"inflammation and cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tissue-renewal","display_name":"tissue renewal","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6954264640808105},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5670328140258789},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5633713603019714},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5532429218292236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.552976131439209},{"id":"https://openalex.org/C2779087070","wikidata":"https://www.wikidata.org/wiki/Q5005943","display_name":"c-jun","level":4,"score":0.5469964742660522},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5340301990509033},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4587216377258301},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.45114797353744507},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.44034141302108765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37803971767425537},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3717382550239563},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.3537176847457886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34534478187561035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3242855668067932},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24078276753425598},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18837353587150574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15874812006950378},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09677344560623169},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004052","descriptor_name":"Diethylnitrosamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0603499103","doi":"https://doi.org/10.1073/pnas.0603499103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0603499103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16807293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16807293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1502270","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1502270/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1502270","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1502270/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2407524486","display_name":null,"funder_award_id":"ES-04151","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3109222642","display_name":"DETECTION AND MODELS OF TOXICANT EXPOSURE","funder_award_id":"P42ES010337","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G33598641","display_name":"Role of Inflammation in tumor promotion and progression","funder_award_id":"R01CA118165","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G388099241","display_name":null,"funder_award_id":"AI-043477","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5908391392","display_name":"INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME                           ","funder_award_id":"R37ES004151","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6657780598","display_name":"Regulation of NF-kappaB and IKK by proinflammatory stimuli","funder_award_id":"R01AI043477","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7507149306","display_name":"Stress Signaling Pathways in Toxicity and Disease","funder_award_id":"R01ES006376","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000884500","display_name":"NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation","funder_award_id":"R37AI043477","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1494354791","https://openalex.org/W1523142723","https://openalex.org/W1536999296","https://openalex.org/W1537712767","https://openalex.org/W1553712313","https://openalex.org/W1563090311","https://openalex.org/W1929153087","https://openalex.org/W1945598588","https://openalex.org/W1955049958","https://openalex.org/W1976382352","https://openalex.org/W1980138415","https://openalex.org/W1986427635","https://openalex.org/W1988924112","https://openalex.org/W1990752073","https://openalex.org/W1992970966","https://openalex.org/W1994219871","https://openalex.org/W2004141049","https://openalex.org/W2016961672","https://openalex.org/W2024131284","https://openalex.org/W2027962951","https://openalex.org/W2031073046","https://openalex.org/W2040532363","https://openalex.org/W2042260090","https://openalex.org/W2043493252","https://openalex.org/W2046056065","https://openalex.org/W2046440869","https://openalex.org/W2050516456","https://openalex.org/W2057942179","https://openalex.org/W2059194853","https://openalex.org/W2060532442","https://openalex.org/W2075964433","https://openalex.org/W2076515532","https://openalex.org/W2076987462","https://openalex.org/W2077880395","https://openalex.org/W2089082314","https://openalex.org/W2093005090","https://openalex.org/W2097672870","https://openalex.org/W2103637700","https://openalex.org/W2105846857","https://openalex.org/W2110879481","https://openalex.org/W2114111268","https://openalex.org/W2117282734","https://openalex.org/W2124076790","https://openalex.org/W2127649862","https://openalex.org/W2130550745","https://openalex.org/W2133984207","https://openalex.org/W2137257146","https://openalex.org/W2154823420","https://openalex.org/W2165523086","https://openalex.org/W2169385554","https://openalex.org/W2170915150","https://openalex.org/W2325720000","https://openalex.org/W2407956211","https://openalex.org/W2417104161","https://openalex.org/W2557080683","https://openalex.org/W4237329722","https://openalex.org/W6605431418"],"related_works":["https://openalex.org/W2137257146","https://openalex.org/W2144390748","https://openalex.org/W4245854641","https://openalex.org/W2921059280","https://openalex.org/W7099375395","https://openalex.org/W1993293045","https://openalex.org/W2162297313","https://openalex.org/W1990924586","https://openalex.org/W2139137652","https://openalex.org/W2332036511"],"abstract_inverted_index":{"A":[0],"major":[1],"link":[2],"between":[3],"inflammation":[4],"and":[5,72,99,154,162,175,195,211],"cancer":[6],"is":[7,68,75,107],"provided":[8],"by":[9,70],"NF-kappaB":[10,32,52],"transcription":[11],"factors.":[12],"Ikkbeta(Deltahep)":[13,42,90,129],"mice,":[14],"which":[15],"specifically":[16],"lack":[17],"IkappaB":[18],"kinase":[19,58],"beta":[20],"(IKKbeta),":[21],"an":[22],"activator":[23],"of":[24,151,169,180,191,205],"NF-kappaB,":[25],"in":[26,33,61,89,126,218],"hepatocytes,":[27],"are":[28,44],"unable":[29],"to":[30,35,46,64,86,141,187],"activate":[31],"response":[34],"proinflammatory":[36],"stimuli,":[37],"such":[38],"as":[39],"TNF-alpha.":[40],"Surprisingly,":[41],"mice":[43,91,119,134],"hypersusceptible":[45],"diethylnitrosamine":[47],"(DEN)-induced":[48],"hepatocarcinogenesis.":[49,143],"Because":[50],"defective":[51],"activation":[53,60],"promotes":[54],"sustained":[55],"c-Jun":[56],"N-terminal":[57],"(JNK)":[59],"cells":[62],"exposed":[63],"TNF-alpha,":[65],"whose":[66],"expression":[67,150],"induced":[69],"DEN,":[71],"JNK":[73,93,212],"activity":[74],"required":[76],"for":[77,110,121],"normal":[78],"hepatocyte":[79,111,173,193],"proliferation,":[80,161,178,197],"we":[81],"examined":[82],"whether":[83],"increased":[84],"susceptibility":[85],"DEN-induced":[87,142,172],"hepatocarcinogenesis":[88],"requires":[92],"activation.":[94],"Hepatocytes":[95],"express":[96],"both":[97,132],"JNK1":[98,106,123,136,181],"JNK2,":[100],"but":[101],"previous":[102],"studies":[103],"indicate":[104],"that":[105,202],"more":[108],"important":[109],"proliferation.":[112],"We":[113],"therefore":[114],"investigated":[115],"this":[116,183],"hypothesis":[117],"using":[118],"homozygous":[120],"a":[122,215],"deficiency":[124],"either":[125],"wild-type":[127],"or":[128],"backgrounds.":[130],"In":[131,185],"cases,":[133],"lacking":[135],"were":[137],"much":[138],"less":[139],"susceptible":[140],"This":[144],"impaired":[145],"tumorigenesis":[146],"correlated":[147],"with":[148],"decreased":[149],"cyclin":[152],"D":[153],"vascular":[155],"endothelial":[156],"growth":[157],"factor,":[158],"diminished":[159],"cell":[160],"reduced":[163],"tumor":[164],"neovascularization.":[165],"Whereas":[166],"hepatocyte-specific":[167],"deletion":[168],"IKKbeta":[170],"augmented":[171],"death":[174,194],"cytokine-driven":[176],"compensatory":[177,196],"disruption":[179],"abrogated":[182],"response.":[184],"addition":[186],"underscoring":[188],"the":[189,203,209],"importance":[190],"JNK1-mediated":[192],"these":[198],"results":[199],"strongly":[200],"suggest":[201],"control":[204],"tissue":[206],"renewal":[207],"through":[208],"IKK":[210],"pathways":[213],"plays":[214],"key":[216],"role":[217],"liver":[219],"carcinogenesis.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
