{"id":"https://openalex.org/W2018395149","doi":"https://doi.org/10.1016/j.tiv.2010.06.012","title":"Hexavalent chromium inhibited the expression of RKIP of heart in vivo and in vitro","display_name":"Hexavalent chromium inhibited the expression of RKIP of heart in vivo and in vitro","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2018395149","doi":"https://doi.org/10.1016/j.tiv.2010.06.012","mag":"2018395149","pmid":"https://pubmed.ncbi.nlm.nih.gov/20600800"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2010.06.012","doi":"https://doi.org/10.1016/j.tiv.2010.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2010.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102190013","display_name":"Huoy\u2010Rou Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huoy-Rou Chang","raw_affiliation_strings":["Department of Biomedical Engineering, I-Shou University, Dashu Shiang, Kaohsiung County, Taiwan. huoy@isu.edu.tw","Department of Biomedical Engineering, I-Shou University, Dashu Shiang, Kaohsiung County, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, I-Shou University, Dashu Shiang, Kaohsiung County, Taiwan. huoy@isu.edu.tw","institution_ids":["https://openalex.org/I98298690"]},{"raw_affiliation_string":"Department of Biomedical Engineering, I-Shou University, Dashu Shiang, Kaohsiung County, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089361057","display_name":"Der\u2010An Tsao","orcid":"https://orcid.org/0009-0004-5407-6681","observed_orcids":["https://orcid.org/0009-0004-5407-6681"]},"institutions":[{"id":"https://openalex.org/I64045040","display_name":"Fooyin University","ror":"https://ror.org/03pfmgq50","country_code":"TW","type":"education","lineage":["https://openalex.org/I64045040"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Der-An Tsao","raw_affiliation_strings":["Department Medical Technology, Fooyin University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Medical Technology, Fooyin University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I64045040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087473188","display_name":"Wei\u2010Chang Tseng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Chang Tseng","raw_affiliation_strings":["Department of Biomedical Engineering, I\u2010Shou University, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, I\u2010Shou University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.2162,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.52603464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"25","issue":"1","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexavalent-chromium","display_name":"hexavalent chromium","score":1.0},{"id":"https://openalex.org/keywords/rkip","display_name":"RKIP","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myocardial-cells","display_name":"myocardial cells","score":0.5879999995231628},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/sodium-dichromate","display_name":"sodium dichromate","score":0.7409999966621399},{"id":"https://openalex.org/keywords/chronic-dietary-exposure","display_name":"chronic dietary exposure","score":0.5170000195503235},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9800000190734863},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.40400001406669617},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.700729250907898},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.652077853679657},{"id":"https://openalex.org/C511782168","wikidata":"https://www.wikidata.org/wiki/Q725","display_name":"Chromium","level":2,"score":0.5923117399215698},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.58748459815979},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5285103917121887},{"id":"https://openalex.org/C2781468121","wikidata":"https://www.wikidata.org/wiki/Q2660666","display_name":"Hexavalent chromium","level":3,"score":0.5146385431289673},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4919883906841278},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.45239630341529846},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43650758266448975},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4283144474029541},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42367273569107056},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4171525239944458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.274253785610199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22858890891075134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06944099068641663},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002840","descriptor_name":"Chromates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002840","descriptor_name":"Chromates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002840","descriptor_name":"Chromates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002857","descriptor_name":"Chromium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017608","descriptor_name":"Chromium Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017608","descriptor_name":"Chromium Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017608","descriptor_name":"Chromium Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tiv.2010.06.012","doi":"https://doi.org/10.1016/j.tiv.2010.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2010.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:20600800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20600800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1487628315","https://openalex.org/W1512720088","https://openalex.org/W1964630467","https://openalex.org/W1965776519","https://openalex.org/W1968983767","https://openalex.org/W1975403276","https://openalex.org/W1976384077","https://openalex.org/W1979008438","https://openalex.org/W1983442034","https://openalex.org/W1998400602","https://openalex.org/W2001793865","https://openalex.org/W2003366520","https://openalex.org/W2005644335","https://openalex.org/W2009579027","https://openalex.org/W2012848818","https://openalex.org/W2012976406","https://openalex.org/W2023743690","https://openalex.org/W2031012234","https://openalex.org/W2037975163","https://openalex.org/W2045374242","https://openalex.org/W2047909039","https://openalex.org/W2058068665","https://openalex.org/W2075746960","https://openalex.org/W2083028740","https://openalex.org/W2089185822","https://openalex.org/W2092516111","https://openalex.org/W2105905118","https://openalex.org/W2107990933","https://openalex.org/W2126344279","https://openalex.org/W2130546974","https://openalex.org/W2136627244","https://openalex.org/W2142242441","https://openalex.org/W2142900283","https://openalex.org/W4211087176","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2255391679","https://openalex.org/W3092237957","https://openalex.org/W1604339619","https://openalex.org/W6888933628","https://openalex.org/W2941324044","https://openalex.org/W2969482230","https://openalex.org/W4296923897","https://openalex.org/W3156516591","https://openalex.org/W3091808904","https://openalex.org/W3031472574"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}