{"id":"https://openalex.org/W2018428587","doi":"https://doi.org/10.1097/00005344-198609000-00002","title":"Acute and Chronic Effects of a New Calcium Inhibitor, Nicardipine-on Renal Hemodynamics in Hypertension","display_name":"Acute and Chronic Effects of a New Calcium Inhibitor, Nicardipine-on Renal Hemodynamics in Hypertension","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W2018428587","doi":"https://doi.org/10.1097/00005344-198609000-00002","mag":"2018428587","pmid":"https://pubmed.ncbi.nlm.nih.gov/2429087"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-198609000-00002","doi":"https://doi.org/10.1097/00005344-198609000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198609000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021677112","display_name":"M Chaignon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Chaignon","raw_affiliation_strings":["rielle, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rielle, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017074424","display_name":"M Bellet","orcid":"https://orcid.org/0000-0002-5364-6951","observed_orcids":["https://orcid.org/0000-0002-5364-6951"]},"institutions":[{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Bellet","raw_affiliation_strings":["rielle, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rielle, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041047423","display_name":"Michel Lucsko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Lucsko","raw_affiliation_strings":["rielle, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rielle, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096727149","display_name":"Catherine Rapound","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Rapound","raw_affiliation_strings":["rielle, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rielle, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210156825"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083949255","display_name":"J Gu\u00e9don","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Guedon","raw_affiliation_strings":["rielle, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"rielle, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210156825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156825"],"apc_list":null,"apc_paid":null,"fwci":3.283,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.91630578,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"5","first_page":"892","last_page":"897"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicardipine","display_name":"nicardipine","score":1.0},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7250000238418579},{"id":"https://openalex.org/keywords/renal-hemodynamics","display_name":"renal hemodynamics","score":0.984000027179718},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.9869999885559082},{"id":"https://openalex.org/keywords/renal-vascular-resistance","display_name":"renal vascular resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/filtration-fraction","display_name":"filtration fraction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.9210000038146973},{"id":"https://openalex.org/keywords/renal-vasodilation","display_name":"renal vasodilation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sodium-retention","display_name":"sodium retention","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2778043224","wikidata":"https://www.wikidata.org/wiki/Q729213","display_name":"Nicardipine","level":3,"score":0.9706084132194519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7076371908187866},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5373173952102661},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4782487452030182},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4039978086948395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3292008936405182},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3219428062438965}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009529","descriptor_name":"Nicardipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-198609000-00002","doi":"https://doi.org/10.1097/00005344-198609000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198609000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:2429087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2429087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022753639","https://openalex.org/W2064052055","https://openalex.org/W1997758915","https://openalex.org/W2091844294","https://openalex.org/W2042528891","https://openalex.org/W2036530832","https://openalex.org/W1981679479","https://openalex.org/W1979385578","https://openalex.org/W32981601","https://openalex.org/W2438270199"],"abstract_inverted_index":{"Renal":[0],"hemodynamics":[1],"and":[2,14,38,81,108,146,168,197,206,218],"natriuresis":[3],"were":[4],"studied":[5],"in":[6,62,84,111,164],"10":[7],"hypertensive":[8],"patients":[9],"without":[10],"renal":[11,63,85,143,181,194],"failure,":[12],"2":[13,124],"4":[15],"h":[16,49,125],"after":[17,50,171,212],"oral":[18],"intake":[19],"of":[20,31,57,184,216],"30":[21,32],"mg":[22,33],"nicardipine;":[23,185],"then,":[24],"nicardipine":[25,58],"was":[26,42,114,155,189,210,233],"given":[27],"at":[28],"a":[29,36,82,222],"dose":[30,56,215],"three":[34],"times":[35],"day":[37,47,142],"the":[39,45,51,109,122,140,179,213,226],"hemodynamic":[40],"study":[41,227],"repeated":[43],"on":[44],"6th":[46,141],"(2":[48],"morning":[52],"dose).":[53],"The":[54],"first":[55,123,214],"produced":[59],"an":[60],"increase":[61],"blood":[64,195],"flow":[65,196],"(from":[66,88,126],"888":[67],"+/-":[68,72,90,94,128,132],"45":[69],"to":[70,92,130,201],"999":[71],"59":[73],"ml/min":[74],"1.73":[75],"m2,":[76],"p":[77,98,135],"less":[78,99,136],"than":[79,100,137],"0.01)":[80],"decrease":[83,110,224],"vascular":[86,144],"resistances":[87,145],"0.16":[89],"0.01":[91,95],"0.12":[93],"arbitrary":[96],"unit,":[97],"0.05).":[101,138],"Glomerular":[102],"filtration":[103,112,147,153,187,198],"rate":[104,154,188],"did":[105,158],"not":[106,115,159,190],"change":[107],"fraction":[113,148,199],"significant.":[116],"Sodium":[117],"excretion":[118],"increased":[119],"markedly":[120],"during":[121,225],"0.17":[127],"0.04":[129],"0.29":[131],"0.06":[133],"mmol/min,":[134],"On":[139],"remained":[149],"lowered":[150],"whereas":[151,193],"glomerular":[152,186],"unchanged.":[156],"Nicardipine":[157],"produce":[160],"any":[161],"significant":[162,223],"alteration":[163],"plasma":[165,169],"renin":[166],"activity":[167],"aldosterone":[170],"acute":[172],"or":[173],"chronic":[174],"administration.":[175],"These":[176],"results":[177],"confirm":[178],"potent":[180],"vasodilatory":[182],"effect":[183,209],"significantly":[191],"altered":[192],"returned":[200],"normal":[202],"levels.":[203],"An":[204],"early":[205],"transient":[207],"natriuretic":[208],"observed":[211],"nicardipine,":[217],"body":[219],"weight":[220],"showed":[221],"indicating":[228],"that":[229],"no":[230],"sodium":[231],"retention":[232],"induced":[234],"by":[235],"nicardipine.":[236]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}