{"id":"https://openalex.org/W2018447297","doi":"https://doi.org/10.1002/ana.21325","title":"Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase\u20103\u03b2","display_name":"Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase\u20103\u03b2","publication_year":2008,"publication_date":"2008-03-04","ids":{"openalex":"https://openalex.org/W2018447297","doi":"https://doi.org/10.1002/ana.21325","mag":"2018447297","pmid":"https://pubmed.ncbi.nlm.nih.gov/18318434"},"language":"en","primary_location":{"id":"doi:10.1002/ana.21325","doi":"https://doi.org/10.1002/ana.21325","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.21325","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009317100","display_name":"Masashi Kitazawa","orcid":"https://orcid.org/0000-0003-2165-8197","observed_orcids":["https://orcid.org/0000-0003-2165-8197"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Kitazawa","raw_affiliation_strings":["Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697-4545, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697-4545, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054933485","display_name":"Dan N. Trinh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan N. Trinh","raw_affiliation_strings":["Department of Neurobiology and Behavior University of California, Irvine Irvine CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior University of California, Irvine Irvine CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026487650","display_name":"Frank M. LaFerla","orcid":"https://orcid.org/0000-0003-2324-6911","observed_orcids":["https://orcid.org/0000-0003-2324-6911"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank M. LaFerla","raw_affiliation_strings":["Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026487650"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":9.8962,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.98417565,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"64","issue":"1","first_page":"15","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inclusion-body-myositis","display_name":"inclusion body myositis","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cytotoxic-cd8-t-cells","display_name":"CD8+ cytotoxic T lymphocytes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.921999990940094},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.6259999871253967},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tau-kinases","display_name":"tau kinases","score":0.4020000100135803},{"id":"https://openalex.org/keywords/lithium-chloride","display_name":"lithium chloride","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7559369802474976},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.7167894840240479},{"id":"https://openalex.org/C2777327098","wikidata":"https://www.wikidata.org/wiki/Q1848471","display_name":"Inclusion body myositis","level":3,"score":0.7014007568359375},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6878231167793274},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.5985028743743896},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5709673166275024},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.5346174836158752},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4457052946090698},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4446493089199066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4162417948246002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.395177960395813},{"id":"https://openalex.org/C2781232998","wikidata":"https://www.wikidata.org/wiki/Q1433212","display_name":"Myositis","level":2,"score":0.37063509225845337},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3591097593307495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3306106925010681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31857356429100037},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.27978891134262085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19008469581604004},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.1473413109779358},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07152622938156128}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018979","descriptor_name":"Myositis, Inclusion Body","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018979","descriptor_name":"Myositis, Inclusion Body","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018979","descriptor_name":"Myositis, Inclusion Body","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.21325","doi":"https://doi.org/10.1002/ana.21325","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.21325","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:18318434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18318434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1513139207","display_name":"Modulating IBM pathology in transgenic mice","funder_award_id":"R01AG020335","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2159001932","display_name":null,"funder_award_id":"AR054695","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G78220912","display_name":null,"funder_award_id":"AG 20335","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W175460259","https://openalex.org/W1487347788","https://openalex.org/W1970460796","https://openalex.org/W1972011377","https://openalex.org/W1976445933","https://openalex.org/W1980745617","https://openalex.org/W1989036097","https://openalex.org/W1992878000","https://openalex.org/W1996337928","https://openalex.org/W1999103268","https://openalex.org/W2002079745","https://openalex.org/W2004673811","https://openalex.org/W2006152491","https://openalex.org/W2021696285","https://openalex.org/W2023136593","https://openalex.org/W2028797559","https://openalex.org/W2036909935","https://openalex.org/W2043488710","https://openalex.org/W2054183594","https://openalex.org/W2062438894","https://openalex.org/W2064041290","https://openalex.org/W2071218913","https://openalex.org/W2074699048","https://openalex.org/W2076320493","https://openalex.org/W2077798289","https://openalex.org/W2078961126","https://openalex.org/W2082829109","https://openalex.org/W2087745495","https://openalex.org/W2097773756","https://openalex.org/W2100866942","https://openalex.org/W2105704879","https://openalex.org/W2110888808","https://openalex.org/W2122974699","https://openalex.org/W2138321088","https://openalex.org/W2145250227","https://openalex.org/W2153966730","https://openalex.org/W2158118180","https://openalex.org/W2165531374","https://openalex.org/W2322448084","https://openalex.org/W2413360166","https://openalex.org/W4232498783","https://openalex.org/W4234342645"],"related_works":["https://openalex.org/W3216724377","https://openalex.org/W2090594016","https://openalex.org/W2008503247","https://openalex.org/W2025920010","https://openalex.org/W4414801197","https://openalex.org/W2054405108","https://openalex.org/W2058718042","https://openalex.org/W2081509319","https://openalex.org/W2179800838","https://openalex.org/W2055074706"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Inclusion":[1],"body":[2],"myositis":[3],"(IBM)":[4],"is":[5],"an":[6],"inflammatory":[7],"muscle":[8,73],"disease,":[9],"although":[10],"the":[11,22,64,67,83,140,179,225],"role":[12,181],"of":[13,34,42,58,148,182],"inflammation":[14,26,51,59,125],"remains":[15],"to":[16,77,206],"be":[17],"elucidated.":[18],"Here,":[19],"we":[20,191],"address":[21],"mechanisms":[23],"by":[24,62,95,139,197,217],"which":[25,47,218],"modulates":[27],"Abeta":[28,112],"and":[29,49,66,89,100,123,163,173],"tau,":[30],"two":[31],"hallmark":[32],"features":[33],"this":[35,135,185],"disease.":[36,186],"METHODS:":[37],"A":[38],"transgenic":[39],"mouse":[40],"model":[41],"IBM":[43,71,170],"was":[44,52,114,137,195],"utilized":[45],"in":[46,107,117,129,184,229],"acute":[48,88,122],"chronic":[50,90,124],"induced":[53],"via":[54,224],"lipopolysaccharide.":[55],"The":[56,132],"effects":[57],"were":[60,75,175],"assessed":[61],"analyzing":[63],"myopathological":[65],"behavioral":[68],"phenotype.":[69],"Human":[70],"skeletal":[72,108,130,230],"biopsies":[74],"investigated":[76],"determine":[78],"concordance":[79],"with":[80],"data":[81],"from":[82],"animal":[84],"model.":[85],"RESULTS:":[86],"Both":[87,121],"lipopolysaccharide":[91],"exposure":[92],"augmented":[93],"infiltration":[94],"CD8(+)":[96],"cytotoxic":[97],"T":[98],"cells":[99],"increased":[101,111],"amyloid":[102],"precursor":[103],"protein":[104],"steady-state":[105],"levels":[106],"muscle,":[109,171],"whereas":[110],"generation":[113],"observed":[115],"only":[116],"chronically":[118],"treated":[119],"mice.":[120],"enhanced":[126,207],"tau":[127,141,161,208,222],"phosphorylation":[128,162],"muscle.":[131,231],"mechanism":[133,216],"underlying":[134],"effect":[136],"mediated":[138],"kinase,":[142],"glycogen":[143],"synthase":[144],"kinase-3beta":[145],"(GSK-3beta).":[146],"Suppression":[147],"GSK-3beta":[149,172,183,194,226],"activity":[150],"using":[151],"either":[152],"a":[153,214],"specific":[154],"inhibitor":[155],"or":[156],"lithium":[157],"chloride":[158],"significantly":[159],"reduced":[160],"partially":[164],"rescued":[165],"motor":[166],"impairment.":[167],"In":[168],"human":[169],"phospho-tau":[174],"colocalized,":[176],"further":[177],"supporting":[178],"pathogenic":[180],"Using":[187],"C2C12":[188],"myoblast":[189],"cultures,":[190],"found":[192],"that":[193],"activated":[196],"proinflammatory":[198,219],"cytokines":[199],"(interleukin-1beta,":[200],"interleukin-6,":[201],"tumor":[202],"necrosis":[203],"factor-alpha),":[204],"leading":[205],"phosphorylation.":[209],"INTERPRETATION:":[210],"Our":[211],"results":[212],"identify":[213],"molecular":[215],"stimuli":[220],"affect":[221],"pathology":[223],"signaling":[227],"pathway":[228]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
