{"id":"https://openalex.org/W2018400201","doi":"https://doi.org/10.1016/0014-5793(92)80053-j","title":"17O NMR and FT\u2010IR study of the ionization state of peptides in aprotic solvents Application to Leu\u2010enkephalin","display_name":"17O NMR and FT\u2010IR study of the ionization state of peptides in aprotic solvents Application to Leu\u2010enkephalin","publication_year":1992,"publication_date":"1992-02-24","ids":{"openalex":"https://openalex.org/W2018400201","doi":"https://doi.org/10.1016/0014-5793(92)80053-j","mag":"2018400201","pmid":"https://pubmed.ncbi.nlm.nih.gov/1544442"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(92)80053-j","doi":"https://doi.org/10.1016/0014-5793(92)80053-j","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)80053-j","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024503854","display_name":"Ioannis P. Gerothanassis","orcid":"https://orcid.org/0000-0002-3745-9902","observed_orcids":["https://orcid.org/0000-0002-3745-9902"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I.P. Gerothanassis","raw_affiliation_strings":["Department of Chemistry, University of Ioannina, Greece","Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111617722","display_name":"Nicolaos Birlirakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N. Birlirakis","raw_affiliation_strings":["Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069382253","display_name":"Theodoros Karayannis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"T. Karayannis","raw_affiliation_strings":["Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067511191","display_name":"Vassilios Tsikaris","orcid":"https://orcid.org/0000-0002-2847-7340","observed_orcids":["https://orcid.org/0000-0002-2847-7340"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"V. Tsikaris","raw_affiliation_strings":["Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061869135","display_name":"Maria Sakarellos\u2010Daitsiotis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M. Sakarellos-Daitsiotis","raw_affiliation_strings":["Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110025978","display_name":"C. Sakarellos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Sakarellos","raw_affiliation_strings":["Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Ioannina, PO Box 1186, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085707172","display_name":"BERNARD VITOUX","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Vitoux","raw_affiliation_strings":["Laboratory of Macromolecular Physical Chemistry, URA-CNRS-494, ENSIC-INPL, BP 451, 54001 Nancy Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Macromolecular Physical Chemistry, URA-CNRS-494, ENSIC-INPL, BP 451, 54001 Nancy Cedex, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037361600","display_name":"Michel Marraud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Marraud","raw_affiliation_strings":["Laboratory of Macromolecular Physical Chemistry, URA-CNRS-494, ENSIC-INPL, BP 451, 54001 Nancy Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Macromolecular Physical Chemistry, URA-CNRS-494, ENSIC-INPL, BP 451, 54001 Nancy Cedex, France","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"298","issue":"2-3","first_page":"188","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.19370000064373016,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.07079999893903732,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leu-enkephalin","display_name":"leu-enkephalin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/zwitterionic-state","display_name":"zwitterionic state","score":0.8659999966621399},{"id":"https://openalex.org/keywords/aprotic-solvents","display_name":"aprotic solvents","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dimethyl-sulfoxide","display_name":"dimethyl sulfoxide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.828000009059906},{"id":"https://openalex.org/keywords/17o-nmr","display_name":"17O NMR","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ftir-spectroscopy","display_name":"FTIR spectroscopy","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.871666431427002},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6632456183433533},{"id":"https://openalex.org/C2777803847","wikidata":"https://www.wikidata.org/wiki/Q325101","display_name":"Enkephalin","level":4,"score":0.5755863785743713},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5582348108291626},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.5522746443748474},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4906681776046753},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.47632747888565063},{"id":"https://openalex.org/C2777621412","wikidata":"https://www.wikidata.org/wiki/Q6533903","display_name":"Leu-enkephalin","level":5,"score":0.4709133803844452},{"id":"https://openalex.org/C163111631","wikidata":"https://www.wikidata.org/wiki/Q1952454","display_name":"Carbon-13 NMR","level":2,"score":0.4324296712875366},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.289486825466156},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.13591447472572327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06029656529426575},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004743","descriptor_name":"Enkephalin, Leucine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(92)80053-j","doi":"https://doi.org/10.1016/0014-5793(92)80053-j","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(92)80053-j","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:1544442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1544442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1507111798","https://openalex.org/W1971281008","https://openalex.org/W2020939010","https://openalex.org/W2022566356","https://openalex.org/W2027459721","https://openalex.org/W2045625096","https://openalex.org/W2046203654","https://openalex.org/W2064927965","https://openalex.org/W2072473162","https://openalex.org/W2159478621","https://openalex.org/W2494953600","https://openalex.org/W4210858769"],"related_works":["https://openalex.org/W2159478621","https://openalex.org/W2137459580","https://openalex.org/W2072473162","https://openalex.org/W2167471830","https://openalex.org/W2053056545","https://openalex.org/W1971281008","https://openalex.org/W3209599094","https://openalex.org/W1989251167","https://openalex.org/W1998483593","https://openalex.org/W1504884279"],"abstract_inverted_index":{"The":[0],"ionization":[1],"state":[2,39,57],"of":[3,17,25,49],"Leu-enkephalin":[4,33,51],"in":[5,36,40,54],"DMSO":[6],"and":[7,20],"MeCN/DMSO":[8,41],"(4/1)":[9,42],"solution":[10,28],"was":[11],"studied":[12],"by":[13],"the":[14,37,50,55,59],"combined":[15],"use":[16],"17O":[18],"NMR":[19],"FT-IR":[21],"spectroscopy.":[22],"After":[23],"lyophilization":[24],"an":[26],"aqueous":[27],"at":[29],"nearly":[30],"neutral":[31],"pH,":[32],"essentially":[34],"exists":[35],"uncharged":[38],"solution.":[43],"In":[44],"pure":[45],"DMSO,":[46],"only":[47],"40%":[48],"molecules":[52],"are":[53],"zwitterionic":[56],"under":[58],"same":[60],"conditions.":[61]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
