{"id":"https://openalex.org/W2018392694","doi":"https://doi.org/10.1158/1538-7445.am2012-1337","title":"Abstract 1337: Novel model of pancreatic cancer induced by smoking compound NNK","display_name":"Abstract 1337: Novel model of pancreatic cancer induced by smoking compound NNK","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2018392694","doi":"https://doi.org/10.1158/1538-7445.am2012-1337","mag":"2018392694"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-1337","doi":"https://doi.org/10.1158/1538-7445.am2012-1337","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1337","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027819516","display_name":"Chang\u2010Hwan Park","orcid":"https://orcid.org/0000-0002-2995-8779","observed_orcids":["https://orcid.org/0000-0002-2995-8779"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChangHwan Park","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082074815","display_name":"In Soek Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"In Soek Lee","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074664857","display_name":"Claudia J. Nitsche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Nitsche","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058247283","display_name":"Andreas Gerloff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas Gerloff","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109180275","display_name":"Vay Liang W. Go","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vay Liang W. Go","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017375931","display_name":"Paul J. Grippo","orcid":"https://orcid.org/0000-0002-6374-1282","observed_orcids":["https://orcid.org/0000-0002-6374-1282"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Grippo","raw_affiliation_strings":["2Feinberg School of Medicine, Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Feinberg School of Medicine, Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053893604","display_name":"Stephen Jacob Pandol","orcid":"https://orcid.org/0000-0003-0818-6017","observed_orcids":["https://orcid.org/0000-0003-0818-6017"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Pandol","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018920137","display_name":"Anna S. Gukovskaya","orcid":"https://orcid.org/0000-0003-3737-5335","observed_orcids":["https://orcid.org/0000-0003-3737-5335"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna S. Gukovskaya","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063303902","display_name":"Mouad Edderkaoui","orcid":"https://orcid.org/0000-0002-2549-8242","observed_orcids":["https://orcid.org/0000-0002-2549-8242"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mouad Edderkaoui","raw_affiliation_strings":["1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA & VA Greater Los Angeles Healthcare System, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"1337","last_page":"1337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nnk","display_name":"NNK","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.8330000042915344},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.5249999761581421},{"id":"https://openalex.org/keywords/cigarette-smoke-extract","display_name":"cigarette smoke extract","score":0.8130000233650208},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pancreatic-fibrosis","display_name":"pancreatic fibrosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/stellate-cells","display_name":"stellate cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/ductal-adenocarcinoma","display_name":"ductal adenocarcinoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pancreatic-ductal-cells","display_name":"pancreatic ductal cells","score":0.6729999780654907},{"id":"https://openalex.org/keywords/carcinogenesis-models","display_name":"carcinogenesis models","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.6079999804496765},{"id":"https://openalex.org/keywords/akt-inhibition","display_name":"AKT inhibition","score":0.6299999952316284},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.3499999940395355},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.35199999809265137},{"id":"https://openalex.org/keywords/smoking-as-risk-factor","display_name":"smoking as risk factor","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8063284754753113},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7263435125350952},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.539709210395813},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5290754437446594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5167690515518188},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5029386878013611},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5001115798950195},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46654725074768066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33890825510025024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24008283019065857},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07185420393943787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-1337","doi":"https://doi.org/10.1158/1538-7445.am2012-1337","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1337","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8899999856948853,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058520388","https://openalex.org/W2064419778","https://openalex.org/W4200365660","https://openalex.org/W1964724801","https://openalex.org/W2045344024","https://openalex.org/W2002571658","https://openalex.org/W2100559817","https://openalex.org/W4409942821","https://openalex.org/W2777044935","https://openalex.org/W2574524493"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"&":[2],"Aims:":[3],"Cigarette":[4],"smoking":[5,21,44,69,339,359,387],"is":[6,403],"a":[7,100,261,347,404],"major":[8],"risk":[9],"factor":[10],"for":[11,102,144,429],"pancreatic":[12,23,31,84,113,173,198,210,218,256,269,356,383,409],"cancer.":[13],"However,":[14],"the":[15,40,63,150,195,209,213,232,245,250,283,338,353,378,394,399,421,426],"molecular":[16,332],"signaling":[17],"mechanisms":[18],"through":[19,365],"which":[20,56],"promotes":[22],"cancer":[24,32,50,229,357,372,384,410],"remain":[25],"unknown.":[26],"Experimental":[27],"models":[28],"of":[29,42,65,112,120,154,197,208,217,234,247,255,267,314,334,350,355,367,382,396,398,407,420,425],"smoking-induced":[30,408],"have":[33,57],"not":[34],"been":[35],"developed.":[36],"Here":[37],"we":[38],"studied":[39],"effect":[41,64,284,341],"cigarette":[43,68],"compound:":[45],"nitrosamine":[46],"4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone":[47],"(NNK)":[48],"on":[49,72,342],"progression":[51,207,248,354,373,397],"in":[52,77,80,82,130,149,168,171,201,263,276,325,328,352,374],"Elastase-Kras":[53],"(EL-Kras)":[54],"mice,":[55],"mutated/activated":[58],"Kras.":[59],"We":[60],"further":[61],"determined":[62],"NNK":[66,97,155,189,205,271,290,301,307,318],"and":[67,79,90,123,170,185,222,225,237,265,274,294,298,312,319,327,331,344,388],"extract":[70],"(CSE)":[71],"cell":[73],"death":[74],"pathways":[75],"both":[76,235,324],"vivo":[78,326],"vitro":[81],"human":[83,138,315],"ductal":[85,139,238,251,316],"cells.":[86,270,317],"Methods:":[87],"Wild":[88],"type":[89,280],"EL-Kras":[91,202,375],"transgenic":[92],"mice":[93,172,281,376],"were":[94,106,125,142],"injected":[95],"with":[96,182,186,220,260],"(100mg/Kg)":[98],"once":[99],"week":[101,109,148],"4":[103],"weeks.":[104],"Mice":[105],"sacrificed":[107],"one":[108],"later.":[110],"Analysis":[111],"lesions,":[114],"adenocarcinoma,":[115],"as":[116,118],"well":[117],"measurement":[119],"fibrosis,":[121],"inflammation,":[122],"proliferation":[124],"performed":[126],"by":[127,134,163,177,358,386],"immunohistochemistry.":[128],"Apoptosis":[129,160],"tissue":[131,174],"was":[132,161,175,258,285],"assessed":[133,162,176],"TUNEL":[135],"assay.":[136],"Immortalized":[137],"cells":[140,169,230,239,242,296],"HPDE6":[141],"cultured":[143],"up":[145],"to":[146,212,249,306,392],"1":[147],"presence":[151],"or":[152,157,308],"absence":[153],"(1nM-1\u00b5M)":[156],"CSE":[158,309,320],"(4ng/ml-4\u00b5g/ml).":[159],"measuring":[164,178],"DNA":[165],"fragmentation.":[166],"Autophagy":[167],"autophagic":[179],"marker":[180],"LC3-II":[181],"western":[183],"blot":[184],"immunofluorescence.":[187],"Results:":[188],"injections":[190],"significantly":[191],"increased":[192,321],"(8":[193],"times)":[194],"number":[196],"neoplastic":[199],"lesions":[200,211],"mice.":[203],"Importantly,":[204,289],"induced":[206,385],"adenocarcinoma":[214,252,257],"stage.":[215],"Staining":[216],"tumors":[219],"amylase":[221],"cytokeratines":[223],"7":[224],"9":[226],"showed":[227],"that":[228,241],"present":[231],"phenotype":[233],"acinar":[236],"indicating":[240,346],"are":[243],"at":[244],"stage":[246],"phenotype.":[253],"Stimulation":[254],"associated":[259],"decrease":[262],"autophagy":[264,273,313,364],"apoptosis":[266,275,311,343],"exocrine":[268],"inhibited":[272,310,363],"pancreas":[277],"from":[278],"wild":[279],"but":[282],"much":[286],"less":[287],"pronounced.":[288],"injection":[291],"stimulated":[292,302],"fibrosis":[293],"stellate":[295],"recruitment":[297],"activation.":[299],"Furthermore,":[300],"inflammation.":[303],"Similarly,":[304],"exposure":[305],"Akt":[322,335,351,362,401],"phosphorylation":[323],"vitro.":[329],"Pharmacological":[330],"inhibition":[333],"kinase":[336,402],"reversed":[337],"inhibitory":[340],"autophagy,":[345],"central":[348],"role":[349],"compounds.":[360],"Further,":[361],"regulation":[366],"AMPK":[368],"phosphorylation.":[369],"Conclusion:":[370],"NNK-induced":[371],"represents":[377],"first":[379],"mouse":[380],"model":[381],"can":[389],"be":[390],"utilized":[391],"understand":[393],"mechanism":[395],"disease.":[400],"key":[405],"mediator":[406],"progression.":[411],"Citation":[412],"Format:":[413],"{Authors}.":[414],"{Abstract":[415],"title}":[416],"[abstract].":[417],"In:":[418],"Proceedings":[419],"103rd":[422],"Annual":[423],"Meeting":[424],"American":[427],"Association":[428],"Cancer":[430,441],"Research;":[431],"2012":[432],"Mar":[433],"31-Apr":[434],"4;":[435],"Chicago,":[436],"IL.":[437],"Philadelphia":[438],"(PA):":[439],"AACR;":[440],"Res":[442],"2012;72(8":[443],"Suppl):Abstract":[444],"nr":[445],"1337.":[446],"doi:1538-7445.AM2012-1337":[447]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
