{"id":"https://openalex.org/W2018432142","doi":"https://doi.org/10.1038/cddis.2014.307","title":"DJ-1 interactions with \u03b1-synuclein attenuate aggregation and cellular toxicity in models of Parkinson\u2019s disease","display_name":"DJ-1 interactions with \u03b1-synuclein attenuate aggregation and cellular toxicity in models of Parkinson\u2019s disease","publication_year":2014,"publication_date":"2014-07-24","ids":{"openalex":"https://openalex.org/W2018432142","doi":"https://doi.org/10.1038/cddis.2014.307","mag":"2018432142","pmid":"https://pubmed.ncbi.nlm.nih.gov/25058424","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4123098"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2014.307","doi":"https://doi.org/10.1038/cddis.2014.307","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2014.307","pdf_url":"https://www.nature.com/articles/cddis2014307.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2018432142"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2014307.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056639259","display_name":"Lisa Zondler","orcid":"https://orcid.org/0000-0001-6760-4499","observed_orcids":["https://orcid.org/0000-0001-6760-4499"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Zondler","raw_affiliation_strings":["Department of NeuroDegeneration and Restorative Research, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of NeuroDegeneration and Restorative Research, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061182046","display_name":"Leonor Miller\u2010Fleming","orcid":"https://orcid.org/0000-0002-3593-6461","observed_orcids":["https://orcid.org/0000-0002-3593-6461"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"L Miller-Fleming","raw_affiliation_strings":["1] Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal [2] Department of Genetics, University of Leicester, Leicester LE1 7RH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal [2] Department of Genetics, University of Leicester, Leicester LE1 7RH, UK","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I153648349","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082062153","display_name":"Mariaelena Repici","orcid":"https://orcid.org/0000-0002-9420-528X","observed_orcids":["https://orcid.org/0000-0002-9420-528X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Repici","raw_affiliation_strings":["Department of Genetics, University of Leicester, Leicester LE1 7RH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Leicester, Leicester LE1 7RH, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020798178","display_name":"Susana A. Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-8025-2624","observed_orcids":["https://orcid.org/0000-0002-8025-2624"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"S Gon\u00e7alves","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056030772","display_name":"Sandra Tenreiro","orcid":"https://orcid.org/0000-0001-7272-5842","observed_orcids":["https://orcid.org/0000-0001-7272-5842"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"S Tenreiro","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039463080","display_name":"Rita Rosado-Ramos","orcid":"https://orcid.org/0000-0002-1294-9227","observed_orcids":["https://orcid.org/0000-0002-1294-9227"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"R Rosado-Ramos","raw_affiliation_strings":["Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008055701","display_name":"Cristine Betzer","orcid":"https://orcid.org/0000-0001-5429-3548","observed_orcids":["https://orcid.org/0000-0001-5429-3548"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"C Betzer","raw_affiliation_strings":["Danish Research Institute of Translational Neuroscience - Dandrite, Department of Biomedicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Institute of Translational Neuroscience - Dandrite, Department of Biomedicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060595555","display_name":"Kees R. Straatman","orcid":"https://orcid.org/0000-0002-9812-492X","observed_orcids":["https://orcid.org/0000-0002-9812-492X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K R Straatman","raw_affiliation_strings":["Centre for Core Biotechnology Services, University of Leicester, Leicester LE1 7RH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Core Biotechnology Services, University of Leicester, Leicester LE1 7RH, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051399477","display_name":"Poul Henning Jensen","orcid":"https://orcid.org/0000-0002-4439-9020","observed_orcids":["https://orcid.org/0000-0002-4439-9020"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P H Jensen","raw_affiliation_strings":["Danish Research Institute of Translational Neuroscience - Dandrite, Department of Biomedicine, Aarhus University, Aarhus, Denmark","Department of Biomedicine, Danish Research Institute of Translational Neuroscience - Dandrite, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Institute of Translational Neuroscience - Dandrite, Department of Biomedicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Biomedicine, Danish Research Institute of Translational Neuroscience - Dandrite, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036156104","display_name":"Flaviano Giorgini","orcid":"https://orcid.org/0000-0001-7881-9508","observed_orcids":["https://orcid.org/0000-0001-7881-9508"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"F Giorgini","raw_affiliation_strings":["Department of Genetics, University of Leicester, Leicester LE1 7RH, UK","Department of Genetics, University of Leicester, Leicester, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Leicester, Leicester LE1 7RH, UK","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"Department of Genetics, University of Leicester, Leicester, UK;","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014020587","display_name":"Tiago F. Outeiro","orcid":"https://orcid.org/0000-0003-1679-1727","observed_orcids":["https://orcid.org/0000-0003-1679-1727"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE","PT"],"is_corresponding":true,"raw_author_name":"T F Outeiro","raw_affiliation_strings":["1] Department of NeuroDegeneration and Restorative Research, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany [2] Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of NeuroDegeneration and Restorative Research, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany [2] Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210116730","https://openalex.org/I4392738257","https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5014020587","https://openalex.org/A5036156104"],"corresponding_institution_ids":["https://openalex.org/I141596103","https://openalex.org/I153648349","https://openalex.org/I4210116730","https://openalex.org/I4392738257","https://openalex.org/I74656192"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":6.3959,"has_fulltext":true,"cited_by_count":166,"citation_normalized_percentile":{"value":0.97222389,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"5","issue":"7","first_page":"e1350","last_page":"e1350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dj-1","display_name":"DJ-1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8989999890327454},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.902999997138977},{"id":"https://openalex.org/keywords/familial-parkinson-s-disease-mutations","display_name":"familial Parkinson's disease mutations","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7250000238418579},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae-model","display_name":"Saccharomyces cerevisiae model","score":0.7649999856948853},{"id":"https://openalex.org/keywords/chaperone-activity","display_name":"chaperone activity","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.706963300704956},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5973986983299255},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5693604946136475},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5690637826919556},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.43095800280570984},{"id":"https://openalex.org/C2777916540","wikidata":"https://www.wikidata.org/wiki/Q24767155","display_name":"Synuclein","level":5,"score":0.42028170824050903},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40531012415885925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39669567346572876},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3807027339935303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3777417540550232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2665718197822571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21259915828704834},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17464399337768555},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1138429045677185},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071617","descriptor_name":"Protein Deglycase DJ-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/cddis.2014.307","doi":"https://doi.org/10.1038/cddis.2014.307","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2014.307","pdf_url":"https://www.nature.com/articles/cddis2014307.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmid:25058424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25058424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4123098","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4123098/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmh:oai:publications.aston.ac.uk:38877","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/id/eprint/38877/","pdf_url":"https://publications.aston.ac.uk/id/eprint/38877/1/cddis2014307.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/10154642","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/DJ-1_interactions_with_-synuclein_attenuate_aggregation_and_cellular_toxicity_in_models_of_Parkinson_s_disease_/10154642","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:goescholar:1/12113","doi":null,"is_oa":true,"landing_page_url":"http://resolver.sub.uni-goettingen.de/purl?gs-1/12113","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journalArticle"},{"id":"pmh:oai:lra.le.ac.uk:2381/31942","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/31942","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/32956","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gs-1/12113","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/631d6f69-b91b-4dde-8804-4f347df4f95d","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/631d6f69-b91b-4dde-8804-4f347df4f95d","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zondler, L, Miller-Fleming, L, Repici, M, Gon\u00e7alves, S, Tenreiro, S, Rosado-Ramos, R, Betzer, C, Straatman, K R, Jensen, P H, Giorgini, F & Outeiro, T F 2014, 'DJ-1 interactions with \u03b1-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease', Cell Death & Disease, vol. 5, pp. e1350. https://doi.org/10.1038/cddis.2014.307","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/cddis.2014.307","doi":"https://doi.org/10.1038/cddis.2014.307","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2014.307","pdf_url":"https://www.nature.com/articles/cddis2014307.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2785406040","display_name":null,"funder_award_id":"G-0902","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"}],"funders":[{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018432142.pdf","grobid_xml":"https://content.openalex.org/works/W2018432142.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W57813201","https://openalex.org/W1501828178","https://openalex.org/W1521938930","https://openalex.org/W1523693806","https://openalex.org/W1527671059","https://openalex.org/W1967603366","https://openalex.org/W1968413329","https://openalex.org/W1973413977","https://openalex.org/W1973474734","https://openalex.org/W1973608140","https://openalex.org/W1978163054","https://openalex.org/W1980504496","https://openalex.org/W1987054851","https://openalex.org/W1988215967","https://openalex.org/W1991362023","https://openalex.org/W1992017428","https://openalex.org/W1992241406","https://openalex.org/W1999469282","https://openalex.org/W2015932693","https://openalex.org/W2022116515","https://openalex.org/W2028502345","https://openalex.org/W2034887565","https://openalex.org/W2036890934","https://openalex.org/W2037079848","https://openalex.org/W2038303832","https://openalex.org/W2040042139","https://openalex.org/W2041966991","https://openalex.org/W2043291430","https://openalex.org/W2048585321","https://openalex.org/W2054066978","https://openalex.org/W2054868321","https://openalex.org/W2059803654","https://openalex.org/W2065028661","https://openalex.org/W2065409333","https://openalex.org/W2065710720","https://openalex.org/W2075906033","https://openalex.org/W2080857749","https://openalex.org/W2081159413","https://openalex.org/W2084146695","https://openalex.org/W2087424776","https://openalex.org/W2091214947","https://openalex.org/W2101995697","https://openalex.org/W2111372299","https://openalex.org/W2114051156","https://openalex.org/W2117822586","https://openalex.org/W2121696598","https://openalex.org/W2125553412","https://openalex.org/W2129755489","https://openalex.org/W2132182347","https://openalex.org/W2134412560","https://openalex.org/W2141918542","https://openalex.org/W2143516878","https://openalex.org/W2149024783","https://openalex.org/W2154717765","https://openalex.org/W2158930854","https://openalex.org/W2159081975","https://openalex.org/W2169466661","https://openalex.org/W2171873547","https://openalex.org/W2743254891"],"related_works":["https://openalex.org/W7221505373","https://openalex.org/W4413411837","https://openalex.org/W3210922238","https://openalex.org/W1576937064","https://openalex.org/W1481208581","https://openalex.org/W2758343154","https://openalex.org/W1967603366","https://openalex.org/W224531124","https://openalex.org/W2005389045"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"(PD)":[2],"is":[3,54],"a":[4,55,207],"devastating":[5],"neurodegenerative":[6],"disorder":[7],"characterized":[8],"by":[9,220],"the":[10,15,21,71,80,204],"loss":[11],"of":[12,23,36,51,158,166,182],"neurons":[13],"in":[14,26,61,70,87,133,140,147,188,214],"substantia":[16],"nigra":[17],"pars":[18],"compacta":[19],"and":[20,48,113,115,119,131,135,201,210],"presence":[22],"Lewy":[24],"bodies":[25],"surviving":[27],"neurons.":[28],"These":[29],"intracellular":[30],"protein":[31,59,100],"inclusions":[32],"are":[33,90],"primarily":[34],"composed":[35],"misfolded":[37],"\u03b1-synuclein":[38],"(aSyn),":[39],"which":[40],"has":[41,95,99],"also":[42,138],"been":[43],"genetically":[44],"linked":[45],"to":[46,76,218],"familial":[47,77,212],"sporadic":[49],"forms":[50,165],"PD.":[52],"DJ-1":[53,74,114,125,148,159,167,176,183,200,215],"small":[56],"ubiquitously":[57],"expressed":[58],"implicated":[60],"several":[62,144],"pathways":[63],"associated":[64],"with":[65,128],"PD":[66,88,219],"pathogenesis.":[67],"Although":[68],"mutations":[69,146,213],"gene":[72],"encoding":[73],"lead":[75],"early-onset":[78],"PD,":[79],"exact":[81],"mechanisms":[82],"responsible":[83],"for":[84,206],"its":[85],"role":[86],"pathogenesis":[89],"still":[91],"elusive.":[92],"Previous":[93],"work":[94],"found":[96,123,155,173],"that":[97,124,136,156,174,196,211],"DJ-1--which":[98],"chaperone-like":[101],"activity--modulates":[102],"aSyn":[103,112,129,161,202],"aggregation.":[104],"Here,":[105],"we":[106,154,172],"investigated":[107],"possible":[108],"physical":[109],"interactions":[110,198],"between":[111,199],"any":[116],"consequent":[117],"functional":[118],"pathological":[120],"relevance.":[121],"We":[122],"interacts":[126],"directly":[127],"monomers":[130],"oligomers":[132],"vitro,":[134],"this":[137,150,169],"occurs":[139],"living":[141],"cells.":[142],"Notably,":[143],"PD-causing":[145],"constrain":[149],"interaction.":[151],"In":[152],"addition,":[153],"overexpression":[157],"reduces":[160],"dimerization,":[162],"whereas":[163],"mutant":[164],"impair":[168],"process.":[170],"Finally,":[171],"human":[175],"as":[177,179],"well":[178],"yeast":[180],"orthologs":[181],"reversed":[184],"aSyn-dependent":[185],"cellular":[186],"toxicity":[187],"Saccharomyces":[189],"cerevisiae.":[190],"Taken":[191],"together,":[192],"these":[193,222],"data":[194],"suggest":[195],"direct":[197],"constitute":[203],"basis":[205],"neuroprotective":[208],"mechanism":[209],"may":[216],"contribute":[217],"disrupting":[221],"interactions.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
