{"id":"https://openalex.org/W2018396843","doi":"https://doi.org/10.1371/journal.pone.0056037","title":"Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia","display_name":"Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia","publication_year":2013,"publication_date":"2013-02-07","ids":{"openalex":"https://openalex.org/W2018396843","doi":"https://doi.org/10.1371/journal.pone.0056037","mag":"2018396843","pmid":"https://pubmed.ncbi.nlm.nih.gov/23409118","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3567006"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0056037","doi":"https://doi.org/10.1371/journal.pone.0056037","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056037","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056037&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056037&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000649115","display_name":"Wai Yee Phong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]},{"id":"https://openalex.org/I4405278259","display_name":"Life Sciences Institute","ror":"https://ror.org/05gtb7e09","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405278259"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wai Yee Phong","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Singapore, Singapore","Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Singapore, Singapore","institution_ids":["https://openalex.org/I4405253178"]},{"raw_affiliation_string":"Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100521766","display_name":"Wenwei Lin","orcid":"https://orcid.org/0009-0004-2276-7410","observed_orcids":["https://orcid.org/0009-0004-2276-7410"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405278259","display_name":"Life Sciences Institute","ror":"https://ror.org/05gtb7e09","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405278259"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Wenwei Lin","raw_affiliation_strings":["Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore","Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (SMART), CREATE NUS Campus, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259"]},{"raw_affiliation_string":"Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (SMART), CREATE NUS Campus, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055334453","display_name":"Srinivasa P. S. Rao","orcid":"https://orcid.org/0000-0002-7156-5725","observed_orcids":["https://orcid.org/0000-0002-7156-5725"]},"institutions":[{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Srinivasa P. S. Rao","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Singapore, Singapore","institution_ids":["https://openalex.org/I4405253178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068752989","display_name":"Thomas Dick","orcid":"https://orcid.org/0000-0002-9604-9452","observed_orcids":["https://orcid.org/0000-0002-9604-9452"]},"institutions":[{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Thomas Dick","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Singapore, Singapore","institution_ids":["https://openalex.org/I4405253178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037392493","display_name":"Sylvie Alonso","orcid":"https://orcid.org/0000-0001-7044-414X","observed_orcids":["https://orcid.org/0000-0001-7044-414X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405278259","display_name":"Life Sciences Institute","ror":"https://ror.org/05gtb7e09","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405278259"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":true,"raw_author_name":"Sylvie Alonso","raw_affiliation_strings":["Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore","Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (SMART), CREATE NUS Campus, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259"]},{"raw_affiliation_string":"Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (SMART), CREATE NUS Campus, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089521333","display_name":"K\u00e9vin Pethe","orcid":"https://orcid.org/0000-0003-0916-8873","observed_orcids":["https://orcid.org/0000-0003-0916-8873","https://orcid.org/0000-0003-0297-0150"]},"institutions":[{"id":"https://openalex.org/I4405253178","display_name":"Novartis Institute For Tropical Diseases","ror":"https://ror.org/00cn3vx82","country_code":"SG","type":"facility","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210124465","https://openalex.org/I4405253178"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kevin Pethe","raw_affiliation_strings":["Novartis Institute for Tropical Diseases, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institute for Tropical Diseases, Singapore, Singapore","institution_ids":["https://openalex.org/I4405253178"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5037392493"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405278259","https://openalex.org/I63966007"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.536,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94975041,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"2","first_page":"e56037","last_page":"e56037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/phosphofructokinase","display_name":"phosphofructokinase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6389999985694885},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/non-replicating-mycobacteria","display_name":"non-replicating mycobacteria","score":0.9729999899864197},{"id":"https://openalex.org/keywords/metabolic-intermediates","display_name":"metabolic intermediates","score":0.6629999876022339},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.5640000104904175},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.5049999952316284},{"id":"https://openalex.org/keywords/metabolic-versatility","display_name":"metabolic versatility","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C122245378","wikidata":"https://www.wikidata.org/wiki/Q14771739","display_name":"Phosphofructokinase","level":4,"score":0.8236465454101562},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.7962455749511719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6907787322998047},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.671855628490448},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6466327905654907},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.5912238955497742},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46155357360839844},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4493216276168823},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.44670403003692627},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.4454894959926605},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.43487048149108887},{"id":"https://openalex.org/C2777790778","wikidata":"https://www.wikidata.org/wiki/Q74566546","display_name":"Glucose 6-phosphate","level":3,"score":0.4283263385295868},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4266367554664612},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3361518383026123},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.2708115875720978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18368929624557495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005636","descriptor_name":"Fructosephosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023061","descriptor_name":"Gene Order","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025221","descriptor_name":"Phosphofructokinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025221","descriptor_name":"Phosphofructokinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0056037","doi":"https://doi.org/10.1371/journal.pone.0056037","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056037","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056037&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2570877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3567006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23409118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23409118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3567006","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3567006/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/109239","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/109239","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:20f90622311042d7ad4b1f267d59ca0f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/20f90622311042d7ad4b1f267d59ca0f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 2, p e56037 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0056037","doi":"https://doi.org/10.1371/journal.pone.0056037","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056037","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056037&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018396843.pdf","grobid_xml":"https://content.openalex.org/works/W2018396843.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1521424334","https://openalex.org/W1559223366","https://openalex.org/W1587777700","https://openalex.org/W1657643071","https://openalex.org/W1727768056","https://openalex.org/W1864461701","https://openalex.org/W1934542416","https://openalex.org/W1973789730","https://openalex.org/W1987233255","https://openalex.org/W1988456320","https://openalex.org/W1991233072","https://openalex.org/W2000497556","https://openalex.org/W2007097682","https://openalex.org/W2008402427","https://openalex.org/W2014950143","https://openalex.org/W2016587287","https://openalex.org/W2018209201","https://openalex.org/W2018292120","https://openalex.org/W2020011621","https://openalex.org/W2025243776","https://openalex.org/W2034599009","https://openalex.org/W2036965767","https://openalex.org/W2047597508","https://openalex.org/W2053867514","https://openalex.org/W2059642777","https://openalex.org/W2060259273","https://openalex.org/W2064589630","https://openalex.org/W2069000577","https://openalex.org/W2069179741","https://openalex.org/W2078290231","https://openalex.org/W2079767141","https://openalex.org/W2081992608","https://openalex.org/W2082535511","https://openalex.org/W2090707513","https://openalex.org/W2099183065","https://openalex.org/W2105722865","https://openalex.org/W2113308049","https://openalex.org/W2123084649","https://openalex.org/W2128482141","https://openalex.org/W2140354550","https://openalex.org/W2153785989","https://openalex.org/W2154292013","https://openalex.org/W2158023121","https://openalex.org/W2214648072","https://openalex.org/W2419293116"],"related_works":["https://openalex.org/W7095823121","https://openalex.org/W2090364595","https://openalex.org/W3128164384","https://openalex.org/W4400136935","https://openalex.org/W1959728062","https://openalex.org/W4411784396","https://openalex.org/W2293312435","https://openalex.org/W2106523569","https://openalex.org/W2282051678","https://openalex.org/W2054225806"],"abstract_inverted_index":{"Metabolic":[0],"versatility":[1],"has":[2,46],"been":[3,101],"increasingly":[4],"recognized":[5],"as":[6,136],"a":[7,67,91,233],"major":[8],"virulence":[9],"mechanism":[10],"that":[11,33,51,63,113,145,161,173,190,267,276],"enables":[12],"Mycobacterium":[13],"tuberculosis":[14,45,122,225],"to":[15,60,103,210,254,270],"persist":[16],"in":[17,21,40,55,77,85,107,120,156,198,232,244],"many":[18,37],"microenvironments":[19],"encountered":[20],"its":[22],"host.":[23,43],"Glucose":[24],"is":[25,34,52,88,115,130,178,217,239,286,292],"one":[26],"of":[27,70,147,159,166,176,185,192,201,214,272,280],"the":[28,41,82,116,148,152,167,174,182,199,212,245,289,295],"most":[29],"abundant":[30],"carbon":[31,71,138],"sources":[32],"exploited":[35],"by":[36,90],"pathogenic":[38],"bacteria":[39],"human":[42],"M.":[44,108,121,224],"an":[47],"intact":[48],"glycolytic":[49,149,290],"pathway":[50,150,291],"highly":[53,179],"conserved":[54],"all":[56],"clinical":[57],"isolates":[58],"sequenced":[59],"date":[61],"suggesting":[62,189],"glucose":[64,135,177,243],"may":[65],"represent":[66],"non-negligible":[68],"source":[69],"and":[72,87,98],"energy":[73],"for":[74,132,181,228,252],"this":[75,222,247],"pathogen":[76],"vivo.":[78],"Fructose-6-phosphate":[79],"phosphorylation":[80],"represents":[81],"key-committing":[83],"step":[84,154],"glycolysis":[86,268],"catalyzed":[89],"phosphofructokinase":[92],"(PFK)":[93],"activity.":[94],"Two":[95],"genes,":[96],"pfkA":[97],"pfkB":[99],"have":[100],"annotated":[102],"encode":[104],"putative":[105],"PFK":[106,118,153],"tuberculosis.":[109],"Here,":[110],"we":[111,143,171],"show":[112],"PFKA":[114,129],"sole":[117,137],"enzyme":[119],"with":[123,127,163,219],"no":[124],"functional":[125],"redundancy":[126],"PFKB.":[128],"required":[131],"growth":[133],"on":[134],"source.":[139],"In":[140,221],"co-metabolism":[141],"experiments,":[142],"report":[144],"disruption":[146],"at":[151,255,294],"results":[155],"intracellular":[157],"accumulation":[158,191,271],"sugar-phosphates":[160],"correlated":[162],"significant":[164,260],"impairment":[165],"cell":[168],"viability.":[169],"Concomitantly,":[170],"found":[172],"presence":[175],"toxic":[180,194,274,284],"long-term":[183,278],"survival":[184,279],"hypoxic":[186,215,281],"non-replicating":[187,235],"mycobacteria,":[188],"glucose-derived":[193,273],"metabolites":[195,275],"does":[196],"occur":[197],"absence":[200],"sustained":[202],"aerobic":[203],"respiration.":[204],"The":[205],"culture":[206],"medium":[207,246],"traditionally":[208],"used":[209],"study":[211,265],"physiology":[213],"mycobacteria":[216],"supplemented":[218],"glucose.":[220],"medium,":[223],"can":[226],"survive":[227],"only":[229],"7-10":[230],"days":[231,258],"true":[234],"state":[236],"before":[237],"death":[238],"observed.":[240],"By":[241],"omitting":[242],"period":[248],"could":[249],"be":[250],"extended":[251],"up":[253],"least":[256],"40":[257],"without":[259],"viability":[261],"loss.":[262],"Therefore,":[263],"our":[264],"suggests":[266],"leads":[269],"limits":[277],"mycobacteria.":[282],"Such":[283],"effect":[285],"exacerbated":[287],"when":[288],"disrupted":[293],"PKF":[296],"step.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}