{"id":"https://openalex.org/W2018444640","doi":"https://doi.org/10.1111/apa.12813","title":"Growth hormone treatment improves vitality and behavioural issues in children with Prader-Willi syndrome","display_name":"Growth hormone treatment improves vitality and behavioural issues in children with Prader-Willi syndrome","publication_year":2014,"publication_date":"2014-09-26","ids":{"openalex":"https://openalex.org/W2018444640","doi":"https://doi.org/10.1111/apa.12813","mag":"2018444640","pmid":"https://pubmed.ncbi.nlm.nih.gov/25263744"},"language":"en","primary_location":{"id":"doi:10.1111/apa.12813","doi":"https://doi.org/10.1111/apa.12813","is_oa":false,"landing_page_url":"https://doi.org/10.1111/apa.12813","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015953033","display_name":"Birgitta B\u00f6hm","orcid":"https://orcid.org/0000-0002-9406-0930","observed_orcids":["https://orcid.org/0000-0002-9406-0930"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Birgitta B\u00f6hm","raw_affiliation_strings":["Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Childrens' Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Childrens' Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022847398","display_name":"E. Martin Ritz\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E Martin Ritz\u00e9n","raw_affiliation_strings":["Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Childrens' Hospital, Stockholm, Sweden","Pediatric Endocrinology, Q2-08, Karolinska Hospital Solna, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Childrens' Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Pediatric Endocrinology, Q2-08, Karolinska Hospital Solna, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110141166","display_name":"Ann Christin Lindgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ann Christin Lindgren","raw_affiliation_strings":["Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Childrens' Hospital, Stockholm, Sweden","Sachs Children's Hospital, South Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Childrens' Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Sachs Children's Hospital, South Hospital, Stockholm, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015953033"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.5284,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81757586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"104","issue":"1","first_page":"59","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.1534000039100647,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prader-willi-syndrome","display_name":"Prader-Willi syndrome","score":1.0},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/behavioral-problems","display_name":"behavioral problems","score":0.6430000066757202},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.7269999980926514},{"id":"https://openalex.org/keywords/treatment-withdrawal","display_name":"treatment withdrawal","score":0.48500001430511475},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9020000100135803},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.7540000081062317},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.6230000257492065},{"id":"https://openalex.org/keywords/vitality","display_name":"vitality","score":0.6930000185966492},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7973973751068115},{"id":"https://openalex.org/C2778135454","wikidata":"https://www.wikidata.org/wiki/Q5611754","display_name":"Growth hormone treatment","level":4,"score":0.7201134562492371},{"id":"https://openalex.org/C2777871287","wikidata":"https://www.wikidata.org/wiki/Q7502090","display_name":"Short stature","level":2,"score":0.6868891716003418},{"id":"https://openalex.org/C2779829227","wikidata":"https://www.wikidata.org/wiki/Q7936872","display_name":"Vitality","level":2,"score":0.6856103539466858},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.6221020221710205},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.592195451259613},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5633638501167297},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.47906550765037537},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4523608684539795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4288892149925232},{"id":"https://openalex.org/C100480397","wikidata":"https://www.wikidata.org/wiki/Q7836899","display_name":"Treatment and control groups","level":2,"score":0.416912317276001},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4151632785797119},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3775585889816284},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.221055269241333},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002652","descriptor_name":"Child Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011218","descriptor_name":"Prader-Willi Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011218","descriptor_name":"Prader-Willi Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011218","descriptor_name":"Prader-Willi Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/apa.12813","doi":"https://doi.org/10.1111/apa.12813","is_oa":false,"landing_page_url":"https://doi.org/10.1111/apa.12813","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},{"id":"pmid:25263744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25263744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta paediatrica (Oslo, Norway : 1992)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W40537840","https://openalex.org/W570392417","https://openalex.org/W1967383091","https://openalex.org/W1973861950","https://openalex.org/W1980782305","https://openalex.org/W1988694399","https://openalex.org/W1992468072","https://openalex.org/W2044084293","https://openalex.org/W2057302315","https://openalex.org/W2061188548","https://openalex.org/W2064682059","https://openalex.org/W2065899830","https://openalex.org/W2066072523","https://openalex.org/W2071847472","https://openalex.org/W2114957217","https://openalex.org/W2115256256","https://openalex.org/W2138717728","https://openalex.org/W2146441223","https://openalex.org/W2146607527","https://openalex.org/W2153868160","https://openalex.org/W2228405279","https://openalex.org/W4211142904","https://openalex.org/W4232553376","https://openalex.org/W4236757670","https://openalex.org/W4255846400","https://openalex.org/W6601631003","https://openalex.org/W6680376689"],"related_works":["https://openalex.org/W2115107426","https://openalex.org/W3080982298","https://openalex.org/W1982515676","https://openalex.org/W85148199","https://openalex.org/W2044084293","https://openalex.org/W2495006305","https://openalex.org/W2058640006","https://openalex.org/W1984645891","https://openalex.org/W2135351399","https://openalex.org/W2045874163"],"abstract_inverted_index":{"AIM:":[0],"Prader-Willi":[1,32,196],"syndrome":[2,33],"is":[3,174],"a":[4,55,59,89,149,155,162,187],"neurogenetic":[5],"disorder,":[6],"with":[7,31,195],"characteristics":[8],"such":[9],"as":[10],"obesity,":[11],"short":[12],"stature,":[13],"muscular":[14],"weakness,":[15],"intellectual":[16,112],"deficiencies":[17],"and":[18,37,43,50,86,120,128,161],"deviant":[19],"social":[20],"behaviour.":[21,44],"This":[22],"study":[23,177],"evaluated":[24],"whether":[25],"growth":[26,66,166,182],"hormone":[27,67,183],"treatment":[28,56,63,81,143,184],"of":[29,117,152],"children":[30,136,147,194],"resulted":[34],"in":[35,82,92,100,158,164,190,193],"possible":[36],"lasting":[38],"effects":[39],"on":[40],"their":[41],"cognition":[42],"METHODS:":[45],"We":[46,171],"randomised":[47],"six":[48],"girls":[49],"13":[51],"boys":[52],"to":[53,178,186],"either":[54],"group":[57,64,77],"or":[58],"control":[60,76],"group.":[61],"The":[62,131],"received":[65,88],"(Genotropin(\u00ae)":[68],"0.033":[69],"mg/kg/day)":[70],"for":[71,103],"2":[72],"years,":[73],"while":[74],"the":[75,83,93,110,115,118,126,135,146,175],"did":[78],"not":[79],"receive":[80],"first":[84,127,176],"year":[85],"then":[87,98],"double":[90],"dose":[91],"second":[94,129],"year.":[95],"Treatment":[96],"was":[97,123,144],"stopped":[99],"both":[101],"groups":[102,108],"6":[104],"months.":[105],"RESULTS:":[106],"Both":[107],"showed":[109,137,148],"same":[111],"disabilities":[113],"at":[114],"start":[116],"study,":[119],"no":[121],"difference":[122],"found":[124],"after":[125],"years.":[130],"parents":[132],"reported":[133],"that":[134,180],"increased":[138],"vitality":[139],"during":[140],"treatment.":[141],"When":[142],"stopped,":[145],"marked":[150],"exacerbation":[151],"behavioural":[153,191],"problems,":[154],"significant":[156],"increase":[157],"body":[159],"fat":[160],"decrease":[163],"insulin-like":[165],"factor":[167],"1":[168],"levels.":[169],"CONCLUSION:":[170],"believe":[172],"this":[173],"show":[179],"abrupt-ceasing":[181],"led":[185],"successive":[188],"deterioration":[189],"problems":[192],"syndrome.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
