{"id":"https://openalex.org/W2018459966","doi":"https://doi.org/10.2337/diab.41.3.368","title":"Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance","display_name":"Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2018459966","doi":"https://doi.org/10.2337/diab.41.3.368","mag":"2018459966","pmid":"https://pubmed.ncbi.nlm.nih.gov/1551497"},"language":"en","primary_location":{"id":"doi:10.2337/diab.41.3.368","doi":"https://doi.org/10.2337/diab.41.3.368","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.41.3.368","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040133166","display_name":"Eve Van Cauter","orcid":"https://orcid.org/0000-0002-2156-6148","observed_orcids":["https://orcid.org/0000-0002-2156-6148"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Eve Van Cauter","raw_affiliation_strings":["Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010517384","display_name":"Fabienne Mestrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Fabienne Mestrez","raw_affiliation_strings":["Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041165497","display_name":"Jeppe Sturis","orcid":"https://orcid.org/0000-0001-9938-5278","observed_orcids":["https://orcid.org/0000-0001-9938-5278"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Jeppe Sturis","raw_affiliation_strings":["Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110267395","display_name":"Kenneth S. Polonsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Kenneth S Polonsky","raw_affiliation_strings":["Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago\u2008Illinois\u2008School of Medicine, Universite Libre de Bruxelles\u2008Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.2928,"has_fulltext":false,"cited_by_count":886,"citation_normalized_percentile":{"value":0.98498459,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"41","issue":"3","first_page":"368","last_page":"377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secretion-rate","display_name":"insulin secretion rate","score":0.9330000281333923},{"id":"https://openalex.org/keywords/c-peptide-kinetics","display_name":"C-peptide kinetics","score":0.9079999923706055},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.8560000061988831},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7950000166893005},{"id":"https://openalex.org/keywords/body-surface-area","display_name":"body surface area","score":0.7900000214576721},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7590000033378601},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.7839999794960022},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2778875212","wikidata":"https://www.wikidata.org/wiki/Q419107","display_name":"C-peptide","level":3,"score":0.8319547176361084},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6375124454498291},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.551973283290863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5515994429588318},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5511625409126282},{"id":"https://openalex.org/C18206936","wikidata":"https://www.wikidata.org/wiki/Q378749","display_name":"Clearance rate","level":2,"score":0.518059492111206},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4473079741001129},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34474629163742065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3113458752632141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1872924566268921}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001830","descriptor_name":"Body Surface Area","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001830","descriptor_name":"Body Surface Area","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001830","descriptor_name":"Body Surface Area","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.41.3.368","doi":"https://doi.org/10.2337/diab.41.3.368","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.41.3.368","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.41.3.368","doi":"https://doi.org/10.2337/diabetes.41.3.368","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.41.3.368","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:1551497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G251850210","display_name":null,"funder_award_id":"DK-31842","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2807054497","display_name":null,"funder_award_id":"DK 20595","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5309915925","display_name":null,"funder_award_id":"DK-41814","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G849573465","display_name":"SLEEP AND CIRCADIAN RHYTHMICITY IN GLUCOSE REGULATION","funder_award_id":"R01DK041814","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979180498","https://openalex.org/W2003194328","https://openalex.org/W2055274914","https://openalex.org/W2143153043","https://openalex.org/W3130423362","https://openalex.org/W2116695275","https://openalex.org/W2081189796","https://openalex.org/W2021956155","https://openalex.org/W2035884829","https://openalex.org/W2181752507"],"abstract_inverted_index":{"Insulin":[0],"secretion":[1,63,238,270,278,283,346],"rates":[2,347],"can":[3],"be":[4,56],"accurately":[5],"estimated":[6],"from":[7,34,248,302,321,348],"plasma":[8,349],"C-peptide":[9,16,27,53,80,106,153,193,216,331,350,356],"levels":[10,351],"with":[11,138,251,295,306,324,352],"a":[12,66,116,208],"two-compartment":[13],"model":[14],"for":[15,52,215,275,355],"distribution":[17,101,107,136,154],"and":[18,58,85,102,108,128,184,201,225,285,288],"degradation.":[19],"In":[20],"previous":[21],"studies,":[22],"the":[23,35,98,139,190,276,280,286,289,303,310,328,334],"kinetic":[24,103],"parameters":[25,51,104,191,214,231,262,297,317,329,354,362],"of":[26,43,77,100,105,122,126,130,135,141,152,181,192,222,235,256,291,312,327,330,366],"clearance":[28,54,217,332,357],"were":[29,186,195],"derived":[30,361],"in":[31,69,82,91,115,120,161,164,172,176,198,233,242,333],"each":[32,70,243],"subject":[33,244],"decay":[36,67,75],"curve":[37,68],"observed":[38],"after":[39],"bolus":[40],"intravenous":[41],"injection":[42],"biosynthetic":[44,78],"human":[45,79],"C-peptide.":[46],"To":[47],"determine":[48],"whether":[49],"standard":[50,213,230,258,296,316,353],"could":[55],"defined":[57],"used":[59],"to":[60,211,343],"calculate":[61],"insulin":[62,237,269,345],"without":[64,363],"obtaining":[65],"subject,":[71],"we":[72],"analyzed":[73],"200":[74],"curves":[76],"obtained":[81,250,294,305],"normal,":[83,199],"obese,":[84,200],"non-insulin-dependent":[86],"diabetes":[87],"mellitus":[88],"subjects":[89,174],"studied":[90],"our":[92],"laboratory.":[93],"This":[94,150],"analysis":[95],"showed":[96],"that":[97,272,322,339],"volume":[99,134,155],"metabolism":[109],"vary":[110],"by":[111,145,245,299],"less":[112],"than":[113,163,175,260,359],"30%":[114],"population":[117],"highly":[118],"heterogeneous":[119],"terms":[121],"age,":[123],"sex,":[124,183,224],"degree":[125,129,140,221],"obesity,":[127,223],"glucose":[131],"tolerance.":[132],"The":[133,166,254],"correlated":[137],"obesity":[142],"as":[143],"quantified":[144],"body":[146],"surface":[147],"area":[148],"(BSA).":[149],"dependence":[151],"on":[156,205,315],"BSA":[157],"was":[158,169,227,318],"more":[159],"marked":[160],"men":[162],"women.":[165],"long":[167],"half-life":[168],"slightly":[170],"longer":[171],"elderly":[173],"younger":[177],"adults.":[178],"When":[179],"effects":[180],"BSA,":[182],"age":[185,226],"taken":[187],"into":[188,219],"account,":[189],"kinetics":[194],"very":[196],"similar":[197],"diabetic":[202],"subjects.":[203],"Based":[204],"these":[206],"findings,":[207],"simple":[209],"procedure":[210],"derive":[212],"taking":[218],"account":[220],"defined.":[228],"These":[229],"resulted":[232],"estimations":[234],"mean":[236,281],"rates,":[239],"which":[240],"differed":[241,298],"only":[246,300],"10-12%":[247],"those":[249],"individual":[252,261,307],"parameters.":[253,308],"approach":[255],"using":[257],"rather":[259,358],"did":[263],"not":[264,319],"systematically":[265],"underestimate":[266],"or":[267],"overestimate":[268],"so":[271],"group":[273],"values":[274,304],"fasting":[277],"rate,":[279,284],"24-h":[282],"number":[287],"amplitude":[290],"secretory":[292],"pulses":[293],"1-2%":[301],"Furthermore,":[309],"accuracy":[311],"measurements":[313],"based":[314],"different":[320],"associated":[323],"replicate":[325],"determinations":[326],"same":[335],"subject.":[336],"We":[337],"conclude":[338],"it":[340],"is":[341],"possible":[342],"estimate":[344],"individually":[360],"significant":[364],"loss":[365],"accuracy.":[367]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":40},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":46},{"year":2017,"cited_by_count":36},{"year":2016,"cited_by_count":44},{"year":2015,"cited_by_count":46},{"year":2014,"cited_by_count":41},{"year":2013,"cited_by_count":46},{"year":2012,"cited_by_count":30}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}