{"id":"https://openalex.org/W2018447001","doi":"https://doi.org/10.1371/journal.pone.0076532","title":"Altered Colonic Mucosal Polyunsaturated Fatty Acid (PUFA) Derived Lipid Mediators in Ulcerative Colitis: New Insight into Relationship with Disease Activity and Pathophysiology","display_name":"Altered Colonic Mucosal Polyunsaturated Fatty Acid (PUFA) Derived Lipid Mediators in Ulcerative Colitis: New Insight into Relationship with Disease Activity and Pathophysiology","publication_year":2013,"publication_date":"2013-10-18","ids":{"openalex":"https://openalex.org/W2018447001","doi":"https://doi.org/10.1371/journal.pone.0076532","mag":"2018447001","pmid":"https://pubmed.ncbi.nlm.nih.gov/24204637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3799829"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0076532","doi":"https://doi.org/10.1371/journal.pone.0076532","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0076532","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076532&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076532&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002481122","display_name":"Mojgan Masoodi","orcid":"https://orcid.org/0000-0001-9840-1731","observed_orcids":["https://orcid.org/0000-0001-9840-1731"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["CA","GB"],"is_corresponding":true,"raw_author_name":"Mojgan Masoodi","raw_affiliation_strings":["Nestl\u00e9 Institute of Health Sciences, Lausanne, Switzerland ; Medical Research Council, Cambridge, Cambridgeshire, United Kingdom ; Department of Nutritional Sciences, University of Toronto, Ontario, Canada","Department of Nutritional Sciences, University of Toronto, Ontario, Canada","Medical Research Council, Cambridge, Cambridgeshire, United Kingdom","Nestl\u00e9 Institute of Health Sciences, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Institute of Health Sciences, Lausanne, Switzerland ; Medical Research Council, Cambridge, Cambridgeshire, United Kingdom ; Department of Nutritional Sciences, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Nutritional Sciences, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Medical Research Council, Cambridge, Cambridgeshire, United Kingdom","institution_ids":["https://openalex.org/I90344618"]},{"raw_affiliation_string":"Nestl\u00e9 Institute of Health Sciences, Lausanne, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049223847","display_name":"Daniel S. Pearl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090003","display_name":"Portsmouth Hospitals NHS Trust","ror":"https://ror.org/009fk3b63","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210090003"]},{"id":"https://openalex.org/I4210122580","display_name":"Taunton & Somerset NHS Foundation Trust","ror":"https://ror.org/02y5f7327","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210122580","https://openalex.org/I4401726752"]},{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Daniel S. Pearl","raw_affiliation_strings":["Department of Gastroenterology, Portsmouth Hospital NHS Trust, Portsmouth, Hampshire, United Kingdom","Department of Gastroenterology, Taunton and Somerset NHS Foundation Trust, Taunton, Somerset, United Kingdom","Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Portsmouth Hospital NHS Trust, Portsmouth, Hampshire, United Kingdom","institution_ids":["https://openalex.org/I4210090003"]},{"raw_affiliation_string":"Department of Gastroenterology, Taunton and Somerset NHS Foundation Trust, Taunton, Somerset, United Kingdom","institution_ids":["https://openalex.org/I4210122580"]},{"raw_affiliation_string":"Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072128455","display_name":"Michael J. Eiden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Eiden","raw_affiliation_strings":["Medical Research Council, Cambridge, Cambridgeshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council, Cambridge, Cambridgeshire, United Kingdom","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067586693","display_name":"Janis Kay Shute","orcid":"https://orcid.org/0000-0002-6586-7583","observed_orcids":["https://orcid.org/0000-0002-6586-7583"]},"institutions":[{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Janis K. Shute","raw_affiliation_strings":["Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026234250","display_name":"J F Brown","orcid":"https://orcid.org/0000-0002-3901-6814","observed_orcids":["https://orcid.org/0000-0002-3901-6814"]},"institutions":[{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James F. Brown","raw_affiliation_strings":["Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, Hampshire, United Kingdom","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074645101","display_name":"Philip C. Calder","orcid":"https://orcid.org/0000-0002-6038-710X","observed_orcids":["https://orcid.org/0000-0002-6038-710X"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210118229","display_name":"NIHR Southampton Biomedical Research Centre","ror":"https://ror.org/01qqpzg67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip C. Calder","raw_affiliation_strings":["Human Development and Health Academic Unit, University of Southampton, Southampton, United Kingdom","NIHR Biomedical Research Centre in Nutrition, University Hospitals Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Development and Health Academic Unit, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"NIHR Biomedical Research Centre in Nutrition, University Hospitals Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111517632","display_name":"Timothy M Trebble","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090003","display_name":"Portsmouth Hospitals NHS Trust","ror":"https://ror.org/009fk3b63","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy M. Trebble","raw_affiliation_strings":["Department of Gastroenterology, Portsmouth Hospital NHS Trust, Portsmouth, Hampshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Portsmouth Hospital NHS Trust, Portsmouth, Hampshire, United Kingdom","institution_ids":["https://openalex.org/I4210090003"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5002481122","https://openalex.org/A5049223847"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4210090003","https://openalex.org/I4210122580","https://openalex.org/I63072094","https://openalex.org/I90344618"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.0796,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.90888962,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"10","first_page":"e76532","last_page":"e76532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lipid-mediators","display_name":"lipid mediators","score":0.8080000281333923},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.9629999995231628},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/thromboxane","display_name":"thromboxane","score":0.7089999914169312},{"id":"https://openalex.org/keywords/5-hydroxyeicosatetraenoic-acid","display_name":"5-hydroxyeicosatetraenoic acid","score":0.8550000190734863},{"id":"https://openalex.org/keywords/5-aminosalicylates","display_name":"5-aminosalicylates","score":0.9290000200271606},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.375},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8013581037521362},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6711917519569397},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.6461209654808044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6050504446029663},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5166809558868408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5002121925354004},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4949905276298523},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.49388939142227173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4333886504173279},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4133041799068451},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4008308947086334},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20128512382507324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.124549001455307}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000636","descriptor_name":"Aminosalicylic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001094","descriptor_name":"Arachidonate 5-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0076532","doi":"https://doi.org/10.1371/journal.pone.0076532","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0076532","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076532&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2808954","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3799829","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3799829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3799829","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24204637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24204637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:359822","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1371/journal.pone.0076532>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.798.9244","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.798.9244","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e5/8b/pone.0076532.PMC3799829.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:28fa51e5102849a884926378d24d766e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/28fa51e5102849a884926378d24d766e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 10, p e76532 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0076532","doi":"https://doi.org/10.1371/journal.pone.0076532","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0076532","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076532&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5516535400","display_name":"Proposal to enhance linked research in human fat metabolism &amp; pathophysiology between MRC HNR, MRC MDU and MRC EU","funder_award_id":"MC_PC_13030","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311064","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018447001.pdf","grobid_xml":"https://content.openalex.org/works/W2018447001.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1497700962","https://openalex.org/W1539392991","https://openalex.org/W1552275448","https://openalex.org/W1555174877","https://openalex.org/W1857468674","https://openalex.org/W1905191652","https://openalex.org/W1930299866","https://openalex.org/W1964574002","https://openalex.org/W1972262472","https://openalex.org/W1973088723","https://openalex.org/W1974720245","https://openalex.org/W1986521679","https://openalex.org/W1986684675","https://openalex.org/W1989701577","https://openalex.org/W2007187686","https://openalex.org/W2022941470","https://openalex.org/W2023213942","https://openalex.org/W2025645627","https://openalex.org/W2026042748","https://openalex.org/W2030536796","https://openalex.org/W2031189083","https://openalex.org/W2031781687","https://openalex.org/W2036760530","https://openalex.org/W2051088212","https://openalex.org/W2051279958","https://openalex.org/W2056629400","https://openalex.org/W2066042734","https://openalex.org/W2078078010","https://openalex.org/W2078906054","https://openalex.org/W2082676707","https://openalex.org/W2082951744","https://openalex.org/W2088435132","https://openalex.org/W2091387052","https://openalex.org/W2095143416","https://openalex.org/W2095754840","https://openalex.org/W2105311242","https://openalex.org/W2111648846","https://openalex.org/W2112273094","https://openalex.org/W2113042578","https://openalex.org/W2115934424","https://openalex.org/W2116318925","https://openalex.org/W2121650731","https://openalex.org/W2123260578","https://openalex.org/W2127850870","https://openalex.org/W2128457170","https://openalex.org/W2130648981","https://openalex.org/W2136757780","https://openalex.org/W2139987412","https://openalex.org/W2141541678","https://openalex.org/W2153171578","https://openalex.org/W2156345493","https://openalex.org/W2162311264","https://openalex.org/W2164602079","https://openalex.org/W2166525518","https://openalex.org/W2182497626","https://openalex.org/W2322570099","https://openalex.org/W2397846938","https://openalex.org/W2461782476","https://openalex.org/W2472196002","https://openalex.org/W4213140182","https://openalex.org/W4251972739"],"related_works":["https://openalex.org/W7097940223","https://openalex.org/W2332580420","https://openalex.org/W2964309688","https://openalex.org/W2943890951","https://openalex.org/W2329381520","https://openalex.org/W2149371194","https://openalex.org/W1964574002","https://openalex.org/W6912169344","https://openalex.org/W3093952648","https://openalex.org/W2792830072"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Ulcerative":[1],"colitis":[2],"(UC)":[3],"is":[4,98,218],"a":[5,29],"relapsing":[6,106,131],"inflammatory":[7,88,190],"disorder":[8],"of":[9,25,80,96,102,144,158,177,188,196],"unconfirmed":[10],"aetiology,":[11],"variable":[12,59],"severity":[13,95,153,176],"and":[14,22,45,53,64,134,152,165,173,203,211],"clinical":[15,55,60],"course,":[16],"characterised":[17],"by":[18,118,198],"progressive":[19],"histological":[20,182],"inflammation":[21,97],"with":[23,100,130,148,175,236],"elevation":[24],"eicosanoids":[26,38],"which":[27],"have":[28],"known":[30],"pathophysiological":[31],"role":[32],"in":[33,48,67,76,90,105,170,220],"inflammation.":[34,222],"Therapeutic":[35],"interventions":[36],"targetting":[37],"(5-aminosalicylates":[39],"(ASA))":[40],"are":[41,167],"effective":[42],"first":[43],"line":[44],"adjunctive":[46],"treatments":[47,233],"mild-moderate":[49,213],"UC":[50,197],"for":[51],"achieving":[52],"sustaining":[54],"remission.":[56],"However,":[57],"the":[58,87,142,149,241],"response":[61,68],"to":[62,69,140,209,230,234],"5-ASA":[63],"frequent":[65],"deterioration":[66],"cyclo-oxygenase":[70],"(COX)":[71],"inhibitors,":[72],"has":[73],"prompted":[74],"an":[75],"depth":[77],"simultaneous":[78],"evaluation":[79],"multiple":[81],"lipid":[82,103,114,146,243],"mediators":[83,115],"(including":[84],"eicosanoids)":[85],"within":[86],"milieu":[89],"UC.":[91,107,132],"We":[92],"hypothesised":[93],"that":[94],"associated":[99],"alteration":[101],"mediators,":[104,147],"DESIGN:":[108],"Study":[109],"was":[110],"case-control":[111],"design.":[112],"Mucosal":[113],"were":[116,138],"determined":[117,179],"LC-MS/MS":[119],"lipidomics":[120,201],"analysis":[121,202],"on":[122,240],"mucosal":[123,145,242],"biopsies":[124],"taken":[125],"from":[126],"patients":[127,235],"attending":[128],"outpatients":[129],"Univariate":[133],"multivariate":[135],"statistical":[136],"analyses":[137],"used":[139,208],"investigate":[141],"association":[143],"disease":[150],"state":[151],"graded":[154],"histologically.":[155],"RESULTS:":[156],"Levels":[157],"PGE2,":[159],"PGD2,":[160],"TXB2,":[161],"5-HETE,":[162],"11-HETE,":[163],"12-HETE":[164],"15-HETE":[166],"significantly":[168],"elevated":[169],"inflamed":[171],"mucosa":[172],"correlate":[174],"inflammation,":[178],"using":[180],"validated":[181],"scoring":[183],"systems.":[184],"CONCLUSIONS:":[185],"Our":[186],"approach":[187,226],"capturing":[189],"mediator":[191,244],"signature":[192],"at":[193],"different":[194],"stages":[195],"combining":[199],"comprehensive":[200],"computational":[204],"modelling":[205],"could":[206,227],"be":[207,228],"classify":[210],"predict":[212],"inflammation;":[214],"however,":[215],"predictive":[216],"index":[217],"diminished":[219],"severe":[221],"This":[223],"new":[224],"technical":[225],"developed":[229],"tailor":[231],"drug":[232],"active":[237],"UC,":[238],"based":[239],"profile.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
