{"id":"https://openalex.org/W2018458181","doi":"https://doi.org/10.1016/0014-2964(80)90230-3","title":"Management of CLL patients after chlorambucil therapy. Special value of a second RAI staging","display_name":"Management of CLL patients after chlorambucil therapy. Special value of a second RAI staging","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W2018458181","doi":"https://doi.org/10.1016/0014-2964(80)90230-3","mag":"2018458181","pmid":"https://pubmed.ncbi.nlm.nih.gov/7398721"},"language":"en","primary_location":{"id":"doi:10.1016/0014-2964(80)90230-3","doi":"https://doi.org/10.1016/0014-2964(80)90230-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2964(80)90230-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210204293","display_name":"European Journal of Cancer (1965)","issn_l":"0014-2964","issn":["0014-2964","1879-2995"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer (1965)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072027146","display_name":"Mauricette Michallet","orcid":"https://orcid.org/0000-0002-7338-1081","observed_orcids":["https://orcid.org/0000-0002-7338-1081","https://orcid.org/0000-0002-3448-2832"]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Michallet","raw_affiliation_strings":["Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France","institution_ids":["https://openalex.org/I2800555055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113544233","display_name":"J.J. Sotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.J. Sotto","raw_affiliation_strings":["Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France","institution_ids":["https://openalex.org/I2800555055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071644844","display_name":"J-C. Moulin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.J. Moulin","raw_affiliation_strings":["Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France","institution_ids":["https://openalex.org/I2800555055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109296592","display_name":"J Arvieux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Arvieux","raw_affiliation_strings":["Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France","institution_ids":["https://openalex.org/I2800555055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068212745","display_name":"Daniel Hollard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Hollard","raw_affiliation_strings":["Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe Hospitalies des Affections Sanguines et Tumorales, Service d'h\u00e9matologie clinique, Centre Hospitalier R\u00e9gional et Universitaire de Grenoble, 38700 La Tronche, France","institution_ids":["https://openalex.org/I2800555055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800555055"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.12848777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"16","issue":"4","first_page":"511","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/chlorambucil","display_name":"chlorambucil","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rai-staging","display_name":"Rai staging","score":0.8529999852180481},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6629999876022339},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8240000009536743},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6470000147819519},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/splenic-fibrosis","display_name":"splenic fibrosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2777866208","wikidata":"https://www.wikidata.org/wiki/Q415939","display_name":"Chlorambucil","level":4,"score":0.9908000230789185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7767595648765564},{"id":"https://openalex.org/C2776309230","wikidata":"https://www.wikidata.org/wiki/Q580383","display_name":"Splenectomy","level":3,"score":0.6928088665008545},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5935855507850647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5770145654678345},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.5266991257667542},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.46696025133132935},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4322485029697418},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.42394447326660156},{"id":"https://openalex.org/C3018657049","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Complete remission","level":3,"score":0.41734570264816284},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3593975305557251},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2595088481903076},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002699","descriptor_name":"Chlorambucil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-2964(80)90230-3","doi":"https://doi.org/10.1016/0014-2964(80)90230-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2964(80)90230-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210204293","display_name":"European Journal of Cancer (1965)","issn_l":"0014-2964","issn":["0014-2964","1879-2995"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer (1965)","raw_type":"journal-article"},{"id":"pmid:7398721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7398721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W154103547","https://openalex.org/W597342481","https://openalex.org/W1975709841","https://openalex.org/W1993996437","https://openalex.org/W2016942386","https://openalex.org/W2024976324","https://openalex.org/W2073178466","https://openalex.org/W2111264738","https://openalex.org/W2148794704","https://openalex.org/W2168140407","https://openalex.org/W2272635336","https://openalex.org/W2408903340","https://openalex.org/W2409184228","https://openalex.org/W2412982267","https://openalex.org/W2413905195","https://openalex.org/W2418071183","https://openalex.org/W2436070001","https://openalex.org/W2467740524"],"related_works":["https://openalex.org/W1979855930","https://openalex.org/W2135832236","https://openalex.org/W2078249396","https://openalex.org/W1964742152","https://openalex.org/W2317888977","https://openalex.org/W2402196518","https://openalex.org/W2005703489","https://openalex.org/W2268239296","https://openalex.org/W2062196395","https://openalex.org/W4230380114"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
