{"id":"https://openalex.org/W2018439734","doi":"https://doi.org/10.1111/j.1365-2265.1977.tb01300.x","title":"THE DEVELOPMENT OF A RADIOIMMUNOASSAY FOR THE MEASUREMENT OF HUMAN PLASMA ARGININE VASOPRESSIN","display_name":"THE DEVELOPMENT OF A RADIOIMMUNOASSAY FOR THE MEASUREMENT OF HUMAN PLASMA ARGININE VASOPRESSIN","publication_year":1977,"publication_date":"1977-08-01","ids":{"openalex":"https://openalex.org/W2018439734","doi":"https://doi.org/10.1111/j.1365-2265.1977.tb01300.x","mag":"2018439734","pmid":"https://pubmed.ncbi.nlm.nih.gov/891002"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2265.1977.tb01300.x","doi":"https://doi.org/10.1111/j.1365-2265.1977.tb01300.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1977.tb01300.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108547981","display_name":"Peter H Baylis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"P. H. BAYLIS","raw_affiliation_strings":["Department of Medicine, Queen Elizabeth Hospital, Birmingham","Dept of Medicine, Queen Elizabeth Hospital, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Queen Elizabeth Hospital, Birmingham","institution_ids":["https://openalex.org/I2799307867"]},{"raw_affiliation_string":"Dept of Medicine, Queen Elizabeth Hospital, Birmingham","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103743641","display_name":"David A. Heath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. A. HEATH","raw_affiliation_strings":["Department of Medicine, Queen Elizabeth Hospital, Birmingham","Dept of Medicine, Queen Elizabeth Hospital, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Queen Elizabeth Hospital, Birmingham","institution_ids":["https://openalex.org/I2799307867"]},{"raw_affiliation_string":"Dept of Medicine, Queen Elizabeth Hospital, Birmingham","institution_ids":["https://openalex.org/I2799307867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108547981"],"corresponding_institution_ids":["https://openalex.org/I2799307867"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":7.1402,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.96988087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"7","issue":"2","first_page":"91","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.9319999814033508},{"id":"https://openalex.org/keywords/iodination","display_name":"iodination","score":0.6539999842643738},{"id":"https://openalex.org/keywords/chloramine-t","display_name":"chloramine-T","score":0.7269999980926514},{"id":"https://openalex.org/keywords/plasma-osmolality","display_name":"plasma osmolality","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.6029999852180481},{"id":"https://openalex.org/keywords/water-loading","display_name":"water loading","score":0.9909999966621399},{"id":"https://openalex.org/keywords/diabetes-insipidus","display_name":"diabetes insipidus","score":0.968999981880188},{"id":"https://openalex.org/keywords/syndrome-of-inappropriate-antidiuretic-hormone-secretion","display_name":"syndrome of inappropriate antidiuretic hormone secretion","score":0.9729999899864197},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7699999809265137},{"id":"https://openalex.org/keywords/postural-changes","display_name":"postural changes","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.8839502930641174},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.8649201393127441},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8302860260009766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8298872709274292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.681456446647644},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6135348081588745},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.5695961713790894},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5186569094657898},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.48616716265678406},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.47654348611831665},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.4324682950973511},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2612203359603882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19953209161758423},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12214338779449463},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.102876216173172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10158756375312805},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003681","descriptor_name":"Dehydration","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003919","descriptor_name":"Diabetes Insipidus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2265.1977.tb01300.x","doi":"https://doi.org/10.1111/j.1365-2265.1977.tb01300.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1977.tb01300.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:891002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/891002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320339","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1893651774","https://openalex.org/W1979599420","https://openalex.org/W1981079465","https://openalex.org/W1983079964","https://openalex.org/W1983649348","https://openalex.org/W1984984454","https://openalex.org/W2014650477","https://openalex.org/W2021391386","https://openalex.org/W2022801480","https://openalex.org/W2030483106","https://openalex.org/W2070483306","https://openalex.org/W2080720168","https://openalex.org/W2081880912","https://openalex.org/W2083560034","https://openalex.org/W2086266014","https://openalex.org/W2089023356","https://openalex.org/W2089552860","https://openalex.org/W2090311811","https://openalex.org/W2100173304","https://openalex.org/W2109672705","https://openalex.org/W2235243453","https://openalex.org/W2337472110","https://openalex.org/W2397089018","https://openalex.org/W2466147675","https://openalex.org/W4236143111","https://openalex.org/W4241744842","https://openalex.org/W6655716868"],"related_works":["https://openalex.org/W1997633506","https://openalex.org/W1984984454","https://openalex.org/W2045422932","https://openalex.org/W2235243453","https://openalex.org/W2022801480","https://openalex.org/W2324148036","https://openalex.org/W2083280828","https://openalex.org/W2071896423","https://openalex.org/W2024542663","https://openalex.org/W2034322347"],"abstract_inverted_index":{"A":[0,78,152],"radioimmunoassay":[1],"for":[2],"AVP":[3,9,94,109,123,129,139,162,169,195],"capable":[4,66],"of":[5,29,37,67,71,90,92,107,182,193,212],"measuring":[6],"human":[7],"plasma":[8,97,108,122,161,164,194],"is":[10,65,75,83,110],"described.":[11],"Iodination":[12],"was":[13,31,188],"performed":[14],"by":[15,22,118],"the":[16,180,191],"chloramine":[17],"T":[18],"method":[19,114],"and":[20,57,73,87,135,163,179],"purified":[21],"chromatography":[23],"on":[24,190],"Sephadex":[25],"G-25.":[26],"Specific":[27],"activity":[28],"125I-AVP":[30],"1710":[32],"+/-":[33,131,142,214,219],"155":[34],"Ci/mmol.":[35],"Antiserum":[36],"high":[38],"affinity":[39],"(Keq":[40],"=":[41,140],"2.7":[42],"X":[43],"10(11)":[44],"1/mol)":[45],"has":[46,115,157,171],"been":[47,116,158,173],"raised":[48],"in":[49,85,121,149,175,196],"rabbits,":[50],"which":[51],"shows":[52],"slight":[53],"cross-reactivity":[54],"with":[55,60,177],"LVP":[56],"negligible":[58],"reactivity":[59],"oxytocin.":[61],"The":[62,103,113],"aqueous":[63],"assay":[64],"detecting":[68],"0.4":[69],"fmol":[70],"AVP/tube":[72],"it":[74],"highly":[76,153],"reproducible.":[77],"F":[79],"lorisil":[80],"extraction":[81],"technique":[82],"described":[84],"detail":[86],"gives":[88],"recovery":[89],"70%":[91],"synthetic":[93],"added":[95],"to":[96,217],"over":[98],"a":[99],"wide":[100],"physiological":[101],"range.":[102],"lowest":[104],"detectable":[105],"concentration":[106,124,170],"0.3":[111],"pmol/l.":[112],"validated":[117],"studying":[119],"changes":[120],"following":[125,206],"overnight":[126],"dehydration":[127],"(plasma":[128,138],"=3.46":[130],"1.89":[132],"(SD)":[133],"pmol/l),":[134,144],"water":[136],"loading":[137],"1.54":[141],"0.59":[143,215],"P":[145,222],"less":[146,223],"than":[147,224],"0.005,":[148],"normal":[150],"subjects.":[151],"significant":[154],"positive":[155],"correlation":[156],"found":[159,189],"between":[160],"osmolality":[165],"(r":[166],"=+0.75).":[167],"Plasma":[168],"also":[172],"determined":[174],"patients":[176],"DI":[178],"syndrome":[181],"inappropriate":[183],"ADH":[184],"secretion.":[185],"No":[186],"effect":[187],"level":[192],"normally":[197],"hydrated":[198],"volunteers":[199],"undergoing":[200],"postural":[201],"change":[202],"but":[203],"levels":[204],"rose":[205],"strenuous":[207],"exercise":[208],"from":[209],"basal":[210],"concentrations":[211],"1.57":[213],"pmol/l":[216],"4.77":[218],"3.43":[220],"pmol/l,":[221],"0.01.":[225]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}