{"id":"https://openalex.org/W2018403116","doi":"https://doi.org/10.1111/j.1471-4159.2008.05766.x","title":"Altered hippocampal long\u2010term synaptic plasticity in mice deficient in the PGE2 EP2 receptor","display_name":"Altered hippocampal long\u2010term synaptic plasticity in mice deficient in the PGE2 EP2 receptor","publication_year":2008,"publication_date":"2008-11-06","ids":{"openalex":"https://openalex.org/W2018403116","doi":"https://doi.org/10.1111/j.1471-4159.2008.05766.x","mag":"2018403116","pmid":"https://pubmed.ncbi.nlm.nih.gov/19012750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2605769"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2008.05766.x","doi":"https://doi.org/10.1111/j.1471-4159.2008.05766.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2008.05766.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2605769","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031043065","display_name":"Hongwei Yang","orcid":"https://orcid.org/0000-0003-1042-247X","observed_orcids":["https://orcid.org/0000-0003-1042-247X"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongwei Yang","raw_affiliation_strings":["Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409987","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-6558-791X","observed_orcids":["https://orcid.org/0000-0002-6558-791X"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082516184","display_name":"RICHARD M. BREYER","orcid":"https://orcid.org/0000-0001-5828-4403","observed_orcids":["https://orcid.org/0000-0001-5828-4403"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Breyer","raw_affiliation_strings":["Department of Medicine and Pharmacology, Vanderbilt University, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Pharmacology, Vanderbilt University, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100741518","display_name":"Chu Chen","orcid":"https://orcid.org/0000-0003-2267-8050","observed_orcids":["https://orcid.org/0000-0003-2267-8050","https://orcid.org/0000-0002-8952-573X"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chu Chen","raw_affiliation_strings":["Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100741518"],"corresponding_institution_ids":["https://openalex.org/I75420490"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.7827,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.81798289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"108","issue":"1","first_page":"295","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ep2-receptor","display_name":"EP2 receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7649999856948853},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.75},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7770000100135803},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.6449999809265137},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8190000057220459},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.828000009059906},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.7059999704360962},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.7570000290870667},{"id":"https://openalex.org/keywords/granule-neurons","display_name":"granule neurons","score":0.5860000252723694},{"id":"https://openalex.org/keywords/water-maze-learning","display_name":"water maze learning","score":0.492000013589859},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.7631264328956604},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.7612926959991455},{"id":"https://openalex.org/C178592051","wikidata":"https://www.wikidata.org/wiki/Q28208812","display_name":"Prostaglandin E2 receptor","level":4,"score":0.7190383076667786},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6289236545562744},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.48589271306991577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48303279280662537},{"id":"https://openalex.org/C2776168963","wikidata":"https://www.wikidata.org/wiki/Q7168164","display_name":"Perforant path","level":4,"score":0.4644510746002197},{"id":"https://openalex.org/C125667969","wikidata":"https://www.wikidata.org/wiki/Q7662036","display_name":"Synaptic fatigue","level":4,"score":0.4607800543308258},{"id":"https://openalex.org/C95293801","wikidata":"https://www.wikidata.org/wiki/Q7662035","display_name":"Synaptic augmentation","level":4,"score":0.43068087100982666},{"id":"https://openalex.org/C29561615","wikidata":"https://www.wikidata.org/wiki/Q14565715","display_name":"Neural facilitation","level":4,"score":0.4239594042301178},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.4170001745223999},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.416089802980423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39508676528930664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35499733686447144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35109269618988037},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30663758516311646},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2829093933105469},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.22871103882789612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12280049920082092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11724609136581421}],"mesh":[{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055585","descriptor_name":"Physical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058307","descriptor_name":"Receptors, Prostaglandin E, EP2 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1471-4159.2008.05766.x","doi":"https://doi.org/10.1111/j.1471-4159.2008.05766.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2008.05766.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:19012750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19012750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2605769","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2605769","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2605769","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2605769","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurochem","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2440397094","display_name":"Research Center for Pharmacology and Drug Toxicology","funder_award_id":"P50GM015431","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2701928386","display_name":"Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity","funder_award_id":"R01NS054886","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3964639659","display_name":"Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience","funder_award_id":"P20RR016816","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320311497","display_name":"Olympus","ror":"https://ror.org/01v0pgv63"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1505868918","https://openalex.org/W1526354182","https://openalex.org/W1529603379","https://openalex.org/W1543238801","https://openalex.org/W1557741015","https://openalex.org/W1567735918","https://openalex.org/W1574945783","https://openalex.org/W1964184107","https://openalex.org/W1967678975","https://openalex.org/W1970774262","https://openalex.org/W1977816613","https://openalex.org/W1979861588","https://openalex.org/W1988888086","https://openalex.org/W1990605920","https://openalex.org/W1990966758","https://openalex.org/W2004016651","https://openalex.org/W2007581115","https://openalex.org/W2008424322","https://openalex.org/W2018042319","https://openalex.org/W2020629791","https://openalex.org/W2035527730","https://openalex.org/W2043906255","https://openalex.org/W2049511526","https://openalex.org/W2066448413","https://openalex.org/W2067035162","https://openalex.org/W2077224272","https://openalex.org/W2081688069","https://openalex.org/W2081901335","https://openalex.org/W2082452520","https://openalex.org/W2083843309","https://openalex.org/W2091646105","https://openalex.org/W2097376951","https://openalex.org/W2121612337","https://openalex.org/W2129746956","https://openalex.org/W2137004069","https://openalex.org/W2141186235","https://openalex.org/W2148012784","https://openalex.org/W2151014103","https://openalex.org/W2158960911","https://openalex.org/W2162272827","https://openalex.org/W2165593971","https://openalex.org/W2168232713","https://openalex.org/W2168480206","https://openalex.org/W2169473035"],"related_works":["https://openalex.org/W2043839521","https://openalex.org/W2535255747","https://openalex.org/W2091646105","https://openalex.org/W2793608389","https://openalex.org/W2137004069","https://openalex.org/W2030206142","https://openalex.org/W2141186235","https://openalex.org/W1977816613","https://openalex.org/W2769740311","https://openalex.org/W2164974480"],"abstract_inverted_index":{"Our":[0,183],"laboratory":[1],"demonstrated":[2],"previously":[3],"that":[4,40,82,92,101,186,200],"PGE2-induced":[5],"modulation":[6],"of":[7,113,149,173],"hippocampal":[8,30,45,187,206],"synaptic":[9,32,122,143,166,189,208],"transmission":[10,123,144,167],"is":[11,20,27,191,203],"via":[12],"a":[13],"pre-synaptic":[14],"PGE2":[15,114],"EP2":[16,25,56,77,85,98,109,118,129,139,157,180],"receptor.":[17],"However,":[18],"little":[19],"known":[21],"about":[22],"whether":[23],"the":[24,44,55,73,136,164,197],"receptor":[26,119],"involved":[28],"in":[29,51,54,64,72,76,83,97,108,128,138,156,179,193,196],"long-term":[31,41,93,188,207],"plasticity":[33,190,209],"and":[34,61,124,159,210],"cognitive":[35,211],"function.":[36,212],"Here":[37],"we":[38],"show":[39,185],"potentiation":[42,94],"at":[43],"perforant":[46],"path":[47],"synapses":[48],"was":[49,79,95,145,168],"impaired":[50,192],"mice":[52,194],"deficient":[53,195],"(KO),":[57],"while":[58],"membrane":[59],"excitability":[60],"passive":[62],"properties":[63],"granule":[65],"neurons":[66],"were":[67],"normal.":[68],"Importantly,":[69],"escape":[70],"latency":[71],"water":[74],"maze":[75],"KO":[78,140,158],"longer":[80],"than":[81],"age-matched":[84],"wild-type":[86],"littermates":[87],"(WT).":[88],"We":[89],"also":[90],"observed":[91],"potentiated":[96],"WT":[99,130,160,181],"animals":[100],"received":[102],"lipopolysaccharide":[103],"(LPS,":[104],"i.p.),":[105],"but":[106,132],"not":[107],"KO.":[110],"Bath":[111],"application":[112,148,172],"or":[115,176],"butaprost,":[116],"an":[117,151],"agonist,":[120],"increased":[121],"decreased":[125],"paired-pulses":[126],"ratio":[127],"mice,":[131],"failed":[133],"to":[134],"induce":[135],"changes":[137],"mice.":[141],"Meanwhile,":[142],"elevated":[146],"by":[147,171],"forskolin,":[150],"adenylyl":[152],"cyclase":[153],"activator,":[154],"both":[155],"animals.":[161,182],"In":[162],"addition,":[163],"PGE2-enhanced":[165],"significantly":[169],"attenuated":[170],"PKA,":[174],"IP3":[175],"MAPK":[177],"inhibitors":[178],"results":[184],"EP2,":[198],"suggesting":[199],"PGE2-EP2":[201],"signaling":[202],"important":[204],"for":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}