{"id":"https://openalex.org/W2018460481","doi":"https://doi.org/10.1016/j.ijid.2007.12.017","title":"CD4 validation for the World Health Organization classification and clinical staging of HIV/AIDS in a developing country","display_name":"CD4 validation for the World Health Organization classification and clinical staging of HIV/AIDS in a developing country","publication_year":2008,"publication_date":"2008-10-22","ids":{"openalex":"https://openalex.org/W2018460481","doi":"https://doi.org/10.1016/j.ijid.2007.12.017","mag":"2018460481","pmid":"https://pubmed.ncbi.nlm.nih.gov/18945632"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijid.2007.12.017","doi":"https://doi.org/10.1016/j.ijid.2007.12.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2007.12.017","pdf_url":"http://www.ijidonline.com/article/S1201971208014392/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ijidonline.com/article/S1201971208014392/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111978520","display_name":"Jameela Edathodu","orcid":"https://orcid.org/0000-0002-8688-7946","observed_orcids":["https://orcid.org/0000-0002-8688-7946"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Jameela Edathodu","raw_affiliation_strings":["King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia. jameelaedathodu@yahoo.com","King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia. jameelaedathodu@yahoo.com","institution_ids":["https://openalex.org/I2800965796"]},{"raw_affiliation_string":"King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079114077","display_name":"Batool Ali","orcid":"https://orcid.org/0000-0001-6744-0092","observed_orcids":["https://orcid.org/0000-0001-6744-0092"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Batool Ali","raw_affiliation_strings":["King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065395331","display_name":"Abdulrahman A. Alrajhi","orcid":"https://orcid.org/0000-0003-0780-6093","observed_orcids":["https://orcid.org/0000-0003-0780-6093"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdulrahman A. Alrajhi","raw_affiliation_strings":["King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Faisal Hospital and Research Centre, Thakassussi Street, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111978520"],"corresponding_institution_ids":["https://openalex.org/I2800965796"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":0.8879,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.75256935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"13","issue":"2","first_page":"243","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0746999979019165,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-aids","display_name":"HIV/AIDS","score":0.8220000267028809},{"id":"https://openalex.org/keywords/who-clinical-staging","display_name":"WHO clinical stage","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9459999799728394},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.4180000126361847},{"id":"https://openalex.org/keywords/hiv-diagnosis","display_name":"HIV diagnosis","score":0.4440000057220459},{"id":"https://openalex.org/keywords/saudi-arabia","display_name":"Saudi Arabia","score":0.6830000281333923},{"id":"https://openalex.org/keywords/developing-countries","display_name":"developing countries","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7951939105987549},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6264703273773193},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.6065648794174194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5192642211914062},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5006217956542969},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.41576218605041504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.348978728055954},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3446482717990875},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.11974707245826721},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012529","descriptor_name":"Saudi Arabia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014944","descriptor_name":"World Health Organization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijid.2007.12.017","doi":"https://doi.org/10.1016/j.ijid.2007.12.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2007.12.017","pdf_url":"http://www.ijidonline.com/article/S1201971208014392/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:18945632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18945632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1016/j.ijid.2007.12.017","doi":"https://doi.org/10.1016/j.ijid.2007.12.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2007.12.017","pdf_url":"http://www.ijidonline.com/article/S1201971208014392/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018460481.pdf","grobid_xml":"https://content.openalex.org/works/W2018460481.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W40597467","https://openalex.org/W105330680","https://openalex.org/W2002918673","https://openalex.org/W2022516334","https://openalex.org/W2090693471","https://openalex.org/W2094562745","https://openalex.org/W2095548819","https://openalex.org/W4252979211","https://openalex.org/W4285719527","https://openalex.org/W6601673395"],"related_works":["https://openalex.org/W1540502610","https://openalex.org/W2242993550","https://openalex.org/W2581553395","https://openalex.org/W3022375719","https://openalex.org/W2077561731","https://openalex.org/W2052456302","https://openalex.org/W2585586493","https://openalex.org/W7100520719","https://openalex.org/W2090405521","https://openalex.org/W2002918673"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"validate":[2],"the":[3,19,36,42,56,106,109,116,121,149,154,161,194,200,214,223,226],"World":[4],"Health":[5],"Organization":[6],"(WHO)":[7],"clinical":[8,71,111,163,236],"staging":[9,237],"and":[10,61,120,137,151,178,191,210,225,238],"classification":[11,239],"of":[12,21,32,44,58,89,91,108,113,118,132,158,213,240],"HIV/AIDS":[13,114,241],"using":[14],"CD4+":[15,83,122,143,184,202,228,245],"T-lymphocyte":[16,84,123,144,185,203,229,246],"counts":[17,186,230],"in":[18,41,148,153,205],"setting":[20],"a":[22,28,78,98],"developing":[23],"country.":[24],"METHODS:":[25],"This":[26],"was":[27,75,94,105,146,165,217,231],"retrospective":[29],"chart":[30],"review":[31],"HIV-infected":[33,49],"adults":[34],"at":[35,73,115,160,167,171,175,180,193,207,211],"national":[37],"HIV":[38,92],"referral":[39],"clinic":[40],"Kingdom":[43],"Saudi":[45],"Arabia.":[46],"Four":[47],"hundred":[48],"individuals":[50,54,159],"were":[51,68,127,135,139,187],"reviewed.":[52],"All":[53],"under":[55],"age":[57],"15":[59],"years":[60],"those":[62],"who":[63],"had":[64],"received":[65],"antiretroviral":[66],"therapy":[67],"excluded.":[69],"WHO":[70,110,162,235],"stage":[72,168,172,176,181,208],"presentation":[74],"determined":[76],"by":[77,97],"single":[79],"reviewer.":[80,100],"The":[81,101,141,156,197,220,234],"first":[82],"count":[85,145,204],"within":[86],"6":[87],"months":[88],"diagnosis":[90,119],"infection":[93],"then":[95],"abstracted":[96],"different":[99],"main":[102],"outcome":[103],"measure":[104],"comparison":[107],"stages":[112,164,216,224],"time":[117],"counts.":[124,247],"RESULTS:":[125],"Data":[126],"available":[128],"for":[129],"191":[130],"individuals,":[131],"whom":[133],"123":[134],"men":[136,150],"68":[138],"women.":[140,155],"mean":[142,201,227],"281/mm(3)":[147],"425/mm(3)":[152],"distribution":[157],"110":[166],"I,":[169],"10":[170],"II,":[173],"36":[174],"III,":[177],"35":[179],"IV.":[182],"Mean":[183],"457,":[188],"337,":[189],"188,":[190],"86/mm(3)":[192],"respective":[195],"stages.":[196],"difference":[198],"between":[199,222],"patients":[206],"IV":[209],"each":[212],"other":[215],"significant;":[218],"p<0.0001.":[219],"correlation":[221],"-0.65.":[232],"CONCLUSION:":[233],"correlates":[242],"well":[243],"with":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}