{"id":"https://openalex.org/W2018393380","doi":"https://doi.org/10.1002/jbt.20419","title":"Subchronic microcystin\u2010lr exposure increased hepatic apoptosis and induced compensatory mechanisms in mice","display_name":"Subchronic microcystin\u2010lr exposure increased hepatic apoptosis and induced compensatory mechanisms in mice","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2018393380","doi":"https://doi.org/10.1002/jbt.20419","mag":"2018393380","pmid":"https://pubmed.ncbi.nlm.nih.gov/22447675"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.20419","doi":"https://doi.org/10.1002/jbt.20419","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.20419","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008105762","display_name":"Noelia Lezcano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Noelia Lezcano","raw_affiliation_strings":["Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113776068","display_name":"Daniela Sed\u00e1n","orcid":"https://orcid.org/0009-0007-7666-0370","observed_orcids":["https://orcid.org/0009-0007-7666-0370"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210157909","display_name":"Centro de Investigaci\u00f3n y Desarrollo en Criotecnolog\u00eda de Alimentos","ror":"https://ror.org/04v30e006","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210157909","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Daniela Sed\u00e1n","raw_affiliation_strings":["Laboratorio de Toxicologi\u0301a General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","Laboratorio de Toxicolog\u00eda General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Toxicologi\u0301a General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157909","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Laboratorio de Toxicolog\u00eda General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157909","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003620024","display_name":"Ignacio Lucotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ignacio Lucotti","raw_affiliation_strings":["Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias Me\u0301dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","Centro de Investigaciones Cardiovasculares, CCT\u2010La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias Me\u0301dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT\u2010La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036411287","display_name":"Leda Giannuzzi","orcid":"https://orcid.org/0000-0001-8525-4349","observed_orcids":["https://orcid.org/0000-0001-8525-4349"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210157909","display_name":"Centro de Investigaci\u00f3n y Desarrollo en Criotecnolog\u00eda de Alimentos","ror":"https://ror.org/04v30e006","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210157909","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Leda Giannuzzi","raw_affiliation_strings":["Laboratorio de Toxicologi\u0301a General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","Laboratorio de Toxicolog\u00eda General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Toxicologi\u0301a General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157909","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Laboratorio de Toxicolog\u00eda General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157909","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031841716","display_name":"Leticia Vittone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Leticia Vittone","raw_affiliation_strings":["Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias Me\u0301dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","Centro de Investigaciones Cardiovasculares, CCT\u2010La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias Me\u0301dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT\u2010La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041980375","display_name":"Dar\u0131\u0301o Andrinolo","orcid":"https://orcid.org/0000-0001-6593-5294","observed_orcids":["https://orcid.org/0000-0001-6593-5294"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210157909","display_name":"Centro de Investigaci\u00f3n y Desarrollo en Criotecnolog\u00eda de Alimentos","ror":"https://ror.org/04v30e006","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210157909","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Dar\u00edo Andrinolo","raw_affiliation_strings":["Laboratorio de Toxicologi\u0301a General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","Laboratorio de Toxicolog\u00eda General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Toxicologi\u0301a General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157909","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Laboratorio de Toxicolog\u00eda General, CIDCA-CCT-La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157909","https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072492556","display_name":"Cecilia Mundi\u00f1a\u2010Weilenmann","orcid":"https://orcid.org/0009-0004-6374-8494","observed_orcids":["https://orcid.org/0009-0004-6374-8494"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Cecilia Mundi\u00f1a\u2010Weilenmann","raw_affiliation_strings":["Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias Me\u0301dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","Centro de Investigaciones Cardiovasculares, CCT\u2010La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT-La Plata CONICET, Facultad de Ciencias Me\u0301dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Centro de Investigaciones Cardiovasculares, CCT\u2010La Plata CONICET, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, 1900 La Plata. Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072492556"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210152408","https://openalex.org/I874386039"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":1.5301,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.78403098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"4","first_page":"131","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcystin-lr","display_name":"microcystin-LR","score":1.0},{"id":"https://openalex.org/keywords/subchronic-exposure","display_name":"subchronic exposure","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hepatic-apoptosis","display_name":"hepatic apoptosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7319999933242798},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7760000228881836},{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha-tubulin","display_name":"alpha-tubulin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cytoskeleton-disruption","display_name":"cytoskeleton disruption","score":0.9700000286102295},{"id":"https://openalex.org/keywords/compensatory-mechanisms","display_name":"compensatory mechanisms","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cyanotoxins","display_name":"cyanotoxins","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.731815755367279},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7267154455184937},{"id":"https://openalex.org/C2780299475","wikidata":"https://www.wikidata.org/wiki/Q6839436","display_name":"Microcystin-LR","level":4,"score":0.6592731475830078},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.658973217010498},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5994491577148438},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5904911756515503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4968445599079132},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4856368601322174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4839901924133301},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.4563560485839844},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4452199935913086},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3869308531284332},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3621479868888855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34783321619033813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21636447310447693},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.16136488318443298},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15256819128990173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13776564598083496},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052998","descriptor_name":"Microcystins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D052998","descriptor_name":"Microcystins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D052998","descriptor_name":"Microcystins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.20419","doi":"https://doi.org/10.1002/jbt.20419","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.20419","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:22447675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22447675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1602148084","https://openalex.org/W1968964136","https://openalex.org/W1973210866","https://openalex.org/W1977532369","https://openalex.org/W1977712275","https://openalex.org/W1987623343","https://openalex.org/W1990491339","https://openalex.org/W2000810227","https://openalex.org/W2004256319","https://openalex.org/W2007648109","https://openalex.org/W2013752282","https://openalex.org/W2015799627","https://openalex.org/W2024413216","https://openalex.org/W2025198517","https://openalex.org/W2032903606","https://openalex.org/W2033844584","https://openalex.org/W2054334092","https://openalex.org/W2056074767","https://openalex.org/W2062289724","https://openalex.org/W2064248967","https://openalex.org/W2066584829","https://openalex.org/W2067620677","https://openalex.org/W2080089609","https://openalex.org/W2081284668","https://openalex.org/W2086429432","https://openalex.org/W2091583229","https://openalex.org/W2096863173","https://openalex.org/W2097092816","https://openalex.org/W2100984403","https://openalex.org/W2102089093","https://openalex.org/W2113586978","https://openalex.org/W2116168733","https://openalex.org/W2129912039","https://openalex.org/W2131487223","https://openalex.org/W2140810361","https://openalex.org/W2156801294","https://openalex.org/W2169474553","https://openalex.org/W2187704760","https://openalex.org/W2397091071","https://openalex.org/W2413562571","https://openalex.org/W4388277315"],"related_works":["https://openalex.org/W2025447517","https://openalex.org/W7097410202","https://openalex.org/W2581103504","https://openalex.org/W2552876474","https://openalex.org/W1599713647","https://openalex.org/W2161269223","https://openalex.org/W1977271463","https://openalex.org/W1979860922","https://openalex.org/W2102089093","https://openalex.org/W2021336850"],"abstract_inverted_index":{"Acute":[0],"lethal":[1],"cytotoxicity":[2],"of":[3,37,73,85,89,101,149,161,166],"microcystin-LR":[4],"(MC-LR),":[5],"a":[6],"toxin":[7],"produced":[8],"by":[9],"fresh-water":[10],"cyanobacteria,":[11],"has":[12],"been":[13],"attributed":[14],"to":[15,114,144,169],"protein":[16],"phosphatases":[17],"type":[18,21],"1":[19],"and":[20,25,34,67,87,91,97,140,164],"2A":[22],"(PP1/PP2A)":[23],"inhibition":[24],"reactive":[26],"oxygen":[27],"species":[28],"(ROS)":[29],"generation.":[30],"However,":[31],"the":[32,102,133,145],"effects":[33,148,154],"molecular":[35],"mechanisms":[36,168],"prolonged,":[38],"sublethal":[39],"MC-LR":[40,62,151],"exposure":[41],"are":[42],"less":[43],"known.":[44],"We":[45],"studied":[46],"mice":[47],"intraperitonealy":[48],"injected":[49],"with":[50,158],"saline":[51],"or":[52,71],"25":[53],"\u03bcg":[54],"MC-LR/kg":[55],"for":[56],"28":[57],"days":[58],"(every":[59],"2":[60],"days).":[61],"induced":[63],"apoptosis":[64,139],"in":[65,69,124,156],"liver":[66],"not":[68],"kidneys":[70],"heart":[72],"treated":[74],"animals.":[75],"Liver":[76],"also":[77],"showed":[78],"decreased":[79,108],"\u03b1-tubulin":[80],"levels":[81],"(45.56%":[82],"\u00b1":[83,95,99,111,116],"7.65%":[84],"controls)":[86],"activation":[88,160],"p38-MAPK":[90],"CaMKII":[92],"pathways":[93],"(137.93%":[94],"11.64%":[96],"419.35%":[98],"67.83%":[100],"control":[103],"group,":[104],"respectively).":[105],"PP1/PP2A":[106],"activity":[107,128],"from":[109],"1.82":[110],"0.23":[112],"(controls)":[113],"0.91":[115],"0.98":[117],"mU/mg":[118],"(MC-LR-treated":[119],"mice);":[120],"however,":[121],"no":[122],"difference":[123],"total":[125,171],"Ser/Thr":[126,172],"phosphatase":[127,173],"was":[129],"found":[130],"between":[131],"both":[132],"groups.":[134],"The":[135],"results":[136],"demonstrated":[137],"that":[138],"cytoskeleton":[141],"disruption":[142],"contributed":[143],"hepatic":[146],"cytotoxic":[147],"subchronic":[150],"administration.":[152],"These":[153],"occurred":[155],"association":[157],"sustained":[159],"signaling":[162],"cascades":[163],"development":[165],"compensatory":[167],"maintain":[170],"activity.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
