{"id":"https://openalex.org/W2018398159","doi":"https://doi.org/10.1179/016911106779498966","title":"Milnacipran hydrochloride for the treatment of postherpetic neuralgia","display_name":"Milnacipran hydrochloride for the treatment of postherpetic neuralgia","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W2018398159","doi":"https://doi.org/10.1179/016911106779498966","mag":"2018398159"},"language":"en","primary_location":{"id":"doi:10.1179/016911106779498966","doi":"https://doi.org/10.1179/016911106779498966","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016911106779498966","pdf_url":null,"source":{"id":"https://openalex.org/S52047856","display_name":"The Pain Clinic","issn_l":"0169-1112","issn":["0169-1112","1568-5691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pain Clinic","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088593877","display_name":"Makiko Komori","orcid":"https://orcid.org/0000-0003-0718-5725","observed_orcids":["https://orcid.org/0000-0003-0718-5725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Makiko Komori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109139659","display_name":"Akiko Fukuuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Fukuuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010602749","display_name":"Tomoko Mae","orcid":"https://orcid.org/0009-0007-3104-8233","observed_orcids":["https://orcid.org/0009-0007-3104-8233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko Mae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110665257","display_name":"Keiko Nishiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiko Nishiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111558468","display_name":"Miwako Kawamata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miwako Kawamata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028329455","display_name":"Makoto Ozaki","orcid":"https://orcid.org/0000-0001-7841-6661","observed_orcids":["https://orcid.org/0000-0001-7841-6661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Makoto Ozaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14458017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"5-6","first_page":"421","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.27149999141693115,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/milnacipran","display_name":"milnacipran","score":0.9490000009536743},{"id":"https://openalex.org/keywords/postherpetic-neuralgia","display_name":"postherpetic neuralgia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antidepressant-treatment","display_name":"antidepressant treatment","score":0.49799999594688416},{"id":"https://openalex.org/keywords/refractory-neuropathic-pain","display_name":"refractory neuropathic pain","score":0.7749999761581421},{"id":"https://openalex.org/keywords/herpes-zoster","display_name":"herpes zoster","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pain-score-reduction","display_name":"pain score reduction","score":0.5479999780654907},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2780199185","wikidata":"https://www.wikidata.org/wiki/Q421058","display_name":"Milnacipran","level":4,"score":0.9896275997161865},{"id":"https://openalex.org/C2778866549","wikidata":"https://www.wikidata.org/wiki/Q1714245","display_name":"Postherpetic neuralgia","level":3,"score":0.8926681280136108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7787714004516602},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.6661087274551392},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6591712236404419},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.48789191246032715},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4564715325832367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20392665266990662},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.14498889446258545},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1179/016911106779498966","doi":"https://doi.org/10.1179/016911106779498966","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016911106779498966","pdf_url":null,"source":{"id":"https://openalex.org/S52047856","display_name":"The Pain Clinic","issn_l":"0169-1112","issn":["0169-1112","1568-5691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pain Clinic","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1988679022","https://openalex.org/W1992782119","https://openalex.org/W1996260204","https://openalex.org/W2032865655","https://openalex.org/W2049348898","https://openalex.org/W2057621238","https://openalex.org/W2084271334","https://openalex.org/W2150883260"],"related_works":["https://openalex.org/W2071709883","https://openalex.org/W1964941904","https://openalex.org/W2150883260","https://openalex.org/W2123741978","https://openalex.org/W1993369032","https://openalex.org/W2054169483","https://openalex.org/W1991353203","https://openalex.org/W2057196714","https://openalex.org/W2151256165","https://openalex.org/W2382519720"],"abstract_inverted_index":{"We":[0,136],"studied":[1],"the":[2,50,110],"effect":[3],"of":[4,28,52,80,98,123],"milnacipran":[5,101,124,139],"hydrochloride,":[6],"a":[7,25,33],"newly":[8],"developed":[9],"serotonin-noradrenaline-reuptake-inhibitor":[10],"antidepressant":[11],"with":[12,19,100,109,144],"minimal":[13],"side":[14,132],"effects,":[15],"in":[16,142],"12":[17],"patients":[18,23,143],"postherpetic":[20,145],"neuralgia.":[21],"All":[22],"had":[24],"pain":[26,45,56],"score":[27,94],"at":[29,76],"least":[30],"40":[31],"on":[32],"visual-analogue":[34],"scale":[35],"(VAS)":[36],"ranging":[37],"from":[38],"0":[39],"(no":[40],"pain)":[41],"to":[42,60,89,148],"100":[43],"(worst":[44],"possible),":[46],"3":[47],"months":[48],"after":[49,95],"resolution":[51],"herpes":[53],"zoster.":[54],"Their":[55],"did":[57],"not":[58,65],"respond":[59],"nerve":[61],"blocks":[62],"and":[63],"could":[64],"be":[66],"adequately":[67],"controlled":[68],"by":[69],"currently":[70],"used":[71],"drugs.":[72],"Milnacipran":[73],"was":[74,85,125],"given":[75],"an":[77],"initial":[78],"dose":[79,84,122],"15":[81],"mg/day.":[82],"The":[83,91,119],"then":[86],"adjusted":[87],"according":[88],"symptoms.":[90],"mean":[92,120],"VAS":[93],"8":[96],"weeks":[97],"treatment":[99],"(28.0":[102],"\u00b1":[103,114,127],"17.5)":[104],"significantly":[105],"decreased,":[106],"as":[107],"compared":[108],"baseline":[111],"value":[112],"(68.0":[113],"16.9,":[115],"p":[116],"<":[117],"0.05).":[118],"daily":[121],"52.0":[126],"35.1":[128],"mg.":[129],"No":[130],"relevant":[131],"effects":[133],"were":[134],"observed.":[135],"conclude":[137],"that":[138],"is":[140],"useful":[141],"neuralgia":[146],"refractory":[147],"conventional":[149],"treatment.":[150]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}