{"id":"https://openalex.org/W2018434022","doi":"https://doi.org/10.1021/jm0308850","title":"New Analogues of Amonafide and Elinafide, Containing Aromatic Heterocycles: Synthesis, Antitumor Activity, Molecular Modeling, and DNA Binding Properties","display_name":"New Analogues of Amonafide and Elinafide, Containing Aromatic Heterocycles: Synthesis, Antitumor Activity, Molecular Modeling, and DNA Binding Properties","publication_year":2004,"publication_date":"2004-02-07","ids":{"openalex":"https://openalex.org/W2018434022","doi":"https://doi.org/10.1021/jm0308850","mag":"2018434022","pmid":"https://pubmed.ncbi.nlm.nih.gov/14998328"},"language":"en","primary_location":{"id":"doi:10.1021/jm0308850","doi":"https://doi.org/10.1021/jm0308850","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0308850","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103424213","display_name":"Miguel F. Bra\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Miguel F. Bra\u00f1a","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073834262","display_name":"M\u00f3nica Cacho","orcid":"https://orcid.org/0000-0001-6270-5370","observed_orcids":["https://orcid.org/0000-0001-6270-5370"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Cacho","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103254694","display_name":"Mario Antonio Garc\u00eda","orcid":"https://orcid.org/0000-0002-0304-9665","observed_orcids":["https://orcid.org/0000-0002-0304-9665"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mario A. Garc\u00eda","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013691561","display_name":"Beatriz de Pascual\u2010Teresa","orcid":"https://orcid.org/0000-0002-1101-0373","observed_orcids":["https://orcid.org/0000-0002-1101-0373"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz de Pascual-Teresa","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043199638","display_name":"Ana Ramos","orcid":"https://orcid.org/0000-0003-2984-4672","observed_orcids":["https://orcid.org/0000-0003-2984-4672"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Ramos","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109129983","display_name":"M. Teresa Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Teresa Dom\u00ednguez","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jos\u00e9 M. Pozuelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Pozuelo","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062349108","display_name":"Cristina Abradelo","orcid":"https://orcid.org/0000-0001-7297-1357","observed_orcids":["https://orcid.org/0000-0001-7297-1357"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Abradelo","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047789308","display_name":"Fernanda Rey-Stolle","orcid":"https://orcid.org/0000-0002-0873-4485","observed_orcids":["https://orcid.org/0000-0002-0873-4485"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Fernanda Rey-Stolle","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mercedes Yuste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mercedes Yuste","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002483385","display_name":"M\u00f3nica B\u00e1\u00f1ez-Coronel","orcid":"https://orcid.org/0000-0002-1511-4209","observed_orcids":["https://orcid.org/0000-0002-1511-4209"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica B\u00e1\u00f1ez-Coronel","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040208664","display_name":"Juan Carlos Lacal","orcid":"https://orcid.org/0000-0002-1908-2777","observed_orcids":["https://orcid.org/0000-0002-1908-2777"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Carlos Lacal","raw_affiliation_strings":["Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentos de Ciencias Qu\u00edmicas, Biolog\u00eda Celular, Bioqu\u00edmica y Biolog\u00eda Molecular, Matem\u00e1ticas, F\u00edsica Aplicada y Fisicoqu\u00edmica, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanizaci\u00f3n Montepr\u00edncipe, 28668-Boadilla del Monte, Madrid, Spain and Instituto de Investigaciones Biom\u00e9dicas, CSIC, Arturo Duperier 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103424213"],"corresponding_institution_ids":["https://openalex.org/I118091203"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0372,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.91169384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"47","issue":"6","first_page":"1391","last_page":"1399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.23800000548362732,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naphthalimide","display_name":"naphthalimide","score":0.7070000171661377},{"id":"https://openalex.org/keywords/dna-intercalators","display_name":"DNA intercalators","score":0.7590000033378601},{"id":"https://openalex.org/keywords/furan","display_name":"furan","score":0.5460000038146973},{"id":"https://openalex.org/keywords/thiophene","display_name":"thiophene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heteroarenes","display_name":"heteroarenes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.968999981880188},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.9890000224113464},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9576296806335449},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7095178365707397},{"id":"https://openalex.org/C2778659115","wikidata":"https://www.wikidata.org/wiki/Q243992","display_name":"Furan","level":2,"score":0.6951901316642761},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6552790999412537},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.642731249332428},{"id":"https://openalex.org/C2779953032","wikidata":"https://www.wikidata.org/wiki/Q305364","display_name":"Thiophene","level":2,"score":0.6307646632194519},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.5686516165733337},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.5309749841690063},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.516982913017273},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4531328082084656},{"id":"https://openalex.org/C25057246","wikidata":"https://www.wikidata.org/wiki/Q1344441","display_name":"Molecular mechanics","level":3,"score":0.41782301664352417},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.24338608980178833},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.20256084203720093},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20116093754768372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19656112790107727},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11526069045066833}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007094","descriptor_name":"Imides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007094","descriptor_name":"Imides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007094","descriptor_name":"Imides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007364","descriptor_name":"Intercalating Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007364","descriptor_name":"Intercalating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007364","descriptor_name":"Intercalating Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053644","descriptor_name":"Naphthalimides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm0308850","doi":"https://doi.org/10.1021/jm0308850","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0308850","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:14998328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14998328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1970028441","https://openalex.org/W2004134464","https://openalex.org/W2008889418","https://openalex.org/W2024071413","https://openalex.org/W2036988950","https://openalex.org/W2038909709","https://openalex.org/W2054405179","https://openalex.org/W2057440410","https://openalex.org/W2061250423","https://openalex.org/W2075855826","https://openalex.org/W2080208938","https://openalex.org/W2085298685","https://openalex.org/W2086243700","https://openalex.org/W2086892948","https://openalex.org/W2094992186","https://openalex.org/W2165633081","https://openalex.org/W3004986444"],"related_works":["https://openalex.org/W2085925430","https://openalex.org/W4372342545","https://openalex.org/W2065796293","https://openalex.org/W2094992186","https://openalex.org/W2090529326","https://openalex.org/W2089493387","https://openalex.org/W1972196941","https://openalex.org/W1985587173","https://openalex.org/W1974154174","https://openalex.org/W2074822663"],"abstract_inverted_index":{"Amonafide-":[0],"and":[1,4,52,78],"elinafide-related":[2],"mono":[3],"bisintercalators,":[5],"modified":[6],"by":[7,74],"the":[8,19,87,95,99],"introduction":[9],"of":[10,62,98],"a":[11],"pi-excedent":[12],"furan":[13],"or":[14],"thiophene":[15],"ring":[16],"fused":[17,100],"to":[18,84],"naphthalimide":[20],"moiety,":[21],"have":[22,27,55,81],"been":[23],"synthesized.":[24],"These":[25,67],"compounds":[26,59],"shown":[28],"an":[29],"interesting":[30],"antitumor":[31],"profile.":[32],"The":[33],"best":[34],"compound,":[35],"9,":[36],"was":[37],"2.5-fold":[38],"more":[39],"potent":[40],"than":[41],"elinafide":[42],"against":[43],"human":[44],"colon":[45],"carcinoma":[46],"cells":[47],"(HT-29).":[48],"Molecular":[49],"dynamic":[50],"simulations":[51],"physicochemical":[53],"experiments":[54],"demonstrated":[56],"that":[57,86],"these":[58],"are":[60],"capable":[61],"forming":[63],"stable":[64],"DNA":[65,88],"complexes.":[66],"results,":[68],"together":[69],"with":[70],"those":[71],"previously":[72],"reported":[73],"us":[75,83],"for":[76],"imidazo-":[77],"pyrazinonaphthalimide":[79],"analogues,":[80],"prompted":[82],"propose":[85],"binding":[89],"process":[90],"does":[91],"not":[92],"depend":[93],"on":[94],"electronic":[96],"nature":[97],"heterocycle.":[101]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
